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Understanding Anesthesiology - The Global Regional Anesthesia ...

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Myoglobinuria<br />

When pathological muscle injury or breakdown occurs, myoglobin is released into the bloodstream<br />

and can be filtered by the kidney, causing acute tubular necrosis and acute renal failure.<br />

Some causes of myoglobinuria are malignant hyperthermia, compartment syndrome, limb<br />

ischemia and traumatic crush injury.<br />

Myoglobinuria is treated by addressing the underlying cause, where possible. Volume resuscitation<br />

is key. Alkalization of the urine (by the administration of an intravenous bicarbonate<br />

infusion) is also used.<br />

Related Glossary Terms<br />

Dantrolene, Malignant hyperthermia, Ryanodine<br />

Index<br />

Find Term<br />

Chapter 5 - Malignant Hyperthermia

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