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Emerging cytokines and cytokine signalling molecules as ...

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Kin<strong>as</strong>e Inhibitors<br />

• Protein kin<strong>as</strong>es (= phosphotransfer<strong>as</strong>es) are<br />

components of signaling pathways<br />

• Several Janus kin<strong>as</strong>e inhibitors are being<br />

tested in clinical trials for autoimmune<br />

dise<strong>as</strong>es<br />

• Jak family consits of 4 members: Jak1, Jak2,<br />

Jak3 <strong>and</strong> Tyk2

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