Understanding Anesthesiology - The Global Regional Anesthesia ...

Non-depolarizing muscle relaxants
The non-depolarizing muscle relaxants (NDMR) are those which achieve muscle relaxation
through competitive-inhibition of the acetylcholine receptor at the neuromuscular junction.
Unlike the depolarizing muscle relaxants (such as succinylcholine), the non-depolarizers do
not cause a contraction of the muscle prior to achieving relaxation. Examples include rocuronium,
cis-atracrurium, pancuronium and atracurium.
The use of NDMR must be monitored carefully using a peripheral nerve stimulator, to avoid
excessive paralysis and inadequate return of strength at the end of the procedure, so-called
“residual block”. The effect of NDMR is antagonized using anticholinesterase agents.
Related Glossary Terms
Acetylcholine, Anticholinesterase, Atracurium, Awareness, Cholinesterase, Cis-Atracurium,
Competitive inhibitor, Extubation, Four A’s of anesthesia, Laudanosine, Myasthenia gravis,
Neostigmine, Neuromuscular junction, Nicotinic, Pancuronium, Peripheral nerve stimulator,
Residual block, Rocuronium
Index
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Chapter 3 - General Anesthesia
Chapter 3 - General Anesthesia
Chapter 3 - General Anesthesia
Chapter 6 - Muscle Relaxants
Chapter 6 - Muscle Relaxants
Chapter 6 - Muscle Relaxants
Chapter 6 - Muscle Relaxants