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Understanding Anesthesiology - The Global Regional Anesthesia ...

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Competitive inhibitor<br />

Competitive inhibition occurs when the inhibitor (e.g. drug) binds to an active site (the receptor)<br />

thus preventing the binding of the physiologic molecule that would normally attach<br />

there to exert its effect. Non-depolarizing muscle relaxants act by competitive inhibition at<br />

the nicotinic acetylcholine receptor.<br />

By contrast, non-competitive inhibition occurs when a drug acts by reducing the activity of<br />

an enzyme (for example) and exerts this effect whether the enzyme is attached to its substrate<br />

or not. <strong>The</strong> inhibitor, in this case, is not competing for receptor sites.<br />

Related Glossary Terms<br />

Acetylcholine, Neuromuscular junction, Nicotinic, Non-depolarizing muscle relaxants<br />

Index<br />

Find Term<br />

Chapter 3 - General <strong>Anesthesia</strong><br />

Chapter 6 - Muscle Relaxants<br />

Chapter 6 - Muscle Relaxants<br />

Chapter 6 - Muscle Relaxants<br />

Chapter 6 - Muscle Relaxants<br />

Chapter 6 - Miscellaneous

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