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Understanding Anesthesiology - The Global Regional Anesthesia ...

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DANTROLENE<br />

Dantrolene is used in the treatment of malignant hyperthermia.<br />

It is the only specific and direct treatment of<br />

malignant hyperthermia. It is also used in the treatment<br />

of neuroleptic malignant syndrome.<br />

It is a direct skeletal muscle relaxant which acts at the<br />

muscle cellular level, possibly at the ryanodine receptor..<br />

It is administered intravenously in 2.5 mg/kg<br />

doses until clinical signs show reversal of the hypermetabolic<br />

state (usual total dose

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