Final Programme - The British Society for Rheumatology

Welcome to Glasgow . . .
Final Programme
BSR and BHPR
Annual Meetings 2009
and 25 th Anniversary Celebrations
28 April - 01 May 2009
SECC, Glasgow
www.bsrconference.org.uk
Programme production kindly supported by: Chugai/Roche

Acknowledgements
The British Society for Rheumatology would like to thank the following
companies for their contribution to the success of Rheumatology ’09,
in particular for support in the areas listed below:
Abbott for their support of the BSR Innovation in Rheumatology Awards.
Pfizer for their support of the BSR Medical Student Bursaries and sponsorship
of the speaker preview room.
Chugai Roche for supporting the production of the event announcements and the
final programme as well as their sponsorship of the signage.
Schering Plough for their support of the BSR Young Investigator Awards as well as
their sponsorship of delegate registration and the pocket programme.
Merck, Sharpe and Dohme for providing notepads and pens for the delegate bags.
Wyeth for their sponsorship of the delegate bags.
Abbott, Chugai Roche, Schering Plough, UCB and Wyeth for supporting the
provision of educational satellite symposia for delegates.
We would also like to thank our exhibitors for their attendance at Rheumatology ’09.
The exhibition adds an exciting and interactive element to the conference and is much
valued by delegates and so we thank all our exhibitors for their continued support.
BSR, Bride House, 18-20 Bride Lane, London EC4Y 8EE
Telephone: +44 (0) 20 7842 0900 Fax: +44 (0) 20 7842 0901
Email: conferences@rheumatology.org.uk
Website: www.rheumatology.org.uk www.bsrconference.org.uk
A Company limited by guarantee with charitable status VAT No. 404 5637 66
Company Reg. No. 3470316 Charity Reg. No. 1067124
BSR Final Programme has been printed on: 9lives uncoated 100% recycled

Contents
General Information 2
BSR Prizes and Awards 4
Venue Layout Diagram 5
Meeting at a glance 7
Registration and Exhibition Opening Hours 10
BSR Annual Meeting | 28 April - 01 May 2009
Scientific Programme Tuesday 11
Scientific Programme Wednesday 21
Scientific Programme Thursday 27
Scientific Programme Friday 41
Poster Viewing One Wednesday 47
Poster Viewing Two Thursday 67
Poster Viewing Three Friday 89
Exhibition Floor Plan 109
Exhibitors Details 110
Abstract Reviewers 116
1

General Information for Delegates:
Welcome to Glasgow and thank you for attending Rheumatology ’09. We hope the conference proves
to be an exciting and worthwhile experience for all attendees.
Delegate Code of Conduct
We strive to ensure that our event is a positive
experience for all and ask that delegates abide by
the following code of conduct:
• The BSR cannot guarantee capacity in any
particular session. Although we will do our best
to avoid disappointment, there may be occasions
when a room is full. Legally we are not allowed
to let you into a room in this circumstance and
neither BSR nor venue staff will tolerate verbal
abuse.
• Badges must be worn, in plain sight, at all times.
If your badge is lost, immediately report to the
registration desk for a replacement.
• Delegates are responsible for all their property.
Neither the BSR nor the venue accepts liability
for loss of or damage to personal items.
• Bags and packages must be in your possession at
all times. The safety and security of delegates is
paramount and unattended items may cause
security alerts.
The BSR reserves the right to remove any persons
from the event if they are deemed to be acting
inappropriately. No refund will be due in this instance.
Name Badges
Your name badge permits you access to all scientific
sessions on the days for which you have registered.
Exceptions apply only where previously specified
(i.e. Primary Care Workshops) or where the session
room has reached its capacity. You are also permitted
access to the Exhibition Hall during open hours.
The electronic badging system has been put in place
for your safety and to ensure spaces in sessions are
only taken by people who are entitled to be there.
It is essential that you visibly display your badge at all
times as BSR personnel will not allow persons without
badges to access sessions or exhibition areas.
Event personnel will be stationed around the venue to
scan your badge periodically. We do this for the dual
purpose of maintaining security and to record your
presence at the conference to adhere to our CPD
responsibilities. We do not track which sessions you
attend nor give this information to any third parties.
To ensure that you presence at the conference is
recorded for CPD, please make sure your badge is
scanned for each day of the conference that you
attend.
Important Fire Safety Information
Seating capacity in all sessions is set according to
Fire Safety regulations and cannot be exceeded.
Standing in the aisles or against walls is not
permitted in any circumstances and will result in
you being asked to leave the session room.
To assist in the smooth and prompt running of all
sessions we ask that delegates do the following:
• Seat yourself as far forward as possible and start
seating in the centre of the row.
• Fill all seats from the centre, ensuring that spare
seats are on the outside of rows and therefore
obvious and easy to access for late comers.
• If you are not permitted entry to a full session,
please step back from the door and form a queue.
You will only be admitted entry if others leave.
Abstract Supplement
As usual, all accepted abstracts have been published
as a supplement the journal Rheumatology.
A complimentary copy of this supplement has been
provided for all delegates on arrival at the event, and
will already be in your delegate pack given to you at
the registration desk. Subscribers to the journal will
also be able to access this in advance of the
meeting, at http://rheumatology.oxfordjournals.org.
2

Catering
Your registration fee for the conference includes lunch,
tea and coffee for each day that you are registered.
All catering will be served within the main exhibition in
Hall 5. Please refer to the “Meeting at a Glance”
section for timings.
CPD
We have been informed by the CPD office of the Royal
College of Physicians that we are limited to 6 credits
per day. Therefore, the annual meeting will earn you
the following:
Tuesday 28 April 2009 6
Wednesday 29 April 2009 6
Thursday 30 April 2009 6
Friday 01 May 2009 6
A certificate of attendance is included in your
delegate bag.
Speaker Preview
Check-in is expected of all speakers
The speaker preview room is located in the Gala Room
of the Clyde Building. Please check-in to the speaker
preview room to upload and check your presentation
on arrival at the SECC and no later than two hours
prior to your session start time.
Disclaimer
Please note that the BSR accepts no responsibility
for views expressed by speakers at the event.
Accommodation Agents Contact Details
If you have booked through our appointed
accommodation agents, Virtuoso, you can
contact them with queries directly on:
Tel: 00 44 (0) 845 310 3333
Fax: 00 44 (0) 1462 437 876
Email: hotels@virtuosoltd.com
Prayer space
A quiet, non-denominational room will be available to
anyone requiring space and privacy for prayer during
the meeting. This is located in the Katrine Room, in
the Seminar Suite.
Under 16s
Unfortunately it is not permissible for children under
the age of 16 to have access to the meeting because
we do not have sufficient liability insurance to cover a
minor should it be required.
No Smoking
The SECC is a non smoking venue.
First Aid
Trained first-aiders will be on duty throughout the
conference opening hours; please contact one of the
organisers or the SECC staff. The First Aid Suite is
situated at the east end of the SECC concourse and
staffed by qualified first aid staff.
Business Centre
BSR Annual Meeting | 28 April - 01 May 2009
On-site Contacts
If you have a query on-site regarding Rheumatology
’09, please contact a member of the organising
secretariat via the registration desk.
Louis Bellintani – BSR Events Officer
Stephanie Tame – BSR Senior Events Officer
Hannah Gardner – BSR Senior Events Officer
James Glavin – BSR Head of Education,
Events and Journal
Local Information
If your query relates to the SECC or the local area,
please visit the SECC Information Desk, located at
the east end of the main concourse at entrance 5A
of the exhibition hall (Hall 5)
3
The SECC provide complimentary wireless internet
access to all delegates. Please ask at the registration
desk for the code.
Fax, photocopying and other business services are
available via the SECC Business Centre / Information
Desk. This unit is located on the concourse along
from the east entrance to the SECC.
Charges will apply.
Presentation Relay Room
In instances where rooms become overcapacity we
have set up a presentation relay room in the Gala
Room of the Clyde building. Should you be prevented
from entering a session room please check with SECC
or BSR staff if the session is being simultaneously
streamed into this room.

BSR Prizes and Awards
Prize Giving Ceremony
The Prize Giving ceremony will be held on
Wednesday 29 April 16.00 - 16.30,
in the Clyde Auditorium.
Innovation in Rheumatology Awards
supported by Abbott Laboratories
A representative from Abbott will be present.
Innovation in Practice (Category 1)
Dr Clive Kelly
Title: How to reduce and mortality from chest infections
in patients with rheumatoid arthritis
Innovation in Development (Category 2)
Dr Fraser Birrell
Title: Inflammatory arthritis group clinics: a feasible
model for an annual clinic
Dr Edward Vital (210)
Title: How to manage non-response to rituximab?
Predictors and outcome of retreatment provide a
treatment algorithm
Ms Natalia Wegner (OP4)
Title: Endogenously citrullinated proteins from
Porphyromonas gingivalis as a candidate source of
priming autoantigens in rheumatoid arthritis
Michael Mason Prize
Dr Karim Raza
Title: Early rheumatoid arthritis: the window narrows
Garrod Prize
Dr Elizabeth Jury
Title: The role of lipid rafts in lupus T cell pathology
Young Investigator Award
supported by Schering Plough
A representative from Schering Plough will be present.
Dr Isma Atchia (OP14)
Title: Musculoskeletal ultrasound predicts response
to corticosteroid injection in moderate-severe hip
osteoarthritis
Dr Michele Bombardieri (OP19)
Title: IL-23 Overexpression as immunological
signature of subclinical intestinal inflammation in
ankylosing spondylitis
Dr Emma Derrett-Smith (PO1)
Title: Vasculopathy in a TGF-β; dependent
mouse model of systemic sclerosis
Dr Sahena Haque (OP39)
Title: Impaired endothelial progenitor cell function
and early atherosclerosis in systemic lupus
eeythematosus (SLE)
Medical Student Bursaries supported by Pfizer
Ms Jasmine Ehsanullah (OP74)
Title: The importance of anti-thrombin antibodies
in the antiphospholipid syndrome
Ms Emma Maclaren (171)
Title: Parenteral methotrexate: is it worth it?
Miss Joanne Anderson (176)
Title: An investigation of the media coverage of
tocilizumab
Miss Carly Turner (6)
Title: Expression of the peroxiredoxin-based antioxidant
system in peripheral blood lymphocytes in rheumatoid
arthritis
Ms Emma Johnstone (159)
Title: Acro-Osteolysis in systemic sclerosis: relationship
to degree of digital ischaemia and to calcinosis
Mr Alexander Oldroyd (245)
Title: Does depo-provera decrease bone mineral
density in the lumbar spine and femoral neck
4

5
BSR Annual Meeting | 28 April - 01 May 2009

Meeting at a Glance
28 April - 01 May 2009
Meeting at a Glance
28 April - 01 May 2009

Additional Meetings
Tuesday 28 April 2009
Open Meetings
12.30-14.00 BSR Standards Guidelines and Audit Working Group – lunch provided Carron Room
12.30-14.00 Arthritis and Musculoskeletal Alliance – lunch provided Seminar Suite
Wednesday 29 April 2009
Open Meetings
12.00-13.30 British Society for Rheumatology Biologics Register – lunch provided Hall 1
12.00-13.30 Rheumatologists At Training – lunch provided Dochart Room
Meeting at a glance | 28 April - 01 May 2009
Closed Meetings
09.30-10.30 AS guideline Ness Room
12.00-13.30 Rheumatology Editorial Board Meeting Leven Room
12.00-13.30 BHPR Research Group Morar Room
12.00-13.30 Sjögrens Board Meeting Ness Room
13.30-15.30 CAC Regional Chairs Meeting Ness Room
18.40-19.40 Pharmacists Meeting Leven Room
Thursday 30 April 2009
Open Meetings
07.30-08.30 CMF Breakfast Carron Room B
Closed Meetings
07.00-09.00 NRAS Medical Advisors Ness Room
08.00-09.00 ERAN AGM Morar Room
12.30-14.30 Physiotherapist Meeting Ness Room
14.30-16.30 Website Editorial Board Meeting Ness Room
As usual, all rooms are in high demand throughout Rheumatology ’09 and the turnaround time between
sessions is very tight. It is essential that all meetings/sessions commence and conclude on time. Any over-run
will have a severe impact on the remainder of a scientific programme.
If you are attending any of the above meetings please ensure that you arrive promptly in order to
avoid a late start and any resultant over-run.
7

Meeting at a Glance - Tuesday 28 April 2009 Meeting at a Glance - Wednesday 29 April 2009
07.30 Registration opens
08.30 Poster Viewing including Tea/Coffee Hall 5
09.00 Primary Care: Management of the foot and ankle Lomond Auditorium
09.30 Science: A biology of lupus Hall 1
10.00 BSR: Anti-phospholipid BSR: Predicting prognosis BHPR: Droitwich Lecture
syndrome (10.00-12.00) and treatment response Clyde Auditorium
Lomond Auditorium in OA (10.00-12.00) Hall 1
10.00 Exhibition opens Tea/Coffee Hall 5
10.30 Primary Care: Management Science: A biology of BSR: The liver and
of the foot and ankle lupus Hall 1 rheumatic disease
Lomond Auditorium Forth Room
11.00 arc/BSR: Research and your career Dochart Room
11.00 BHPR: Pursuing a clinical research BHPR: RA clinical issues Clyde Room
career Forth Room
12.00 Lunch Hall 5 BHPR: The NRAS/EPP CIC RA
• BSR BR open meeting Hall 1 self-management programme
• RATs meeting Dochart Room Lomond Auditorium
12.30 Lunch Hall 5
• ARMA Seminar Suite
• SGAWG Carron Room
13.30 BSR & BHPR: Plenary Oral Presentation of Abstracts Clyde Auditorium
15.30 Tea/Coffee Hall 5
14.00 Primary Care: Primary Care: Science: A biology BSR: Advances in BSR: Managing
Musculoskeletal Management of the of lupus Hall 1 joint replacement back pain
problems in childhood foot and ankle surgery Clyde
Alsh Room Boisdale Room (Pre-booked workshop attendees only) Forth Room Auditorium
16.00 Tea/Coffee Hall 5
16.30 Primary Care: Primary Care: Science: BSR: Concurrent oral presentation
Management Recognising A biology of of abstracts
of the foot ankylosing lupus Hall 1 • Spondyloarthritis Clyde Auditorium
and ankle spondylitis • Paediatric and adolescent
Boisdale Room Alsh Room rheumatology Forth Room
(Pre-booked workshop • Osteoarthritis Carron Room
attendees only)
• Novel autoantigens Dochart Room
• Aetiopathogenesis Seminar Suite
16.00 Prize Giving and Heberden Oration: Prof Stuart Ralston Clyde Auditorium
17.40 RATs training workshop BSR: Special interest groups
Lomond Auditorium • Scleroderma Alsh Room A
• Osteoarthritis Alsh Room B
• Interstitial lung disease Boisdale Room A
• Cardiovascular co-morbidity in RA Boisdale Room B
• Vasculitis Carron Room
• Heritible disorders of connective tissue Dochart Room A
• Osteoporosis Dochart Room B
• Systemic lupus erythematosus Morar/Ness Room
19.10 Satellite Symposia:
• Abbott Forth Room
• Wyeth Hall 1
18.00 Welcome Buffet Reception and Now and Then Exhibit Hall 5
19.30 Satellite Symposia
• Chugai Roche Forth Room
• Schering Plough Hall 1

Meeting at a Glance - Thursday 30 April 2009 Meeting at a Glance - Friday 01 May 2009
08.30 Poster Viewing Hall 5 BHPR special interest groups:
• Rheumatoid Arthritis Boisdale Room A
• CTD Boisdale Room B
• Osteoporosis Carron Room A
08.30 Poster Viewing Hall 5
10.00 State of the Art Lecture: BHPR: Research issues and Prize Giving
Prof Richard Jones Clyde Auditorium Lomond Auditorium
(09.30) BHPR AGM Dochart Room
11.00 Tea/Coffee Hall 5
10.00 Tea/Coffee Hall 5
10.30 BSR: BSR and BSR: BSR: BHPR: Psycho- BHPR:
Vasculitis BHPR: Health Genetics of Biomedical social issues Partnerships
Clyde and work common research from in foot
Auditorium Lomond rheumatic networks – childhood healthcare
Auditorium disease the Canadian through Forth Room
Hall 1 experience adult life
Dochart Room Boisdale Room
12.30 Lunch Hall 5 • BSR AGM Alsh Room BHPR: Writing for
publication (12.45-14.15)
Hall 1
14.30 BSR: Oral Presentation of Abstracts BHPR: Oral Presentation of Abstracts Hall 1
• Rheumatoid arthritis Clyde Auditorium
• Pain and fatigue Forth Room
• Case reports Lomond Auditorium
• Vascular biology and vasculitis Alsh Room
• Connective tissue disease Boisdale Room
• Education research Dochart Room
11.30 Political Slot: BSR: BSR: New BHPR: BHPR: Clinical
NICE and the Management of immunosup- Qualitative update on
BSR Hall 1 unusual bone pressants studies of self- spondylodisease
Lomond management in arthropathies
Forth Room Auditorium osteoarthritis Boisdale Room
Alsh Room
13.00 Lunch Hall 5 BSR: Special interest groups
• Musculoskeletal health for the multi ethnic minority
Carron Room A
• Polymyalgia rheumatica and giant cell arteritis Carron Room B
• Sjögrens syndrome Dochart Room A
• Paediatric and adolescent rheumatology Dochart Room B
• Sport and exercise medicine Leven Room
• Musculoskeletal ultrasound Morar/Ness Room
14.00 Exhibition closes BHPR: Designing solutions not problems
Forth Room
15.00 BSR: Setting up a fracture liaison service BSR: Psoriasis and the scoring systems
Lomond Auditorium Forth Room
16.30 Tea/Coffee Hall 5
17.00 Meeting closes
17.00 Heberden Round: Prof Patricia Woo Clyde Auditorium
18.00 Satellite Symposium
• UCB Forth Room
19.35 Coaches to BSR social event
20.00 BSR social event - 25th Anniversary celebrations, Kelvingrove (Welcome drinks from 19.30, carriages 00.30)

Registration and Exhibition Opening Hours
Registration Desk Opening Hours
Tuesday 28 April 2009 07.30 – 19.30
Wednesday 29 April 2009 08.00 – 19.15
Thursday 30 April 2009 08.00 – 18.00
Friday 01 May 2009 08.00 – 15.00
Exhibition Opening Hours
Tuesday 28 April 2009 10.00 – 19.30
Wednesday 29 April 2009 08.30 – 17.00
Thursday 30 April 2009 08.30 – 17.00
Friday 01 May 2009 08.00 – 14.00
Please note that exhibitors are only asked to be present in the exhibition hall
during catering breaks and special Hall 5 events such as the Welcome Reception
and Poster Viewing.
BSR is 25!
We are celebrating our 25th anniversary with an exhibition devoted to BSR, past and present.
Visit the BSR stand and see the history of rheumatology spanning back to 1768. See how
rheumatology has changed over the last 25 years with memories from past presidents and
BSR members. Come and celebrate with us at our annual social event with a five-piece band
and four course dinner! Tickets are available from the registration desk at £25 for members
and £55 for non members.
10

Scientific Programme
Tue 28 April 2009
Scientific Programme
Tuesday 28 April 2009

BSR Scientific Programme 2009
Tuesday 28 April 2009
09.00-10.00 Primary Care: Management of the foot and ankle Lomond Auditorium
Dr Simon Bowman, Dr Shrish Dubey, Dr Elspeth Wise and Dr Phillip Helliwell
• Introduction and background – Dr Shirish Dubey and Dr Simon Bowman
• Anatomy – Dr Tony Redmond and Dr Philip Helliwell
10.00-10.30 Exhibition opens Hall 5
Tea/Coffee
10.30-12.30 Primary Care: Management of the foot and ankle Lomond Auditorium
Dr Simon Bowman, Dr Shrish Dubey, Dr Elspeth Wise and Dr Phillip Helliwell
• Soft tissue disorders and their treatment – Dr Deborah Turner, Dr Philip Helliwell,
Dr Wendy Smith, Ms Heidi Siddle, Dr Anne-Maree Keenan and Dr Ruth Semple
• Video of examination Dr Elspeth Wise
Scientific Programme | Tuesday 28 April 2009
Science: A biology of lupus Hall 1
Prof David Isenberg
• Genetics: how to study the genome and identify the really bad genes in lupus –
Prof Tim Wise
Multiple genes contribute to the risk of developing SLE. The advent of genome-wide genetic
association analysis has dramatically increased our understanding of the genetic basis of
SLE and is shedding light on the pathogenesis of this disease.
• Apoptosis: defects and deficiencies – Prof Martin Herrman
The impaired removal of apoptotoc cells and either low phagocytic activities or the
production of inflammatory cytokines are key elements in SLE pathogenesis. This talk
explores these events in more detail.
• The role of complement in lupus – Prof Marina Botto
The lecture will illustrate how complement contributes to modulate the innate and
adaptive immune response in SLE.
• Is interferon alpha the key cytokine in lupus? – Prof Lars Ronnblom
Patients with SLE have an increased expression of type I interferon (IFN) regulated genes
due to a continuous production of IFN-alpha. What are the reasons behind the IFN-alpha
production and is it important in the etiopathogenesis of the disease?
This topic will be discussed during the session, as well as possible clinical consequences
of this knowledge.
BSR: The liver and rheumatic disease Forth Room
Prof Chris Denton
• Viral hepatitis – Dr Martin Prince
Demographic and social changes mean that the prevalence of chronic viral hepatitis is
increasing with implications for all specialties. Viral hepatitis and its treatment may lead
directly to rheumatological complications or complicate choice of immunosuppressive
therapy.
11

• Hepatic complications of anti-rheumatic therapies – Dr Ian Bruce
This talk will focus on non-infection related hepatic complications of anti-rheumatic drugs
especially DMARDs and anti-TNF agents. It will consider prescribing issues associated with
relevant co-morbid conditions and the potential of genetics and additional biomarkers for
more personalised prescribing of these agents.
• Liver complications of connective tissue disease – Prof Andy Burroughs
Hepatic abnormalities in association with rheumatic disease are due to drugs and less
frequently due to specific hepatic disease associations. Minor abnormalities of LFTs are
frequent and often normalize with control of active rheumatic disease. Arthralgia is common
in many chronic liver diseases, due to different mechanisms and rarely due to specific
rheumatological disease.
11.00-13.00 Research and your career – your questions answered Dochart Room
A joint arc/BSR initiative
Prof Alan Silman, Prof David Scott, Dr D Bax
Tired of doing the same job? Stuck in a rut and looking for something to put a spring
in your step?
There are opportunities for research at any stage in your career, so come along and find out more
from current researchers, hear about their experiences, discover how to approach research
whatever the stage or type of career you are undertaking. Get the chance to meet and talk with
others, learn about the opportunities for funding from arc and others and how to choose
projects and find supervisors.
• Undertaking a career in clinical research Dr Mohini Gray
• Continuing research as an established clinician
• Establishing a research career as an AHP Dr Deborah Turner
• Establishing independence as a scientist Dr Carl Goodyear
• Research funding opportunities Dr Liz Waterman, arc
12.30-14.00 Lunch Hall 5
Arthritis and Musculoskeletal Alliance open meeting Seminar Suite
What has ARMA been up to in the last year? Ros Meek Director of ARMA will provide an overview
of ongoing activity. Ailsa Bosworth Co Chair of the Rheumatology Futures Group will present the
findings of the report by the health think tank The Kings Fund, on the perceptions of patients and
professionals of rheumatoid arthritis care which was launched earlier this year. This will be
followed by an update and mini debate on the contribution of primary care to musculoskeletal
health which will be led by Dr Alan Nye. Alan is a GP and Chief Executive of Pennine MSK
Partnership. He is also clinical lead on the 18 weeks team at the DH.
BSR Standards Guidelines and Audit Working Group open meeting Carron Room
The Draft BSR RA Biologics Guidelines – introduced by Dr Chris Deighton, this is an opportunity to
get a copy of and discuss the draft guidelines
The results of the first BSR national audit – this is the chance to hear the first results of the audit
on time for diagnosis to 1st DMARDS, which many of you took part in at the end of last year.
12

14.00-16.00 Primary Care: Management of the foot and ankle - limited spaces available
Boisdale Room
Dr Simon Bowman, Dr Shrish Dubey, Dr Elspeth Wise and Dr Phillip Helliwell
• Examination practical – Dr John Dickson, Dr Deborah Turner, Dr Wendy Smith,
Ms Heidi Siddle, Dr Anne-Maree Keenan, Dr Ruth Semple, Dr Philip Helliwell,
Dr Simon Bowman,
Dr Shirish Dubey, Dr Tony Redmond, Dr Elspeth Wise, Mr Michael Backhouse
• Quiz - Dr Philip Helliwell and Dr Elspeth Wise
Primary Care: Musculoskeletal problems in childhood Alsh Room
Dr Clive Ryder
A practical approach to the assessment and early management of children’s
musculoskeletal problems.
Science: A biology of lupus Hall 1
Prof David Isenberg
B cell abnormalities
• Lessons from experimental models – Prof Rizgar Mageed
This presentation will summarise progress in understanding mechanisms of autoimmunity in
murine lupus. Key findings will be discussed in the context of relevance to human systemic
lupus erythematosus.
• B regs: the facts! – Dr Claudia Mauri
We have recently identified the existence of regulatory B cells in the peripheral blood of
healthy individuals and demonstrate that they strongly suppress Th1 differentiation. In
patients with active SLE, Bregs produce less IL-10, and lack the functional suppressive
capacity of their healthy counterparts. In addition we will discuss our recent findings on the
effect of rituximab therapy on the function of repopulating B regs.
• B cell activating factors: block and benefit? – Dr Claudia Penarossi
• B cells in SLE: a suitable case for treatment? – Prof David Isenberg
The notion that B lymphocyte abnormalities are integral to the development of SLE is
supported by open clinical trial data that their removal is invariably beneficial. However,
problems remain about optimal dosing, the rate of return of the B cells and how this
links to clinical flare.
Scientific Programme | Tuesday 28 April 2009
BSR: Advances in joint replacement surgery Forth Room
Dr Paul Bowness
• How to run a combined orthopaedic/rheumatology service – Dr Paul Bowness
The benefits and practicalities of setting up a multidisciplinary rheumatology/orthopaedic
service in the biologic era will be discussed, together with the description of individual cases.
• Rheumatoid surgery of the shoulder and elbow – Prof Andrew Carr
The role of arthroscopic debridement, synovectomy, osteotomy and joint replacement
surgery. Advantages of assessing outcome using patient reported outcome measures
(PROs). Influence of implant design, diagnosis and stage of disease on outcome.
Complications of arthroplasty and their management.
• When to operate on the rheumatoid neck – Miss Jennifer Brown
A brief review of therapeutic and prophylactic indications for surgery on the rheumatoid
cervical spine.
• Lower limb surgery in RA – Mr Roger Gundle
A discussion current indications for surgical procedures to the hip and knee, with comments
on hip resurfacing and unicompartmental knee replacement, focussing on the particular
needs of patients with RA.
13

BSR: Managing back pain: where do we go from here? An epidemiological and
intervention perspective Clyde Auditorium
Prof Alan Silman
• Back pain: an epidemiological update on risk factors for onset and outcome –
Prof Gary McFarlane
• Management: what works and what doesn’t – Dr Danielle Van der Windt
Most randomised trials on the effectiveness of interventions for back pain show large and
significant improvements of pain and function within intervention groups, but very little
difference between different types of treatment. The question is to what extent this response
is specific to the intervention itself, or is determined by characteristics of the patient, the
care provider, or the setting in which the intervention is given. Some new developments in
back pain research will be presented that focus on optimising treatment effects, and
address these non-specific elements in the management of back pain.
• Challenges in improving outcome for patients – Prof Peter Croft
The talk will consider whether we can make back pain care more effective in primary care. It
will discuss the extent to which we are getting research evidence into practice, the need for
new models of primary care in order to deliver effective treatment, and whether the real
challenge is to deliver public health interventions in primary care to deliver long-term
reductions in chronic pain and disability in the whole population.
16.00-16.30 Tea/Coffee Hall 5
16.30-18.00 Primary Care: Management of the foot and ankle - limited spaces available
Boisdale Room
Dr Simon Bowman, Dr Shrish Dubey, Dr Elspeth Wise and Dr Phillip Helliwell
• Taping/insoles/injections (workshops) – Dr Ann-Maree Keenan, Ms Heidi Siddle,
Dr Philip Helliwell, Dr Tony Redmond, Dr Deborah Turner, Mr Michael Backhouse,
Dr Wendy Smith, Dr Ruth Semple, Dr Simon Bowman
• Summary and close – Dr Simon Bowman and Dr Shirish Dubey
Primary Care: Recognising ankylosing spondylitis Alsh Room
Dr Andrew Keat and Mrs Claire Harris, Specialist Physiotherapist
Ankylosing spondylitis, spotting it in the community, assessing it and why it is important to do.
Science: A biology of lupus Hall 1
Prof David Isenberg
T cell Abnormalities
• T cell abnormalities and the role of tregs – Prof Michael Ehrenstein
Regulatory T cells play a key role in controlling autoimmunity. In SLE both effector and
regulatory T cells are malfunctioning. Understanding these defects are key to identifying
new avenues of therapy.
• Responses to T cell peptides: towards a new therapeutic approach – Prof Sylvianne Muller
14

16.30-18.00 Concurrent Oral Presentations of Abstracts
Novel autoantigens Dochart Room
OP1
OP2
CITRULLINATED α-ENOLASE - A MAJOR AUTOANTIGEN LINKING SMOKING AND HLA-DRB1
SHARED EPITOPE TO RHEUMATOID ARTHRITIS
Karin Lundberg 1 , Hiba Mahdi 2 , Benjamin Fisher 1 , Henrik Kallberg 3 , Darren Plant 4 , Johan
Ronnelid 5 , Peter Charles 1 , Bo Ding 3 , Deborah Symmons 4 , Patrick J. Venables 1 , Lars Klareskog 2 ;
1
Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom;
2
Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden; 3 Institute for Environmental
Medicine, Karolinska Institutet, Stockholm, Sweden; 4 Arthritis Research Campaign Epidemiology
Unit, University of Manchester, Manchester, United Kingdom; 5 Unit of Clinical Immunology,
Uppsala University, Uppsala, Sweden
IDENTIFICATION BY PROTEOMIC ANALYSIS OF CHAPERONES AND CITRULLINATED
GLYCOLYTIC ENZYMES AS CANDIDATE AUTOANTIGENS IN EARLY RHEUMATOID ARTHRITIS
Vincent Goeb 1 , Marlene Thomas-L’Otellier 2 , Romain Daveau 2 , Roland Charlionet 2 ,
Patrice Fardellone 3 , Xavier Le Loet 1 , Francois Tron 2 , Daniele Gilbert 2 , Olivier Vittecoq 1 ;
1
Rheumatology and Inserm U905, University Hospital, Rouen, France; 2 Immunology and Inserm
U905, University Hospital, Rouen, France; 3 Rheumatology, University Hospital, Amiens, France
Scientific Programme | Tuesday 28 April 2009
OP3
OP4
T CELL RESPONSES TO CITRULLINATED AGGRECAN PEPTIDE IN RHEUMATOID ARTHRITIS
Alexei von Delwig, James Locke, John H. Robinson, Wan-Fai Ng;
Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University,
Newcastle upon Tyne, United Kingdom
YOUNG INVESTIGATOR AWARD WINNER
ENDOGENOUSLY CITRULLINATED PROTEINS FROM PORPHYROMONAS GINGIVALIS
AS A CANDIDATE SOURCE OF PRIMING AUTOANTIGENS IN RHEUMATOID ARTHRITIS
Natalia Wegner 1 , Sigrun Eick 2 , Aneta Sroka 3 , Ky-Anh Nguyen 4 , Jan Potempa 3,5 , Patrick Venables 1 ;
1
Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom;
2
Department of Medical Microbiology, University Hospital Jena, Jena, Germany; 3 Department
of Microbiology, Jagiellonian University, Krakow, Poland; 4 Institute of Dental Research,
Westmead Centre for Oral Health, Sydney, NSW, Australia; 5 Department of Biochemistry,
University of Georgia, Athens, GA
OP5
INFLAMMATORY POLYARTHRITIS PATIENTS WITH ANTI-CYCLIC CITRULLINATED PEPTIDE
(ANTI-CCP) ANTIBODIES DO NOT BENEFIT FROM EARLY TREATMENT IN TERMS OF
LONG-TERM FUNCTIONAL DISABILITY AS WELL AS THOSE WITHOUT ANTI-CCP ANTIBODIES
Tracey Farragher 1 , Mark Lunt 1 , Diane Bunn 2 , Deborah Symmons 1 ;
1
arc Epidemiology Unit, The University of Manchester, Manchester, United Kingdom;
2
Norfolk Arthritis Register, Norfolk and Norwich University Hospital, Norfolk, United Kingdom
OP6
OXIDATIVE MODIFICATIONS TO C1Q INCREASE THE SENSITIVITY OF AN ANTI-C1Q ELISA IN
THE DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS
Brent Ryan 1 , Paul G. Winyard 1 , Nick Viner 1 , Richard Haigh 1 , Miriam Haas 1 , Ahuva Nissim 2 ,
David Isenberg 3 , Paul Eggleton 1 ;
1
Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United
Kingdom; 2 Barts and The London Medical School, London, United Kingdom; 3 Centre for
Rheumatology, University College London, London, United Kingdom.
15

Paediatric and adolescent rheumatology Forth Room
OP7
OP8
OP9
SENSITIVITY OF MUSCULOSKELETAL HISTORY IN CHILDREN IS POOR - THE NEED TO SCREEN
ALL JOINTS
Iain Goff 1 , Amy Rowan 2 , Belinda J. Bateman 5 , Mark Friswell 4,6 , Andrea Myers 3,6 , Helen E. Foster 6,4 ;
1
Education Department, Northumbria Healthcare NHS Foundation Trust, North Shields, United
Kingdom; 2 School of Medicine, University of Newcastle upon Tyne, Newcastle, United Kingdom;
3
Department of Rheumatology, Northumbria Healthcare NHS Foundation Trust, North Shields,
United Kingdom; 4 Department of Rheumatology, Newcastle upon Tyne Hospitals NHS Foundation
Trust, Newcastle, United Kingdom; 5 Department of Paediatrics, Northumbria Healthcare NHS
Foundation Trust, North Shields, United Kingdom; 6 Newcastle Musculoskeletal Research Group,
University of Newcastle upon Tyne, Newcastle, United Kingdom
THE PREVALENCE OF HYPERMOBILITY IN UK SCHOOL CHILDREN: WHERE SHOULD THE LINE
BE DRAWN?
Jacqui Clinch 1,2 , Rita Doerner 2 , Emma Clark 2 , Shea Palmer 3 , Jon Tobias 2 ;
1
Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, United Kingdom; 2 Academic
Rheumatology Unit, University of Bristol, Bristol, United Kingdom; 3 University of West of England,
Bristol, United Kingdom
ACZ885 (CANAKINUMAB), A NEW IL-1 BETA BLOCKING MONOCLONAL ANTIBODY HAS A
BENEFICIAL EFFECT IN CHILDREN WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS (SJIA)
Nicolino Ruperto 1 , Pierre Quartier 2 , Nico Wulffraat 3 , Anna Loy 1 , Richard Mouy 2 , Pat Woo 4 , Berent
Prakken 3 , Brigitte Bader-Meunier 2 , Emanuele Noseda 5 , Christiane Rordorf 5 , Alberto Martini 1 ;
1
Pediatria II - PRINTO, IRCCS G. Gaslini, Largo Gaslini, Genova, Italy; 2 Unit’e d’Immunologie,
Hospital Necker Enfants Malades,Hematologie et Rhumatologie Pediatrique, Paris, France; 3 Dept
Pediatric Immunology, University Medical Center Utrecht, Utrecht, Netherlands; 4 Centre
of Paediatric and Adolescent Rheumatology, The Windeyer Institute, London, United Kingdom;
5
Novartis Pharma AG, Basel, Switzerland
OP10
OP11
OP12
PUTATIVE AUTOIMMUNE SUSCEPTIBILITY LOCI; TENR-IL2-IL21, IL7R, CTLA4 AND LAF4,
ARE ASSOCIATED WITH JUVENILE IDIOPATHIC ARTHRITIS
Anne Hinks 1 , Steve Eyre 1 , Anne Barton 1 , Paul Martin 1 , Edward Flynn 1 , Xiayi Ke 1 , Jon Packham 2 ,
Jane Worthington 1 , Wendy Thomson 1 ;
1
arc epidemiology unit, University of Manchester, Manchester, United Kingdom; 2 Haywood Hospital,
University Hospital of North Staffordshire, Stoke-on-Trent, United Kingdom
GENERATION OF NOVEL PHARMACOGENOMIC CANDIDATES IN THE RESPONSE TO
MTX IN JUVENILE IDIOPATHIC ARTHRITIS (JIA): CORRELATION BETWEEN GENE EXPRESSION
AND GENOTYPE
Halima Moncrieffe 1 , Simona Ursu 1 , Nipurna Jina 2 , Anne M. Hinks 3 , Paul Martin 3 , Wendy Thomson 3 ,
Lucy R. Wedderburn 1 ;
1
Rheumatology Unit, UCL Institute of Child Health, London, United Kingdom; 2 Molecular
Haematology and Cancer Biology Unit, UCL Institute of Child Health, London, United Kingdom;
3
Arthritis Research Campaign (arc)-Epidemiology Unit, University of Manchester, Manchester,
United Kingdom
INCIDENCE OF CHILDHOOD SCLERODERMA IN THE UK AND IRELAND
Ariane L. Herrick 1,2 , Holly Ennis 1 , Alan Silman 1 , Eileen M. Baildam 3 ;
1
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom; 2 Salford Royal
NHS Foundation Trust, Salford, United Kingdom; 3 Alder Hey Children’s NHS Foundation Trust,
Liverpool, United Kingdom
16

Osteoarthritis Carron Room
OP13
OP14
A COMMUNITY-BASED INTEGRATED REHABILITATION PROGRAMME FOR
CHRONIC KNEE PAIN
Mike Hurley 1 , Sally Jessop 2 , Nicki Walsh 3 , Julie Ratcliffe 4 ;
1
Academic Physiotherapy, King’s College London, London, United Kingdom; 2 Physiotherapy
Department, West Kent Primary Care Trust, Sevenoaks, United Kingdom; 3 Faculty of Health and
Life Sciences, University of the West of England, Bristol, United Kingdom; 4 Division of Health
Sciences, University of South Australia, Brisbane, United Kingdom
YOUNG INVESTIGATOR AWARD WINNER
MUSCULOSKELETAL ULTRASOUND PREDICTS RESPONSE TO CORTICOSTEROID INJECTION IN
MODERATE-SEVERE HIP OSTEOARTHRITIS
Ismaël Atchia 1,2 , David Kane 2 , Mike R. Reed 1 , John Isaacs 2 , Fraser Birrell 1,2 ;
1
Northumbria Healthcare NHS Foundation Trust, Northumberland, United Kingdom;
2
Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle
Upon Tyne, United Kingdom
Scientific Programme | Tuesday 28 April 2009
OP15
OP16
EPIDEMIOLOGICAL AND MOLECULAR EVIDENCE FOR THE CHONDROPROTECTIVE EFFECT OF
GARLIC IN OSTEOARTHRITIS
Frances Williams 1 , Rose Davidson 2 , Jane Skinner 2 , Kirsty Culley 2 , Yongping Bao 2 , Aedin Cassidy 2 ,
Ian Clark 2 , Alex MacGregor 1,2 ;
1
Department of Twin Research and Genetic Epidemiology, Kings College, London, United
Kingdom; 2 University of East Anglia, Norwich, United Kingdom
CORRELATION OF SYNOVITIS WITH PROTEASE-ACTIVATED RECEPTOR-2 EXPRESSION
IN OSTEOARTHRITIS
Elizabeth B. Kelso 1 , William R. Ferrell 1 , John C. Lockhart 2 , David A. Walsh 3 , J. Alastair Gracie 1 ,
Iain B. McInnes 1 ;
1
Centre for Rheumatic Diseases, University of Glasgow, Glasgow, United Kingdom;
2
Science and Engineering, University of the West of Scotland, Paisley, United Kingdom;
3
Rheumatology, University of Nottingham, Nottingham, United Kingdom
OP17
OP18
SHAPE OF THE FEMORAL HEAD AND NECK CORRELATES WITH CLINICAL FEATURES OF
OA AND CAN PREDICT PROGRESSION TO TOTAL HIP REPLACEMENT
Jennifer S. Gregory 1 , Rebecca J. Barr 1 , Kanako Yoshida 1 , David M. Reid 1 , Richard M. Aspden 1 ,
Alan J. Silman 5 , Gillian Hosie 4 , Salvatore Alesci 2 , Gary J. Macfarlane 3 ;
1
Division of Applied Medicine, University of Aberdeen, Aberdeen, United Kingdom; 2 Discovery
Translational Medicine, Wyeth Research, Collegeville, PA; 3 Division of Applied Health Science,
University of Aberdeen, Aberdeen, United Kingdom; 4 Primary Care Rheumatology Society,
Northallerton, United Kingdom; 5 Department of Rheumatology, University of Manchester,
Manchester, United Kingdom
RESTRICTED SELF-CARE AND LOOKING AFTER THE HOME IN ADULTS 50 YEARS AND
OLDER WITH HAND OSTEOARTHRITIS; PREVALENCE AND LINKS WITH JOINT SPECIFIC
CHARACTERISTICS
Yeliz Greenhill, Ross Wilkie, Elaine Nicholls, Helen Myers, Michelle Marshall, Susan Hill,
Krysia Dziedzic;
Arthritis Research Campaign National Primary Care Centre, Keele University,
Newcastle-under-Lyme, United Kingdom
17

Spondyloarthritis Clyde Auditorium
OP19
OP20
OP21
OP22
IL-23 OVEREXPRESSION AS IMMUNOLOGICAL SIGNATURE OF SUBCLINICAL
INTESTINAL INFLAMMATION IN ANKYLOSING SPONDYLITIS
Michele Bombardieri 1 , Francesco Ciccia 2 , Alfonso Principato 2 , Claudio Tripodo 2 , Sergio Peralta 2 ,
Giovanni Triolo 2 , Costantino Pitzalis 1 ;
1
Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The
London School of Medicine, London, United Kingdom; 2 University of Palermo, Palermo, Italy
IL-12 AND IL-23 SECRETION BY DENDRITIC CELLS IN SPONDYLOARTHROPATHY
Claudia Prevosto, Jane C. Goodall, Hill J. Gaston;
Medicine, University of Cambridge, Cambridge, United Kingdom
EFFECTIVE TREATMENT FOR JOINT AND SKIN SYMPTOMS WITH ADALIMUMAB IN
COMBINATION WITH VARIOUS DISEASE-MODIFYING ANTIRHEUMATIC DRUGS (DMARDS) IN
PATIENTS WITH PSORIATIC ARTHRITIS (PSA): RESULTS OF THE STEREO TRIAL
Neil McHugh 2 , Filip van den Bosch 1 , Erik Røedevand 3 , Palle Holck 4 , Martina Kron 5 , Sonja Kary 5 ,
Hartmut Kupper 5 ;
1
University Hospital, Ghent, Belgium; 2 Royal National Hospital, Bath, United Kingdom; 3 St Olavs
Hospital, Trondheim, Norway; 4 Regionshospitalet Silkeborg, Silkeborg, Denmark; 5 Abbott GmbH
& Co KG, Ludwigshafen, Germany
GOLIMUMAB ADMINISTERED SUBCUTANEOUSLY EVERY FOUR WEEKS IN PSORIATIC
ARTHRITIS: 52-WEEK EFFICACY AND SAFETY RESULTS OF THE GO-REVEAL STUDY
Iain McInnes 1 , Philip Mease 3 , Gerald Krueger 4 , Dafna Gladman 5 , Juan Gomez-Reino 6 , Kim Papp 7 ,
Frederick Murphy 8 , Michael Mack 9 , Julie Zrubek 9 , Arthur Kavanaugh 2 ;
1
University of Glasgow, Glasgow, United Kingdom; 2 University of California San Diego, La Jolla, CA;
3
Swedish Medical Center and Seattle Rheumatology Associates, Seattle, WA; 4 University of Utah,
Salt Lake City, UT; 5 University of Toronto, Toronto, ON, Canada; 6 Hospital Clinico University,
Santiago, Spain; 7 Probity Medical Research, Waterloo, ON, Canada; 8 Altoona Center for Clinical
Research, Duncansville, PA; 9Centocor Research and Development, Inc., Malvern, PA
OP23
OP24
EVALUATING ANKYLOSING SPONDYLITIS QUALITY OF LIFE (EASI-QOL): RELIABILITY AND
VALIDITY OF A NEW PATIENT REPORTED OUTCOME MEASURE
Kirstie L. Haywood 1,4 , Andrew M. Garratt 2 , Emma L. Healey 3,4 , Kelvin P. Jordan 4 ,
Jon C. Packham 3,4 ; 1 Royal College of Nursing Research Institute, School of Health and Social
Studies, University of Warwick, Coventry, CV4 7AL, United Kingdom; 2 National Resource Centre
for Rehabilitation in Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; 3 Staffordshire
Rheumatology Centre, Haywood Hospital, Stoke-on-Trent, Staffordshire, United Kingdom; 4 Arthritis
Research Campaign National Primary Care Centre, Keele University, Staffordshire, ST5 5BG,
United Kingdom
THE EFFECT OF SOCIAL DEPRIVATION IN ANKYLOSING SPONDYLITIS
Emma L. Healey 1,2 , Kirstie L. Haywood 3,1 , Kelvin P. Jordan 1 , Andrew M. Garratt 4 , Jon C. Packham 2,1 ;
1
Arthritis Research Campaign National Primary Care Centre, Keele University,
Newcastle-under-Lyme, United Kingdom; 2 Staffordshire Rheumatology Centre, Haywood Hospital,
Stoke-on-Trent, United Kingdom; 3 RCN Research Institute, School of Health & Social Studies,
Warwick University, Coventry, United Kingdom; 4 National Resource Centre for Rehabilitation in
Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
18

Aetiopathogenesis of rheumatic disease Seminar Suite
OP25
OP26
OP27
FUNCTIONAL ROLE OF DR3 IN INFLAMMATORY ARTHRITIS: A NOVEL TARGET FOR THERAPY?
Anwen S. Williams 1 , Melanie J. Bull 2 , Zarabeth Mecklenburgh 2 , Claudia J. Calder 2 , Jason P.
Twohig 2 , Carole Elford 3 , Bronwen Evans 3 , Aymen Al-Shamkhani 4 , Eddie Wang 2 ; 1 Rheumatology,
Cardiff University, Cardiff, United Kingdom; 2 Medical Biochemistry and Immunology, Cardiff
University, Cardiff, United Kingdom; 3 Child Health, Cardiff University, Cardiff, United Kingdom;
4
Cancer Science Division, University of Southampton, Southampton, United Kingdom
DOES LIGHT PLAY A ROLE IN THE PATHOGENESIS OF INFLAMMATORY JOINT DESTRUCTION?
Catherine Swales, David Mahoney, Paul Wordsworth, Nick Athanasou, Afsie Sabokbar;
Nuffield Department of Orthopaedic Surgery, Botnar Research Centre, University of Oxford,
Oxford, United Kingdom
LOCALLY GENERATED GLUCOCORTICOIDS, RATHER THAN PRO-INFLAMMATORY CYTOKINES,
DIRECTLY REGULATE SYNOVIAL DKK-1 EXPRESSION IN INFLAMMATORY ARTHRITIS
Rowan S. Hardy 1 , Mohammad Ahasan 1 , Pushpa Patel 1 , Elizabeth Rabbitt 1 , Andrew Filer 2 ,
Karim Raza 2 , Paul Stewart 1 , Chris Buckley 2 , Mark S. Cooper 1 ;
1
School of Clinical and Experimental Medicine, The University of Birmingham, Birmingham, United
Kingdom; 2 Immunity and Infection, The University of Birmingham, Birmingham, United Kingdom
Scientific Programme | Tuesday 28 April 2009
OP28
OP29
OP30
INTRACELLULAR SIGNALLING IN RESPONSE TO WOUNDING OF CONNECTIVE TISSUES
Fiona Watt, Athanasios Didangelos, Matthew Peirce, Robin Wait, Jeremy Saklatvala;
Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom
ANALYSIS OF DISEASED POSTERIOR TIBIALIS TENDON SPECIMENS REVEALS COMMON
MOLECULAR PATHOGENESIS OF TENDINOPATHY AT DIFFERENT ANATOMICAL SITES
Graham Riley 1,4 , Anthony Corps 4 , Nicholas Avery 3 , Valerie Curry 4 , Andrew Robinson 2 ,
Rebecca Harrall 4 , Brian Hazleman 4 ;
1
School of Biological Sciences, University of East Anglia, Norwich, United Kingdom; 2 Department
of Trauma and Orthopaedics, Addenbrooke’s Hospital, Cambridge, United Kingdom; 3 Matrix
Biology Research Group, University of Bristol, Bristol, United Kingdom; 4 Rheumatology Research
Unit, Addenbrooke’s Hospital, Cambridge, United Kingdom
THE SERUM RESPONSE PROGRAMME LEADS TO CONVERGENCE OF TRANSCRIPTIONAL
PROFILES IN RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS SYNOVIAL FIBROBLASTS
Andrew Filer 1 , Philipp Antczak 2 , Greg Parsonage 1 , Steve Kissane 1 , Holly Legault 3 , Margot O’Toole 3 ,
Karim Raza 1 , Dagmar Scheel-Toellner 1 , Christopher D. Buckley 1 , Francesco Falciani 2 ;
1
Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom;
2
School of Biosciences, University of Birmingham, Birmingham, United Kingdom;
3
Wyeth Research, Cambridge, MA
18.00-19.30 Welcome Reception Hall 5
Now and Then Exhibition and Address
19

19.30-21.00 Satellite Symposia
Chugai/Roche Forth Room
Introduction – future pathways in RA care – Prof Paul Emery
Making policy work in practice – Dr Anthony Redmond
Future pathways – a clinical review – Prof John Isaacs
Cytokine inhibition and the IL-6 pathway – Dr Ernest Choy
IL-6 receptor inhibition in practice – Prof Paul Emery
Question & answer session – Prof Paul Emery/All
Summary and close
Schering Plough Hall 1
Milestones in rheumatology
Nicky Campbell, investigative journalist, asks tough questions about the past,
present and future of RA management.
The journey so far – Prof Peter Taylor
At the crossroads – Dr Mark Quinn
The road ahead – Prof Iain McInnes
Panel discussion – led by Nicky Campbell
20

Scientific Programme
Wed 29 April 2009
Scientific Programme
Wednesday 29 April 2009

BSR Scientific Programme 2009
Wednesday 29 April 2009
08.30-10.00 Poster Viewing Hall 5
10.00-12.00 BSR: Antiphospholipid syndrome Lomond Auditorium
Dr Ian Giles and Dr David D’Cruz
• An overview of recent developments in the pathogenesis and treatment of APS – Dr Ian Giles
This introductory session will provide an overview of the most important recent scientific
and clinical developments in the field of antiphospholipid syndrome related research.
• Mechanisms of thrombosis – Prof Anisur Rahman
This talk will summarise the ways in which antiphospholipid antibodies are believed to act
upon endothelial cells, monocytes, platelets and the clotting cascade to promote thrombosis
in the antiphospholipid syndrome.
• Mechanisms of pregnancy morbidity – Prof Lesley Regan
Antiphospholipid antibody syndrome is now recognised to be the most important treatable
cause of recurrent miscarriage. The mechanisms of pregnancy failure are primarily defective
embryonic implantation and thrombosis of the placental vascular tree.
• New targeted therapies – Prof Silvia Pierangeli
The talk will cover current therapies and the associated problems and limitations of such
treatments in antiphospholipid syndrome (APS). Based on new knowledge on
pathophysiology of the disease and molecular targets recognised by antiphospholipid
antibodies, new emerging therapies will be thoroughly discussed.
• Controversies in current management – Dr Munther Khamashta
Evidence based treatment recommendations for selected patients with aPL associated
thromboembolism can now be made based on published literature. However, numerous
questions remain unanswered. These questions include the optimal management of patients
with arterial thrombosis in the setting of persistently positive aPL, optimal management of
patients who suffer recurrent thrombosis despite therapeutic anticoagulation and
refinement of current diagnostic tests to allow more confident assignment of patients with
suspected APS.
Scientific Programme | Wednesday 29 April 2009
BSR: Predicting prognosis and treatment response in OA Hall 1
Dr Nigel Arden
• Epidemiology of progression in osteoarthritis – Dr Fraser Birrell
• Animal models of progressions – Dr Wim Van den Berg
This talk will summarise animal models of OA, illustrate progression of OA joint pathology
and show ways of target identification and validation.
• Progression in clinical trials – Prof Tim Spector
• Response to therapy – Prof Mike Doherty
10.00-10.50 Droitwich Lecture Clyde Auditorium
Chair: Mrs Diana Finney
Prof Jim Woodurn
What is hidden in the shoes? How to find your RA patients’ real clinical CV.
Hidden away in shoes, the feet of our RA patients are often overlooked and poorly understood.
Giving this year’s Droitwich Lecture, Prof Jim Woodburn will attempt to arm delegates with the
knowledge and understanding to challenge this day-to-day clinical problem.
21

11.00-12.00 BHPR: Pursuing a clinical research career Forth Room
Mr Douglas Lauchlin
• Attractions of a clinical research career and how to get started – Dr Candy McCabe
This workshop will discuss how to get started in clinical research, the opportunities for
progression from a lone researcher to leading your own research team, how to fund research
along the way and to combine clinical practice and academic study. The speakers will bring a
range of perspectives from the novice researcher to the highly experienced and all will focus on
the very practical aspects of this most rewarding career pathway.
• Is there life outside work? Undertaking a higher degree while in clinical practice –
Ms Julie Taylor
The seminar follows a personal journey of a nurse specialist studying for a masters degree
whilst juggling clinical workload, studying and family life. It focuses on advice that was given,
that which was taken and that which was ignored - analysing in hindsight if the correct path
was followed.
• Developing your clinical research career: fellowships and other routes –
Prof Jim Woodburn
This presentation will summarise the available fellowship options for early-senior career
researchers in the field via the research councils, medical charities, NHS and other
organisations. The author will share his experiences on how to develop successful fellowships
based on the cornerstone principles of the ‘Person, Place and Project’.
• Creating a team and a programme of clinical research – Prof Sarah Hewlett
This presentation will look at the transition from lone researcher to leading a research team,
including building a portfolio of research, team building, and the highs and lows of fitting in
clinical and teaching commitments.
11.00-12.00 BHPR: RA clinical issues Clyde Auditorium
Mrs Diana Finney and Dr Stewart Glaspole
• Joint aspiration and injection – Dr Andy Hassell
This talk will cover: the indications for joint aspiration and for for intra-articular steroid injection;
possible side-effects; general procedural aspects; and the technical aspects for aspirating and
injecting common target joints.
• NICE RA management guidelines – Dr Chris Deighton
The NICE RA Management Guidelines were published in February 2009, and give the
opportunity to raise the quality of care for our patients. The key recommendations will be
reviewed and justified, and resource implications for the multidisciplinary team considered.
12.00-13.30 Lunch Hall 5
BSR BR open meeting Hall 1
Introduction – Professor David Isenberg
Update on the register – Professor Deborah Symmons and Dr Kimme Hyrich
Looking to the future
Ankylosing spondylitis – Dr Andrew Keat
TNF alpha drug switching – where are we now? – Debbie Smith
Where are we going with the register? – Professor David Isenberg
RATs Meeting Dochart Room
22

12.15-13.30 BHPR: The NRAS/EPP CIC RA self-management programme - health
professionals and patients working together Lomond Auditorium
Mrs Trish Cornell
• What is the rationale and evidence behind self-care and self-management? – Ms Sue Oliver
Healthcare professionals refer to terms such as self-care, patient education,
self-management and in recent years patient empowerment yet what do these terms mean
to the patient? How do we support the patient in these principles and how do we ensure
support for such approaches in the current healthcare system?
• Why a disease specific self-management programme for RA and experiences of running a
trial programme – Ms Alisa Bosworth and Ms Maggie Carr
This presentation will focus on background to this collaboration, progress of the programme
to date and results of initial pilots, experience of working in equal partnership with a person
with RA to deliver the RA self-management programme, and value of healthcare
professional tutor in RA.
• Patient experience of being involved in the trial programme – Ms Susan Winder
How the NRAS Trial programme has helped me and how it could be a real support
to others with RA.
Scientific Programme | Wednesday 29 April 2009
13.30-15.30 BSR & BHPR shared session
Plenary Oral Presentation of Abstracts Clyde Auditorium
Dr Deborah Bax and Mrs Diana Finney
PO1
PO2
PO3
YOUNG INVESTIGATOR AWARD WINNER
VASCULOPATHY IN A TGF-β DEPENDENT MOUSE MODEL OF SYSTEMIC SCLEROSIS
Emma C. Derrett-Smith, Audrey Dooley, Korsa Khan, Xu Shi-Wen, Patricia De Winter,
David Abraham, Christopher P Denton;
Centre for Rheumatology, UCL (Royal Free Campus), London, United Kingdom
COMBINED EFFECTS OF THREE INDEPENDENT SNPS INCREASE THE RISK ESTIMATE FOR
RA AT 6Q23
Gisela Orozco, Anne Hinks, Steve Eyre, Xiayi Ke, Laura J. Gibbons, John Bowes, Year
Consortium, Ukrag Consortium, Wendy Thomson, Anne Barton, Jane Worthington;
ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY ON ADDITION OF 6-MONTH
INDUCTION THERAPY WITH INFLIXIMAB TO TRIPLE DMARD PLUS PREDNISOLONE THERAPY
IN PATIENTS WITH EARLY ACTIVE RHEUMATOID ARTHRITIS: HIGH REMISSION RATES AND
NO JOINT DESTRUCTION DURING FIRST 2 YEARS. THE NEO-RACO STUDY
Marjatta Leirisalo-Repo 1 , Hannu Kautiainen 2 , Leena Laasonen 3 , Timo Möttönen 4 ,
Pekka Hannonen 5,8 , Markku Korpela 6 , Markku Kauppi 7 , Oili Kaipiainen-Seppänen 8 ,
Riitta Luosujärvi 1 , Harri Blåfield 9 , Eeva Moilanen 10 ;
1
Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; 2 Rheumatology,
Rheumatism Foundation Hospital, Heinola, Finland; 3 Radiology, Helsinki University Central
Hospital, Helsinki, Finland; 4 Medicine, Turku University Central Hospital, Turku, Finland;
5
Medicine, Jyväskylä Central Hospital, Jyväskylä, Finland; 6 Rheumatology, Tampere University
Hospital, Tampere, Finland; 7 Rheumatology, Rheumatism Foundation Hospital, Heinola, Finland;
8
Medicine, Kuopio University Hospital, Kuopio, Finland; 9 Medicine, Seinäjoki Central Hospital,
Seinäjoki, Finland; 10 The Immunopharmacology Research Group, Medical School, University of
Tampere, Tampere, Finland
23

PO4
PO5
NOVEL ANALYSIS OF MARGOLIS PAIN DIAGRAM ALLOWS IDENTIFICATION OF UNDERLYING
VERTEBRAL FRACTURE
Emma Clark 1 , Alison Hutchinson 1 , Eugene McCloskey 2 , Mike Stone 3 , James Martin 4 ,
Ashok Bhalla 5 , Jon Tobias 1 ;
1
University of Bristol, Bristol, United Kingdom; 2 University of Sheffield, Sheffield, United
Kingdom; 3 Bone Research Unit, Llandough Hospital, Penarth, United Kingdom; 4 Royal Glamorgan
Hospital, Llantrisant, United Kingdom; 5 Royal National Hospital for Rheumatic Diseases, Bath,
United Kingdom
DEVELOPMENT AND INITIAL VALIDATION OF THE BRISTOL RA FATIGUE MULTI-DIMENSIONAL
QUESTIONNAIRE (BRAF-MDQ)
Joanna K. Nicklin 1 , John Kirwan 2 , Fiona Cramp 1 , Marie Urban 1 , Sarah Hewlett 1 ;
1
Faculty of Health and Life Sciences, University of West of England, Bristol, United Kingdom;
2
Academic Rheumatology, University of Bristol, Bristol, United Kingdom
PO6
LAY SYMPTOM ATTRIBUTIONS FOR KNEE PAIN AND HAND PAIN: A CROSS-SECTIONAL STUDY
George Peat, June Handy, Christian Mallen, Sue Hill, Krysia Dziedzic;
Arthritis Research Campaign National Primary Care Centre, Keele University, Keele,
United Kingdom
15.30-16.00 Tea/Coffee Hall 5
16.00-17.30 Prize Giving and
Heberden Oration Clyde Auditorium
Chair: Dr Deborah Bax
Prof Stuart Ralston
Thirty years’ progress in bone disease
Prof Ralston will review advances in our understanding the causes of bone disease over the past
three decades and how this has impacted on diagnosis and management.
17.40-19.10 BSR: Special interest groups
Heritable disorders of connective tissue and musculoskeletal pain Dochart Room A
Convenors: Rodney Grahame; Anthony Jones
Recent advances in the understanding of pain as it might relate to the chronic pain in EDS
Prof Praveen Anand
Fibromyalgia, dysautonomia, hypermobility and positional myelopathy
Dr Andrew Holman
Discussion introduced by Prof Peter Beighton, Emeritus Professor of Genetics,
University of Cape Town
Interstitial lung disease in RA and CTD Boisdale Room A
Convenor: Clive Kelly
Update on clinical management of RA-ILD – Clive Kelly
Multi centre study of RA-ILD – progress and development – Judy Dawson
Coordinating data collection and storage for multi centre study – Will Dixon
24

Osteoarthritis Alsh Room B
Convenor: Fraser Birrell
Introduction and overview: goals of meeting – Fraser Birrell
UK multicentre osteoarthritis audit – Mike Pieri
Meaningful patient involvement – Cheryl Koehn/Jo Cumming
Clinical studies group for OA and related disorders update: challenges and solutions –
Philip Conaghan/Paul Dieppe
Cardiovascular co-morbidity in rheumatoid arthritis Boisdale Room B
Convenor: George Kitas
Cardiovascular disease and inflammation – Prof Gordon Lowe
Trial in rheumatoid arthritis of lisinopril (TRALIS) – Dr Frances Hall
The effects of rosuvastatin in rheumatoid arthritis – Dr Pradeep Kumar
Trial of atorvastatin for the primary prevention of cardiovascular events in rheumatoid arthritis
(TRACE RA): Progress to date – Prof George Kitas, Professor Jill Belch,
Prof Deborah Symmons
Systemic lupus erythematosus Morar/Ness Room
Convenor: Ian Bruce
Rituximab in neuropsychiatric lupus: initial experience and trial proposal – M Zandi
What we have learned so far from SLE trials? – Prof C Gordon
A UK lupus biologics prospective cohort study – Dr I Bruce
Open forum for potential collaborative studies
Scientific Programme | Wednesday 29 April 2009
Osteoporosis Dochart Room B
Convenor: Emma Clarke
Incorporation of FRAX into routine DXA reporting – Prof Juliet Compston
Use of MXA / IVA in clinical practice – Dr Nicky Peel
Bisphosphonates, osteoporosis and PPIs – Prof Cyrus Cooper
Scleroderma Alsh Room A
Convenor: Chris Denton
Bullet or bomb: the future of scleroderma treatment – Prof Chris Denton
Tyrosine kinase inhibitors for treatment of systemic sclerosis – imatinib and beyond –
Dr Oliver Distler
High intensity immunosuppression for dcSSc – Prof Jaap van Laar
When to treat SSc lung fibrosis – applying a data-driven algorithm – Prof Athol Wells
What matters to patients – results of the second Raynaud’s and Scleroderma Association
questionnaire – Mrs Anne Mawdsley
Vasculitis Carron Room
Convenor: Raashid Luqmani
EUVAS trials update – David Jayne/Raashid Luqmani
New proposals for diagnostic criteria study – Richard Watts/Raashid Luqmani
Impact of vasculitis guidelines: what shall we do with them? – David Carruthers
Classification and diagnostic criteria in vasculitis project – Neil Basu
Assessment of children with vasculitis – Nick Wilkinson/Raashid Luqmani
OMERACT update of disease assessment in systemic vasculitis: where are we now? –
Raashid Luqmani
25

RATs training workshop Lomond Auditorium
Trainee dilemmas - can a mentoring scheme help?
Mentorship refers to a developmental relationship in which a more experienced person helps a
less experienced person. It is intended to do something different from educational or clinical
supervision. A mentor should provide an impartial sounding board that may be useful at many
stages in your career.
Programme
Introduction to mentoring and how the scheme is rolling out in the north west deanery –
Dr Neil Snowden, Consultant Rheumatologist, North Manchester General Hospital
Case studies of trainee dilemmas. Expert panel and group discussion
Round-up and discussion about possible implementation
19.10-20.40 Satellite Symposia
Abbott Forth Room
Time to act: evidence, commissioning and politics in inflammatory arthritis
(RA, PsA and AS) – Dr Duncan Porter
Early disease intervention: what are we looking for? – Dr Duncan Porter
Excellence as rheumatologists: evidence the route to optimum outcomes? – Dr Mark Quinn
Beyond joints and pain: cardiovascular disease a comorbidity model in rheumatoid
arthritis – Dr Ian Bruce and Prof Naveed Sattar
Commissioning for better outcomes: getting your PCT onside – Andrew Riley, Stoke PCT
Are your patients working? Employment, retention and the importance of managing
inflammatory arthritis (RA, AS and PsA) – John Robertson, MP Glasgow
Question time - Panel, led by chair
Wyeth Hall 1
Changing practice in rheumatoid arthritis
Prof Chris Buckley
Chairman’s welcome and agenda overview
How do we get greater access to anti-TNF agents for RA? – Dr Chris Deighton
Are biologic guidelines evidence based? – Prof Paul Emery
10 years experience of treating to target – Prof Piet Van Riel
Discussion
Chairman’s summary and close
26

Scientific Programme
Thu 30 April 2009
Scientific Programme
Thursday 30 April 2009

BSR Scientific Programme 2009
Thursday 30 April 2009
08.30-10.00 Poster Viewing Hall 5
08.30-09.30 BHPR SIGs
Rheumatoid arthritis Boisdale Room A
Convenor: Janet Cushnaghan
Fatigue: predictors of fatigue and the evidence for intervention –
Sarah Hewlett and Louise Pollard
Self-assessment of joint counts as indicators of disease severity in RA –
Chandra Chattopadhyay and Caroline Tierney
Scientific Programme | Thursday 30 April 2009
Connective tissue disease Boisdale Room B
Convenor: Sue Brown
Scleroderma: managing a multi-system disease
Managing Raynaud’s, calcinosis and ulcers – Sue Brown RNHRD
Managing gastro-intestinal complications of scleroderma – Dr Geraldine Brough
Managing cardio-pulmonary complications of scleroderma – Dr John Pauling
Living with scleroderma – Naomi Reay
Osteoporosis Carron Room A
09.30-10.00 BHPR AGM Dochart Room
10.00-10.30 Tea/Coffee Hall 5
10.30-12.30 BSR: Vasculitis Clyde Auditorium
Dr Richard Watts
• Management of Behcet’s disease – Prof Hassan Yazici
• Viral vasculitis – Prof Loic Guillevin
Vasculitides are sometimes the consequence of virus infections. It is the case for HBV pol
yarteritis nodosa and more frequently for HCV-associated cryoglobulinemia. Several other
infections agents have been considered responsible for vasculitis. When present, treatment
of vasculitis is based also on the treatment of viral infection, and not only on
corticosteroids and immunosuppressants.
• Takayasu’s arteritis – Dr Justin Mason
Takayasu’s arteritis is a challenging condition for the rheumatologist, from difficulties in
diagnosis to lack of an evidence base for treatment. However, advances in our
understanding of disease pathogenesis, diagnostic imaging and treatment are being
made, and will be reviewed in detail.
27

• When is vasculitis not vasculitis? – Dr Raashid Luqmani
The systemic vasculitides are a set of unusual diseases characterised by blood vessel
inflammation leading to organ damage, failure or death if untreated, and an early
diagnosis is important in order to initiate effective therapy often with potent
immunosuppressive agents such as cyclophosphamide and glucocorticoid. However,
the differential diagnosis is very wide, with patients presenting to a number of different
specialists; it is important for the clinician to discriminate between active vasculitis and
conditions which mimic vasculitis, such as sepsis, atherosclerosis or cancer.
BSR and BHPR joint session: Health and work Lomond Auditorium
Prof Alan Silman
• Work and musculoskeletal health: challenges and opportunities – Dr Ross Wilkie
Musculoskeletal disorders are the most frequently cited cause for the problems of ill
health that threaten work ability in the United Kingdom. The challenge that this presents will
be reviewed and the opportunities explored for all stakeholders involved in the management
of musculoskeletal conditions.
• Vocational rehabilitation: what works, for whom, and when? – Prof Gordon Waddell
This talk will present the findings of a review of the scientific evidence on vocational
rehabilitation: what works, for whom and when? and discuss the implications for clinical
and workplace management.
• Dame Carol Black’s review and response to parliament’s reaction – Dame Carol Black
The lecture will cover the Government’s response to my review “Working for a Healthier
Tomorrow”. It will discuss in greater depth some of the initiatives which are of importance to
all of those interested in musculoskeletal disease.
BSR: Genetics of common rheumatic disease Hall 1
Prof Alex MacGregor
• The rough guide to the RA genome – Prof Jane Worthington
• New genes for old joints - the future of OA genetics – Prof John Loughlin
• Genomewide Association studies - what to do after the party – Prof Matthew Brown
• Personalised genomics – Prof Tim Spector
This talk will cover the current state of personalised genomics, the use of do-it-yourself
internet companies and the predictive value of genome-wide scans for an individual for a
range of common diseases and traits.
BHPR: Psychosocial issues from childhood through adult life Boisdale Room
Ms Keri Hutchinson and Mrs Lindsay Hawley
• JIA and family function: implications for transitional care – Dr Jenny Waite-Jones
JIA can create a medicalised family life, through three identifiable phases of symptom onset,
searching for an explanation and diagnosis/ post diagnosis experiences. During transition to
adult care it is useful for staff to be aware of past family experiences, to avoid a potential
fourth phase, as according to some families, this can “feel like starting all over again.”
• Coping with rheumatoid arthritis – Dr Sarah Ryan
This presentation will explore the impact of RA on mood and social support with practical
advise regarding the role of the health professional. Studies where health professionals
have impacted positively on coping will also be discussed.
• Sore feet, sore face – Ms Vickie Cameron
This presentation explores the psychosocial issues surrounding foot pain, and asks the
question ‘who is at the end of the feet?’ The way that the foot is managed in podiatry
rheumatology is challenged and considers if the podiatrist’s focus is too biomedical.
28

• Sexual problems: the patient’s perspective – Dr Jackie Hill
Rheumatic diseases have the potential to affect all areas of a patient’s life, including their
sexual life. The problems that patients with RA, OA and fibromyalgia encounter will be
discussed in this talk.
• The impact of psychosocial influences on quality of life in osteoarthritis –
Dr Anne-Marie Keenan
The focus of this presentation is to report the findings of a study (n=248) which
investigated the impact of physical and psychosocial aspects of quality of life and found
that the single most important factor in predicting quality of life was anxiety, which has
received little attention in assessment and treatment of OA. While function and age also
contributed to QoL, pain only had an indirect impact, either through decreased function
or increased anxiety. This study highlights the importance of psychological factors in
determining quality of life in those with osteoarthritis.
• The impact of ankylosing spondylitis on work in the UK – Dr Jon Packham
The impact of ankylosing spondylitis on effectiveness at work (presenteeism), time off
work (absenteeism) and unemployment in a large cohort of patients from across the UK.
Scientific Programme | Thursday 30 April 2009
BSR: Biomedical research networks – the Canadian experience Dochart Room
Dr Fraser Birrell
• Introduction and welcome
• Brief history, goals, structure of CAN – Prof John Esdaile
• Consumer involvement in CAN and the networks – Prof Cheryl Kohen
• CAN’s clinical research teams – Prof John Esdaile
• CAN’s basic science teams – Prof Robin A. Poole
• Current State of Musculoskeletal Network Research in the UK – Dr Deborah Symmons
• Open forum: are there lessons from Canada?
BHPR: Partnerships in foot healthcare Forth Room
Ms Andrea Graham and Dr Jill Firth
• Medical and non medical management of foot problems in patients with psoriatic
arthritis – Prof Iain McInnes and Ms Elaine Hyslop
This lecture will discuss the common conditions that arise in patients with psoriatic
arthritis in the foot and ankle area. The overarching approach to diagnosis will be
discussed, after which the key investigation, including optimal imaging modalities will be
considered. Medical and surgical therapeutics will be reviewed and the expected clinical
outcome for patients defined.
• Medical and non medical management of foot problems in patients with juvenile
idiopathic arthritis – Dr Janet Gardner Medwin and Mr Gordon Hendry
• Foot and ankle triage service – how the barriers were broken –
Mr Sethil Kumar and Dr Colin Thomson
This session will discuss how a multidisciplinary team approach to orthopaedic foot and
ankle services leads to a reduction in waiting times and improved patient satisfaction.
Future development of the service will also be discussed.
• A multidisciplinary ultrasound guided joint injection clinic – Dr Debbie Turner and
Mrs Mhairi Brandon
An allied health profession lead ultrasound guided joint injection clinic has been running
in Glasgow for five years and has provided a mechanism to improve patient care and an
infrastructure to support training in both injection therapy and diagnostic ultrasound
imaging. This presentation will provide a reflective summary on the development, day
to day practical issues and outcomes from running a musculoskeletal ultrasound joint
injection clinic.
29

12.30-14.30 Lunch Hall 5
BSR AGM Alsh Room
(Lunch will be available at the meeting)
12.45-14.15 BHPR: Writing for publication Hall 1
Ms Emma Healey
• How to get an article published: the editor’s perspective – Dr Sarah Ryan
This presentation will focus on the five ‘rights’ of publishing including the ‘right’ topic in the
‘right’ journal at the ‘right’ time. Barriers and solutions to publishing for health
professionals will also be discussed.
• How to write a qualitative article – Ms Liz Hale
How to construct a qualitative article, with examples of layout style. Perils, pitfalls, and
points to remember. How to manage reviewer, editorial and reader expectations.
• How to get quantitative research published – Dr Alison Hammond
This presentation will address: the structure of quantitative papers; what to ensure you
include; the CONSORT statement for non-pharmacolgical studies; and pitfalls and errors
to (try to) avoid.
• How to write a conference abstract – Prof Sarah Hewlett
This presentation will explore the benefits of writing abstracts, how to get started, how
to get it into just 250-300 words, how to upload it, and then tips for presentation
(and pitfalls!).
14.30-16.30 Concurrent Oral Presentation of Abstracts
Pain and fatigue Forth Room
OP31
IDENTIFICATION OF MODIFIABLE PERSONAL FACTORS THAT PREDICT LOW BACK PAIN
IN NURSING STUDENTS: A PROSPECTIVE STUDY
Tim Mitchell 1 , Peter O’Sullivan 1 , Angus Burnett 2 , Leon Straker 1 , Jenny Thornton 1 , Anne Smith 1 ;
1
Curtin University, Perth, WA, Australia; 2 Edith Cowan University, Perth, WA, Australia
OP32
THE EFFECT OF MILNACIPRAN ON EVOKED PAIN IN FIBROMYALGIA:
A PSYCHOPHYSICAL AND FUNCTIONAL MRI ANALYSIS
Ernest Choy 1 , Serena Carville 1 , Steven Williams 1 , Karin Jensen 2 , Eva Kosek 2 , Martin Ingvar 2 ,
Peter Fransson 3 , Hanke Marcus 3 , Frank Petzke 3 , Yves Mainguy 4 , Rick Gracely 5 ;
1
King’s College London, London, United Kingdom; 2 Karolinska Institutet, Stockholm, Sweden;
3
University Hospital of Cologne, Cologne, Germany; 4 Pierre Fabre Medicament, Laberge, France;
5
University of North Carolina, Chapel Hill, NC
OP33
EFFECTIVE MANAGEMENT OF FIBROMYALGIA WITH GRADED EXERCISE THERAPY
Natasha E. McNeilly 1 , Suzanne Miles 1 , Rebecca Pollin 1 , Verity Appleyard 1 , Kate Carr 1 ,
Karen O’Brenovic 3 , Karen M. Douglas 2 ;
1
Rheumatology Physiotherapy, Dudley Group of Hospitals NHS Trust, Dudley, United Kingdom;
2
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Dudley, United Kingdom;
3
Clinical Audit Department, Dudley Group of Hospitals NHS Trust, Dudley, United Kingdom
OP34
GRADED MOTOR IMAGERY PROGRAMMES IN COMPLEX REGIONAL PAIN SYNDROME:
ONE SIZE DOESN’T FIT ALL?
Jane Hall 1,2 , Catherina Mattheus 1 , Candida S. McCabe 1,2 ;
1
Bath Centre for Pain Services, Royal National Hospital for Rheumatic Diseases, Bath,
United Kingdom; 2 School for Health, University of Bath, Bath, United Kingdom
30

OP35
OP36
OP37
GENETIC VARIATION IN THE SEROTONIN PATHWAY IS ASSOCIATED WITH CHRONIC
WIDESPREAD PAIN: RESULTS FROM THE EPIFUND STUDY
Barbara I. Nicholl 1 , Kate L. Limer 1 , Gary J. Macfarlane 2 , Wendy Thomson 1 , Kelly A. Davies 1 ,
John McBeth 1 ;
1
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom;
2
Aberdeen Pain Research Collaboration (Epidemiology Group), University of Aberdeen,
Aberdeen, United Kingdom
GENETIC VARIATION IN THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS GENES MAY
INFLUENCE SUSCEPTIBILTY TO MUSCULOSKELETAL PAIN: RESULTS FROM THE
EPIFUND STUDY
Kate L. Limer 1 , Barbara I. Nicholl 1 , Gary J. Macfarlane 2 , Wendy Thomson 1 , Kelly A. Davies 1 ,
John McBeth 1 ;
1
ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom;
2
University of Aberdeen, Aberdeen, United Kingdom
RHEUMATOID ARTHRITIS PATIENTS’ INTERPRETATION OF THE DAS PATIENT GLOBAL
USED AT BRISTOL ROYAL INFIRMARY
Tessa Sanderson 1 , Michael Calnan 2 , Marianne Morris 3 , Pam Richards 4 , Sarah Hewlett 1 ;
1
Academic Rheumatology, University of the West of England, Bristol, United Kingdom;
2
Centre for Health Services Studies, University of Kent, Canterbury, United Kingdom;
3
Centre for Appearance Research, University of the West of England, Bristol, United Kingdom;
4
Academic Rheumatology, University of Bristol, Bristol, United Kingdom
Scientific Programme | Thursday 30 April 2009
OP38
DEVELOPMENT AND INITIAL VALIDATION OF SHORT SCALES TO MEASURE SEVERITY,
EFFECT AND ABILITY TO COPE WITH FATIGUE IN RA
Joanna K. Nicklin 1 , John Kirwan 2 , Fiona Cramp 1 , Sarah Hewlett 1 ;
1
Faculty of Health and Life Sciences, University of West of England, Bristol, United Kingdom;
2
Academic Rheumatology, University of Bristol, Bristol, United Kingdom
Vascular biology and vasculitis Alsh Room
OP39
OP40
YOUNG INVESTIGATOR AWARD WINNER
IMPAIRED ENDOTHELIAL PROGENITOR CELL FUNCTION AND EARLY ATHEROSCLEROSIS
IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
Sahena Haque 1 , Chadi Rakieh 2 , Michael C. Jackson 3 , M. Y. Alexander 4 , Ian N. Bruce 1 ;
1
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom; 2 Translational
Medicine, University of Manchester, Manchester, United Kingdom; 3 Faculty of Life Sciences,
University of Manchester, Manchester, United Kingdom; 4 Cardiovascular Medicine, University
of Manchester, Manchester, United Kingdom
COMPLEMENT DYSREGULATION LINKS ACCELERATED ATHEROSCLEROSIS AND
GLOMERULONEPHRITIS IN SLE
Myles J. Lewis 1 , Talat H. Malik 1 , Liliane M. Fossati-Jimack 1 , Daniele Carassiti 1 ,
Terence H. Cook 2 , Dorian O. Haskard 3 , Marina Botto 1 ;
1
Molecular Genetics & Rheumatology Section, Imperial College, London, United Kingdom;
2
Histopathology Dept, Imperial College, London, United Kingdom; 3 BHF Cardiovascular
Medicine Unit, Imperial College, London, United Kingdom
31

OP41
THE EFFECTS OF A REDUCTION IN DISEASE ACTIVITY ON MICROVASCULAR FUNCTION,
MACROVASCULAR FUNCTION AND ARTERIAL STIFFNESS IN PATIENTS WITH
RHEUMATOID ARTHRITIS
Aamer Sandoo 2,1 , Jet Veldhuijzen van Zanten 2,1 , Jacqueline P. Smith 1 , George S. Metsios 1,3 ,
Antonios Stavropoulos-Kalinoglou 1,3 , Douglas Carroll 2 , George D. Kitas 1 ;
1
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Dudley, United Kingdom;
2
School of Sport and Exercise Sciences, University of Birmingham, Birmingham, United
Kingdom; 3 School of Sport, Performing Arts & Leisure, Wolverhampton University,
Wolverhampton, United Kingdom
OP42
BIMODAL MORTALITY RISK IN WEGENER’S GRANULOMATOSIS
Raashid A. Luqmani 1 , Christopher Edwards 2 , David Culliford 3 , Joe Maskell 4 , David Jayne 5 ,
Nigel Arden 2 ;
1
Rheumatology Department, Botnar Research Centre, University of Oxford, Oxford, United
Kingdom; 2 Rheumatology Department, Southampton General Hospital, Southampton, United
Kingdom; 3 Research & Development Support Unit, University of Southampton, Southampton,
United Kingdom; 4 PHSMS, University of Southampton, Southampton, United Kingdom;
5
Nephrology Department, Addenbrooke’s Hospital, Cambridge, United Kingdom
OP43
OP44
IS THERE SPATIAL CLUSTERING OF ANCA-ASSOCIATED VASCULITIS IN THE UK?
Richard Watts 1 , Divya Nelson 1 , Janice Mooney 1 , Alex MacGregor 1 , David Scott 2 ;
1
Health and Social Sciences Research Institute, University of East Anglia, Norwich,
United Kingdom; 2 Department of Rheumatology, Norfolk and Norwich University Foundation
NHS Trust, Norwich, United Kingdom
USING THE BIRMINGHAM VASCULITIS ACTIVITY SCORE (VERSION 3) FOR
DIAGNOSING VASCULITIS
Chetan Mukhtyar 1 , Denise Brown 1 , Catherine Hall 2 , John McLaren 2 , Raashid Luqmani 1 ;
1
University of Oxford, Oxford, United Kingdom; 2 University of Edinburgh, Edinburgh,
United Kingdom
OP45
DISEASE ACTIVITY, QUALITY OF LIFE AND ADVERSE EVENTS IN THE FIRST TWO YEARS
OF POLYMYALGIA RHEUMATICA
B. Dasgupta 1 , A. Hutchings 2 , J. Hollywood 1 , D. Lamping 2 , N. Gendi 3 , K. Chakravarty 9 ,
D. G. Scott 5 , B. Bourke 6 , E. Choy 7 , B. Silverman 4 , C. Pease 8 ;
1
Southend University Hospital, Westcliff, United Kingdom; 2 London School of Hygiene & Tropical
Medicine, Westcliff, United Kingdom; 3 Basildon & Thurrock Hospital, Basildon, United Kingdom;
4
Addenbrookes Hospital, Cambridge, United Kingdom; 5 Norfolk & Norwich Hospital, Norwich,
United Kingdom; 6 St Georges Hospital, Tooting, United Kingdom; 7 Kings College Hospital,
London, United Kingdom; 8 Leeds General Infirmary, Leeds, United Kingdom;
9
Queens Hospital, Romford, United Kingdom
OP46
FACTORS AT DIAGNOSIS PREDICTING THE OUTCOME OF POLYMYALGIA RHEUMATICA:
DURATION OF STEROID THERAPY, OCCURRENCE OF RELAPSES, AND LATE DEVELOPMENT
OF GIANT CELL ARTERITIS
Sarah L. Mackie 1 , Elizabeth M. Hensor 1 , Bipin Bhakta 2 , Colin T. Pease 2 ;
1
University of Leeds, Leeds, United Kingdom; 2 Leeds Teaching Hospitals NHS Trust,
Leeds, United Kingdom
32

Rheumatoid arthritis Clyde Auditorium
OP47
OP48
LONG-TERM SAFETY OF RITUXIMAB: 6-YEAR FOLLOW-UP OF THE RA CLINICAL TRIALS
AND RE-TREATMENT POPULATION
Ronald F. van Vollenhoven 1 , Paul Emery 2 , Clifton O. Bingham III 3 , Edward Keystone 4 ,
Roy Fleischmann 5 , Karen A. Rowe 6 , Marianne Sweetser 7 , Ope Osikoya 6 , Ariella Kelman 8 ,
Ravi M. Rao 6 ;
1
Karolinska University Hospital, Stockholm, Sweden; 2 Leeds General Infirmary, Leeds, United
Kingdom; 3 Johns Hopkins University, Baltimore, MD; 4 University of Toronto, Toronto, ON,
Canada; 5 University of Texas Southwestern Medical Center at Dallas, Dallas, TX; 6 Roche
Products Ltd, Welwyn Garden City, United Kingdom; 7 Biogen Idec Inc, Cambridge, MA;
8Genentech, Inc., South San Francisco, CA
GOLIMUMAB, A HUMANTNF-ALPHA ONOCLONAL ANTIBODY, IN RHEUMATOID ARTHRITIS
PATIENTS PREVIOUSLY TREATED WITH ANTI-TNF-ALPHA AGENTS (GO-AFTER STUDY)
Paul Wordsworth 1 , Josef Smolen 2 , Jonathan Kay 3 , Mittie K. Doyle 4 , Robert Landewe 5 ,
Eric L. Matteson 6 , Y. Zhou 7 , E. C. Hsia 4 , M. U. Rahman 4 , for the GO-AFTER Study
Investigators 7 ;
1
Nuffield Orthopaedic Centre, Oxford, United Kingdom; 2 Medical University of Vienna/Hietzing
Hospital, Vienna, Austria; 3 Massachusetts General Hospital/Harvard Medical School, Boston,
MA; 4 Centocor R&D, Inc./U Penn Med School, Philadelphia, PA; 5 University Hospital
Maastricht, Maastricht, Netherlands; 6 Mayo Clinic, Rochester, MN; 7 Centocor Research
and Development, Inc., Malvern, PA
Scientific Programme | Thursday 30 April 2009
OP49
RAPID INHIBITION OF PROGRESSION OF STRUCTURAL DAMAGE WITH CERTOLIZUMAB
PEGOL, A NOVEL SC PEGYLATED, FC-FREE ANTI-TNF
Desiree van der Heijde 1 , Michael Weinblatt 2 , Robert Landewé 3 , Niti Goel 4 , Roy Fleischmann 5 ;
1
Leiden University Medical Center, Leiden, Netherlands; 2 Brigham and Women’s Hospital,
Boston, MA; 3 University Hospital Maastricht, Maastricht, Netherlands; 4 UCB, Smyrna, GA;
5
University of Texas Southwestern Medical Center, Dallas, TX
OP50
ADALIMUMAB AND METHOTREXATE COMBINATION THERAPY IN PATIENTS WITH EARLY
RA SUSTAINS CLINICAL REMISSON AND RESPONSE THROUGH 5 YEARS OF
ADALIMUMAB TREATMENT
Aileen L. Pangan 5 , Ferdinand C. Breedveld 1 , Arthur Kavanaugh 2 , Piet van Riel 3 , Kaushik Patra 4 ,
John L. Perez 4 ;
1
University Medical Center, Leiden, Netherlands; 2 UCSD Center for Innovative Therapy, La Jolla,
CA; 3 University Medical Centre, Nijmegen, Netherlands; 4 Abbott Laboratories, Parsippany, NJ;
5
Abbott Laboratories, Abbott Park, IL
OP51
TOCILIZUMAB SIGNIFICANTLY IMPROVES PATIENT OUTCOMES REGARDLESS OF PRIOR
INADEQUATE RESPONSE TO TUMOUR NECROSIS FACTOR ANTAGONISTS IN
RHEUMATOID ARTHRITIS
P. Emery 1 , E. Keystone 2 , H. P. Tony 3 , A. Law 4 , T. Woodworth 4 , J. Kremer 5 ;
1
Leeds Teaching Hospitals Trust, University of Leeds, Leeds, United Kingdom; 2 Mount Sinai
Hospital, Toronto, ON, Canada; 3 Medizinische Klinik II, Würzburg, Germany; 4 Roche, Welwyn,
United Kingdom; 5 University of Leeds, Leeds, NY
33

OP52
OP53
OP54
MATRIX RISK MODEL FOR PREDICTION OF RAPID RADIOGRAPHIC PROGRESSION IN
RHEUMATOID ARTHRITIS
Nathan Vastesaeger 1 , Stephen Xu 2 , Daniel Aletaha 3 , E.William St. Clair 4 , Josef Smolen 3 ;
1
Centocor BV, Leiden, Netherlands; 2 Centocor R&D, Malvern, PA; 3 Medical University of Vienna,
Vienna, Austria; 4 Duke University Medical Center, Durham, NC
METHOTREXATE THERAPY ASOCIATES WITH REDUCED PREVALENCE OF THE METABOLIC
SYNDROME IN RHEUMATOID ARTHRITIS: MORE THAN JUST AN ANTI-INFLAMMATORY EFFECT
Tracey E. Toms, Vasileios F. Panoulas, Karen M. Douglas, George D. Kitas;
Rheumatology, Dudley Group of Hospitals NHS Trust, Dudley, United Kingdom
FACTORS ASSOCIATED WITH WORK DISABILITY IN RHEUMATOID ARTHRITIS PATIENTS:
RESULTS FROM THE BSR BIOLOGICS REGISTER (BSRBR)
Suzanne. M.M. Verstappen, Kath D. Watson, Katie McGrother, Deborah P.M. Symmons, Kimme
L. Hyrich, On behalf of the BSR Biologics Register;
arc Epidemiology, the University of Manchester, Manchester, United Kingdom
Case reports Lomond Auditorium
OP55
OP56
OP57
OP58
RITUXIMAB IS EFFECTIVE IN REFRACTORY INFLAMMATORY EYE DISEASE ASSOCIATED WITH
RHEUMATOID ARTHRITIS
Sadra I. Razzaq 2 , Kathryn E. Moss 2 , Ahmed Kamal 3 , C. Estrach 1 , R. N. Thompson 1 ,
S. Chauhan 4 , Robert J. Moots 1 ;
1
Rheumatology, University Hospital Aintree, Liverpool, United Kingdom; 2 Medicine, University
of Liverpool, Liverpool, United Kingdom; 3 Opthalmology, University Hospital Aintree, Liverpool,
United Kingdom; 4 General Medicine, Government Medical College & Hospital Chandigarh,
Chandigarh, India
SPONTANEOUS PNEUMOMEDIASTINUM SECONDARY TO REFRACTORY
DERMATOMYOSITIS SUCCESSFULLY TREATED WITH RITUXIMAB: A CASE REPORT
AND REVIEW OF THE LITERATURE
Martin A. Lee, David G. Hutchinson;
Rheumatology, Royal Cornwall Hospital, Truro, United Kingdom
RITUXIMAB AS PRIMARY THERAPY FOR PULMONARY HAEMORRHAGE IN SYSTEMIC
LUPUS ERYTHEMATOSUS
Chetan B. Narshi, Seema Haider, Charlotte M. Ford, David A. Isenberg, Ian P. Giles;
Centre for Rheumatology Research, University College Hospital, London, United Kingdom
RASBURICASE IN TREATMENT FAILURE GOUT
Derek R. Baxter 1 , Martin E. Perry 1 , Roger D. Sturrock 1 , Laura Johnstone 2 ;
1
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, United Kingdom;
2
Area Medicines Information Centre, Glasgow Royal Infirmary, Glasgow, United Kingdom
OP59
THE VITAMIN D AND CALCIUM CHALLENGE TEST
Adrian Peall 1 , Gwennan Hughes 2 , James Martin 2 ;
1
Rheumatology, University Hospital Wales, Cardiff, United Kingdom;
2
Rheumatology, Royal Glamorgan Hospital, Llantrisant, United Kingdom
34

OP60
OP61
OP62
SLE WITH C1Q DEFICIENCY TREATED WITH FRESH FROZEN PLASMA (FFP):
A TEN YEAR EXPERIENCE
P. Mehta1, P. J. Norsworthy 1 , M. J. Walport 2 , M. Botto 1 , M. C. Pickering 1 ;
1
Molecular Genetics & Rheumatology Section, Hammersmith Hospital, London,
United Kingdom; 2 The Wellcome Trust, London, United Kingdom
A CASE OF SJÖGREN’S SYNDROME WITH RENAL TUBULAR ACIDOSIS AND CENTRAL
PONTINE MYELINOLYSIS
Kathryn Watson, Sureshni de Fonseka, Damodharan Suresh;
University College London Hospital Trust, London, United Kingdom
PERSISTANT PAIN AT THE 1ST CMC JOINT MISDIAGNOSED FOR YEARS
Ahmad Al-Shami 1 , James Taylor 2 ;
1
Rheumatology, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary,
Leicester, United Kingdom; 2 Rheumatology, Northampton General Hospital NHS Trust,
Northampton, United Kingdom.
Scientific Programme | Thursday 30 April 2009
Education research Dochart Room
OP63
OP64
OP65
USE OF ‘GALS’ IN CLINICAL PRACTICE. WHY ARE WE STILL FAILING?
K. Chakravarty, Mathura Selvarajah, Hamida Begum, Jasmin Sajna;
Rheumatology Deprtment, Queens Hospital, Romford, United Kingdom
AN EVIDENCE AND PRACTICE BASED REGIONAL MUSCULOSKELETAL EXAMINATION FOR
SCHOOL AGED CHILDREN - PREMS
Tim Rapley 1,2 , Ben Heaven 1 , Carl May 1,2 , Lesley Kay 2,1 , Helen Foster 2,1 ;
1
Institute of Health & Society, Newcastle University, Newcastle, United Kingdom; 2 Institute of
Cellular Medicine, Newcastle University, Newcastle, United Kingdom
PEER-ASSISTED LEARNING BY MEDICAL STUDENTS IMPROVES MUSCULOSKELETAL
SYSTEM EXAMINATION SKILLS
Martin E. Perry 1 , Joanne Burke 2 , Lorraine Friel 1 , Max Field 1 ;
1
Centre for Rheumatic Disease, Glasgow Royal Infirmary, Glasgow, United Kingdom;
2
Department of Medical Education, The University of Glasgow, Glasgow, United Kingdom
OP66
OP67
BECOMING ESTABLISHED: LEARNING ABOUT ANKYLOSING SPONDYLITIS (AS) FROM THE
PATIENT’S PERSPECTIVE
Ben Thompson 1 , Tim J. Rapley 2 , Wendy Broderick 3 , Carl R. May 2 , Lesley J. Kay 1 ;
1
Newcastle Musculoskeletal Research Group, Newcastle University, Newcastle-upon-Tyne,
United Kingdom; 2 Institute of Health and Society, Newcastle University, Newcastle-upon-Tyne,
United Kingdom; 3 National Ankylosing Spondylitis Society (NASS), Tyne and Wear Branch,
United Kingdom
VALIDATION OF THE EDUCATIONAL NEEDS ASSESSMENT TOOL IN 6 RHEUMATIC
DISEASES
Mwidimi Ndosi 1 , Jackie Hill 1 , Alan Tennant 2 , Claire Hale 3 , Ade Adebajo 4 ;
1
Academic & Clinical Unit for Musculoskeletal Nursing, University of Leeds, Leeds, United
Kingdom; 2 Academic Department of Rehabilitation Medicine, University of Leeds, Leeds,
United Kingdom; 3 School of Healthcare, University of Leeds, Leeds, United Kingdom;
4
Rheumatology Department, Barnsley Hospital NHS Foundation Trust, Barnsley, United
Kingdom
35

OP68
OP69
HOW READABLE ARE THE RHEUMATOLOGY INFORMATION LEAFLETS WE GIVE OUR PATIENTS?
Wendy Holden 1 , Joseph Joseph 2 ;
1
Rheumatology, Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke,
United Kingdom; 2 Rheumatology, Aretaeion Private Hospital, Nicosia, Cyprus
INTERPRETATION AND UTILISATION OF THE STANFORD HEALTH ASSESSMENT
QUESTIONNAIRE DISABILITY INDEX (HAQ-DI) AMONGST RHEUMATOLOGISTS IN
TRAINING IN THE UNITED KINGDOM
John D. Pauling 1 , Raj Sengupta 1 , David R. Blake 1,2 ;
1
Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom;
2
School for health, University of Bath, Bath, United Kingdom
OP70
NEW EDUCATIONAL TECHNIQUES IN RHEUMATOLOGY: IMPLEMENTING A MULTI MEDIA
VIRTUAL LEARNING ENVIRONMENT FOR RHEUMATOLOGY EDUCATION AND RESEARCH
James Bateman 1,2 , David Davies 2 , Maggie E. Allen 1 ;
1
Department of Rheumatology, University Hospital Coventry and Warwickshire, Coventry,
United Kingdom; 2 Warwick Medical School, University of Warwick, Warwick, United Kingdom
Connective tissue disease Boisdale Room
OP71
OP72
OP73
IN ADULT IDIOPATHIC INFLAMMATORY MYOPATHIES (IIM), THE HLA-DRB1*03-ASSOCIATED
INCREASED RISK FOR DEVELOPING ANTI-JO-1 ANTIBODIES IS EXACERBATED IN SMOKERS
Suresh Adimulam 1 , Hector Chinoy 1 , Kathryn Edge 1 , Chester V. Oddis 3 , William.E R. Ollier 2 , Robert
G. Cooper 1 ;
1
The University of Manchester Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust,
Manchester, United Kingdom; 2 Centre for Integrated Genomic Medical Research, University of
Manchester, Manchester, United Kingdom; 3 Division of Rheumatology,
University of Pittsburgh, pittsburgh, PA
IN UK CAUCASIAN ADULT AND JUVENILE-ONSET DERMATOMYOSITIS (DM), THE VITAMIN D
RECEPTOR GENE (VDR) IS ASSOCIATED WITH POSSESSION OF ANTI-155/140 ANTIBODIES
Sabrina R. Kapoor 1 , Hector Chinoy 2,3 , Lucy R. Wedderburn 4 , Chester V. Oddis5, Neil J. McHugh6,
William E. Ollier 2 , Robert G. Cooper 3 ;
1
Rheumatology, Russells Hall Hospital, Dudley, United Kingdom; 2 Centre for Integrated Genomic
Medical Research,, University of Manchester, Manchester, United Kingdom;
3
The University of Manchester Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust,
Salford, United Kingdom; 4 Rheumatology Unit, Institute of Child Health, UCL, London, United
Kingdom; 5 Division of Rheumatology & Clinical Immunology, University of Pittsburgh School of
Medicine,, Pittsburgh,, PA; 6 Rheumatology Dept, Royal National Hospital for Rheumatic Diseases,
Bath, United Kingdom
SHOULD HEADACHE BE INCLUDED IN DISEASE ACTIVITY MEASURES OF NPSLE?
Pamela L. Peterson 1,2 , Franklyn A. Howe 3 , Phil Rich 5 , A. Clifton 5 , Chris A. Clark 4 ,
John S. Axford 2 ;
1
Rheumatology, Newcastle Foundation Trust, Newcastle Upon Tyne, United Kingdom; 2 Academic
Rheumatology, St George’s University, London, London, United Kingdom;
3
Basic Medical Sciences, St George’s University, London, London, United Kingdom;
4
Dept Child Health, UCL, London, United Kingdom; 5 Neuroradiology, St George’s Hospital,
London, United Kingdom
36

OP74
OP75
OP76
MEDICAL STUDENT BURSARY WINNER
THE IMPORTANCE OF ANTI-THROMBIN ANTIBODIES IN THE ANTIPHOSPHOLIPID
SYNDROME
Jasmine Ehsanullah, Anisur Rahman, Ian Giles;
Centre for Rheumatology, Department of Medicine, University College, London,
United Kingdom
OBSERVATIONAL STUDY OF TREATMENT OUTCOME IN EARLY DIFFUSE CUTANEOUS
SYSTEMIC SCLEROSIS
Ariane L. Herrick 1 , Mark Lunt 1 , Nina Whidby 1 , Holly Ennis 1 , Alan Silman 1 , Neil McHugh 2 ,
Christopher P. Denton 3 ;
1
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom; 2 Royal National
Hospital for Rheumatic Diseases, Bath, United Kingdom; 3 Royal Free Hospital, London,
United Kingdom
CLINICAL AND SEROLOGICAL HALLMARKS OF SYSTEMIC SCLEROSIS OVERLAP
SYNDROMES
Angela Pakozdi, Svetlana I. Nihtyanova, Geraldine M. Brough, Carol M. Black,
Christopher P. Denton;
Centre for Rheumatology, Royal Free Hospital, London, United Kingdom
Scientific Programme | Thursday 30 April 2009
OP77
OP78
TADALAFIL IS EFFECTIVE IN THE MANAGEMENT OF RESISTANT SECONDARY RAYNAUD’S
PHENOMENON AND IMPROVES ENDOTHELIAL FUNCTION
Padmanabha Shenoy 1 , Vikas Agarwal 1 , Sudeep Kumar 2 , Sunil Choudhary 2 , Lalan Jha 2 ,
Uttam Singh 3 , Ramnath Misra 1 ;
1
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences,
Lucknow, India; 2 Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical
Sciences, Lucknow, United Kingdom; 3 Department of Biostatistics, Sanjay Gandhi Post
Graduate Institute of Medical Sciences, Lucknow, United Kingdom
STRESS SIGNAL TRANSDUCTION PATHWAYS ACTIVATED IN EPIDERMAL KERATINOCYTES
IN SYSTEMIC SCLEROSIS
Nima H. Aden, Anna Nuttall, Shiwen Xu, Chris Denton, Carol Black, David Abraham,
Richard Stratton;
Centre for Rheumatology, Royal Free Hospital and University College Medical School, London,
United Kingdom
BHPR Concurrent Oral Presentation of Abstracts Hall 1
OP79
GROUP CLINICS CAN DELIVER EFFECTIVE CARE FOR RHEUMATOID ARTHRITIS:
A FEASIBLE MODEL FOR AN ANNUAL REVIEW CLINIC
Fraser Birrell;
1
Rheumatology, Northumbria Healthcare NHS Foundation Trust, Newcastle, United Kingdom;
2
Newcastle University, Newcastle, United Kingdom
OP80
SELF-REPORTED HAND FUNCTION AND ADAPTATION BEHAVIOUR IN
COMMUNITY-DWELLING OLDER ADULTS OVER AN 18-MONTH PERIOD
Helen Myers 1 , Elaine Nicholls 1 , George Peat 1 , Danielle van der Windt 1,2 , Krysia Dziedzic 1 ;
1
Arthritis Research Campaign National Primary Care Centre, Keele University, Keele,
United Kingdom; 2 EMGO Institute, VU University Medical Center, Amsterdam, Netherlands
37

OP81
OP82
OP83
A CONTROLLED STUDY OF PLANTAR FOOT PRESSURES IN PATIENTS WITH
RHEUMATOID ARTHRITIS
Ruth P. Allen 1 , James Beacroft 1 , Cathy J. Bowen 1 , Anita Gay 1 , Lindsey Hooper 1 ,
Jane H. Burridge 1 , Christopher J. Edwards 2,3 , Nigel K. Arden 4,5 ;
1
School of Health Sciences, University of Southampton, Southampton, United Kingdom;
2
Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton,
United Kingdom; 3 Wellcome Trust Clinical Research Facility, Southampton University Hospitals
NHS Trust, Southampton, United Kingdom; 4 MRC Epidemiology Resource Centre, University of
Southampton, Southampton, United Kingdom; 5 Musculoskeletal Biomedical Research Unit,
University of Oxford, Oxford, United Kingdom
IMPROVING SKILL-MIX IN RHEUMATOLOGY: HIGH QUALITY OF CARE FROM AN
INDEPENDENTLY PRESCRIBING RHEUMATOLOGY PHARMACIST PRACTITIONER
Richard Copeland 1,2 , Fraser Birrell 3,4 ;
1
Pharmacy, Northumbria Healthcare NHS Foundation Trust, Ashington, United Kingdom;
2
School of Pharmacy, University of Sunderland, Sunderland, United Kingdom; 3 Rheumatology,
Northumbria Healthcare NHS Foundation Trust, Ashington, United Kingdom; 4 School of Clinical
Medical Sciences, Newcastle University, Newcastle, United Kingdom
MEASURING THE IMPACT OF FOOT DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS
COMMENCING ANTI TNF-BIOLOGIC THERAPY USING THE LEEDS FOOT IMPACT SCALE
Heidi J. Siddle 1 , Domini J. Bryer 2 , Philip S. Helliwell 1 ;
1
Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom;
2
Rheumatology Department, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
OP84
AN AUDIT ON SERUM 25-HYDROXY VITAMIN D IN A RHEUMATOLOGY OUT-PATIENT CLINIC
Kate M. Wilkinson 1 , John A. Reynolds 1 , Jacqueline L. Berry 2,1 , Ian N. Bruce 1 , Rachel Gorodkin 1 ,
Kimme Hyrich 1 , Alan Silman 1 , Pauline Ho 1 ;
1
Kellgren Centre for Rheumatology, Manchester Royal Infirmary, Manchester, United Kingdom;
2
Vitamin D Research Group, Manchester Royal Infirmary, Manchester, United Kingdom
OP85
OP86
THE EFFORT PROJECT: A QUALITATIVE EXPLORATION OF ORTHOSES AND FOOTWEAR
PROVISION FOR PEOPLE WITH RHEUMATOID ARTHRITIS (RA)
Maggie McArthur, Bryony Crompton;
School of Aliied Health Professions, University of East Anglia, Norwich, United Kingdom
A COMPARISON OF A COMPUTER GAME-BASED EXERCISE SYSTEM WITH CONVENTIONAL
APPROACHES OF EXERCISE THERAPY IN RHEUMATOLOGY PATIENTS
Kirsti McCormack 1 , Diarmaid Fitzgerald 1 , Oliver Fitzgerald 2 , Brian Caulfield 1 ;
1
School of Physiotherapy, University College Dublin, Belfield, Dublin 4, Ireland; 2 Rheumatology
Unit, Our Lady`s Hospice, Harold`s Cross, Dublin, Ireland
16.30-17.00 Tea/Coffee Hall 5
17.00-18.00 Heberden Round Clyde Auditorium
Chair: Dr Deborah Bax
Prof Patricia Woo
More than meets the eye
This lecture will explore the clinical heterogeneity and outcomes of conditions diagnosed as
juvenile idiopathic arthritis. Cases will be presented to illustrate classical clinical observations
can provide direction to laboratory investigations, results from which can in turn lead to choice
of therapies.
38

18.00-19.30 Satellite Symposia
UCB Forth Room
Steering an optimal course for patients with rheumatoid arthritis
Welcome – Prof Peter C Taylor
What does Alice want? – Alice Peterson
Bound for a response to treatment?: managing and meeting patient expectations –
Mrs Trish Cornell
Mapping effective patient pathways: a rapid response as a predictor of a sustained response –
Prof Peter C Taylor
The productive patient, a new destination: patient-reported outcomes in clinical
decision-making – Dr Chris Edwards
Patient/rheumatology team partnership: working together to achieve optimum outcomes for
patients – Alice Peterson
19.35 Coaches to BSR Social Event
20.00-00.30 BSR social event
25th Anniversary dinner dance
Kelvingrove art gallery and museum
(Welcome drinks from 19.30, concludes at 00.30)
Scientific Programme | Thursday 30 April 2009
39

Scientific Programme
Fri 01 May 2009
Scientific Programme
Friday 01 May 2009

BSR Scientific Programme 2009
Friday 01 May 2009
08.30-10.00 Poster Viewing including Tea/Coffee Hall 5
10.00-11.00 State of the Art Lecture Clyde Auditorium
Nanotechnology in medicine
Prof Richard Jones
Nanotechnology refers to our developing capability to manipulate matter on the nanoscale.
This is the length-scale of the fundamental processes of cell biology, so we should expect
that medical interventions on this length-scale – nanomedicine – to grow in importance.
The session will explore’ current and prospective applications of nanomedicine, particularly in
targeted drug delivery and diagnostic devices, before discussing what might and might not be
possible in the longer term.
Scientific Programme | Friday 01 May 2009
BHPR: Research issues and Prize Giving Lomond Auditorium
Dr Ross Wilkie and Mrs Diana Finney
• Rheumatology health professionals and their current practice - results from
the BHPR/RCN survey – Dr Jackie Hill
BHPR and the RCN Rheumatology Forum have conducted a joint survey to gain insight
of the demographics and current rheumatology practice of the multidisciplinary team.
The preliminary results will be presented in this paper
• Funding opportunities – Mr Mike Patnick
• Priority areas for UK clinical studies in osteoarthritis and crystal diseases – Dr George Peat
• Prize Giving and NRAS presentation
11.00-11.30 Tea/Coffee Hall 5
11.30-13.00 Political Slot: NICE and the BSR Hall 1
Dr Chris Deighton
• The advantages of NICE rheumatology guidelines and technology appraisals –
Prof David L Scott
National standards enable patients with long-term conditions to access treatments in an
era of limited healthcare budgets. NICE provides a framework to achieve equity between
different patient groups, including patients with rheumatic diseases.
• The disadvantages of NICE rheumatology guidelines and technology appraisals –
Dr Chris Deighton
Rheumatology technology appraisals have lead to a number of appeals, suggesting that
stakeholders disagree with the results. This talk will consider the problems that lead to this
dissatisfaction.
• NICE technology appraisals methodology: working effectively with health care
professionals – Prof David Barnett Chair of NICE Appraisal Committee
NICE technology appraisal guidance to the NHS is developed on the basis of a robust
review of the evidence available on both clinical and cost effectiveness. It is important
that all stakeholders are fully consulted during the development of the guidance. The input
from clinical professionals is especially relevant to ensure both consistency between
appraisals and that the final guidance is implemented appropriately.
• Discussion
41

BSR: Management of unusual bone disease Forth Room
Prof Paul Wordsworth
• New insights in skeletal development – Prof William Horton
Achondroplasia and related human chondrodysplasias are due to activating mutations of
transmembrane receptor, FGFR3, a key negative regulator in linear bone growth. Evidence
suggests that they act in part by interfering with the normal turnover of the activated
receptor. Strategies to reduce stability of the mutant receptors are being developed to
potentially stimulate bone growth in these conditions.
• Matrix disorders in skeletal dysplasia – Dr Michael Briggs
The skeletal dysplasias are a clinically and genetically heterogeneous group of diseases.
Mutations in the genes encoding cartilage structural proteins can cause a distinct group of
autosomal dominant phenotypes, the disease mechanisms of which will be discussed.
• Running a skeletal dysplasia clinic – Prof Paul Wordsworth
Input from many disciplines is required for optimal management of these rare and often
complex disorders. This will be illustrated by the multidisciplinary approach of the Oxford
Skeletal Dysplasia Clinic in this presentation. A brief approach to the categorisation of these
dysplasias will be presented, including useful websites and approaches to management.
BHPR: Qualitative studies of self-management in osteoarthritis Alsh Room
Prof Pauline Ong
• Providing information to support self-management of OA – Mrs Janet Grime
This talk will examine the role and value of providing patients with information on their
chronic condition from a professional, lay and organisational perspective and report on
a project which developed written material on OA to help support patient self-management.
• Decision making by people with knee OA about self-management of their pain and
disability – Dr Claire Jinks and Mr Andrew Morden
This session will explore what factors shape people’s decision-making to self-manage knee
OA and will discuss supported self-management in primary care.
• Providing information to support self-management of OA – Prof Pauline Ong
This session will consider the contested nature of self-management and report on a project
in which patients and health professionals developed written material on OA.
BSR: New immunosuppressants Lomond Auditorium
Prof Hill Gaston
• Mycophenolate mofetil in the treatment of SLE – Dr Liz Lightstone
Mycophenolate mofetil (MMF) has transformed the treatment options for lupus nephritis.
Establishing its role in induction therapy generated the largest randomised controlled trials
in lupus nephritis ever undertaken. However, with the advent of newer treatment options
such as Rituximab, has it had its day or will it reign supreme over cyclophosphamide?
This session will review the evidence for the role of MMF in the treatment of lupus nephritis,
the limitations to its effectiveness and new therapeutic strategies.
• Leflunomide and deoxyspergualin in the treatment of vasculitis – Prof Wolfgang Gross
• The role of methotrexate in the management of vasculitis – Dr Christian Pagnoux
Methotrexate is used to treat various vasculitides: in GCA it is used as a steroid-sparing
agent, in Wegener’s and MPA it can be as effective as azathioprine in maintaining remission,
and it is an alternative to cyclophosphamide for induction therapy in localized Wegener’s.
It has a relatively good safety profile, but should be used prudently when renal function
is impaired.
42

13.00-14.00 Lunch Hall 5
BHPR: Clinical update on spondyloarthropathies Boisdale Room
Dr Anthony Redmond
• AS – Dr Lesley Kay
• PsA – Ms Kate Gadsby
This talk will provide an update on the assessment and treatments available for patients
with psoriatic arthritis and incorporating NICE guidance into clinical practice.
13.00-15.00 BSR Special interest groups
Sport and exercise medicine Leven Room
Convenor: Dr Jonathan Rees
How to manage exercise induced lower leg pain
Exercise induced lower leg pain – introduction, differential diagnosis and investigations –
Dr Jonathan Rees
Rehabilitation / assessment of exercise induced lower leg pain – Jayne McLenaghan
Exercise induced lower leg pain – conservative management –
Lt Col Jonathan Houghton MRCP, MFSEM
Pressure study monitoring and surgical management of chronic exertional compartment
syndrome – Squadron Leader Shreshth Datta
Open forum question and answer session
Scientific Programme | Friday 01 May 2009
Musculoskeletal ultrasound Morar/Ness Room
Convenor: Cristina Estrach
Welcome and introduction – Cristina Estrach (Chair) and David Kane (Co-chair)
Liverpool and Nottingham MUS surveys: where are we and where do we want to go? –
Claire Dubois and Ira Pandya
The EULAR courses guidelines. How should we run the BSR courses? – Richard Wakefield
Practical training: the Belfast SpR training program. – Alistair Taggart
MUS and rheumatology research: from simple projects to extraordinary advances –
Peter Taylor
General discussion
Musculo-skeletal health for the multi ethnic minority Carron Room A
Convenor: Kuntal Chakravarty and Ash Samanta
Attitudes to arthritis: an Indian concept – Professor Paul Bacon and Dr Mahendranath
Clinico-pathological conference: lupus in West India – Professor Peter Maddison (Chair),
Professor K Chakravarty (Presenter) and Dr Clive Gratten
Minor etchings in managing rheumatoid arthritis in the ethnic minority groups –
Dr Ash Samanta (Presenter) and Dr Asad Zoma
Future of the group and various research agendas
Polymyalgia rheumatica/giant cell arteritis Carron Room B
Convenor: Bhaskar Dasgupta
HTA proposal – comparison of duplex ultrasonography to temporal artery biopsy in suspected
giant cell arteritis – Raashid Luqmani
National organisation for PMR and GCA – PMR-GCA.UK – scope and objectives – Jean Miller
Proposal for an education booklet on GCA – Wendy Morrison/Frances Borg
Midlands region audit of BSR guidelines on PMRGCA – Ash Samanta
Proposal for an RCT- study of leflunomide in PMR and GCA – Frances Borg
RCTs of biologics in PMRGCA – what is the right design? – Bhaskar Dasgupta
43

Sjögren’s syndrome Dochart Room A
Convenor: Dr Simon Bowman
Collaborative research update: MRC UK Sjögren’s registry (goal - 500 UK patients with primary
SS) (now recruiting) – Dr Fai Ng
Collaborative research update: EULAR project on consensus disease activity and patient
reported outcome tools (now recruiting) – Dr Simon Bowman
Science update: immunology of Sjögren’s syndrome and factors involved in lymphoma risk –
Dr Michele Bombardieri
Clinical update: role of ultrasound in diagnosis and management of SS – Dr Iain Macleod
Paediatric and adolescent rheumatology Dochart Room B
Convenors: Dr Alison Jordan and Dr Liza McCann
What are you doing locally to improve the experience of young people moving from paediatric to
adult rheumatology care?
A discussion of current practice and proposal for audit of services
Research update – Michael Beresford
Training update – Janet McDonagh
14.00-15.30 BHPR: Designing solutions not problems Forth Room
Ms Vicki Cameron and Dr Helen Myers
• I’m too young to have that in my house – Dr Lynne Goodacre
People with rheumatic diseases are amongst the largest users of assistive technologies yet
studies of non-use suggest that up to one third of the devices provided are not used.
This presentation will explore the reasons for non-use with reference to the assessment,
selection and design of products and explore ways in which non-use can be minimised.
• Inclusive design: designing people in – Ms Julia Cassim
• In other people’s shoes: exploring the social life of feet – Ms Fiona Candy
This session will create a focus on the everyday practice of dressing in and wearing clothing,
particularly on the many ways that people experience and understand the aesthetics and
social meanings of footwear. The speaker will draw on recent qualitative research in the
context of rheumatoid arthritis and the wardrobe, and on her experience as a designer
within the fashion industry.
15.00-16.30 BSR: Setting up a fracture liaison service Lomond Auditorium
Dr Gavin Clunie
• The case for a Fracture Liason Service – Dr Stephen Gallacher
The incidence of low trauma fractures is forecast to increase through the first half of the
21st century. This problem will put an increasing load on health care services. A strategic
framework needs to be developed to properly address this problem. One part of this
strategy is the Fracture Liaison Service. This presentation will describe the background
case that is made for fracture secondary prevention and put this in context of other
intervention pathways.
• A secondary care-based FLS in a single hospital – Dr Gavin Clunie
We will discuss the interventions to consider, service implementation and pitfalls of an FLS
in an NHS acute-care facility where NHS targets need to be achieved and services need to
respond appropriately to Healthcare commissioners’ demands.
• A primary care-based FLS – Dr Alun Cooper
Alun is a GP in Crawley and a Trustee of the National Osteoporosis Society. Fragility
fracture is not part of QOF in the GP contract – to help fill this gap Alun’s PCT has agreed
to fund a Primary Care based Fracture Liaison Service to compliment the acute service.
44

• Funding opportunities – Mr Paul Mitchell
National audit of the organisation of services for falls and bone health suggests that
roughly a quarter of hospitals operate a Fracture Liaison Service 1 . In 2009, the
Department of Health is developing a commissioning framework on falls and fragility
fractures which will provide opportunities for healthcare localities that are yet to implement
an FLS to address the secondary fracture prevention care gap 2 .
1
National organisational audit of services for falls and bone health. Royal College of Physicians Clinical
Evaluation and Assessment Unit, London. January 2006.
Available for download from http://www.rcplondon.ac.uk/CLINICAL-STANDARDS/CEEU/CURRENT-
WORK/FALLS/Pages/Audit.aspx
2
“Old age is the new middle age”. Secretary of State for Health. Press Release 21 May 2008.
Available for down load from http://nds.coi.gov.uk/environment/fullDetail.asp?ReleaseID=
368178&NewsAreaID=2&NavigatedFromDepartment=True
BSR: Psoriasis and the scoring systems Forth Room
Dr Chris Lovell
• Lupus and the skin – Dr Simon Meggitt
Cutaneous lupus is a diverse group of related conditions which are potentially scarring,
poorly understood and require different therapeutic approaches to SLE. Diagnosis and
management, including common pitfalls for non-dermatologists, will be discussed.
• What’s new in localised scleroderma – Dr Lindsay Shaw
Localised scleroderma is a potentially disfiguring and disabling condition which is difficult
to predict and monitor. Some recent developments may help our understanding of the
condition.
• Recent developments in psoriasis – Prof Jonathan Barker
Considerable progress has been made in understanding basic pathogenetic mechanisms
in psoriasis resulting in the development of new and more specific immunotherapy for the
disease. In addition it is becoming clear that several important key co-morbidities are
observed in patients with moderate and severe disease, similar to that observed in
rheumatoid arthritis. This talk will focus on key recent advances in psoriasis science and
therapeutics.
Scientific Programme | Friday 01 May 2009
45

Poster Viewing One
Wednesday 29 April 2009
Poster Viewing One
Wed 29 April 2009

Poster Viewing One
Wednesday 29 April 2009, 08.30-10.00
Biology of bone, cartilage and connective tissue disease
Poster No. 1
THE ROLE OF DR3/TL1A IN CARTILAGE DEPLETION CAUSED BY INFLAMMATORY ARTHRITIS
ZaraBeth Newton 1 , Melanie J. Bull 1 , Eddie Wang 1 , Anwen S. Williams 2 ;
1
Medical Biochemistry and Immunology, Cardiff University, Cardiff, United Kingdom;
2
Rheumatology, Cardiff University, Cardiff, United Kingdom
Matrix metalloproteinases and its inhibitors
Poster Viewing One | Wednesday 29 April 2009
Poster No. 2
ASSOCIATION OF OSTEOCHONDRAL ANGIOGENESIS, CARTILAGE LESION AND
BEHAVIOURAL PAIN IN A RAT MODEL OF OSTEOARTHRITIS
David A. Walsh 1 , Paul I. Mapp 1 , Ruth Webster 2 , Jonathan J. Bowyer 2 , Rose A. Maciewicz 2 ;
1
Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom;
2
AstraZeneca, Macclesfield, United Kingdom
Poster No. 3
THE TYPE III 8-10 REPEATS OF FIBRONECTIN INDUCE AGGRECANASE ACTIVITY VIA
ALPHA5BETA1 INTEGRIN AND THE TYPE III 13-14 REPEATS ACT VIA TLR 4 RECEPTORS
Nidhi Sofat, Linda Troeberg, Hideaki Nagase;
Matrix Biology, The Kennedy Institute of Rheumatology, London, United Kingdom
Cell receptor-ligand interaction, signaling, activation and apoptosis
Poster No. 4
SELECTIVE TARGETING OF THE CANONICAL OR ALTERNATIVE NF-κB PATHWAY REVEALS
NEW INSIGHTS INTO MECHANISMS OF B-LYMPHOCYTE SURVIVAL AND SELECTION
Ali S. Jawad 1 , T. E. Taher 2 , A. Rahim 2 , F. D’Acquisto 2 , D. Gould 2 , R. A. Mageed 2 ;
1
Rheumatology, The Royal London Hospital, London, United Kingdom; 2 The Bone and Joint
Research Unit, Barts and the London Queen Mary School of Medicine and Dentistry,
London, United Kingdom
Poster No. 5
ENRICHMENT OF LIPID SPECIFIC IMMUNEREGULATORY T LYMPHOCYTES WITH MAGNETIC
CD1D-MICROBEADS
Joseph P. Sanderson 1 , Martina Wilm 2 , Karen Parker 1 , Richard R. Schmidt 3 ,
Stephan D. Gadola 4,1 ;
1
Division of Infection, Inflammation & Repair, School of Medicine, University of Southampton,
Southampton, United Kingdom; 2 R&D Reagents, Bergisch-Gladbach, Germany; 3 Department
of Chemistry, University of Konstanz, Konstanz, Germany; 4 Department of Rheumatology,
Southampton University Hospitals NHS Trust, Southampton, United Kingdom
47

Poster No. 6
Poster No. 7
Poster No. 8
MEDICAL STUDENT BURSARY WINNER
EXPRESSION OF THE PEROXIREDOXIN-BASED ANTIOXIDANT SYSTEM IN PERIPHERAL
BLOOD LYMPHOCYTES IN RHEUMATOID ARTHRITIS
Carly A. Turner 1 , Katalin E. Szabo 1 , Richard Haigh 2 , Joanna Tarr 1 , Jennifer A. Littlechild 3 ,
Paul Eggleton 1 , Paul G. Winyard 1 ;
1
Peninsula Medical School, Exeter, United Kingdom; 2 Royal Devon and Exeter Health Care Trust,
Exeter, United Kingdom; 3 School of Biosciences, University of Exeter, Exeter, United Kingdom
IMBALANCE OF PRO AND ANTI APOPTOTIC FACTORS IN PATIENTS WITH JSLE COMPARED
TO CONTROLS
Angela J. Midgley, Michael W. Beresford;
Institute of Child Health, University of Liverpool, Liverpool, United Kingdom
ALTERED MEMBRANE CD45 ISOFORM EXPRESSION AND INTRACELLULAR SIGNALLING
DEFECTS IN B CELLS FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS(SLE)
R. A. Mageed 1 , S. Mletzko 1 , M. Varin 1 , J. Duchene 1 , T. Taher 1 , G. Warnes 1 , A. S. Jawad 2 ,
D. A. Isenberg 3 ;
1
The Bone and Joint Research Unit, Barts and the London School of Medicine and Dentistry,
London, United Kingdom; 2 Rheumatology, The Royal London Hospital, London, United Kingdom;
3
Medicine, UCL, London, United Kingdom
Cytokines and inflammatory mediators
Poster No. 9
Poster No. 10
Poster No. 11
Poster No. 12
Poster No. 13
HYDROGEN SULFIDE (H2S) AS A NOVEL MEDIATOR OF CARTILAGE LOSS AND
SYNOVIAL HYPERPLASIA IN RHEUMATOID ARTHRITIS
Matthew Whiteman;
Peninsula Medical School, Institute of Biomedical and Clinical Science, Exeter, United Kingdom
CONCURRENT ROLES OF THE SENSORY NEUROPEPTIDES SUBSTANCE P AND CGRP IN
ENDOTHELIAL CELL PROLIFERATION IN VIVO
Paul I. Mapp, Daniel F. McWilliams, David A. Walsh;
Department of Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
GOUT: OLD DISEASE - NEW THERAPY
Johann Gruber;
Internal Medicine, Innsbruck Medical School, Innsbruck, Austria
ER STRESS SIGNALS PLAY AN IMPORTANT ROLE IN MODULATING CYTOKINE EXPRESSION
BY DENDRITIC CELLS
Jane C. Goodall, Lou Ellis, Louise O’Brien, Hill Gaston;
Medicine, University of Cambridge, Cambridge, United Kingdom
SYNERGISTIC VASCULAR PROTECTION BY STATIN AND RAPAMYCIN IS HO-1, PKCα AND p38
MAPK-DEPENDENT
Shahir S. Hamdulay, Bufei Wang, Dorian Haskard, Justin Mason;
Eric Bywaters Centre, Hammersmith Campus, Imperial College London, London,
United Kingdom
48

Poster No. 14
Poster No. 15
Poster No. 16
CELECOXIB ENHANCES ENDOTHELIAL HO-1 EXPRESSION AND ACTIVITY: A NOVEL
MECHANISM OF VASCULAR CYTOPROTECTION
Shahir S. Hamdulay 1 , Bufei Wang 1 , Dorian 0. Haskard 1 , Caroline Wheeler-Jones 2 ,
Justin Mason 1 ;
1
Eric Bywaters Centre, Hammersmith Campus, Imperial College London, London, United
Kingdom; 2 Department of Veterinary Basic Sciences, Royal Veterinary College, University of
London, London, United Kingdom
PERSISTENT AND ACUTE INFLAMMATORY PAIN INDUCES DIFFERENTIAL EXPRESSION OF
ILβ AND FRACTALKINE MRNA IN THE RAT BRAIN
Helen S. Jerina, Vivienne R. Winrow, Clifford R. Stevens;
School for Health, University of Bath, Bath, United Kingdom
INCREASED CD80 AND CD86 IN THE SERUM OF PATIENTS WITH JSLE COMPARED
TO CONTROLS
Angela J. Midgley, Michael W. Beresford;
Institute of Child Health, University of Liverpool, Liverpool, United Kingdom
Poster Viewing One | Wednesday 29 April 2009
Poster No. 17
Poster No. 18
Poster No. 19
DISTINCT CYTOKINE/CHEMOKINE PROFILES IN RA SYNOVIAL FLUID BASED ON
DIAGNOSIS, THERAPY AND RESPONSE
Helen L. Wright 1 , Roger C. Bucknall 2 , Steven W. Edwards 1 ;
1
Biological Sciences, University of Liverpool, Liverpool, United Kingdom; 2 Rheumatic Diseases
Unit, Royal Liverpool Hospital, Liverpool, United Kingdom
EFFICACY AND SAFETY OF CANAKINUMAB (ACZ885), A FULLY HUMAN
ANTI-INTERLEUKIN-1BETA ANTIBODY, IN CRYOPYRIN-ASSOCIATED PERIODIC FEVER
SYNDROME: RESULTS OF A MULTICENTER, RANDOMIZED, DOUBLE-BLIND,
PHASE III STUDY
Helen Lachmann 1 , Isabelle Kone-Paut 2 , Jasmin Kuemmerle-Deschner 3 , Kieron Leslie 4 , Eric
Hachulla 5 , Pierre Quartier 6 , Xavier Gitton 7 , Neha P. Patel 8 , Karine Lheritier 7 , Philip N. Hawkins 1 ;
1
Royal Free& University college Medical school, London, United Kingdom; 2 Hopital Kremlin
Bicetre, Le Kremlin Bicetre, France; 3 Universitatsklinik, Tuebingen, Germany; 4 UCSF, San
Fransisco, CA; 5 Hopital Claude Huriez, Lille Cedex, France; 6 Unit’e d’Immunologie, Hopital
Necker-Enfants Malades,Hematologie et Rhumatologie Pediatrique, Paris, France; 7 Novartis,
Basel, Switzerland; 8 Novartis, East Hanover, NJ
RHEUMATOID FACTOR INTERFERENCE WITH BEAD-BASED MULTIPLEX
IMMUNOASSAYS PRECLUDES ITS USE IN RHEUMATOID ARTHRITIS
Sarah M. Churchman 1 , Elizabeth A. Horner 1 , Leigh D. Church 2 , Rekha Parmar 1 ,
Frederique Ponchel 1 ;
1
Musculoskeletal Disease, Leeds Institute of Molecular Medicine, Leeds, United Kingdom;
2
Department of Rheumatology, Institute for Biomedical Research, University of Birmingham,
United Kingdom
49

Rheumatoid arthritis – aetiopathogenesis and animal models
Poster No. 20
ROLE OF APOPTOSIS IN THE PATHOGENESIS AND PROGRESSION OF RHEUMATOID
ARTHRITIS AND NON-RESPONSE TO ANTI-TNF THERAPY
Sinisa Savic 1 , Rebeccah Mathews 1 , Karen Henshaw 2 , Sarah Churchman 1 , Maya Buch 2 ,
Domini Bryer 2 , Lydia Coulthard 1 , Paul Emery 2 , Michael F. McDermott 1 ;
1
Experimental Rheumatology, Leeds Institute of Molecular Medicine, Leeds, United Kingdom;
2
Academic Unit of Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, United Kingdom
Poster No. 21
Poster No. 22
CD4+ T CELL RESPONSES TO AUTOANTIGENS IN PATIENTS WITH RHEUMATOID ARTHRITIS
James Locke, Julie Diboll, Susan Tudhope, Alexei von Delwig, John D. Isaacs, Wan-Fai Ng;
Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle
upon Tyne, United Kingdom
ANTIBODIES TO MUTATED CITRULLINATED VIMENTIN (MCV) IN RHEUMATOID ARTHRITIS:
CLINICAL AND GENETIC ASSOCIATIONS
Peter J. Charles 1 , Hannah Poulsom 2 , Darren Plant 3 ;
1
Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, United
Kingdom; 2 Immunology Dept, Imperial College Healthcare NHS Trust, London, United Kingdom;
3
ARC Epidemiology Unit, Univ. Of Manchester, Manchester, United Kingdom
Poster No. 23
CD3+CD8+CD28- CELLS ARE INCREASED IN RHEUMATOID ARTHRITIS (RA) PATIENTS BUT
HAVE DEFICIENT ACTIVITY AND UPREGULATION OF NEGATIVE COSTIMULATORY MOLECULES
Sabrina Ceeraz 1 , Jo Spencer 2 , Ernest H. Choy 1 , Valerie M. Corrigall 1 ;
1
Academic Department of Rheumatology, Kings College London, London, United Kingdom;
2
Department of Immunobiology, Kings College London, London, United Kingdom
Poster No. 24
Poster No. 25
PROTEASE-ACTIVATED RECEPTOR-2 EXPRESSION IN PERIPHERAL BLOOD
MONONUCLEAR CELLS FROM PATIENTS WITH RHEUMATOID ARTHRITIS
Elizabeth Burns 1 , Mohammad B. Nickdel 1 , John C. Lockhart 1 , Martin E. Perry 2 ,
Peter W. Ferrell 3 , Derek Baxter 2 , J. Alastair Gracie 4 , William R. Ferrell 5 , Iain B. McInnes 4 ;
1
School of Engineering and Science, University of the West of Scotland, Paisley, United
Kingdom; 2 Centre for Rheumatic Diseases, Royal Infirmary, Glasgow, United Kingdom;
3
Orthopaedic Surgery, Ninewells Hospital, Dundee, United Kingdom; 4 Division of Immunology,
Infection & Inflammation, University of Glasgow, Glasgow, United Kingdom; 5 Integrative &
Systems Biology, University of Glasgow, Glasgow, United Kingdom
CHARACTERISATION OF JOINT PATHOLOGY IN IL-7 TRANSGENIC MICE: PILOT DATA
Elizabeth A. Horner 1,2 , Xeubin B. Yang 2 , Frederique Ponchel 1 ;
1
Musculoskeletal Disease, Leeds Univeristy, Leeds, United Kingdom;
2
Oral Biology, Leeds Univeristy, Leeds, United Kingdom
Poster No. 26
Poster No. 27
LONG-TERM REMISSION AFTER TNF-BLOCKADE IN EARLY RHEUMATOID ARTHRITIS
IS ASSOCIATED WITH A NORMALISATION OF IMMUNOLOGICAL STATUS
Rekha Parmar, Vincent Goeb, Benazir Saleem, Mark Quinn, Philip G. Conaghan,
Frederique Ponchel, Paul Emery;
LIMM, Section MSK, LMBRU, University of Leeds, Leeds, United Kingdom
CITRULLINATED ALPHA ENOLASE: A MAJOR AUTOANTIGEN IN RA
Andrew J. Kinloch, Robin Wait, Patrick J. Vensbles;
Kennedy Institute, Imperial College London, London, United Kingdom
50

Poster No. 28
Poster No. 29
TURNOVER OF MHC CLASS II MOLECULES MEASURED BY HEAVY WATER LABELLING:
EFFECTS OF ARTHRITIS-ASSOCIATED POLYMORPHISM AND APC ACTIVATION
Robert Busch 1 , Alessandra De Riva 1 , Mike Deery 2 , Sarah McDonald 1 , Daniel G. Lewis 1 ,
Sarah Jackson 3 , Anne Cooke 4 , Les Bluck 3 , Kathryn Lilley 2 ;
1
Dept of Medicine, University of Cambridge, Cambridge, United Kingdom; 2 Cambridge Centre
for Proteomics, University of Cambridge, Cambridge, United Kingdom; 3 Stable Isotope
Laboratory, MRC-HNR Widdowson Labs, Cambridge, United Kingdom; 4 Dept of Pathology,
University of Cambridge, Cambridge, United Kingdom
INHIBITION OF MURINE CHRONIC ARTHRITIS BY A MONOCLONAL ANTIBODY AGAINST
PROTEASE-ACTIVATED RECEPTOR-2
Lynette Dunning 1 , John C. Lockhart 1 , William R. Ferrell 4 , Robin J. Plevin 3 , J. Alastair Gracie 2 ,
Iain B. McInnes 2 , Gary W. Boyd 1 ;
1
School of Engineering & Science, University of the West of Scotland, Paisley, United
Kingdom; 2 Division of Immunology, Infection & Inflammation, University of Glasgow, Glasgow,
United Kingdom; 3 Pharmacology & Physiology, University of Strathclyde, Glasgow, United
Kingdom; 4 Integrative & Systems Biology, University of Glasgow, Glasgow, United Kingdom
Poster Viewing One | Wednesday 29 April 2009
Poster No. 30
Poster No. 31
Poster No. 32
Poster No. 33
REPLICATION STUDY OF NEWLY CONFIRMED RHEUMATOID ARTHRITIS
SUSCEPTIBILITY LOCI
Gisela Orozco, Anne Hinks, Steve Eyre, Xiayi Ke, Laura J. Gibbons, Ukrag Consortium,
Wendy Thomson, Anne Barton, Jane Worthington;
ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
ELEVATED SYNOVIAL FLUID LEVELS OF HYDROGEN SULFIDE (H2S) IN
RHEUMATOID ARTHRITIS: CORRELATION WITH DISEASE ACTIVITY AND OTHER
CLINICAL INFLAMMATORY INDICES
Matthew Whiteman1, Joanna Tarr1, Philip K. Moore3, Richard Haigh2, Paul G. Winyard1;
1Peninsula Medical School, Institute of Biomedical and Clinical Sciences, Exeter, United
Kingdom; 2Rheumatology, Royal Devon and Exeter Hospital Trust, Exeter, United Kingdom;
3Pharmaceutical Science, King’s College, London, United Kingdom
TNF-ALPHA MODULATES TISSUE-SPECIFIC VASCULAR DETERMINANTS
RECOGNIZED IN VIVO BY A PHAGE CLONE DISPLAYING A SYNOVIAL-HOMING
PEPTIDE IN THE HUMAN /SCID MOUSE TRANSPLANTATION MODEL
Toby Garrood, Lewis Lee, Mark Blades, Panagiotis Kamperidis, Costantino Pitzalis;
William Harvey Research Institute, Barts and the London School of Medicine, London,
United Kingdom
PADI4 GENOTYPE IS NOT ASSOCIATED WITH RHEUMATOID ARTHRITIS IN A LARGE UK
CAUCASIAN POPULATION
Marian L. Burr 1 , Haris Naseem 1 , Laura Gibbons 1 , John Bowes 1 , U. Krag 2 , Anne Barton 1 ;
1
arc-Epidemiology Unit, University of Manchester, Manchester, United Kingdom;
2
UK Rheumatoid Arthritis Genetics Consortium, UKRAG, United Kingdom
Poster No. 34
VARIATION IN THE CD226 GENE PREDICTS RESPONSE TO ANTI-TNF THERAPY
IN RHEUMATOID ARTHRITIS
Rachael Tan 1 , Laura J. Gibbons 1 , Catherine Potter 4 , Kimme Hyrich 1 , Ann W. Morgan 2 ,
Anthony G. Wilson 3 , John D. Isaacs 4 , Anne Barton 1 ;
1
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom; 2 University of
Leeds, Leeds, United Kingdom; 3 University of Sheffield, Sheffield, United Kingdom; 4 Newcastle
University, Newcastle, United Kingdom
51

Poster No. 35
Poster No. 36
MICROANATOMICAL STUDIES TO DEFINE FACTORS THAT MAY PREDICT THE
TOPOGRAPHY OF PERIARTICULAR EROSION FORMATION IN ARTHRITIS
Ai Lyn Tan 1 , Michael Benjamin 2 , Uffe M. Døhn 3 , Mikkel Østergaard 3 , Dennis McGonagle 1 ;
1
Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom;
2
School of Biosciences, Cardiff University, Cardiff, United Kingdom; 3 Departments of
Rheumatology and Diagnostic Radiology, Copenhagen University Hospitals,
Copenhagen, Denmark
NOVEL SMALL MOLECULE INHIBITORS OF TNF- AND RANKL-SIGNALING PREVENT
COLLAGEN INDUCED ARTHRITIS
Ejaz Pathan 1 , Emmanuel Coste 2 , Lorraine Rose 2 , Aymen I. Idris 2 , Anna Daroszewska 2,1 ,
Iain R. Greig 3 , Mohini Gray 2,1 , Stuart H. Ralston 2,1 , Rob J. van ‘t Hof 2 ;
1
Rheumatology, Western General Hospital, Edinburgh, United Kingdom; 2 Rheumatology,
University of Edinburgh, Edinburgh, United Kingdom; 3 Medicine and Therapeutics, University
of Aberdeen, Edinburgh, United Kingdom
Functional genomics
Poster No. 37
THE PTPN22 C1858T POLYMORPHISM IS NOT ASSOCIATED WITH SYSTEMIC
RHEUMATIC DISEASES IN BLACK SOUTH AFRICANS
Mohammed Tikly 1,2 , Nimmisha Govind 1,2 , Jacqueline Frost 3,2 , Michele Ramsay 3,2 ;
1
Rheumatology, Chris Hani Baragwanath Hospital, Johannesburg, South Africa; 2 University of
the Witwatersrand, Johannesburg, South Africa; 3 Human Genetics, National Health Laboratory
Services, Johannesburg, South Africa
Stem cells and tissue engineering
Poster No. 38
Poster No. 39
THE EFFECTS OF INFLAMMATORY CYTOKINES FROM ARTHRITIC SYNOVIUM ON SKELETAL
STEM CELL FUNCTION-IMPLICATIONS FOR REPARATIVE STRATEGIES
Emma L. Williams 1,2 , Helmtrud I. Roach 2 , Cyrus Cooper 3,1 , Richard O. Oreffo 2 ,
Christopher J. Edwards 1 ;
1
Rheumatology Department, Southampton University Hospitals NHS Trust, Southampton,
United Kingdom; 2 Bone and Joint Group, University of Southampton, Southampton, United
Kingdom; 3 MRC Epidemiology Resource Centre, University of Southampton, Southampton,
United Kingdom
EFFICACY, LONG-TERM EFFECTS AND COMPLICATIONS OF AUTOLOGOUS T CELL DEPLETED
HAEMATOPOIETIC STEM CELL TRANSPLANTATION FOR CHILDREN WITH SEVERE JUVENILE
IDIOPATHIC ARTHRITIS
Mario Abinun 1 , Paul Veys 2 , Joyce Davidson 3 , Eileen Baildam 4 , Taunton Southwood 5 ,
Polly Livermore 6 , Mark Friswell 1 , Amy Rowan 7 , Helen Foster 7 , Lucy Wedderburn 6 ;
1
Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; 2 Great
Ormond Street Hospital NHS Trust, London, United Kingdom; 3 Royal Hospital for Sick Children,
Yorkhill, Glasgow, United Kingdom; 4 Royal Liverpool Children’s Hospital, Liverpool, United
Kingdom; 5 Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, United Kingdom;
6
Institute of Child Health, University College, London, United Kingdom; 7 Newcastle University,
Newcastle upon Tyne, United Kingdom.
52

Vasculitis
Poster No. 40
Poster No. 41
Poster No. 42
ATYPICAL GIANT CELL ARTERITIS
Sayam R. Dubash, Rob Callaghan;
Rheumatology, Nevill Hall Hospital, Gwent NHS Trust, Abergavenny, United Kingdom
CLINICAL PROFILE OF CRYOGLOBULINEMIA IN RHEUMATIC DISEASE
Subha Arthanari, Mohamed Nisar;
Dept of Rheumatology, Queen’s Hospital, Burton on Trent, United Kingdom
ARE WE MEETING THE STANDARDS FOR TEMPORAL ARTERY BIOPSY IN
GIANT CELL ARTERITIS?
Anushka Soni 1 , Samantha Cragg 3 , Simon Fung 2 , Brendan McDonald 3 ,
Raashid Luqmani 1 ;
1
Rheumatology, Nuffield Orthopaedic Centre, Oxford, United Kingdom; 2 Ophthalmology,
Oxford Eye Hospital, Oxford, United Kingdom; 3 Neuropathology, John Radcliffe Hospital,
Oxford, United Kingdom
Poster Viewing One | Wednesday 29 April 2009
Poster No. 43
WEGENER’S GRANULOMATOSIS PRESENTING AS INTERMENSTRUAL BLEEDING
Sandeep Mukherjee 1 , Wessam Al-Utayem 2 , Lindsey Bergin 2 , John R. Bevan 3 , Richard Hull 1 ;
1
Rheumatology Department, Queen Alexandra Hospital, Portsmouth, United Kingdom;
2
Histopathology Department, Queen Alexandra Hospital, Portsmouth, United Kingdom;
3
Gynaecology Department, Queen Alexandra Hospital, Portsmouth, United Kingdom
Poster No. 44
Poster No. 45
Poster No. 46
Poster No. 47
Poster No. 48
WHAT ARE THE EDUCATIONAL NEEDS OF PATIENTS WITH PRIMARY
SYSTEMIC VASCULITIS?
Janice Mooney 1 , Richard Watts 1 , Fiona Poland 1 , Nicola Spalding 1 , David Scott 2 ;
1
School of Social Sciences, University of East Anglia, Norwich, United Kingdom; 2 Department
of Rheumatology, Norfolk & Norwich University Hospital, Norwich, United Kingdom
EFFICACY AND TOLERABILITY OF LEFLUNOMIDE IN DIFFICULT-TO-TREAT
POLYMYALGIA RHEUMATICA AND GIANT CELL ARTERITIS: A CASE SERIES
C. Dharmapalaiah, F. Borg, B. Dasgupta;
Rheumatology, Southend University Hospital, Westcliff, United Kingdom
GIANT CELL ARTERITIS: AN AUDIT OF EARLY RECOGNITION AND MANAGEMENT
F. Borg, A. Ezeonyegi, W. M. Wong, I. Riaz, T. Gordon, B. Dasgupta;
Southend University Hospital, Westcliff, United Kingdom
TOLERABILITY OF REMISSION-MAINTENANCE AGENTS AFTER INDUCTION THERAPY
IN ANCA ASSOCIATED SYSTEMIC VASCULITIS (AASV)
Maria AL-Deiri 1 , Peter Lanyon 1 , Ellie Sproson 2 , Nick Jones 2 ;
1
Rheumatology, Nottingham University Hospitals, Queens Medical Centre Campus,
Nottingham, United Kingdom; 2 Otolaryngology, Nottingham University Hospitals,
Queens Medical Centre Campus, Nottingham, United Kingdom
LONG TERM OUTCOMES OF B CELL DEPLETION IN REFRACTORY VASCULITIS AND
TIMING OF RE-TREATMENT
Ramin Yazdani 1 , Anshul Sama 2 , Nick Jones 2 , Ian Gaywood 1 , Peter Lanyon 1 ;
1
Rheumatology Department, Nottingham University Hospitals, Nottingham, United Kingdom;
2
Otololaryngology Department, Nottingham University Hospitals, Nottingham, United Kingdom
53

Poster No. 49
A REGIONAL RETROSPECTIVE AUDIT OF TEMPORAL ARTERY BIOPSIES IN PATIENTS WITH
A CLINICAL DIAGNOSIS OF GIANT CELL ARTERITIS
Tazeen J. Ahmed 1 , Sara Burton 2 , William R. Tucker 2 , Kay M. Garmston 2 ,
Alastair L. Hepburn 3 , Raad M. Makadsi 4 , Sian M. Griffith 4 , Patrick D. Kiely 1 , Mark Lloyd 2 ; 1 St
George’s Hospital, London, United Kingdom; 2 Frimley Park Hospital, Frimley, United Kingdom;
3
Worthing Hospital, Worthing, United Kingdom; 4 East Surrey Hospital, Redhill, United Kingdom
SLE and antiphospholipid syndrome
Poster No. 50
Poster No. 51
AN AUDIT OF CARDIOVASCULAR RISK RECORDING AND REDUCTION IN PATIENTS WITH
SYSTEMIC LUPUS ERYTHEMATOSUS
Frances C. Hall 1 , Christopher See 1 , David Chapireau 1 , Ei Phyu Htut 1 , Lapraik Chloe 2 ,
Diana Chin 1 , Mark Lillicrap 3,1 , Kuntal Chakravarty 4 , Nicholas J. Sheehan 5 , Malcolm Stodell 2 ,
Adam Young 6 ;
1
Department of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom;
2
Department of Rheumatology, Luton and Dunstable Hospital, Luton, United Kingdom;
3
Department of Rheumatology, Hinchingbrooke Hospital, Huntingdon, United Kingdom;
4
Department of Rheumatology, Queen’s Hospital, Romford, United Kingdom; 5 Department of
Rheumatology, Edith Cavell Hospital, Peterborough, United Kingdom; 6 Department of
Rheumatology, St Alban’s Hemel NHS Trust, St Alban’s, United Kingdom
ACCULTURATION INDEX AND ITS USE ON PATIENTS’ KNOWLEDGE IN LUPUS DISEASE
Euthalia Roussou 1,2 , Madura Appanna 2 , Khalid Ahmed 3 ;
1
Rheumatology & Rehabilitation, King George Hospital, London, United Kingdom;
2
Barts and the London, School of Medicine and Dentistry, London, United Kingdom;
3
Rheumatology, Princess Alexandra Hospital, Harlow, United Kingdom
Poster No. 52
Poster No. 53
SYSTEMATIC REVIEW AND META-ANALYSIS OF PREGNANCY OUTCOMES
IN LUPUS NEPHRITIS
Charlotte Ford, Cordelia Coltart, David Williams, Ian Giles;
Rheumatology, University College London and Institute for Women’s Health,
London, United Kingdom
PREMATURE ATHEROSCLEROSIS IN THROMBOTIC PRIMARY ANTIPHOSPHOLIPID
SYNDROME
Paul R. Ames 1 , Iole Antinolfi 2 , Giovanna Scenna 2 , Giovanni Gaeta 2 , Annamaria Margarita 2 ,
Maurizio Margaglione 3 ;
1
Royal Preston Hospital, Preston, United Kingdom; 2 Cardarelli Hospital, Naples, Italy;
3
Foggia University, Foggia, Italy
Poster No. 54
AN ANALYSIS OF THE CAUSES AND OUTCOME OF PATIENTS WITH LUPUS
REQUIRING TOTAL JOINT REPLACEMENT
Ana F. Mourão 1,2 , Marta Amaral 1,3 , David Isenberg 1 ;
1
Rheumatology, Centre For Rheumatology, Department of Medicine, University College of
London Hospital, London, United Kingdom., London, United Kingdom; 2 Rheumatology,
Rheumatology Department, Centro Hospitalar de Lisboa Ocidental, Hospital Egas Moniz, EPE,
Lisbon, Portugal., Lisbon, Portugal; 3 Internal Medicine, Autoimmune Diseases Unit, Internal
Medicine Department, Hospital de Curry Cabral, Lisbon, Portugal, Lisbon, Portugal
54

Poster No. 55
Poster No. 56
SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS WITH HYPERMOBILITY SYNDROME
EXPERIENCE HIGHER LEVELS OF CHRONIC PAIN THAN THOSE WITHOUT JOINT
HYPERMOBILITY
Helen E. Harris 1 , Jane Gibson 1 , Adele Osborne 1 , David Chinn 2 , Hazem Youssef 3 ;
1
Rheumatology, NHS Fife, Kirkaldy, United Kingdom; 2 Research and Development, NHS Fife,
Kirkaldy, United Kingdom; 3 Rheumatology, University of Aberdeen, Aberdeen, United Kingdom
DELAY TO DIAGNOSIS IN JUVENILE SLE (JSLE) PATIENTS: PRELIMINARY DATA
FROM THE UK JSLE COHORT STUDY
Clare Pain 2 , Janet Gardner-Medwin 3 , Janet McDonagh 4 , Clarissa Pilkington 5 ,
Rangaraj Satyapal 6 , Jane Tizard 8 , Nick Wilkinson 7 , Michael W. Beresford 1 ;
1
Institute of Child Health, University of Liverpool, Liverpool, United Kingdom; 2 Department of
Rheumatology, Alder Hey Children’s NHS Foundation Trust, Liverpool, United Kingdom;
3
Department of Rheumatology, Royal Hospital for Sick Children, Glasgow, United Kingdom;
4
Department of Rheumatology, Birmingham Children’s Hospital, Birmingham, United
Kingdom; 5 Department of Rheumatology, Great Ormond Street Hospital, London, United
Kingdom; 6 Department of Rheumatology, Queen’s Medical Centre, Nottingham, United
Kingdom; 7 Department of Rheumatology, Nuffield Orthopaedic Centre, Oxford, United
Kingdom; 8 Department of Nephrology, Bristol Royal Hospital for Children, Bristol, United
Kingdom
Poster Viewing One | Wednesday 29 April 2009
Poster No. 57
Poster No. 58
Poster No. 59
Poster No. 60
SYSTEMIC LUPUS ERYTHEMATOSUS: CONCORDANCE AND ACCURACY OF
PATIENT AND PHYSICIAN EXPECTATIONS OF PHYSICAL FUNCTIONING
Sophie Cleanthous 1 , Debbie Cooke 1 , Shashi Hirani 1 , Adrienne Kirk 1 , David Isenberg 2 ,
Stanton Newman 1 ;
1
Unit of Behavioural Medicine, Division of Research Strategy, University College London,
London, United Kingdom; 2 Centre for Rheumatology Research, Division of Medicine,
University College London, London, United Kingdom
FUNCTIONAL ABNORMALITIES OF MYELOID DENDRITIC CELLS IN SYSTEMIC
LUPUS ERYTHEMATOSUS
Chak S. Lau 1,2 , Ou Jin 2 , Sushma Kavikondala 2 , Mo Y. Mok 2 , Albert Chan 2 , Joseph Yeung 2 ;
1
Medicine, University of Dundee, Dundee, United Kingdom; 2 Medicine, University of Hong
Kong, Hong Kong, China
CLINICAL EXPERIENCE WITH ETANERCEPT IN SYSTEMIC LUPUS ERYTHEMATOSUS
PATIENTS
Inmaculada de la Torre Ortega, Francisco Javier López-Longo, Indalecio Monteagudo,
Carlos Manuel González, Luis Carreño;
Rheumatology, Gregorio Marañón Hospital, Madrid, Spain
DYSLIPIDAEMIA IN SLE IS COMMON AND PARTICULARLY PRONOUNCED IN
THE QUIESCENT PHASE OF DISEASE
Sahena Haque 1 , Yasmeen Ahmad 2 , Valentine Charlton-Menys 3 , Paul N. Durrington 3 ,
Bruce N. Ian 1 ;
1
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom; 2 Department
of Rheumatology, Llandudno General Hospital, Llandudno, United Kingdom; 3 Cardiovascular
Medicine, University of Manchester, Manchester, United Kingdom
55

Poster No. 61
Poster No. 62
THE PODOCYTE IN LUPUS NEPHRITIS - HOW DO PATHOGENIC AUTOANTIBODIES EXERT
THEIR EFFECT?
Jessica J. Manson 1 , Elizabeth Jury 1 , Kevin Mills 2 , David A. Isenberg 1 , Anisur Rahman 1 ; 1 Centre
for Rheumatology Research, University College London, London, United Kingdom; 2 Clinical
and Molecular Genetics, Institute of Child Health, University College London, London,
United Kingdom
DIFFERENCES IN APOPTOSIS GENE EXPRESSION IN LYMPHOCYTES FROM SYSTEMIC
LUPUS ERYTHEMATOSUS (SLE) AND RHEUMATOID ARTHRITIS (RA) PATIENTS
Paul Eggleton 1 , Richard Haigh 2 , Nick Viner 3 , Suzanne Donnelly 4 , Lorna W. Harries 1 ,
Giada Alberigo 1 , Paul G. Winyard 1 ;
1
Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, Exeter, United
Kingdom; 2 Rheumatology, Royal Devon and Exeter Foundation Trust, Exeter, United Kingdom;
3
Rheumatology, Torbay Hospital, Torquay, United Kingdom; 4 Rheumatology, Mater Misericordiae
Hospital, Dublin, Ireland
Poster No. 63
STATINS AND HYDROXYCHLOROQUINE CAN PREVENT THE PROCOAGULANT/
THROMBOGENIC PROPERTIES OF ANTIPHOSPHOLIPID ANTIBODIES IN MONOCYTES
Anastasia Lambrianides 1 , Silvia Pierangeli 2 , David Latchman 1 , David Isenberg 1 ,
Anisur Rahman 1 , Ian Giles 1 ;
1
University College London, London, United Kingdom; 2 University of Texas, Galveston, TX
Poster No. 64
Poster No. 65
RITUXIMAB IN CUTANEOUS LUPUS: RESPONSIVENESS DEPENDS ON PATTERN
OF SKIN INVOLVEMENT
Edward M. Vital 1 , Shouvik Dass 1 , Olabambo Ogunbambi 1 , Mark Goodfield 2 , Paul Emery 1 ;
1
Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine,University of Leeds,
Leeds, United Kingdom; 2 Department of Dermatology, Leeds Teaching Hospitals NHS Trust,
Leeds, United Kingdom
RITUXIMAB IN SLE: HIGHLY SENSITIVE FLOW CYTOMETRY ALLOWS EARLY PREDICTION OF
NON-RESPONSE AND RELAPSE
Edward M. Vital 1 , Shouvik Dass 1 , Michael F. Martin 1 , Colin T. Pease 1 , Andrew C. Rawstron 2 ,
Paul Emery 1 ;
1
Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine,University of Leeds,
Leeds, United Kingdom; 2 Haematological Malignancy Diagnostic Service, Leeds Teaching
Hospitals NHS Trust, Leeds, United Kingdom
Poster No. 66
PLASMACYTOID DENDRITIC CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS
Chak S. Lau 1,2 , Ou Jin 2 , Sushma Kavikondala 2 , Mo Y. Mok 2 , Albert W. Chan 2 , Joseph Yeung 2 ;
1
Medicine, University of Dundee, Dundee, United Kingdom; 2 Medicine, University of Hong Kong,
Hong Kong, China
Spondylarthropathies (including psoriatic arthritis)
Poster No. 67
THE BENEFITS OF INTENSIVE EXERCISE AND EDUCATION FOR ANKYLOSING SPONDYLITIS:
A QUANTITATIVE AND QUALITATIVE ANALYSIS
Emma Carroll 1 , Tara Cusack 1 , Rose Galvin 2 , Breon White 3 , Anne-Marie Keown 3 ;
1
UCD School of Physiotherapy and Performance Science, University College Dublin, Dublin,
Ireland; 2 School of Physiotherapy, Trinity College Dublin, Dublin, Ireland; 3 Department of
Physiotherapy, Mater Misericordiae University Hospital, Dublin, Ireland
56

Poster No. 68
Poster No. 69
Poster No. 70
PARADOXICAL ADVERSE EVENTS OF ANTI-TUMOR NECROSIS FACTOR
THERAPIES DURING SPONDYLARTHROPATHIES
Vincent Goeb 1 , Damien Fouache 2 , Nathalie Massy-Guillemant 2 , Gilles Avenel 1 ,
Macha Kozyreff-Meurice 1 , Alain Daragon 1 , Xavier Le Loet 1 , Jean-Francois Menard 1 ,
Catherine Tharasse 2 , Olivier Vittecoq 1 ;
1
Rheumatology, University Hospital, Rouen, France; 2 Pharmacy, University Hospital,
Rouen, France
PROTOTYPE FINGER COIL FOR THE STUDY OF NAIL UNIT IN PSORIATIC ARTHRITIS
PATIENTS USING A LOW FIELD MRI
Ernesto Soscia 4 , Mariangela Atteno 1 , Luisa Costa 1 , Rosario Peluso 1 , Salvatore Iervolino 1 ,
Francesco Caso 1 , Luigi Satragno 3 , Marco A. Cimmino 2 , A. Del Puente 1 , Raffaele Scarpa 1 ;
1
Dpt of Clinical and Experimental Medicine, University Federico II, Naples, Italy;
2
Rheumatology Unit, University of Genoa, Genoa, Italy; 3 ESAOTE, Genoa, Italy;
4
Radiology Unit, University Federico II, Naples, Italy
ANTIBIOTICS TREATMENT OF REACTIVE ARTHRITIS: A SYSTEMATIC REVIEW OF
THE LITERATURE
Helen Linklater, Ernest Choy;
Department of Rheumatology, Kings College Hospital, Denmark Hill, London, United Kingdom
Poster Viewing One | Wednesday 29 April 2009
Poster No. 71
Poster No. 72
Poster No. 73
Poster No. 74
FREQUENCY AND PREDICTORS OF MINIMAL DISEASE ACTIVITY IN AN OBSERVATIONAL
PSA COHORT
Laura C. Coates 1 , Catherine T. Schentag 2 , Ker-Ai Lee 3 , Vinod Chandran 2 , Richard J. Cook 3 ,
Dafna D. Gladman 2 ;
1
Academic Section of MSK Disease, University of Leeds, Leeds, United Kingdom; 2 Toronto
Western Hospital, University Health Network, Toronto, ON, Canada; 3 University of Waterloo,
Waterloo, ON, Canada
AN EXPLORATORY STUDY OF FATIGUE IN ANKYLOSING SPONDYLITIS PATIENTS
Julie Barlow 1 , Lorraine McFarland 1 , Jaya Ravindaran 2 , Philip Perkins 2 ;
1
Self-management Programme, Coventry University, Coventry, United Kingdom;
2
Rheumatology Department, University Hospitals Coventry & Warwickshire, Coventry,
United Kingdom
PHYSICAL THERAPY IN ANKYLOSING SPONDYLITIS
Shirish Dubey 1 , Jane Leeder 2 , Alison Gibb 2 , Karl Gaffney 2 ;
1
Heart of England NHS Trust, Solihull, United Kingdom; 2 Norfolk and Norwich University
Hospital, Norwich, United Kingdom
A RANDOMISED, CONTROLLED TRIAL OF INTRA-ARTICULAR STEROID INJECTIONS
FOR SACROILIAC JOINT (SIJ) PAIN IN SPONDYLOARTHRITIS PATIENTS
Sreekanth Vasireddy 2 , Chandini Rao 3 , Hazel Miller 1 , C. Chattopadhyay 1 ;
1
Dept of Rheumatology, Wrightington Hospital, Wigan, United Kingdom;
2
Dept of Rheumatology, Bolton PCT, Bolton, United Kingdom; 3 Dept of Rheumatology,
Blackpool Victoria Hospital, Blackpool, United Kingdom
57

Poster No. 75
Poster No. 76
Poster No. 77
Poster No. 78
Poster No. 79
Poster No. 80
Poster No. 81
EDUCATION FOR PEOPLE WITH ANKYLOSING SPONDYLITIS: CURRENT PRACTICE IN THE UK
Ben Thompson 1 , Tim J. Rapley 2 , Wendy Broderick 3 , Carl R. May 2 , Lesley J. Kay 1 ;
1
Newcastle Musculoskeletal Research Group, Newcastle University, Newcastle-upon-Tyne,
United Kingdom; 2 Institute of Health and Society, Newcastle University, Newcastle-upon-Tyne,
United Kingdom; 3 National Ankylosing Spondylitis Society (NASS), Tyne and Wear Branch,
United Kingdom
ACHIEVING MINIMAL DISEASE ACTIVITY (MDA) CRITERIA DECREASES PROGRESSION OF
JOINT DAMAGE IN PSORIATIC ARTHRITIS
Laura C. Coates 1 , Catherine T. Schentag 2 , Ker-Ai Lee 3 , Vinod Chandran 2 , Richard J. Cook 3 ,
Dafna D. Gladman 2 ;
1
Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds,
Leeds, United Kingdom; 2 Centre for Prognosis Studies in the Rheumatic Diseases, Toronto
Western Hospital, Toronto, ON, Canada; 3 Statistics and Actuarial Science, University of
Waterloo, Waterloo, ON, Canada
A REGIONAL AUDIT OF COMPLIANCE WITH NICE TA 104 AND 125 IN PSORIATIC ARTHRITIS
Maria Juarez 1 , William Tillett 3 , Robert Marshall 2 , Sandra Green 3 , Elizabeth Price 1 ,
Lyn Williamson 1 , David Collins 1 ;
1
Rheumatology, Great Western Hospital, Swindon, United Kingdom; 2 Rheumatology, University
Hospitals Bristol, Bristol, United Kingdom; 3 Rheumatology, Weston General Hospital, Weston
super Mare, United Kingdom
REFINING THE GENETIC ASSOCIATION BETWEEN ANKYLOSING SPODYLITIS AND ERAP1
David Harvey 1 , Jennifer J. Pointon 1 , Claire Farrar 1 , Louise A. Appleton 1 , Udo Oppermann 2 ,
Matthew A. Brown 1,3 , Bryan P. Wordsworth 1 ;
1
Botnar Research Centre, Oxford, United Kingdom; 2 Structural Genomics Consortium, Oxford,
United Kingdom; 3 Diamantina Institute of Cancer, Brisbane, QLD, Australia
TH17 T CELLS IN ANKYLOSING SPONDYLITIS ARE POLYFUNCTIONAL AND EXPRESS HIGH
LEVELS OF THE CHEMOKINE RECEPTOR CCR6
Paul Bowness 1,2 , Jacqueline Shaw 1 , Kirsty McHugh 1 , Joanna Giles 1 , Simon Kollnberger 1 ;
1
MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe
Hospital, Oxford, United Kingdom; 2 Dept. Rheumatology, Nuffield Orthopaedic Centre NHS Trust,
Oxford, United Kingdom
INTIMA MEDIA WALL THICKNESS (a-IMT) IS INCREASED IN PATIENTS WITH PSORIATIC
ARTHRITIS
Rosario Peluso, Luisa Costa, Francesco Caso, Mariangela Atteno, Salvatore Iervolino,
Antonio Del Puente, Raffaele Scarpa;
Clinical and Experimental Medicine - Rheumatology Unit, University Federico II, Naples, Italy
CANDIDATE GENES FOR ANKYLOSING SPONDYLITIS
Jennifer J. Pointon 1 , Tugce Karaderi 1 , Louise H. Appleton 1 , David Harvey 1 , Claire Farrar 1 ,
Wellcome Trust Case Control Consortium 2 , Matthew A. Brown 3 , Bryan P. Wordsworth 1 ;
1
Nuffield Department of Orthopaedic Surgery, Oxford University, Oxford, United Kingdom;
2
Wellcome Trust Case Control Consortium, Hinxton, Cambridge, United Kingdom;
3
Diamantina Institute of Cancer, Immunology and Metabolic Medicine, University of Queensland,
Brisbane, QLD, Australia
58

Poster No. 82
Poster No. 83
Poster No. 84
A REGION ON CHROMOSOME 16 ASSOCIATED WITH ANKYLOSING SPONDYLITIS
Jennifer J. Pointon 1 , David Harvey 1 , Tugce Karaderi 1 , Louise H. Appleton 1 , Claire Farrar 1 ,
Wellcome Trust Case Control Consortium 2 , Matthew A. Brown 3 , Bryan P. Wordsworth 1 ;
1
Nuffield Department of Orthopaedic Surgery, Oxford University, Oxford, United Kingdom;
2
Wellcome Trust Case Control Consortium, Hinxton, Cambridge, United Kingdom; 3 Diamantina
Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland,
Brisbane, QLD, Australia
PATELLAR TENDON PROPERTIES AND LOWER LIMB FUNCTION IN RHEUMATOID ARTHRITIS
AND ANKYLOSING SPONDYLITIS
Verena Matschke 1,2 , Andrew B. Lemmey 1 , Jeremy G. Jones 1,2 , Peter J. Maddison 1,2 ,
Jeanette M. Thom 1 ;
1
School of Sport, Health and Exercise Sciences, University of Bangor, Bangor, United
Kingdom; 2 Department of Rheumatology, Gwynedd Hospital, North West Wales NHS Trust,
Bangor, United Kingdom
MORTALITY IN PSORIATIC ARTHRITIS - A UK PERSPECTIVE
Caitriona Buckley 1 , Charlotte Cavill 1 , Gordon Taylor 2 , Hazel Kay 2 , Nicola Waldron 1 ,
Eleanor Korendowych 1 , Neil McHugh 1 ;
1
Rheumatology Department, Royal National Hospital for Rheumatic Diseases, Bath,
United Kingdom; 2 Research and Development Support Unit, University of Bath, Bath,
United Kingdom
Poster Viewing One | Wednesday 29 April 2009
Poster No. 85
ASSESSMENT OF CLINICAL EFFICACY IN A RANDOMIZED, DOUBLE-BLIND STUDY OF
ETANERCEPT AND SULPHASALAZINE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
Irene E. van der Horst-Bruinsma 1 , Jurgen Braun 2 , Feng Huang 3 , Ruben Burgos-Vargas 4 ,
Bruce Freundlich 5 , Bonnie Vlahos 5 , Andrew S. Koenig 5 ;
1
Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands;
2
Rheumatology Medical Center, Ruhrgebeit, Herne, Ruhr-University, Bochum, Germany;
3
Department of Rheumatology, Chinese Liberation Army General Hospital, Beijing, China;
4
Hospital General de México and, Universidad Nacional Autónoma de México, Mexico City,
Mexico; 5Global Medical Affairs, Wyeth Research, Collegeville, PA
Poster No. 86
“PITFALLS FOR THE DETECTION OF SACROILIITIS BY MR IMAGING IN A DGH SETTING”.
(RESULTS FROM AN AUDIT)
Euthalia Roussou 1 , Anne Grethe Jurik 3 , Reuben Obaro 2 ;
1
Rheumatology and Rehabilitation, King George Hospital Barking Havering and Redbridge
NHS Trust, London, United Kingdom; 2 Radiology, King George Hospital Barking Havering and
Redbridge NHS Trust, London, United Kingdom; 3 Department of Rheumatology, Aarchus
University Hospital, Aarchus, Denmark
Poster No. 87
TREATMENT OF DMARD RESISTANT KNEE MONOARTHRITIS WITH REPEATED COURSES
OF INTRA-ARTICULAR INFLIXIMAB: AN OBSERVATIONAL STUDY WITH CLINICAL AND
ULTRASOUND MEASURES
Sarah J. Levy 1 , Oliver Wignall 2 , Christine Heron 2 , James Pilcher 2 , Patrick D. Kiely 1 ;
1
Rheumatology, St Georges Healthcare NHS Trust, London, United Kingdom;
2
Radiology, St Georges Healthcare NHS Trust, London, United Kingdom
59

Poster No. 88
HIGHLY EFFECTIVE TREATMENT WITH ADALIMUMAB IN PATIENTS WITH ANKYLOSING
SPONDYLITIS (AS) WITH ADVANCED SPINAL FUSION
Millicent Stone 2 , Martin Rudwaleit 1 , Juan Carlos Torre-Alonso 3 , Wolfgang Spieler 4 , Robert Wong 5 ,
Martina Kron 6 , Sonja Kary 6 , Hartmut Kupper 6 ;
1
Campus Benjamin Franklin, Charité-University Medicine Berlin, Berlin, Germany; 2 Bath Institute
for Rheumatic Diseases, Bath, United Kingdom; 3 Hospital Monte Naranco, Oviedo, Spain;
4
Rheumatologische Schwerpunktpraxis, Zerbst, Germany; 5 Abbott Laboratories, Parsippany, NJ;
6
Abbott GmbH & Co KG, Ludwigshafen, Germany
Poster No. 89
PATIENTS WITH PSORIATIC ARTHRITIS (PsA) TREATED WITH ADALIMUMAB ACHIEVED CLINI-
CAL REMISSION AND GOOD CLINICAL RESPONSES IN THE STEREO TRIAL
Richard Reece 5 , Filip Van den Bosch 1 , Bernhard Manger 2 , Philippe Goupille 3 , Martina Kron 4 ,
Sonja Kary 4 , Hartmut Kupper 4 ;
1
University Hospital, Ghent, Belgium; 2 Universität Erlangen/Nürnberg, Erlangen, Germany;
3
University Hospital, Tours, France; 4 Abbott GmbH & Co KG, Ludwigshafen, Germany;
5
Calderdale and Huddersfield NHS Foundation Trust, Leeds, United Kingdom
Poster No. 90
Poster No. 91
Poster No. 92
Poster No. 93
CLINICAL RESPONSE AND PARTIAL REMISSION SUSTAINED THROUGH 3 YEARS OF
ADALIMUMAB TREATMENT IN THE ATLAS TRIAL
P. Wordsworth 6 , D. van der Heijde 1 , B. A. Dijkmans 2 , M. H. Schiff 3 , A. Kivitz 4 , K. de Vlam 5 ,
S. Ballal 7 , H. Kupper 8 , R. L. Wong 7 , J. Sieper 9 ;
1
Leiden University Medical Center, Leiden, Netherlands; 2 VU Medical Centre and the Jan van
Breeman Institute, Amsterdam, Netherlands; 3 University of Colorado, Denver, CO; 4 Altoona
Center for Clinical Research, Duncansville, PA; 5 KU Leuven, Leuven, Belgium; 6 Nuffield
Orthopaediatric Centre, Oxford, United Kingdom; 7 Abbott Laboratories, Parsippany, NJ; 8 Abbott
GmbH & Co KG, Ludwigshafen, Germany; 9 Charite Universitätsmedizin Berlin, Berlin, Germany
IMPROVEMENT IN LONG-TERM SPINAL MOBILITY IN PATIENTS WITH ANKYLOSING
SPONDYLITIS (AS) IS SUSTAINED DURING UP TO 3 YEARS OF ADALIMUMAB TREATMENT:
3-YEAR ATLAS RESULTS
D. G. Scott 9 , D. van der Heijde 1 , M. H. Schiff 2 , J. Sieper 3 , A. Kivitz 4 , B. A. Dijkmans 5 ,
P. J. Mease 6 , H. Kupper 7 , S. Ballal 8 , R. L. Wong 8 ;
1
Leiden University Medical Center, Leiden, Netherlands; 2 University of Colorado, Denver, CO;
3
Charité Berlin, Berlin, Germany; 4 Altoona Center for Clinical Research, Duncansville, PA; 5 VU
University Medical Center and the Jan van Breemen Institute, Amsterdam, Netherlands; 6 Seattle
Rheumatology Associates, Seattle, WA; 7 Abbott GmbH & Co KG, Ludwigshafen, Germany;
8
Abbott Laboratories, Parsippany, NJ; 9 Norfolk and Norwich University Hospital, Norfolk,
United Kingdom
IN PATIENTS WITH PSORIATIC ARTHRITIS RECEIVING ADALIMUMAB, IMPROVEMENT IN
PSORIASIS IS ASSOCIATED WITH LONG-TERM INHIBITION OF RADIOGRAPHIC
PROGRESSION
E. Choy 1 , D. Gladman 2 , P. J. Mease 3 , C. Ritchlin 4 , M. Olds 5 , R. L. Wong 6 , S. Wang 5 , J. Medich 6 ;
1
King’s College, London, United Kingdom; 2 University of Toronto, Toronto, ON, Canada; 3 Seattle
Rheumatology, Seattle, WA; 4 University of Rochester, Rochester, NY; 5 Abbott Laboratories,
Abbott Park, IL; 6 Abbott Laboratories, Parsippany, NJ
DEVELOPMENT OF A COMPOSITE DISEASE ACTIVITY SCORE IN PSORIATIC ARTHRITIS
Aizad Mumtaz 1 , Phil Gallagher 1 , Brian Kirby 2 , Laura C Coates 3 , Robin Waxman 3 , Philip Helliwell 3 ,
Oliver FitzGerald 1 ;
1
Rheumatology, St Vincents University Hospital, Dublin, Ireland; 2 Dermatology, St Vincents
University Hospital, Dublin, Ireland; 3 Rheumatology, University Of Leeds, Leeds, United Kingdom
60

Poster No. 94
Poster No. 95
GOLIMUMAB, A NEW, HUMAN, TNFα ANTIBODY, IN ANKYLOSING SPONDYLITIS
(AS): 24-WEEK EFFICACY AND SAFETY RESULTS OF THE GO-RAISE STUDY
Jurgen Braun 1 , John Davis 2 , Desiree van der Heijde 3 , Atul Deodhar 4 , Laura Diekman 5 ,
Joachim Sieper 6 , Sung Il Kim 7 , John Han 8 , B. Hsu 8 , Robert Inman 9 , for the GO-RAISE
Study Investigators 8 ;
1
Rheumazentrum Ruhrgebiet, Herne, Germany; 2 University of California, San Francisco, CA;
3
Leiden University Medical Center, Leiden, Netherlands; 4 Oregon Health and Science
University, Portland, OR; 5 University of Texas-Houston, Houston, TX; 6 Charite Hospital, Berlin,
Germany; 7 Pusan National University Hospital, Busan, Korea, South; 8 Centocor Research and
Development, Inc, Malvern, PA; 9 University of Toronto, Toronto, ON, Canada
REVIEW OF PSORIATIC ARTHRITIS IN THE WEST MIDLANDS: ELIGIBILITY FOR
ANTI-TUMOUR NECROSIS FACTOR THERAPY UNDER THE NICE GUIDELINES
James Bateman 1 , Caroline M. Cardy 2 , Sophia Y. Khan 3 , Ajit Menon 4 , Karen Obrenovic 5 ,
Ian F. Rowe 6 , Nicola Erb 3 ;
1
Department of Rheumatology, University Hospital Coventry and Warwickshire, Coventry,
United Kingdom; 2 Department of Rheumatology, Hereford Hospital NHS Trust, Hereford,
United Kingdom; 3 Department of Rheumatology, Dudley Group of Hospitals NHS Trust,
Birmingham, United Kingdom; 4 Department of Rheumatology, University Hospital of North
Staffordshire NHS Trust, Birmingham, United Kingdom; 5 Department of Clinical Audit, Dudley
Group of Hospitals NHS Trust, Worcester, United Kingdom; 6 Department of Rheumatology,
Worcestershire Royal Hospital NHS Trust, Worcester, United Kingdom
Poster Viewing One | Wednesday 29 April 2009
Poster No. 96
IN PATIENTS WITH ANKYLOSING SPONDYLITIS (AS), ADALIMUMAB IMPROVES
INFLAMMATORY BOWEL DISEASE (IBD) AND PSORIASIS (Ps) AND PREVENTS
ANTERIOR UVEITIS (AU) FLARES
Paul Wordsworth 4 , Martin Rudwaleit 1 , Pascal Claudepierre 2 , Eduardo Loza 3 ,
Ignazio Olivieri 5 , Robert L. Wong 6 , Uemit Oezer 7 , Sonja Kary 7 , Hartmut Kupper 7 ;
1
Charité Universitätsmedizin Berlin, Berlin, Germany; 2 Hopital Universitaire Créteil-Paris XII,
Créteil, France; 3 Hospital de Navarra, Pamplona, Spain; 4 Nuffield Orthopaedic Centre, Oxford,
United Kingdom; 5 Ospedale San Carlo di Potenza, Potenza, Italy; 6 Abbott, Parsippany, NJ;
7
Abbott GmbH & Co KG, Ludwigshafen, Germany
Poster No. 97
GOLIMUMAB ADMINISTERED EVERY FOUR WEEKS AS A SUBCUTANEOUS INJECTION IN
PSORIATIC ARTHRITIS: NAIL, ENTHESITIS, AND DACTYLITIS RESPONSE IN THE
RANDOMIZED, PLACEBO-CONTROLLED, GO-REVEAL STUDY
Iain McInnes 1 , Dafna Gladman 2 , Arthur Kavanaugh 3 , Philip Mease 4 , Juan Gomez-Reino 5 ,
Kim Papp 6 , Julie Zrubek 7 , Surekha Mudivarthy 7 , Anna Beutler 7 , Gerald Krueger 8 ;
1
University of Glasgow, Glasgow, United Kingdom; 2 University of Toronto, Toronto, ON, Canada;
3
University of California, San Diego, CA; 4 Swedish Medical Center and Seattle Rheumatology
Associates, Seattle, WA; 5 Hospital Clinico Universitaire, Santiago, Spain; 6 Probity Medical
Research, Waterloo, ON, Canada; 7 Centocor Research and Development, Inc., Malvern, PA;
8
University of Utah, Salt Lake City, UT
Rheumatoid arthritis - treatment
Poster No. 98
WHY IS BIOLOGIC THERAPY NOT PRESCRIBED IN PATIENTS WITH RHEUMATOID
ARTHRITIS AND A HIGH DISEASE ACTIVITY SCORE?: EXPLORATION OF REASONS FROM
A 5 YEAR PROSPECTIVE STUDY (MASCOT)
Rosie Hampson, Lucy Wait, Ann Tierney, Rajan Madhok, Hilary Capell;
Centre for Rheumatic Diseases, Royal Infirmary, Glasgow, United Kingdom
61

Poster No. 99
Poster No. 100
Poster No. 101
SUBCUTANEOUS METHOTREXATE IS SUPERIOR TO ORAL METHOTREXATE IN
THE TREATMENT OF RHEUMATOID ARTHRITIS
Beena Hameed, Kate Hunt, Hugh Jones;
Rheumatology, Kingston Hospital, Kingston Upon Thames, United Kingdom
CAN STANDARD 5 OF THE 2005 BSR GUIDANCE ON RA CARE BE ACHIEVED
WITH A SINGLE 12 MONTHLY REVIEW?
Jo Reed, Ruth Slack, David O’Reilly;
Rheumatology, West Suffolk Hospital, Bury St Edmunds, United Kingdom
AN AUDIT OF CARDIOVASCULAR RISK RECORDING AND REDUCTION IN
PATIENTS WITH RHEUMATOID ARTHRITIS
Frances C. Hall 1 , David Chapireau 1 , Christopher See 1 , Chloe Lapraik 2 , Anne Meadows 3 ,
Gillian Pountain 4 , Kuntal Chakravarty 5 , Nicholas J. Sheehan 3 , Adam Young 6 , Richard Watts 8 ,
David O’Reilly 7 ;
1
Department of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom;
2
Department of Rheumatology, Luton and Dunstable Hospital, Luton, United Kingdom;
3
Department of Rheumatology, The Edith Cavell Hospital, Peterborough, United Kingdom;
4
Department of Rheumatology, Hinchingbrooke Hospital, Huntingdon, United Kingdom;
5
Department of Rheumatology, Queen’s Hospital, Romford, United Kingdom; 6 Department of
Rheumatology, St Alban’s Hemel NHS Trust, St Alban’s, United Kingdom; 7 Department of
Rheumatology, West Suffolk Hospital, Bury-St-Edmunds, United Kingdom; 8 Department of
Rheumatology, Ipswich Hospital, Ipswich, United Kingdom
Poster No. 102
AUDIT OF NATIONAL PATIENT SAFETY AGENCY PATIENT-HELD METHOTREXATE
MONITORING BOOKLETS
C. Bracewell 1 , Neil Gammack 2 , Jacqui Binding 1 , Clive Kelly 1 , Jennifer Hamilton 1 ;
1
Rheumatology Department, Queen Elizabeth Hospital, Gateshead, United Kingdom;
2
Pharmacy Department, Queen Elizabeth Hospital, Gateshead, United Kingdom
Poster No. 103
Poster No. 104
Poster No. 105
Poster No. 106
EARLY RHEUMATOID ARTHRITIS-ARE WE FOLLOWING THE GUIDELINES?
Su-Yin Tan, Smita Bhat, Thomas Pullar;
Rheumatic Diseases Unit, Ninewells Hospital and Medical School, Dundee, United Kingdom
EVOLVING PATTERNS OF BIOLOGIC USE FROM 2001 TO 2008- A DGH EXPERIENCE
Alice Groves, Adele Howe, Shouma Dutta, Stuart M. Linton;
Rheumatology, Nevill Hall Hospital, Gwent, United Kingdom
IS A SINGLE DOSE INTRAMUSCULAR (IM) TRIAMCINOLONE ACETONIDE INJECTION MORE
EFFECTIVE IN TREATING SYMPTOMATIC FLARE IN ESTABLISHED RHEUMATOID ARTHRITIS
THAN EQUIVALENT DOSE OF ORAL PREDNISOLONE?
Yoke-Mei McLoughlin, Gillian Scott, Nancy Mills, Penny Storrs, Frank McKenna;
Rheumatology Dept, Trafford General Hospital, Manchester, United Kingdom
AN AUDIT OF METHOTREXATE MONITORING IN PRIMARY CARE AS PART OF A SHARED CARE
AGREEMENT
Lois A. Lloyd 1 , Anne Breslin 2 , Jeremy Jones 2 ;
1
Dept of Pharmacy, North West Wales NHS Trust, Bangor, United Kingdom;
2
Dept of Rheumatology, North West Wales NHS Trust, Bangor, United Kingdom
62

Poster No. 107
Poster No. 108
Poster No. 109
Poster No. 110
ESTABLISHING THE IMPLICATIONS OF CHRONIC KIDNEY DISEASE (CKD), PARTICULARLY
CKD3, ON CVD RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS (RA)
Anita Weerakoon 1 , Robert C. Nightingale 2 , Gavin P. Clunie 1 ;
1
Rheumatology, The Ipswich Hospital NHS Trust, Ipswich, United Kingdom;
2
Radiology, The Ipswich Hospital NHS Trust, Ipswich, United Kingdom
LEUCOPENIA IN RHEUMATOID ARTHRITIS PATIENTS PRESCRIBED METHOTREXATE
AS COMBINATION OR MONOTHERAPY
Neal D. Reynolds, Mark H. Edwards, Richard G. Hull, Joanna M. Ledingham;
Rheumatology, Queen Alexander Hospital, Portsmouth, United Kingdom
Withdrawn
A STUDY OF ANTI-TNF THERAPY USE FOR RHEUMATOID ARTHRITIS PATIENTS IN WALES
Shouma Dutta;
Rheumatology, Ysbyty Gywnedd, Bangor, United Kingdom
Poster Viewing One | Wednesday 29 April 2009
Poster No. 111
PREDICTING REMISSION IN TRIAL OF INTENSIVE THERAPY IN EARLY RA: HAQ AND
GENDER ARE KEY FACTORS
Margaret H. Ma 1 , David Walker 2 , Andrew Hassell 3 , Ernest H. Choy 1 , David L. Scott 1 ;
1
Rheumatology, King’s College Hospital, London, United Kingdom; 2 Rheumatology, Freeman
Hospital, Newcastle, United Kingdom; 3 Rheumatology, Hayward Hospital,
Stoke On Trent, United Kingdom
Poster No. 112
IS SWITCHING TO A SECOND ANTI-TNF ALPHA AGENT WORTHWHILE? THE TAYSIDE
EXPERIENCE
Smita Bhat 2 , Lyndsey Atterton 1 , Ken Morley 2 , Donna Daugherty 2 ;
1
University of Dundee Medical School, Dundee, United Kingdom; 2 Rheumatic Diseases Unit,
Ninewells Hospital and Medical School, Dundee, United Kingdom
Poster No. 113
WHAT COMPONENT OF THE DAS28 IS MOST LIKELY TO CONTRIBUTE TO RA
PATIENTS BEING CLASSIFIED AS “FAILURES” ON ANTI-TNF?
Fionn Toolis, Sayqa Butt, Kate Gadsby, Chris Deighton;
Department of Rheumatology, Derbyshire Royal Infirmary, Derby, United Kingdom
Poster No. 114
COMPARING OUTCOME FOR THE FIRST 12 MONTHS OF ANTI-TNF THERAPY IN
RHEUMATOID ARTHRITIS (RA) IN STANDARD CLINICAL PRACTICE IN UK
Mandy C. Greenwood, Alan J. Hakim, Simon P. Donnelly, Margaretta M. Rooney, Hasan Tahir;
Rheumatology, Whipps Cross University Hospital, London, United Kingdom
Poster No. 115
THE IMPACT OF ANTI-TNF ON THE WEIGHT OF RHEUMATOID ARTHRITIS PATIENTS
Nicola Alcorn 1 , Ann Tierney 1 , Olivia Wu 2 , Harper Gilmour 2 , Hillary Capell 1 , Rajan Madhok 1 ;
1
Centre Rheumatic Disease, Glasgow Royal Infirmary, Glasgow, United Kingdom;
2
Public Health Department, Glasgow University, Glasgow, United Kingdom
Poster No. 116
SYSTEMATIC REVIEW: COMPARATIVE EFFECTIVENESS OF BIOLOGIC DMARD
THERAPIES VERSUS TRADITIONAL DMARD THERAPIES IN RA
Richard C. Campbell, Gabrielle Kingsley, David Scott;
Rheumatology, Kings College Hospital, London, United Kingdom
63

Poster No. 117
Poster No. 118
Poster No. 119
Poster No. 120
Poster No. 121
ACTIVE RHEUMATOID ARTHRITIS: A CASE STUDY APPROACH INVESTIGATING
HYPNOTHERAPY AND IMAGERY WITHIN A BIOPSYCHOSOCIAL FRAMEWORK
Bryan M. Bennett, Nichola Callow, Jeremy G. Jones;
School of Sport, Health, & Exercise Sciences, Bangor University, Bangor, Gwynedd,
United Kingdom
POOR EFFICACY OF SULPHASALAZINE AS A SECOND DMARD IN PATIENTS WITH ACTIVE
RHEUMATOID ARTHRITIS DESPITE METHOTREXATE TREATMENT
Amjad A. Jilani, Margaret Callan;
Department of Rheumatology, Chelsea and Westminster Foundation trust, London,
United Kingdom
FOUR YEAR OUTCOME DATA IN RHEUMATOID ARTHRITIS (RA) PATIENTS RECEIVING EITHER
ETANERCEPT OR INFLIXIMAB IN STANDARD CLINICAL PRACTICE
Mandy C. Greenwood, Simon P. Donnelly, Margaretta M. Rooney, Alan J. Hakim, Hasan Tahir;
Rheumatology, Whipps Cross University Hospital, London, United Kingdom
AN AUDIT OF GUIDELINES FOR THE EARLY MANAGEMENT OF RHEUMATOID ARTHRITIS IN
A DISTRICT GENERAL HOSPITAL SETTING
Simon Roughneen, Sarah Dunn, Shirley Rigby;
Department of Rheumatology, South Warwickshire General Hospitals NHS Trust, Warwick,
United Kingdom
EVALUATION OF JOINT DAMAGE IN RA PATIENTS TREATED WITH RITUXIMAB: COMPARISON
OF GENANT- AND VAN DER HEIJDE-MODIFIED SHARP RADIOGRAPHIC SCORING
Mark Genovese 1 , Charles Peterfy 2 , Paul Emery 3 , Edward Keystone 4 , Paul-Peter Tak 5 , Stanley B.
Cohen 6 , Julie DiCarlo 2 , David Hagerty 7 , Mathew Cravets 7 , Tim Shaw 8 ;
1
Stanford University, Stanford, CA; 2 Synarc, San Francisco, CA; 3 Leeds General Infirmary, Leeds,
United Kingdom; 4 University of Toronto, Toronto, ON, Canada; 5 Academic Medical Centre,
University of Amsterdam, Amsterdam, Netherlands; 6 Metroplex, Dallas, TX; 7 Biogen Idec,
San Diego, CA; 8 Roche Products Ltd, Welwyn Garden City, United Kingdom
Poster No. 122
LOW DOSE TIMED RELEASE PREDNISONE REDUCES IL-6 IN RA
Lynsey L. Clarke 1 , David S. Jessop 1 , Linda P. Hunt 1 , Rainer H. Straub 2 , Mark G. Perry 1 ,
John R. Kirwan 1 ;
1
University of Bristol, Bristol, United Kingdom; 2 University Hospital Regensburg,
Regensburg, Germany
Poster No. 123
EFFICACY AND SAFETY OF REPEAT TREATMENT COURSES OF RITUXIMAB IN RA PATIENTS
(PTS) WITH INADEQUATE RESPONSE (IR) TO TUMOUR NECROSIS FACTOR (TNF) INHIBITORS:
LONG-TERM EXPERIENCE FROM THE REFLEX STUDY
Edward C. Keystone 1 , Roy M. Fleischmann 2 , Paul Emery 3 , Andrew Chubick 4 ,
Maxime R. Dougados 5 , Andrew R. Baldassare 6 , Joan M. Bathon 7 , Eva W. Hessey 8 ,
David Hagerty 9 , Simon Safa-Leathers 8 ;
1
Mount Sinai Hospital, Toronto, ON, Canada; 2 University of Texas Southwestern Medical Center,
Dallas, TX; 3 Leeds University, Leeds, United Kingdom; 4 Arthritis Centers of Texas, Dallas, TX;
5
Rene Descartes University, Paris, France; 6 Arthritis Consultants Inc., St Louis, MO; 7 The Johns
Hopkins Arthritis Center, Baltimore, MD; 8 Roche Products Ltd, Welwyn Garden City, United
Kingdom; 9 Biogen Idec, San Diego, CA
64

Poster No. 124
Poster No. 125
Poster No. 126
Poster No. 127
SULFASALAZINE DESENSITISATION KIT IS EFFECTIVE AND WORTHWHILE IN
INFLAMMATORY ARTHRITIS - AUDIT OF PRACTICE
Maciej Brzeski;
Rheumatology, Falkirk & District Royal Infirmary, Falkirk, United Kingdom
POTENTIAL COSTS TO THE NATIONAL HEALTH SERVICE FOR THE TREATMENT OF SERIOUS
LOWER RESPIRATORY TRACT INFECTIONS IN RA PATIENTS TREATED WITH DIFFERENT
TNF-α INHIBITORS IN THE UNITED KINGDOM: A PROSPECTIVE 5 YEAR MODEL
James Warburton, Rohit Batta, Maximilian Lebmeier, Volker Koscielny, Manjinder Bains;
Wyeth Pharmaceuticals, Taplow, United Kingdom
PATIENTS FAILING TO RESPOND ON ANTI-TNF TREATMENT - WILL SUBCUTANEOUS
METHOTREXATE HELP?
Thiraupathy Marianayagam, Shilpa Selvan, Ruth Slack, David O’Reilly, Vivek Rajagopal;
Rheumatology, West Suffolk Hospital, Bury St Edmunds, United Kingdom
THE STEROID SPARING EFFECT OF ANTI-TNF TREATMENT IN PATIENTS WITH
RHEUMATOID ARTHRITIS
Laura-Jane Smith, Helen C. Reade, Nicholas J. Sheehan, Sandeep Dahiya;
Department of Rheumatology, Peterborough and Stamford Hospitals NHS Foundation Trust,
Peterborough, United Kingdom
Poster Viewing One | Wednesday 29 April 2009
Poster No. 128
Poster No. 129
Poster No. 130
Poster No. 131
Poster No. 132
FAILURE OF METHOTREXATE THERAPY IN APTIENTS WITH EARLY PERSISTENT
INFLAMMATORY ARTHRITIS: TO SWITCH, TO ADD ANOTHER DMARD, OR TO GO
FOR BIOLOGIC THERAPY?
Yasser El Miedany 1 , Deborah Palmer 1 , Maha El Gaafary 2 , Annie N. Mehanna 3 ;
1
Rheumatology, Darent Valley Hospital, Dartford, United Kingdom; 2 Community, Environmental
and Occupational Medicine, Ain Shams University, Cairo, Egypt; 3 Radiology, Ain Shams
University, Cairo, Egypt
NEUTROPENIA IN PATIENTS TREATED WITH TNF-ALPHA ANTAGONISTS
Jasroop K. Chana, Ishita Patel, Nicola Kennedy, Matthew Adler, Francesca Demetriadi,
Alan Steuer;
Rheumatology, Wexham Park Hospital, Slough, United Kingdom
WITHDRAWAL OF DMARDS IN PATIENTS WITH RHEUMATOID ARTHRITIS: A SYSTEMATIC
REVIEW AND META-ANALYSIS
Rachel O’Mahony 1 , Alison Richards 1 , Chris Deighton 2 , David Scott 3 ;
1
National Collaborating Centre for Chronic Conditions (NCC-CC), Royal College of Physicians,
London, United Kingdom; 2 Department of Rheumatology, Derbyshire Royal Infirmary, Derby,
United Kingdom; 3 Academic and Rheumatology Department, King’s College London, London,
United Kingdom
PARENTERAL METHOTREXATE - WHICH PATIENTS BENEFIT MOST?
Hayley Mainman, Emma Maclaren, Kirstin Scott, Vadivelu Saravanan, Jennifer Hamilton,
Carol Heycock, Clive Kelly;
Rheumatology, Queen Elizabeth Hospital, Gateshead, United Kingdom
INTENSIVE MONITORING MAY ALLOW THE REDUCTION OF THE BIOLOGICS
DOSE IN PATIENTS WITH RHEUMATOID ARTHRITIS
Anurag Bharadwaj, Natasha Jegganathan, Mike Batley, Anthony Hammond;
Rheumatology, Maidstone Hospital, Maidstone, United Kingdom
65

Poster No. 133
Poster No. 134
Poster No. 135
Poster No. 136
NEUTROPENIA WITH ANTI-TNF THERAPY FOR RHEUMATOID ARTHRITIS
Anna E. Litwic 1 , Maxine Tann 2 , Joanna M. Ledingham 2 ;
1
Renal Department, Queen Alexandra Hospital, Portsmouth, United Kingdom; 2 Rheumatology
Department, Queen Alexandra Hospital, Portsmouth, United Kingdom
COMBINATION DMARDS FOR RHEUMATOID ARTHRITIS: A COST-EFFECTIVENESS ANALYSIS
Jonathan Tosh, Allan Wailoo;
Health Economics and Decision Science. School of Health and Related Research, University of
Sheffield, Sheffield, United Kingdom
BASELINE IMMUNOLOGICAL STATUS OF EARLY RHEUMATOID ARTHRITIS PATIENTS PREDICT
RESPONSE TO TREATMENT
Frederique Ponchel, Rekha Parmar, Vincent Goeb, Benazir Saleem, Philip Conaghan,
Paul Emery;
LIMM, Section MSK, LMBRU, University of Leeds, Leeds, United Kingdom
A COMPARISON OF DRUG SURVIVAL TIMES FOR INFLIXIMAB, ADALIMUMAB AND
ETANERCEPT
Joanna M. Pocock 1 , Samir Albreshni 2 , Ruth Slack 2 , Varvara Polydoropoulou 3 , David O’Reilly 2 ,
Andrew J. Östör 1 ;
1
Department of Rheumatology, Addenbrooke’s Hospital, Cambridge, United Kingdom;
2
Department of Rheumatology, West Suffolk Hospital, Bury St Edmunds, United Kingdom;
3
Centre for Applied Medical Statistics, University of Cambridge, Cambridge, United Kingdom
Poster No. 137
Poster No. 138
DOES TEMPORARY DISCONTINUATION OF ANTI TNF-α AGENT ETANERCEPT AFFECT THE
THERAPEUTIC RESPONSE AT SIX MONTH
A. Abhishek, S. Butt, K. Gadsby, C. M. Deighton;
Department of Rheumatology, Derbyshire Royal Infirmary, Derby, United Kingdom
GOAL DIRECTED THERAPY FOR RHEUMATOID ARTHRTIS IN ROUTINE PRACTICE IMPROVES
CONTROL OF DISEASE ACTIVITY AND PREVENTS DETERIORATION IN HAQ
Nicola J. Gullick 1,2 , Stephen P. Oakley 1 , Tim Jones 1 , Alan Mistlin 1 , Jonathan D. Rees 1 ,
Gabriel S. Panayi 1,2 , Bruce W. Kirkham 1 ;
1
RA Centre, Guy’s & St Thomas’ NHS Foundation Trust, London, United Kingdom;
2
Rheumatology, King’s College, London, United Kingdom
Poster No. 139
Poster No. 140
Poster No. 141
QUANTIFERON GOLD SCREENING FOR LATENT TUBERCULOSIS - COST COMPARISON WITH
MANTOUX TESTING
Natasha Jordan, Patricia Kavanagh, Patricia Dooley, Suzanne Donnelly, Geraldine McCarthy,
Conor McCarthy;
Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland
PREDICTION MODEL FOR THERAPEUTIC OUTCOME ASSESSMENT IN PATIENTS WITH EARLY
PERSISTENT INFLAMMATORY ARTHRITIS
Yasser El Miedany 1 , Deborah Palmer 1 , Maha El Gaafary 2 ;
1
Rheumatology, Darent Valley Hospital, Dartford, United Kingdom; 2 Community, Environmental
and Occupational Medicine, Ain Shams University, Cairo, Egypt
HOW WELL DOES IMPROVEMENT IN THE HAQ CORRELATE WITH THE DAS28
IN RA PATIENTS ON ANTI-TNF?
Fionn Toolis, Butt Sayqa, Kate Gadsby, Chris Deighton;
Department of Rheumatology, Derbyshire Royal Infirmary, Derby, United Kingdom
66

Poster Viewing Two
Thursday 30 April 2009
Poster Viewing Two
Thu 30 April 2009

Poster Viewing Two
Thursday 30 April 2009, 08.30-10.00
Sjögren’s syndrome and other connective tissue disorders
Poster No. 142
Poster No. 143
EVALUATION OF PRIMARY AND SECONDARY SJÖGREN’S SYNDROME IN IRAQI PATIENTS
Mohammed H. Munshed 1 , Ziad s. Alrawi 2 ;
1
medicine, baghdad, Iraq; 2 medicine, baghdad, Iraq
A LONGITUDINAL STUDY OF NAILFOLD CAPILLARY ABNORMALITIES IN PATIENTS WITH
IDIOPATHIC INFLAMMATORY MYOPATHIES
Louise K. Mercer 1 , Tonia L. Moore 2 , Hector Chinoy 2 , Andrea K. Murray 2 , Andrew Vail 2 ,
Robert G. Cooper 2 , Ariane L. Herrick 2 ;
1
ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom; 2 The
University of Manchester, Salford Royal NHS Foundation Trust, Salford, United Kingdom
Poster Viewing Two | Thursday 30 April 2009
Poster No. 144
CARDIOVASCULAR RISK FACTORS AND OUTCOMES IN PATIENTS WITH IDIOPATHIC
IMMUNE MYOSITIS
Bryan R. Whelan 1 , Shabina Sultan 2 , David A. Isenberg 1 ;
1
Rheumatology, University College London, London, United Kingdom; 2 Rheumatology,
Bradford Royal Infirmary, Bradford, United Kingdom
Poster No. 145
PATIENT-REPORTED OUTCOMES IN PRIMARY SJÖGREN’S SYNDROME: THE LONG AND
SHORT VERSIONS OF THE PROFILE OF FATIGUE AND DISCOMFORT - SICCA SYMPTOMS
INVENTORY
Simon J. Bowman 1 , John Hamburger 2 , Andrea Richards 2 , Robert J. Barry 3 , Saaeha Rauz 3 ;
1
Rheumatology, University Hospital Birmingham NHS Foundation Trust, Birmingham, United
Kingdom; 2 Oral Medicine, Birmingham Dental Hospital & School, Birmingham, United
Kingdom; 3 Academic Unit of Ophthalmology, University of Birmingham, Birmingham,
United Kingdom
Poster No. 146
Poster No. 147
Poster No. 148
THE SJÖGREN’S SYNDROME DAMAGE INDEX - OUTCOME OVER 10 YEARS
Lada Krylova, David A. Isenberg;
Rheumatology, University College London Hospitals, London, United Kingdom
KILLER-CELL IMMUNOGLOBULIN-LIKE RECEPTOR GENE POLYMORPHISMS
AND PRIMARY SJÖGREN’S SYNDROME
David P. Lowe 1 , Mark A. Cook 2 , Simon J. Bowman 3 , David C. Briggs 1 , United Kingdom
Sjögren’s Interest Group 4 ;
1
Histocompatibility & Immunogenetics, NHS Blood Transfusion Service, Birmingham, United
Kingdom; 2 Haematology, University Hospital Birmingham NHS Foundation Trust, Birmingham,
United Kingdom; 3 Rheumatology, University Hospital Birmingham NHS Foundation Trust,
Birmingham, United Kingdom; 4 UK Sjögren’s Interest Group, UK, United Kingdom
DAMAGE ACCRUAL IN PATIENTS WITH ADULT ONSET IDIOPATHIC IMMUNE MYOSITIS
Bryan R. Whelan 1 , Shabina Sultan 2 , David A. Isenberg 1 ;
1
Rheumatology, University College London, London, United Kingdom;
2
Rheumatology, Bradford Royal Infirmary, Bradford, United Kingdom
67

Poster No. 149
CLASSIFICATION CRITERIA FOR IDIOPATHIC INFLAMMATORY MYOSITIS: COMPARISON OF
THE PERFORMANCE OF ACCEPTED CRITERIA
Helen Linklater 1 , Nicolo’ Pipitone 2 , Michael R. Rose 3 , Fiona Norwood 3 , David L. Scott 1 ,
Patrick A. Gordon 1 ;
1
Department of Rheumatology, Kings College Hospital, Denmark Hill, London, United Kingdom;
2
Rheumatology Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy; 3 Department of
Neurology, Kings College Hospital, Denmark Hill, London, United Kingdom
Scleroderma and related disorders
Poster No. 150
Poster No. 151
AN 8-YEAR RETROSPECTIVE STUDY ON THE PROFILE OF CLINICALLY DIAGNOSED PATIENTS
WITH SCLERODERMA (SYSTEMIC SCLEROSIS) IN UNIVERSITY OF THE PHILIPPINES-
PHILIPPINE GENERAL HOSPITAL (UP-PGH) MEDICAL CENTER: A REVIEW OF 27 CASES
Tom Edward N. Lo, Ester G. Penserga;
Medicine, University of the Philippines, Manila, Philippines
THUMB INVOLVEMENT IN RAYNAUD’S PHENOMENON AS AN INDICATOR
OF UNDERLYING CONNECTIVE TISSUE DISEASE
Batsi Chikura 1,2 , Tonia Moore 2 , Joanne Manning 2 , Andy Vail 3 , Ariane L. Herrick 2 ;
1
Rheumatology, Royal Liverpool University Hospital, Liverpool, United Kingdom; 2 Rheumatic
Diseases Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom;
3
Biostatistics Group, University of Manchester, Manchester, United Kingdom
Poster No. 152
FUNCTIONAL REGULATION OF FIBROSIS BY CUTL1 ISOFORMS
Tetsurou Ikeda 1,2 , Gisela Lindahl 1 , Maria Fragiadaki 2 , Xu Shi-wen 1 , Markella Ponticos 1 , Patricia
Garcia 1 , Christopher Denton 1 , George Bou-Gharios 2 , David Abraham 1 ;
1
Rheumatology, Medical School, University College of London, London, United Kingdom;
2
Renal Medicine, Imperial College, London, United Kingdom
Poster No. 153
Poster No. 154
Poster No. 155
Poster No. 156
TREATMENT OF SKIN DISEASE IN SYSTEMIC SCLEROSIS (SSc): RESPONSE
TO A TARGETED TREATMENT REGIMEN WITH IV CYCLOPHOSPHAMIDE (CYC)
Lesley Ottewell, Karen Walker, Bridget Griffiths;
Department of Rheumatology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom
MULTI-SITE PHOTOPLETHYSMOGRAPHY VASCULAR ASSESSMENT OF AUTONOMIC
FUNCTION IN PATIENTS WITH SYSTEMIC SCLEROSIS
Neil D. McKay 1 , Stephen Hedley 2 , Bridget Griffiths 1 , John Allen 2 ;
1
Dept of Rheumatology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom;
2
Microvascular Diagnostics, Regional Medical Physics Department, Newcastle Upon Tyne,
United Kingdom
RELATIONSHIP OF RESPIRATORY MUSCLES STRENGTH WITH DISEASE DURATION,
PULMONARY FUNCTION, SKIN SCORE AND AGE OF PATIENTS WITH SYSTEMIC SCLEROSIS
Lilia V. Shvets, Mykola A. Stanislavchuk;
Rheumatology, Vinnytsya National Medical University, Vinnytsya, Ukraine
LONG-TERM OUTCOME OF A TARGETED TREATMENT REGIMEN WITH IV
CYCLOPHOSPHAMIDE (CYC) IN PATIENTS WITH SYSTEMIC SCLEROSIS (SSC)
AND INTERSTITIAL LUNG DISEASE (ILD)
Lesley Ottewell, Karen Walker, Bridget Griffiths;
Department of Rheumatology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom
68

Poster No. 157
Poster No. 158
Poster No. 159
DOES ANTI-RNA-POLYMERASE ANTIBODY LEVEL PREDICT ORGAN INVOLVEMENT
OR DISEASE OUTCOME IN PATIENTS WITH SYSTEMIC SCLEROSIS?
Svetlana I. Nihtyanova 1 , Jennifer C. Parker 2 , Carol M. Black 1 , Christopher C. Bunn 2 ,
Christopher P. Denton 1 ;
1
Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital,
London, United Kingdom; 2 Clinical Immunology Department, Royal Free Hospital, London,
United Kingdom
PATIENTS WITH SYSTEMIC SCLEROSIS HAVE AN INCREASED PREVALENCE OF
NON-RESTORATIVE SLEEP AS MEASURED BY THE EPWORTH SCORE
Neil D. McKay 1 , Bridget Griffiths 1 , John Allen 2 ;
1
Dept of Rheumatology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom;
2
Microvascular Diagnostics, Regional Medical Physics Department, Newcastle Upon Tyne,
United Kingdom
MEDICAL STUDENT BURSARY WINNER
ACRO-OSTEOLYSIS IN SYSTEMIC SCLEROSIS - RELATIONSHIP TO DEGREE OF DIGITAL
ISCHAEMIA AND TO CALCINOSIS
Emma M. Johnstone, Charles Hutchinson, Ariane L. Herrick;
University of Manchester, Salford Royal NHS Foundation Trust, Salford, United Kingdom
Poster Viewing Two | Thursday 30 April 2009
Poster No. 160
Poster No. 161
TGF-BETA INDUCTION OF THE MYOFIBROBLAST PHENOTYPE REQUIRES TAK-1
Xu Shiwen 1 , Sunil Parapuram 2 , Daphne Pala 2 , David Carter 2 , Mark Eastwood 3 ,
Christopher Denton 1 , Carol Black 1 , Andrew Leask 2 , David Abraham 1 ;
1
Rheumatology, University College London (Royal Free Campus), London, United Kingdom;
2
University of Western Ontario, London, ON, Canada; 3 University of Westminster, London,
United Kingdom
CONSTITUTIVE NUCLEAR ACCUMULATION OF CBF IN SYSTEMIC SCLEROSIS PULMONARY
FIBROBLASTS: A PUTATIVE TRANSCRIPTIONAL MECHANISM UNDERLYING THE FIBROTIC
PHENOTYPE
Gisela Lindahl 1 , Patricia Leoni 1 , Markella Ponticos 1 , Xu Shi-wen 1 , Elisabetta Renzoni 2 , Alan
Holmes 1 , Carol M. Black 1 , Christopher P. Denton 1 , David J. Abraham 1 ;
1
Rheumatology, UCL Medical School (Royal Free), London, United Kingdom;
2
National Heart and Lung Institute, Imperial College, London, United Kingdom
Poster No. 162
Poster No. 163
NAILFOLD CAPILLARY ABNORMALITIES ARE ASSOCIATED WITH SEVERITY OF
DIGITAL ISCHAEMIA AND ANTICENTROMERE ANTIBODY IN SYSTEMIC SCLEROSIS
Ariane L. Herrick 1 , Moore Tonia 1 , Andrea K. Murray 1 , Whidby Nina 1 , Joanne Manning 1 ,
Andrew Vail 2 ;
1
Rheumatic Diseases Centre, University of Manchester, Salford Royal NHS Foundation Trust,
Salford, United Kingdom; 2 Biostatistics Group, University of Manchester, Salford Royal NHS
Foundation Trust, Salford, United Kingdom
EFFECT OF 8 WEEKS’ ATORVASTATIN ON ENDOTHELIAL FUNCTION IN PATIENTS WITH
SYSTEMIC SCLEROSIS
Hala Y. Sadik 1,2 , Tonia Moore 1 , Andy Vail 1,3 , Andrea Murray 1 , Marina Anderson 4 ,
Blann Andrew 5 , Ariane L. Herrick 1 ;
1
Rheumatic Diseases Centre, University of Manchester, Salford Royal NHS Foundation Trust,
Salford, United Kingdom; 2 Department of Rheumatology, Wirral University Teaching Hospital
NHS Foundation Trust, Wirral, United Kingdom; 3 Health Methodology Research Group,
University of Manchester, Manchester, United Kingdom; 4 Department of Rheumatology,
University Hospital Aintree, Liverpool, United Kingdom; 5 City Hospital, Birmingham,
United Kingdom
69

Poster No. 164
Poster No. 165
Poster No. 166
CONTEMPORARY OUTCOME IN SYSTEMIC SCLEROSIS: IMPROVED SURVIVAL
WITH EARLIER RECOGNITION OF ORGAN-BASED COMPLICATIONS
Edward C. Tang, Svetlana I. Nihtyanova, Christopher P. Denton;
Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital, London,
United Kingdom
MODULATION OF TYPE I COLLAGEN SYNTHESIS AND FIBROBLAST FUNCTION IN SYSTEMIC
SCLEROSIS BY THE GREEN TEA ANTIOXIDANT (-)-EPIGALLOCATECHIN-3-GALLATE
Audrey Dooley 1 , Xu Shiwen 1 , Nima Aden 1 , Thomas Tranah 2 , Nirupa Desai 2 ,
Christopher P. Denton 1 , Carol M. Black 1 , David J. Abraham 1 , Richard Bruckdorfer 2 ;
1
Centre for Rheumatology, University College London Medical School (Royal Free Campus),
London, United Kingdom; 2 Department of Biochemistry, University College London Medical
School (Royal Free Campus), London, United Kingdom
THE ROLE OF FIBROCYTES IN SYSTEMIC SCLEROSIS
Thomas Hügle 1 , Christiaan Huigens 1 , Lesley Ottewell 2 , Alan Tyndall 3 , Bridget Griffiths 2 ,
Jacob M. van Laar 1 ;
1
Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne, United Kingdom;
2
Department of Rheumatology, Freeman Hospital, Newcastle upon Tyne, United Kingdom;
3
Department of Rheumatology, University Hospital Basel, Basel, Switzerland
Poster No. 167
Poster No. 168
ASTIS TRIAL
Jacob M. van Laar 1 , Dominique Farge 2 , Alan Tyndall 3 , ASTIS Trial Investigators 4 ;
1
Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne, United Kingdom;
2
Service Medicine Interne, Hopital St Louis, Paris, France; 3 Rheumatology, University Hospital
Basel, Basel, Switzerland; 4 Study Administration Office, The James Cook University Hospital,
Middlesbrough, United Kingdom
DISRUPTION OF TGFBETA SIGNALLING IN DERMAL FIBROBLASTS DELAYS SKIN WOUND
HEALING AND REDUCES FIBROCYTE RECRUITMENT
Korsa Khan, Rachel Hoyles, Xu Shiwen, David Abraham, Christopher P. Denton;
Centre for Rheumatology and connective tissue diseases, Royal Free and University College
Medical School, London, United Kingdom
Rheumatoid arthritis – treatment
Poster No. 169
Poster No. 170
SOCIO-ECONOMIC STATUS INFLUENCES THE TIMING OF RESPONSE IN
A PROSPECTIVE STUDY OF PATIENTS WITH RHEUMATOID ARTHRITIS
Ann Tierney 1 , Lucy Wait 1 , Rosie Hampson 1 , Alex McConnachie 2 , Claudia-Martina Messow 2 ,
Hilary Capell 1 , Rajan Madhok 1 ;
1
Centre for Rheumatic Diseases, Royal Infirmary, Glasgow, United Kingdom; 2 Robertson Centre
for Biostatistics, University of Glasgow, Glasgow, United Kingdom
DOES MAGNITUDE OF FATIGUE DIFFER BETWEEN ANTI-RHEUMATIC THERAPIES IN 553 RA
PATIENTS TREATED AT MAIDSTONE HOSPITAL?
Richard C. Campbell 2,1 , Michael Batley 1 , Anthony Hammond 1 , Anarag Bharadwaj 1 ,
Gabrielle Kingsley 2 , David Scott 2 ;
1
Rheumatology, Maidstone General Hospital, Maidstone, United Kingdom; 2 Rheumatology,
King’s College Hospital, London, United Kingdom
70

Poster No. 171
Poster No. 172
Poster No. 173
MEDICAL STUDENT BURSARY WINNER
PARENTERAL METHOTREXATE - IS IT WORTH IT?
Emma Maclaren, Hayley Mainman, Kirstin Scott, Carol Heycock, Vadivelu Saravanan,
Jennifer Hamilton, Clive Kelly;
Rheumatology, Queen Elizabeth Hospital, Gateshead, United Kingdom
EFFECTS OF ANT-TNF THERAPY ON WHITE CELL SUBSETS
Richard Hastings 1 , Tina Ding 1 , Sayqa Butt 1 , Kate Gadsby 1 , Weiya Zhang 2 , Rob Moots 3 ,
Chris Deighton 1 ;
1
Rheumatology, Derbyshire Royal Infirmary, Derby, United Kingdom; 2 Academic
Rheumatology, Nottingham City Hospital, Nottingham, United Kingdom; 3 Inflammation
Research Unit, University of Liverpool, Liverpool, United Kingdom
RHEUMATOID ARTHRITIS PATIENTS TREATED WITH TOCILIZUMAB SHOW IMPROVED
HAEMOGLOBIN LEVELS AND FACIT-FATIGUE SCORES
J. S. Smolen 1 , M. Chester Wasko 2 , C. R. Ramos-Remus 3 , E. F. Mysler 4 , B. M. Day 5 ,
C. Wiese 6 , R. Alten 7 ;
1
Department of Rheumatology, Vienna Medical University, Vienna, Austria; 2 University of
Pittsburgh Medical Center, Pittsburgh, PA; 3 Department of Rheumatology, Centro Médico
Occidente, Guadalajara, Mexico; 4 Organización Medica en Investigacion, Buenos Aires,
Argentina; 5 Roche, Nutley, NJ; 6 Roche, Basel, Switzerland; 7 Schlosspark Klinik, Department
of Medicine, Berlin, Germany
Poster Viewing Two | Thursday 30 April 2009
Poster No. 174
ANALYSIS OF NEUTROPHIL COUNTS AND BASELINE DATA IN PATIENTS WITH SERIOUS
INFECTIONS IN RECENT TOCILIZUMAB CLINICAL TRIALS
J. S. Smolen 1 , R. van Vollenhoven 2 , A. Rubbert-Roth 3 , H. Kellner 4 , C. Ramos-Remus 5 ,
B. M. Day 6 , T. Woodworth 7 , M. C. Genovese 8 ;
1
Medical University of Vienna and Heitzing Hospital, Vienna, Austria; 2 Rheumatology Unit,
Karolinska University Hospital, Stockholm, Sweden; 3 Medical Hospital of the University of
Cologne, Cologne, Germany; 4 Department of Rheumatology, Medical Policlinic Ludwig
Maximilians University, Munich, Germany; 5 Department of Rheumatology, Centro Médico
Occidente, Guadalajara, Mexico; 6 Roche, Nutley, NJ; 7 Roche, Welwyn, United Kingdom;
8
Stanford University School of Medicine, Palo Alto, CA
Poster No. 175
Poster No. 176
Poster No. 177
ANALYSIS OF LOW-DENSITY LIPOPROTEIN AND ADVERSE EVENTS IN RHEUMATOID
ARTHRITIS PATIENTS TREATED WITH TOCILIZUMAB PLUS STATINS: DATA FROM FIVE
PHASE III CLINICAL TRIALS
M. C. Genovese 1 , J. S. Smolen 2 , P. Emery 3 , G. Jones 4 , J. S. Lee 5 , E. Alecock 6 , J. M. Kremer 7 ;
1
Stanford University School of Medicine, Palo Alto, CA; 2 Division of Rheumatology,
Internal Medicine III, Medical University of Vienna, Vienna, Austria; 3 Medical Molecular Unit,
University of Leeds, Leeds, United Kingdom; 4 University of Tasmania, Tasmania, TAS,
Australia; 5 Roche, Nutley, NJ; 6 Roche, Welwyn, United Kingdom; 7 Albany Medical College
and The Center for Rheumatology, Albany, NY
MEDICAL STUDENT BURSARY WINNER
AN INVESTIGATION OF THE MEDIA COVERAGE OF TOCILIZUMAB
Joanne F. Anderson;
Rheumatology, Royal Cornwall Hospital, Truro, United Kingdom
TOLEROGENIC DENDRITIC CELLS: A NOVEL THERAPY FOR RHEUMATOID ARTHRITIS
John D. Isaacs, Amy E. Anderson, Jeroen N. Stoop, Rachel A. Harry, David J. Swan,
John H. Robinson, Catharien M. Hilkens;
Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University,
Newcastle upon Tyne, United Kingdom
71

Poster No. 178
Poster No. 179
Poster No. 180
Poster No. 181
Poster No. 182
Poster No. 183
Poster No. 184
RITUXIMAB: A SAFER AND LONGER-LASTING ALTERNATIVE TO SWITCHING TO A SECOND
ANTI-TNF AGENT IN RHEUMATOID ARTHRITIS PATIENTS
Inmaculada de la Torre Ortega, Francisco Javier López Longo, Carlos Manuel González,
Indalecio Monteagudo, Irene Díez-Merchan, Enrique Calvo, Elena Becerra, Luis Carreño;
Rheumatology, Gregorio Marañón Hospital, Madrid, Spain
SMOKING DECREASES THE EFFICACY OF ETANERCEPT IN RHEUMATOID ARTHRITIS
A. Abhishek 1 , S. Butt 1 , K. Gadsby 1 , W. Zhang 2 , C. M. Deighton 1 ;
1
Department of Rheumatology, Derbyshire Royal Infirmary, Derby, United Kingdom; 2 Academic
Rheumatology, University of Nottingham, Nottingham, United Kingdom
DOES TREATMENT WITH RITUXIMAB INDUCE APOPTOSIS IN T LYMPHOCYTES?
Joanna M. Tarr 1 , Katalin Szabo 1 , Richard C. Haigh 1,2 , Nick J. Viner 1,3 , Paul Eggleton 1 ,
Paul G. Winyard 1 ;
1
Peninsula Medical School, Exeter, United Kingdom; 2 Royal Devon and Exeter Hospital, Exeter,
United Kingdom; 3 Torbay Hospital, Torquay, United Kingdom
TREATING EARLY RHEUMATOID ARTHRITIS (RA) INTENSIVELY: UK RHEUMATOLOGISTS
VIEWS AND USE OF COMBINATION DISEASE MODIFYING ANTI-RHEUMATIC DRUGS
(DMARDS)
Toby Garrood 1 , Warren Shattles 1 , David L. Scott 2 ;
1
Department of Rheumatology, East Surrey Hospital, Redhill, United Kingdom; 2 Academic
Department of Rheumatology, Kings College London, London, United Kingdom
GOLIMUMAB SIGNIFICANTLY IMPROVES SELF-REPORTED PRODUCTIVITY IN PATIENTS WITH
RHEUMATOID ARTHRITIS
Paul Wordsworth 5 , Jacqueline Buchanan 1 , Roy Fleischmann 2 , Mark Genovese 3 , Jonathan Kay 4 ,
Elizabeth Hsia 6 , Mittie Doyle 6 , Mahboob Rahman 6 , Chenglong Han 1 , Shreekant Parasuraman 1 ;
1
Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA; 2 University of Texas SW
Medical Center, Dallas, TX; 3 Stanford University, Palo Alto, CA; 4 Massachusetts General
Hospital/Harvard Medical School, Boston, MA; 5 Nuffield Orthopaedic Center, Oxford, United
Kingdom; 6 Centocor Research and Development, Inc/Univ of Pennsylvania Medical School,
Malvern/Philadelphia, PA
PREVALENCE OF RISK FACTORS FOR STATIN-INDUCED MYOPATHY IN RHEUMATOID
ARTHRITIS PATIENTS: DOES THE SLCO1B1 GENE PLAY A ROLE?
Tracey E. Toms, Jacqueline P. Smith, Vasileios F. Panoulas, Karen M. Douglas,
Athanasios N. Saratzis, George D. Kitas;
Rhuematology, Dudley Group of Hospitals NHS trust, Dudley, United Kingdom
GOLIMUMAB SIGNIFICANTLY IMPROVES PHYSICAL FUNCTION, HEALTH-RELATED QUALITY
OF LIFE, AND FATIGUE IN RA(GO-FORWARD STUDY)
Andrea Rubbert 1 , Mark C. Genovese 2 , Ed Keystone 3 , E. C. Hsia 4 , J. Buchanan 5 , Lars Klareskog 6 ,
F. Murphy 7 , Z. Wu 8 , S. Parasuraman 5 , M. U. Rahman 4 ;
1
Univ Hosp Cologne, Cologne, Germany; 2 Stanford Univ, Palo Alto, CA; 3 U Toronto/Mt Sinai
Hosp, Toronto, ON, Canada; 4 Centocor R&D/U Penn Med School, Malvern/Philadelphia, PA;
5
JJPS, LLC, Malvern, PA; 6 Karolinska Inst/Hosp, Stockholm, Sweden; 7 Altoona Ctr for Clin
Research, Duncansville, PA; 8 Centocor R&D, Inc., Malvern, PA
72

Poster No. 185
Poster No. 186
Poster No. 187
EFFICACY OF TOCILIZUMAB RELATIVE TO OTHER BIOLOGIC AGENTS IN PATIENTS WITH
RHEUMATOID ARTHRITIS AND AN INADEQUATE RESPONSE TO TRADITIONAL DMARDs:
A META-ANALYSIS WITH MIXED-TREATMENT COMPARISONS
Gert Bergman 1 , Maarten Boers 2 , Marc C. Hochberg 3 , Adrian Kielhorn 4 , Neil S. Wintfeld 5 ,
Jeroen P. Jansen 6 ;
1
Mapi Values, Houten, Netherlands; 2 VU University Medical Center, Amsterdam, Netherlands;
3
University of Maryland School of Medicine, Baltimore, MD; 4 Roche, Basel, Switzerland;
5
Roche, Nutley, NJ; 6 Mapi Values, Boston, MA
TWO YEARS OF ADALIMUMAB AND METHOTREXATE COMBINATION THERAPY
ASSOCIATED WITH GREATER INHIBITION OF RADIOGRAPHIC PROGRESSION
AFTER 5 YEARS IN PATIENTS WITH EARLY RA
A. L. Pangan 4 , D. van der Heijde 1 , R. Landewe 1 , E. C. Keystone 2 , K. Patra 3 , J. L. Perez 3 ;
1
Leiden University Medical Center, Leiden, Netherlands; 2 University of Toronto, Toronto, ON,
Canada; 3 Abbott Laboratories, Parsippany, NJ; 4 Abbott Laboratories, Abbott Park, IL
IN PATIENTS WITH EARLY RA WHO HAD ACHIEVED A NORMAL CRP, ADALIMUMAB
INHIBITED RADIOGRAPHIC PROGRESSION MORE EFFECTIVELY THAN METHOTREXATE
Paul Emery 1 , Mark Genovese 2 , Ronald F. van Vollenhoven 3 , Eric H. Sasso 4 ;
1
Leeds General Infirmary, Leeds, United Kingdom; 2 Stanford University Medical Center,
Palo Alto, CA; 3 Karolinska Hospital, Stockholm, Sweden; 4 Abbott Laboratories,
Abbott Park, IL
Poster Viewing Two | Thursday 30 April 2009
Poster No. 188
Poster No. 189
Poster No. 190
Poster No. 191
CERTOLIZUMAB PEGOL DEMONSTRATES SIGNIFICANT IMPROVEMENTS IN PAIN AND
QUALITY OF LIFE IN PATIENTS WITH ACTIVE RA DESPITE METHOTREXATE TREATMENT
Peter Taylor 3 , Vibeke Strand 1 , Geoffroy Coteur 2 ;
1
Stanford University School of Medicine, Stanford, CA; 2 Global Health Outcomes Research,
UCB, Braine l’Alleud, Belgium; 3 Kennedy Institute of Rheumatology, London, United Kingdom
SUSTAINED LONG-TERM EFFICACY OF CERTOLIZUMAB PEGOL PLUS METHOTREXATE
IN THE TREATMENT OF RHEUMATOID ARTHRITIS: A 2-YEAR ANALYSIS OF THE RAPID
1 STUDY
Josef Smolen 6 , Ed Keystone 1 , Michael Schiff 2 , Philip Mease 3 , Ronald van Vollenhoven 4 ,
Chintu Desai 5 ;
1
Mount Sinai Hospital, Toronto, ON, Canada; 2 University of Colorado School of Medicine,
Denver, CO; 3 Seattle Rheumatology Associates, Seattle, WA; 4 Karolinska University
Hospital, Stockholm, Sweden; 5 UCB, Slough, United Kingdom; 6Medical University of
Vienna, Vienna, Austria
RHEUMATOID ARTHRITIS OUTCOMES IMPROVE WITH TOCILIZUMAB MONOTHERAPY
REGARDLESS OF DISEASE DURATION
M. Genovese 1 , D. Siri 2 , M. Tomsic 3 , R. Blackburn 4 , T. Woodworth 4 , G. Jones 5 ;
1
Stanford University Medical Center, Palo Alto, CA; 2 Instituto CAICI, Rosario, Peru; 3 University
Medical Centre, Ljubljana, Slovenia; 4 Roche, Welwyn, United Kingdom; 5 University of
Tasmania, Hobart, TAS, Australia
EVALUATION OF HEPATIC AMINOTRANSFERASES AND BILIRUBIN LEVELS DURING
TOCILIZUMAB TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS
J. M. Kremer 1 , Ani K. John 2 , R. Malamet 3 , E. C. Keystone 3 ;
1
Albany Medical College and The Center for Rheumatology, Albany, NY; 2 Roche, Nutley, NJ;
3
University of Toronto, Toronto, ON, Canada
73

Poster No. 192
AN INTERIM ANALYSIS OF LONG-TERM EXTENSION TRIALS OF TOCILIZUMAB IN PATIENTS
WITH RHEUMATOID ARTHRITIS
R. F. van Vollenhoven 1 , J. S. Smolen 2 , H. P. Tony 3 , C. Codding 4 , E. C. Keystone 5 , T. Woodworth 6 ,
E. Alecock 6 , R. Alten 7 ;
1
Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden; 2 Division of
Rheumatology, Internal Medicine III, Medical University of Vienna and 2nd Department
of Medicine, Hietzing Hospital, Vienna,, Austria; 3 Rheumatology & Clinical Immunology,
Medizinische Klinik II, Wuerzburg, Germany; 4 1211 N Shartel Ave Ste 700, Oklahoma City, OK;
5
University of Toronto, Toronto, ON, Canada; 6 Roche, Welwyn, United Kingdom; 7 Teaching hospital
of Charite, University of Berlin, Berlin, Germany
Poster No. 193
Poster No. 194
TOCILIZUMAB IS WELL TOLERATED IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH A
LOW RATE OF SERIOUS ADVERSE EVENTS
J. S. Smolen 1 , A. D. Beaulieu 2 , A. Dikranian 3 , I. Fenton 4 , E. Fisheleva 5 , E. Alecock 5 , P. Emery 6 ;
1
Medical University of Vienna, Vienna, Austria; 2 Centre de Rhumatologie St Louis, Quebec, QC,
Canada; 3 San Diego Arthritis Medical Clinic, San Diego, CA; 4 Deerbrook Medical Associates,
Illinois, IL; 5 Roche, Welwyn, United Kingdom; 6 Medical Molecular Unit,St James’s University,
Leeds, United Kingdom
RELATION BETWEEN YEAR 1 DAS28 STATUS AND 2 YEAR DISEASE ACTIVITY, FUNCTION
AND EMPLOYMENT IN DMARD TREATED RA PATIENTS IN THE EARLY RHEUMATOID
ARTHRITIS NETWORK (ERAN)
Patrick D. Kiely 1,2 , Keeranur Jayakumar 1,3 , Sam Norton 1,4 , Richard Williams 1,5 , David Walsh 1,6 ,
Adam Young 1,3 , On behalf of ERAN centers 1 ;
1
Early Rheumatoid Arthritis Network, St Albans, United Kingdom; 2 Rheumatology, St Georges
Healthcare NHS Trust, London, United Kingdom; 3 Rheumatology, St Albans City Hospital,
St Albans, United Kingdom; 4 Research Design Services, University of Hertfordshire, Hatfield,
United Kingdom; 5 Rheumatology, Hereford Hospitals NHS Trust, Hereford, United Kingdom;
6
Rheumatology, University of Nottingham and Sherwood Forest NHSFT, Nottingham,
United Kingdom
Poster No. 195
Poster No. 196
CONTINUED INHIBITION OF STRUCTURAL DAMAGE IN RHEUMATOID ARTHRITIS PATIENTS
TREATED WITH RITUXIMAB AT 2 YEARS: REFLEX STUDY
Stanley B. Cohen 1 , Edward C. Keystone 2 , Mark Genovese 3 , Paul Emery 4 , Charles Peterfy 5 ,
Paul-Peter Tak 6 , Mathew W. Cravets 7 , Tim Shaw 8 , David Hagerty 7 ; 1 Metroplex Clinical Research
Center, Dallas, TX; 2 University of Toronto, Toronto, ON, Canada; 3 Stanford University, Stanford,
CA; 4 Leeds University, Leeds, United Kingdom; 5 Synarc Inc., San Francisco, CA; 6 Academic
Medical Center/University of Amsterdam, Amsterdam, Netherlands; 7 Biogen Idec Inc.,
San Diego, CA; 8 Roche Products Ltd, Welwyn Garden City, United Kingdom
BENEFIT OF ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS PATIENTS WITH
MODERATE DISEASE ACTIVITY: RESULTS FROM THE BSR BIOLOGICS REGISTER
Kimme Hyrich 1 , Chris Deighton 2 , Kath Watson 1 , . BSRBR Control Centre Consortium 1 , Deborah
Symmons 1 , Mark Lunt 1 , . on behalf of the BSRBR 1 ;
1
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom; 2 Dept of
Rheumatology, Derbyshire Royal Infirmary, Derby, United Kingdom
74

Poster No. 197
Poster No. 198
Poster No. 199
RITUXIMAB IN COMBINATION WITH METHOTREXATE OR LEFLUNOMIDE IN RA: CLINICAL,
IMAGING AND FLOW CYTOMETRIC OUTCOMES
Edward M. Vital 1 , Jane E. Freeston 1 , Shouvik Dass 1 , Laszlo Szabo 1 , Frederique Ponchel 1 ,
Andrew C. Rawstron 2 , Paul Emery 1 ;
1
Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine,University of
Leeds, Leeds, United Kingdom; 2 Haematological Malignancy Diagnostic Service, Leeds
Teaching Hospitals NHS Trust, Leeds, United Kingdom
TOCILIZUMAB IMPROVES AND MAINTAINS HAQ-DI SCORES LONG TERM IN PATIENTS
WITH MODERATE TO SEVERE RHEUMATOID ARTHRITIS: A POOLED ANALYSIS
Pierre Ducournau 1 , Rieke Alten 2 , Ronald van Vollenhoven 3 , Claire Davies 4 ;
1
Roche, Basel, Switzerland; 2 University of Berlin, Berlin, Germany; 3 Karolinska
University Hospital, Stockholm, Sweden; 4 Roche, Welwyn, United Kingdom
CERTOLIZUMAB PEGOL DEMONSTRATES RESPONSE AS EARLY AS WEEK 1 IN
MODERATE-SEVERE RA PATIENTS
Vibeke Strand 3 , Geoffroy Coteur 1 , Lucian Ionescu 2 ;
1
Global Health Outcomes Research, UCB, Braine l’Alleud, Belgium; 2 Global Medical Affairs,
UCB, Anderlecht, Belgium; 3 Stanford University School of Medicine, Stanford, CA
Poster Viewing Two | Thursday 30 April 2009
Poster No. 200
Poster No. 201
Poster No. 202
RAPID AND SIGNIFICANT REDUCTION IN DISEASE ACTIVITY WITH TOCILIZUMAB IN
COMBINATION WITH SIX DIFFERENT DMARDS IN RHEUMATOID ARTHRITIS PATIENTS
WITH AN INADEQUATE RESPONSE TO DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS:
THE TOWARD STUDY
J. J. Gomez-Reino 1 , E. L. Nasonov 2 , J. D. McKay 3 , E. F. Mysler 4 , N. da Silva 5 , E. Alecock 6 ,
T. Woodworth 6 , M. C. Genovese 7 ;
1
Clinical Hospital, Santiago de Compostela University, Santiago de Compostela, Spain;
2
Institute of Rheumatology, Moscow, Russia; 3 Oklahoma State University, Tulsa, OK;
4
Organization for Medical Investigations, Buenos Aires, Argentina; 5 Federal University of
Goiás, Goiania, Brazil, Brazil; 6 Roche, Welwyn, United Kingdom; 7 Stanford University,
Palo Alto, CA
RHEUMATOID ARTHRITIS PATIENTS ACHIEVED RAPID AND SUSTAINED DECREASE
IN BONE AND CARTILAGE DEGRADATION WHEN TREATED WITH TOCILIZUMAB
P. Garnero 1 , E. Mareau 2 , L. Thompson 3 , T. Woodworth 3 ;
1
Synarc, INSERM Research Unit 664, Lyon, France; 2 Synarc, Lyon, France; 3 Roche Products
Ltd, Welwyn, United Kingdom
RHEUMATOID ARTHRITIS PATIENTS WITH INADEQUATE REPONSE TO TUMOUR NECROSIS
FACTOR ANTAGONISTS SHOW RAPID AND SIGNIFICANT IMPROVEMENTS IN CLINICAL
OUTCOME WHEN TREATED WITH TOCILIZUMAB
P. Emery 1 , E. Keystone 2 , H. P. Tony 3 , A. Cantagrel 4 , R. van Vollenhoven 5 , A. Sanchez 6 ,
E. Alecock 7 , J. Lee 8 , J. Kremer 9 ;
1
University of Leeds, Leeds, United Kingdom; 2 Mount Sinai Hospital, Toronto, ON, Canada;
3
Medizinische Klinik II, Würzburg, Germany; 4 Hôpital Rangueil, Toulouse, United Kingdom;
5
Karolinska University Hospital, Stockholm, Sweden; 6 Hospital de Especialidades,
Guadalajara, Mexico; 7 Roche, Welwyn, United Kingdom; 8 Roche, Nutley, NY; 9Albany
Medical Center, Albany, NY
75

Poster No. 203
Poster No. 204
LIPID AND INFLAMMATORY BIOMARKER PROFILES WERE EVALUATED IN FIVE
TOCILIZUMAB PHASE III CLINICAL TRIALS CONDUCTED IN RHEUMATOID ARTHRITIS
PATIENTS
M. C. Genovese 1 , J. S. Smolen 2 , P. Emery 3 , G. Jones 4 , J. S. Lee 5 , E. Alecock 6 , J. M. Kremer 7 ;
1
Stanford University School of Medicine, Palo Alto, CA; 2 Department of Rheumatology Internal
Medicine III, Medical University of Vienna, Vienna, Austria; 3 Medical Molecular Unit, St James
University, Leeds, United Kingdom; 4 University of Tasmania Menzies Research Institute, Hobart,
TAS, Australia; 5 Roche, Nutley, NJ; 6 Roche, Welwyn, United Kingdom; 7 Albany Medical College
and The Center for Rheumatology, Albany, NY
SAFETY OF OTHER BIOLOGIC THERAPIES FOLLOWING RITUXIMAB TREATMENT IN
RA PATIENTS
Mark C. Genovese 1 , Ferdinand C. Breedveld 2 , Paul Emery 3 , Stanley B. Cohen 4 ,
Edward Keystone 5 , Eric Matteson 6 , Yvette Baptiste 7 , Laura Burke 7 , William Reiss 8 ,
Marianne Sweetser 9 , Tim Shaw 7 ;
1
Stanford University, Stanford, CA; 2 Leiden University Medical Centre, Leiden, Netherlands;
3
Leeds General Infirmary, Leeds, United Kingdom; 4 Metroplex Clinical Research Center,
Dallas, TX; 5 University of Toronto, Toronto, ON, Canada; 6 Mayo Clinic, Rochester, MN;
7
Roche, Welwyn Garden City, United Kingdom; 8 Genentech, San Francisco, CA; 9 Biogen
Idec Inc., Cambridge, MA
Poster No. 205
RAPID AND SIGNIFICANT REDUCTION OF DAS28 FOLLOWING TOCILIZUMAB TREATMENT
IN PATIENTS WITH RHEUMATOID ARTHRITIS INADEQUATELY RESPONDING TO
DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS
J. S. Smolen 1 , E. F. Mysler 2 , A. Rubbert-Roth 3 , J. Gomez-Reino 4 , R. Alten 5 , A. Law 6 ,
T. Woodworth 7 , M. Genovese 8 ;
1
Hietzing Hospital, Vienna, Austria; 2 Organization for Medical Investigations, Buenos Aires,
Argentina; 3 University of Cologne, Cologne, Germany; 4 University of Santiago de Compostela,
Santiago de Compostela, Spain; 5 Schlosspark Clinic, University Medicine, Berlin, Germany;
6
Roche, Nutley, NJ; 7 Roche, Welwyn, United Kingdom; 8 Stanford University, Palo Alto, CA
Poster No. 206
CERTOLIZUMAB PEGOL DEMONSTRATES SIGNIFICANT IMPROVEMENTS IN THE
PRODUCTIVITY OF PATIENTS WITH ACTIVE RA, PARTICULARLY IN THE HOME
Paul Emery 4 , Josef Smolen 1 , Oana Purcaru 2 , Lance Richard 3 ;
1
University of Vienna, Vienna, Austria; 2 Global Health Outcomes Research, UCB, Inc,
Brussels, Belgium; 3 Global Health Outcomes Research, UCB, Inc, Slough, United Kingdom;
4
Leeds General Infirmary, Leeds, United Kingdom
Poster No. 207
TOCILIZUMAB DEMONSTRATES SUPERIORITY TO METHOTREXATE MONOTHERAPY
IN PATIENTS WITH RHEUMATOID ARTHRITIS: THE AMBITION STUDY
G. Jones 1 , J. R. Gu 2 , M. Lowenstein 3 , A. Calvo 4 , J. J. Gomez-Reino 5 , D. Siri 6 , M. Tomsic 7 , R.
Blackburn 8 , T. Woodworth 8 , A. Sebba 9 , M. Genovese 10 ;
1
University of Tasmania, Hobart, TAS, Australia; 2 Hospital of Sun Yat-sen University, Guangzhou,
China; 3 Arthritis Center, Palm Harbor, FL; 4 Universidad Peruana, San Felipe Clinic, Peru;
5
University of Santiago de Compostela, Santiago de Compostela, Spain; 6 Instituto CAICI,
Rosario, Argentina; 7 University Medical Centre, Ljubljana, Slovenia; 8 Roche, Welwyn, United
Kingdom; 9 Arthritis Research of Florida, Palm Harbor, FL; 10 Stanford University Medical Center,
Palo Alto, CA
76

Poster No. 208
Poster No. 209
Poster No. 210
DIFFERING DISTRIBUTION OF CERTOLIZUMAB PEGOL, ADALIMUMAB AND INFLIXIMAB IN
THE INFLAMED PAWS OF MICE WITH COLLAGEN-INDUCED ARTHRITIS COMPARED WITH
NORMAL MICE
Andrew Nesbitt, Roger Palframan, Alexander Vugler, Roly Foulkes, Neil Gozzard; Inflammation
Discovery, UCB, Slough, United Kingdom
GOLIMUMAB ADMINISTERED SUBCUTANEOUSLY EVERY 4WEEKS IN ACTIVE
RHEUMATOID ARTHRITIS DESPITE METHOTREXATE: WEEK 24 RESULTS OF
GO-FORWARD STUDY
Andrea Rubbert 1 , Ed Keystone 2 , Mark Genovese 3 , Lars Klareskog 4 , E. C. Hsia 5 , J. Zrubek 6 , Z.
Wu 6 , M. U. Rahman 5 , for the GO-FORWARD Study Investigators 6 ;
1
University Hospital College, Cologne, Germany; 2 University of Toronto/Mount Sinai Hospital,
Toronto, ON, Canada; 3 Stanford University, Palo Alto, CA; 4 Karolinska Institute & Hospital,
Stockholm, Sweden; 5 Centocor Research and Development, Inc/University of Pennsylvania,
Malvern/Philadelphia, PA; 6 Centocor Research and Development, Inc, Malvern, PA
YOUNG INVESTIGATOR AWARD WINNER
HOW TO MANAGE NON-RESPONSE TO RITUXIMAB? PREDICTORS AND OUTCOME OF
RETREATMENT PROVIDE A TREATMENT ALGORITHM
Edward M. Vital 1 , Shouvik Dass 1 , Elizabeth A. Horner 1 , Vincent Goeb 1 , Andrew Rawstron 2 ,
Frederique Ponchel 1 , Paul Emery 1 ;
1
Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine,University of
Leeds, Leeds, United Kingdom; 2 Haematological Malignancy Diagnostic Service, Leeds
Teaching Hospitals NHS Trust, Leeds, United Kingdom
Poster Viewing Two | Thursday 30 April 2009
Poster No. 211
GOLIMUMAB, A NEW HUMAN ANTI-TNF-ALPHA MONOCLONAL ANTIBODY, IN
METHOTREXATE-NAÏVE ACTIVE RHEUMATOID ARTHRITIS (GO-BEFORE STUDY)
Paul Emery 1 , Roy M. Fleischmann 2 , Larry W. Moreland 3 , E. C. Hsia 4 , W. Xu 5 , M. U. Rahman 4 ,
for GO-BEFORE Study Investigators 5 ;
1
University of Leeds, Leeds, United Kingdom; 2 University of Texas/SW Medical Center, Dallas,
TX; 3 University of Pittsburgh, Pittsburgh, PA; 4 Centocor Research and Development,
Inc./University of Pennsylvania, Malvern/Philadelphia, PA; 5 Centocor Research and
Development, Inc., Malvern, PA
Poster No. 212
THE LITHE STUDY DEMONSTRATES THAT TOCILIZUMAB INHIBITS STRUCTURAL JOINT
DAMAGE IN RHEUMATOID ARTHRITIS PATIENTS WITH AN INADEQUATE RESPONSE TO
METHOTREXATE
J. M. Kremer 1 , R. M. Fleischmann 2 , A. M. Halland 3 , J. Brzezcki 4 , T. Woodworth 5 ,
E. Fisheleva 5 , E. Alecock 5 , R. Burgos-Vargas 6 ;
1
Albany Medical College and The Center for Rheumatology, Albany, NY; 2 Metroplex Clinical
Research Center, Dallas, TX; 3 Arthritis Research Center,Panorama Hospital, Cape Town,
South Africa; 4 Oddzial Reumatologiczny, Elblag, Poland; 5 Roche, Welwyn,
United Kingdom; 6 Hospital General de México, Mexico City, Mexico
Paediatric and adolescent rheumatology
Poster No. 213
“TO FIND THE RIGHT ANSWERS, YOU NEED TO ASK THE RIGHT QUESTIONS.”
CONSUMER INVOLVEMENT IN SETTING OUR RESEARCH AGENDA
Helen Hill 1 , Jane Kelly 1 , Sue Kemp 1 , Eileen Baildam 1 , Gavin Cleary 1 , Liza McCann 1 ,
Beresford Michael 2,1 ;
1
Department of Rheumatology, Alder Hey Children’s NHS Foundation Trust, Liverpool, United
Kingdom; 2 Institute of Child Health, University of Liverpool, Liverpool, United Kingdom
77

Poster No. 214
ACCEPTABILITY AND PRACTICALITY OF MUSCULOSKELETAL EXAMINATION (pGALS)
IN ACUTE PAEDIATRIC ASSESSMENT
Iain Goff 1 , Belinda J. Bateman 2 , Andrea Myers 3,4 , Helen E. Foster 4,5 ;
1
Education Department, Northumbria Healthcare NHS Foundation Trust, North Shields, United
Kingdom; 2 Department of Paediatrics, Northumbria Healthcare NHS Foundation Trust, North
Shields, United Kingdom; 3 Department of Rheumatology, Northumbria Healthcare NHS
Foundation Trust, North Shields, United Kingdom; 4 Newcastle Musculoskeletal Research Group,
University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom; 5 Department of
Rheumatology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne,
United Kingdom
Soft tissue and regional musculoskeletal disease, fibromyalgia
Poster No. 215
Poster No. 216
Poster No. 217
RECURRENT GREATER TROCHANTERIC BURSITIS: AN ATYPICAL PRESENTATION
OF DISC PROLAPE/ NERVE ROOT IRRITATION AT L4/5
Yasser El Miedany 1 , Maha El Gaafary 2 , Sally Youssef 1 , Annie N. Mehanna 3 ;
1
Rheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt; 2 Community,
Environmental and Occupational Medicine, Ain Shams University, Cairo, Egypt; 3 Radiology,
Ain Shams University, Cairo, Egypt
OUTCOME OF CARDIOVASCULAR AUTONOMIC TESTING IN SYMPTOMATIC
PATIENTS WITH BENIGN JOINT HYPERMOBILITY SYNDROME
Alan J. Hakim 1 , Chris Mathias 2 , Rodney Grahame 1 ;
1
Department of Rheumatology, University College Hospital, London, United Kingdom; 2 The
Autonomic Unit, National Hospital for Neurology and Neurosurgery, London, United Kingdom
JOINT HYPERMOBILITY & FUNCTIONAL GASTROINTESTINAL DISORDERS - IS CONNECTIVE
TISSUE THE MISSING LINK?
Adam D. Farmer 1 , Natalia Zarate-Lopez 1 , Sahar Mohammed 1 , S Mark Scott 1 ,
Charles H. Knowles 1 , Rodney Grahame 2 , Qasim Aziz 1 ;
1
Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine and
Dentistry, London, United Kingdom; 2 Centre for Rheumatology, University College London
Hospital, London, United Kingdom
Poster No. 218 CLINICAL EVIDENCE OF PARIETAL LOBE DYSFUNCTION IN PATIENTS WITH CRPS TYPE 1
Helen E. Cohen 1,2 , Candy S. McCabe 1,2 , Nigel Harris 1,2 , David R. Blake 1,2 ;
1
Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom; 2 School for Health,
University of Bath, Bath, United Kingdom
Poster No. 219
PERSONAL SOCIAL SUPPORT NETWORKS ARE ASSOCIATED WITH THE
ONSET OF CHRONIC WIDESPREAD PAIN
Lis Cordingley 1 , Barbara Nicholl 2 , John McBeth 2 ;
1
Translational Medicine, University of Manchester, Manchester, United Kingdom;
2
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Poster No. 220
MASSAGE IN CARPAL TUNNEL SYNDROME: A RATIONAL APPROACH
Yasser El Miedany 1 , Maha El Gaafary 2 , Ihab Ahmed 4 , Annie Mehanna 3 , Sally Youssef 1 ;
1
Rheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt; 2 Community,
Environmental and Occupational Medicine, Ain Shams University, Cairo, Egypt; 3 Radiology
Department, Ain Shams University, Cairo, Egypt; 4 Internal Medicine Department, Cairo
University, Cairo, Egypt
78

Poster No. 221
Poster No. 222
IS THERE A WINDOW OF OPPORTUNITY FOR PHYSIOTHERAPY AFTER STEROID
INJECTIONS FOR SHOULDER PAIN? RESULTS FROM A LARGE RANDOMISED TRIAL
Dickon P. Crawshaw 1,2 , Philip Helliwell 1 , Elizabeth M. Hensor 1 , Elaine M. Hay 3 ,
Simon J. Aldous 4 , Philip G. Conaghan 1 ;
1
Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom;
2
Leeds Musculoskeletal and Rehabilitation Service, NHS Leeds, Leeds, United Kingdom;
3
Primary Care Musculoskeletal Research Centre, Keele University, Keele, United Kingdom;
4
Physiotherapy Department, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
EXPERIENCES OF ADDENBROOKE’S HOSPITAL COMPLEX REGIONAL PAIN SYNDROME
CLINIC
Maliha F. Shaikh, Nicholas G. Shenker;
Rheumatology Research Unit, Addenbrooke’s Hospital, Cambridge University Hospitals NHS
Foundation Trust, Cambridge, United Kingdom
Psychology, measurement and management of pain
Poster Viewing Two | Thursday 30 April 2009
Poster No. 223
NECK, SHOULDER AND UPPER ARM PAIN. IS IT ALL IN THE MIND?
Gemma C. Gillings 1 , Emma Wall 1 , Helen Smith 2 , Karen Walker-Bone 1 ;
1
Rheumatology, Brighton and Sussex Medical School, Brighton, United Kingdom;
2
Division of Primary Care, Brighton & Sussex Medical School, Brighton, United Kingdom
Poster No. 224
Poster No. 225
EXPERIMENTAL MODIFICATION OF EXPECTATIONS AND BELIEFS ABOUT PAIN
IN PATIENTS WITH FIBROMYALGIA AND HEALTHY CONTROLS
Christopher Brown, Anthony Jones;
Clinical Neurosciences Research Group, University of Manchester, Manchester,
United Kingdom
THE REPRODUCIBILITY OF PLACEBO ANALGESIA
Debbie Morton 1 , Alison Watson 1 , Wael El-Deredy 2 , Anthony Jones 1 ;
1
Salford Royal Hospital, Salford, United Kingdom; 2 Psychology, Manchester University,
Manchester, United Kingdom
Osteoarthritis
Poster No. 226
Poster No. 227
RADIOGRAPHIC OA IN THE 1ST CMC JOINT AND THE THUMB AS A WHOLE:
ASSOCIATIONS WITH PAIN, CLINICAL FEATURES AND TEST RESULTS
Michelle Marshall 1 , Danielle A. van der Windt 1,2 , Helen Myers 1 , Elaine E. Nicholls 1 ,
Krysia S. Dziedzic 1 ;
1
Arthritis Research Campaign National Primary Care Centre, Keele University, Keele,
United Kingdom; 2 Department of General Practice and EMGO Institute, VU University
medical centre, Amsterdam, Netherlands
THE IMPACT OF CONSTANT AND INTERMITTENT PAIN IN PEOPLE WITH HAND
OSTEOARTHRITIS
Krysia Dziedzic 1 , George Peat 1 , Elaine Nicholls 1 , Helen Myers 1 , Susan Hill 1 ,
Michelle Marshall 1 , Danielle van der Windt 1,2 ;
1
Arthritis Research Campaign National Primary Care Centre, Keele University, Keele,
United Kingdom; 2 EMGO Institute, VU University Medical Centre, Amsterdam, Netherlands
79

Poster No. 228
Poster No. 229
Poster No. 230
A MULTICENTRE AUDIT OF THE MANAGEMENT OF OSTEOARTHRITIS IN THE UNITED
KINGDOM
Michael Pieri 1 , Ramin Yazdani 2 , Nicholas Shenker 3 , Michael Doherty 2 , Fraser Birrell 1,4 ;
1
Northumbria Healthcare NHS Trust, Newcastle Upon Tyne, United Kingdom; 2 City Hospital,
Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom; 3 Addenbrooke’s
Hospital, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom; 4 Newcastle
University, Newcastle Upon Tyne, United Kingdom
KNEE ALIGNMENT IN THE GENERAL POPULATION: IS THERE AN ASSOCIATION WITH
TIBIOFEMORAL AND PATELLOFEMORAL OSTEOARTHRITIS?
Alexandra N. Colebatch 1 , Kelsey M. Jordan 2 , Lyndsey M. Goulston 1 , Elaine M. Dennison 1 ,
Cyrus Cooper 1 , Nigel K. Arden 1,3 ;
1
MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, United
Kingdom; 2 Hayward’s Heath Hospital, Hayward’s Heath, United Kingdom; 3 Biomedical Research
Unit, University of Oxford, Oxford, United Kingdom
OSTEOCHONDRAL ANGIOGENESIS DESPITE INCREASED PROTEASE INHIBITOR
EXPRESSION IN OA
David A. Walsh 1,2 , Rebecca E. Franses 1 , Daniel F. McWilliams 1 ;
1
Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom;
2
Rheumatology, Sherwood Forest NHS Foundation Trust, Mansfield, United Kingdom
Poster No. 231
NSAID USE BEFORE AND AFTER 28068 HIP AND 23634 KNEE ARTHROPLASTIES: RESULTS
FROM THE UK GENERAL PRACTICE RESEARCH DATABASE
Joe Maskell 1 , David Culliford 2 , Mark Mullee 2 , Rafael Azagra 3 , Muhammad Javaid 4 ,
Nigel Arden 3,4 ;
1
PHSMS, University of Southampton, Southampton, United Kingdom; 2 RDSU,
University of Southampton, Southampton, United Kingdom; 3 MRC ERC, University of
Southampton, Southampton, United Kingdom; 4 Botnar NIHR BRU, Nuff Dept Orthopaedics,
University of Oxford, Oxford, United Kingdom
Poster No. 232
LINK BETWEEN THE SEVERITY OF OSTEOARTHRITIS AND THE SHAPE OF THE HIP JOINT
USING DXA IMAGES
Kanako Yoshida 1 , Rebecca J. Barr 1 , Jennifer S. Gregory 1 , Richard M. Aspden 1 , Salvatore Alesci 3 ,
Gary J. Macfarlane 2 , David M. Reid 1 ;
1
Bone and Musculoskeletal Programme, School of Medicine & Dentistry, University of
Aberdeen, Aberdeen, United Kingdom; 2 Epidemiology Research Programme, School of
Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; 3 Discovery
Translational Medicine, Wyeth Research, Collegeville, PA
Poster No. 233
PREDICTORS OF KNEE PAIN AT 15 YEARS IN THE CHINGFORD STUDY - IS THERE AN
INTERACTION BETWEEN BASELINE BODY WEIGHT AND RADIOGRAPHIC OSTEOARTHRITIS?
Lyndsey M. Goulston 1 , Kassim Javaid 3 , Debbie J. Hart 2 , Tim D. Spector 2 , Nigel K. Arden 1,3 ;
1
MRC Epidemiology Resource Centre, University of Southampton, Southampton, United
Kingdom; 2 Twin Research and Genetic Epidemiology Unit, St Thomas’ Hospital - King’s College
London, London, United Kingdom; 3 Biomedical Research Unit, University of Oxford, Oxford,
United Kingdom
80

Poster No. 234
Poster No. 235
PREDICTING OSTEOARTHRITIS PROGRESSION TO TOTAL HIP REPLACEMENT: CAN
WE DO BETTER THAN RISK FACTORS ALONE USING ACTIVE SHAPE MODELLING?
Rebecca J. Barr 1 , Jennifer Gregory 1 , David M. Reid 1 , Richard Aspden 1 , Kanako Yoshida 1 ,
Salvatore Alesci 2 , Gillian Hosie 3 , Alan Silman 4 , Gary J. Macfarlane 5 ;
1
Division of Applied Medicine, University of Aberdeen, Aberdeen, United Kingdom; 2 Discovery
Translational Medicine, Wyeth Research, Collegeville, PA; 3Primary Care Rheumatology
Society, Northallerton, United Kingdom; 4 Department of Rheumatology, University of
Manchester, Manchester, United Kingdom; 5 Division of Applied Health Science, University of
Aberdeen, Aberdeen, United Kingdom
INSIGHTS INTO THE PATHOGENESIS OF PROGRESSIVE FOOT AND ANKLE JOINT
DESTRUCTION FROM A MAGNETIC RESONANCE IMAGING STUDY OF CHARCOT’S
ARTHROPATHY AND OSTEOARTHRITIS
Jill Halstead 1 , Diane Bergin 3 , Julie Madden 2 , Dennis McGonagle 1 ;
1
Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of
Leeds, Leeds, United Kingdom; 2 Department of Rheumatology, Calderdale and Huddersfield
NHS Trust, Halifax, United Kingdom; 3 Department of Radiology, Galway University Hospital,
Galway, Ireland
Poster Viewing Two | Thursday 30 April 2009
Poster No. 236
ANGIOGENESIS IN THE TRANSITION FROM RESOLVING TO PERSISTENT SYNOVITIS
Sadaf Ashraf, Paul I. Mapp, David A. Walsh;
Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
Orthopaedics and rehabilitation
Poster No. 237
INTER-INSTRUMENT RELIABILITY OF TWO GONIOMETERS FOR THE MEASUREMENT OF
HIP RANGE OF MOTION IN SYMPTOM-FREE SUBJECTS AND SUBJECTS WITH HIP OA
Helen P. French, Mary Boyd;
School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland
Metabolic and crystal arthropathies
Poster No. 238
Poster No. 239
AN AUDIT ON MANAGEMENT OF GOUT IN PRIMARY CARE: ARE GENERAL
PRACTITIONERS ADHERING TO GUIDELINES
Balaji Ramabhadran, Nada Hasan, Peter Merry, Karl Gaffney;
Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich,
United Kingdom
HOW IS ACUTE GOUT MANAGED IN PRIMARY CARE?
Edward Roddy, Christian D. Mallen, Samantha L. Hider, Kelvin P. Jordan;
Arthritis Research Campaign National Primary Care Centre, Keele University, Keele,
United Kingdom
81

Osteoporosis and metabolic bone disease
Poster No. 240
BONE MARROW OEDEMA SYNDROME (BMO)OF THE FOOT AND ANKLE AND RESPONSE
TO PAMIDRONATE
Gerard Hall 1 , Neerujah Balachandren 2 ;
1
Rheumatology, The Royal London Hospital, London, United Kingdom; 2 The Medical School,
University College Hospital, London, United Kingdom
Poster No. 241
Poster No. 242
SCREENING HIV-INFECTED MEN FOR LOW BONE MINERAL DENSITY: THE ROLE OF
PERIPHERAL DEXA BONE DENSITOMETRY
Charlotte-Eve S. Short 1 , Simon G. Shaw 1 , Yvonne C. Gilleece 1 , Martin Fisher 1 ,
Karen Walker-Bone 2 ;
1
Department of HIV Medicine, Brighton and Sussex University NHS Hospitals Trust, Brighton
and Hove, United Kingdom; 2 Department of Rheumatology, Brighton and Sussex University
NHS Hospitals Trust, Brighton and Hove, United Kingdom
INFLUENCE OF MARKERS OF BONE TURNOVER ON CALCANEAL QUANTITATIVE
ULTRASOUND: RESULTS FROM THE EUROPEAN MALE AGEING STUDY (EMAS)
Stephen R. Pye 1 , Terence W. O’Neill 1 , Herman Borghs 2 , Dirk Vanderschueren 2 ,
Katrien Venken 2 , Judith E. Adams 3 , Kate A. Ward 3 , Joseph D. Finn 4 , Alan J. Silman 5 ,
Frederick C. Wu 4 , Steven Boonen 2 ;
1
ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom;
2
Katholieke Universiteit Leuven, Leuven, Belgium; 3 Department of Imaging Science and
Biomedical Engineering, The University of Manchester, Manchester, United Kingdom;
4
Department of Endocrinology, The University of Manchester, Manchester, United Kingdom;
5Arthritis Research Campaign, Chesterfield, United Kingdom
Poster No. 243
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-1 IS NEGATIVELY ASSOCIATED WITH
CALCANEAL QUANTITATIVE ULTRASOUND (QUS) PARAMETERS: RESULTS FROM THE
EUROPEAN MALE AGEING STUDY (EMAS)
Stephen R. Pye 1 , Steven Boonen 2 , Herman Borghs 2 , Dirk Vanderschueren 2 , Katrien Venken 2 ,
Judith E. Adams 3 , Kate A. Ward 3 , Joseph D. Finn 4 , Alan J. Silman 5 , Frederick C. Wu 4 ,
Terence W. O’Neill 1 ;
1
ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom;
2
Katholieke Universiteit Leuven, Leuven, Belgium; 3 Department of Imaging Science and
Biomedical Engineering, The University of Manchester, Manchester, United Kingdom;
4
Department of Endocrinology, The University of Manchester, Manchester, United Kingdom;
5
Arthritis Research Campaign, Chesterfield, United Kingdom
Poster No. 244
A PROSPECTIVE EVALUATION MODELLING THE COST AND EFFECTIVENESS
OF THE NOGG GUIDELINE IN PRIMARY CARE FRACTURE PREVENTION
Janki Patel 1 , Wasim Baqir 1,2 , Fraser Birrell 3,4 , On behalf of the Northumbria Osteoporosis
Strategy Group 3,4 ;
1
School of Pharmacy, University of Sunderland, Sunderland, United Kingdom; 2 Pharmacy,
Northumbria Healthcare NHS Foundation Trust, Newcastle, United Kingdom; 3 Rheumatology,
Northumbria Healthcare NHS Foundation Trust, Newcastle, United Kingdom; 4 Rheumatology,
Newcastle University, Newcastle, United Kingdom
82

Poster No. 245
Poster No. 246
Poster No. 247
MEDICAL STUDENT BURSARY WINNER
DOES DEPO-PROVERA DECREASE BONE MINERAL DENSITY IN THE LUMBAR SPINE AND
FEMORAL NECK?
Alexander Oldroyd 1 , Cathi Greenbank 2 , Bronwen Evans 2 , John Halsey 2 , Nicola Goodson 3 ,
Marwan Bukhari 2,3 ;
1
University of Lancaster, Lancaster, United Kingdom; 2 Rheumatology, Royal Lancaster
Infirmary, Lancaster, United Kingdom; 3 Clinical Sciences, University of Liverpool,
Liverpool, United Kingdom
FRACTURE RISK THRESHOLDS FOR INTERVENTION IMPLICIT WITHIN RCP,
NICE TA87 AND NICE TA161 GUIDELINES FOR SECONDARY PREVENTION
Margaret Callan, Ashlynne VanVuuren, Sarah Collis;
Department of Rheumatology, Chelsea and Westminster NHS Foundation Trust,
London, United Kingdom
IS RESPIRATORY FUNCTION ASSOCIATED WITH BONE MASS? RESULTS FROM THE
HERTFORDSHIRE COHORT STUDY
Rafael Azagra 1 , Isabel Reading 1 , Avan Aihie Sayer 1 , Holly Syddall 1 , Seif Shaheen 2 ,
Cyrus Cooper 1 , Elaine Dennison 1 ;
1
Southampton University, MRC Resource Centre, Southampton, United Kingdom;
2
Respiratory Epidemiology and Public Health Group, National Heart and Lung Group,
Imperial College, London, United Kingdom
Poster Viewing Two | Thursday 30 April 2009
Poster No. 248
Poster No. 249
Poster No. 250
Poster No. 251
THE EFFECT OF PRIOR BISPHOSPHONATE THERAPY ON THE SUBSEQUENT BONE
TURNOVER AND BMD RESPONSE TO STRONTIUM RANELATE
Edward T. Middleton, Sue A. Steel, Mo Aye, Sheelagh M. Doherty;
Centre for Metabolic Bone Disease, Hull Royal Infirmary, Hull, United Kingdom
30 YEARS ON: HYPOVITAMINOSIS D IN HEPATOLOGY OUTPATIENTS
Christopher J. Kelly 1 , Ken E. Poole 2,1 , Adrian J. Crisp 1 , David J. Halsall 3 , Bill Griffiths 4 ,
Andrew J. Ostor 1 ;
1
Department of Rheumatology, Addenbrooke’s Hospital, Cambridge University, Cambridge,
United Kingdom; 2 Department of Bone Research, Addenbrooke’s Hospital, Cambridge
University, Cambridge, United Kingdom; 3 Department of Biochemistry, Addenbrooke’s
Hospital, Cambridge University, Cambridge, United Kingdom; 4 Department of Hepatology,
Addenbrooke’s Hospital, Cambridge University, Cambridge, United Kingdom
ONCE-YEARLY ZOLEDRONIC ACID 5 MG INFUSION FOR TREATMENT OF
POSTMENOPAUSAL OSTEOPOROSIS: EFFECTS ON FRACTURE INCIDENCE
IN PATIENT SUBGROUPS FROM THE HORIZON-PFT STUDY
Richard Eastell 1 , Dennis M. Black 2 , Steven Boonen 3 , Alastair R. McLellan 4 ,
Steven R. Cummings 2 , Pierre D. Delmas 5 , Lisa Palermo 2 , Peter Mesenbrink 6 , Jane A. Cauley 7 ;
1
University of Sheffield, Sheffield, United Kingdom; 2 University of California, San Francisco,
CA; 3 Katholieke Universiteit Leuven, Leuven, Belgium; 4 Western Infirmary, Glasgow, United
Kingdom; 5 INSERM Research Unit 831 and University of Lyon, Lyon, France; 6 Novartis
Pharmaceuticals Corporation, East Hanover, NJ; 7 University of Pittsburgh, Pittsburgh, PA
A CASE CONTROL STUDY TO DETERMINE WHETHER BONE IS LEACHED PREDOMINANTLY
FROM THE LUMBAR VERTEBRAE OR THE HIP IN PATIENTS WITH HYPERPARATHYROIDISM
Keith Green, Marwan Bukhari;
Rheumatology Department, Royal Lancaster Infirmary, Lancaster, United Kingdom
83

Poster No. 252
Poster No. 253
COMPARISON OF THE EFFICACY AND SAFETY OF A SINGLE INFUSION OF ZOLEDRONIC
ACID 5 MG WITH DAILY ORAL RISEDRONATE 5 MG IN PATIENTS WITH
GLUCOCORTICOID-INDUCED OSTEOPOROSIS: RESULTS FROM A 1-YEAR RANDOMISED,
DOUBLE-BLIND TRIAL
David M. Reid 1 , Jean-Pierre Devogelaer 2 , Kenneth Saag 3 , Richard Keen 4 , Christian Roux 5 ,
Chak Sing Lau 6 , Jean-Yves Reginster 7 , Philemon Papanastasiou 8 , Taiwo Fashola 8 , Peter
Mesenbrink 9 , Philip Sambrook 10 ;
1
University of Aberdeen, Aberdeen, United Kingdom; 2 Saint-Luc University Hospital, Brussels,
Belgium; 3 University of Alabama at Birmingham, Birmingham, AL; 4 Royal National Orthopaedic
Hospital, Stanmore, United Kingdom; 5 Cochin Hospital, Paris, France; 6 University of Dundee,
Dundee, United Kingdom; 7 University of Liège, Liège, Belgium; 8 Novartis Pharma AG, Basel,
Switzerland; 9 Novartis Pharmaceuticals Corporation, East Hanover, NJ; 10 University of Sydney,
Sydney, NSW, Australia
CHANGES IN THE TREATMENT OF RHEUMATIC DISEASE ACROSS THE WESSEX REGION:
A 10 YEAR UPDATE
Christopher R. Holroyd, Margaret Fletcher, Joanna M. Ledingham;
Rheumatology Department, Queen Alexandra Hospital, Portsmouth, United Kingdom
Health services research, economics and outcomes research
Poster No. 254
Poster No. 255
Poster No. 256
Poster No. 257
THE COST-UTILITY OF ACUPUNCTURE AS AN ADJUNCT TO EXERCISE-BASED
PHYSIOTHERAPY FOR OSTEOARTHRITIS OF THE KNEE
David G. Whitehurst 1 , Stirling Bryan 2 , Elaine Thomas 1 , Elaine M. Hay 1 , Julie Young 1 ,
Nadine E. Foster 1 ;
1
Arthritis Research Campaign National Primary Care Centre, Primary Care Sciences, Keele
University, Keele, United Kingdom; 2 Centre for Clinical Epidemiology & Evaluation, Vancouver
Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada
CAN CHOICES BETWEEN ALTERNATIVE HIP PROSTHESES BE EVIDENCE BASED?
A REVIEW OF THE ECONOMIC EVALUATION LITERATURE
Charlotte Davies 1 , Ian Shemilt 1 , Alexander Macgregor 1 , Miranda Mugford 1 , Paula Lorgelly 2 ;
1
School of Medicine, UEA, Norwich, United Kingdom; 2 Section of Public Health and Health
Policy, University of Glasgow, Glasgow, United Kingdom
PERCEIVED BARRIERS TO INTEGRATED CARE IN RHEUMATOID ARTHRITIS (RA): VIEWS
OF PROVIDERS AND RECIPIENTS OF PRIMARY AND SECONDARY CARE SERVICES
Helen Graves 1 , Louise C. Pollard 1 , Heidi Lempp 1 , Gabrielle H. Kingsley 2 , David L. Scott 1 ;
1
Academic Department of Rheumatology, King’s College London, London, United Kingdom;
2
Department of Rheumatology, University Hospital Lewisham, London,
United Kingdom
MANAGING POLYPHARMACY IN RHEUMATOID ARTHRITIS: UNDERSTANDING HOW PATIENTS
TAKE THEIR MEDICINES
Rod Hughes 1 , Alison Carr 2 , Maggie Walsh 1 , Maggie Carr 1 ;
1
Rheumatology, Ashford and St Peter’s NHS Trust, Chertsey, United Kingdom; 2 Academic
Rheumatology, University of Nottingham, Nottingham, United Kingdom
84

Poster No. 258
Poster No. 259
Poster No. 260
COMPARISON OF LINEAR AND NONLINEAR UTILITY MAPPING BETWEEN HAQ AND
EQ-5D USING POOLED DATA FROM THE TOCILIZUMAB TRIALS OPTION AND LITHE
Pierre Ducournau 1 , Adrian Kielhorn 1 , Neil S. Wintfeld 2 ;
1
Roche, Basel, Switzerland; 2 Roche, Nutley, NJ
HOW DO GENERAL PRACTITIONERS OBTAIN RHEUMATOLOGY ADVICE: A ROLE FOR A
CONSULTANT-LED EMAIL ADVICE SERVICE?
Emyr P. Humphreys 1 , Shireen Habboush 1 , Nia Owens 1 , Tom Lawson 1 , Stefan Siebert 1,2 ;
1
Rheumatology, Princess of Wales Hospital, Abertawe Bro Morgannwg University NHS Trust,
Bridgend, United Kingdom; 2 Swansea University, Swansea, United Kingdom
THE SAFETY AND EFFICACY OF INTRA-ARTICULAR AND INTRA-MUSCULAR STEROID
INJECTIONS IN HIV POSITIVE INDIVIDUALS WITH MUSCULOSKELETAL DISORDERS.
Authors: K.Glennon, K Walker-Bone
Katie Glennon, Karen Walker-Bone;
Rheumatology, Brighton & Sussex Medical School, Brighton, United Kingdom
Poster Viewing Two | Thursday 30 April 2009
Poster No. 261
THE ECONOMIC BURDEN OF LOST PRODUCTIVITY IN A COHORT OF PATIENTS WITH
EARLY RHEUMATOID ARTHRITIS (RA): Early Rheumatoid Arthritis Network (ERAN)
Wei Zhang 1 , Nick Bansback 1 , Adam Young 2 , David Walsh 3,4 , Patrick Keily 5,2 , Aslam Anis 1 ;
1
Centre for Health Evaluation & Outcome Sciences, University of British Columbia,
Vancouver, BC, Canada; 2 Early Rheumatoid Arthritis Network (ERAN), c/o St Albans City
Hospital, St Albans, United Kingdom; 3 Academic Rheumatology, University of Nottingham,
City Hospital, Nottingham, United Kingdom; 4 Rheumatology, Sherwood Forest Hospitals NHS
Foundation Trust, Nottingham, United Kingdom; 5 Rheumatology, St George’s Hospital,
London, United Kingdom
Poster No. 262
PRE-TREATMENT TMPT PHARMACOGENETIC TESTING AND RISK OF NEUTROPAENIA
IN PATIENTS TREATED WITH AZATHIOPRINE: RESULTS FROM THE TPMT AZATHIOPRINE
RESPONSE TO GENOTYPING AND ENZYME TESTING (TARGET) TRIAL
William G. Newman 1,2 , Katherine Payne 2 , Karen Tricker 2 , Stephen A. Roberts 2,1 ,
Emily A. Fargher 2 , Sudeep Pushpakom 1,2 , Jane Alder 2 , Kay Poulton 1 , Julie Andrews 2 ,
Gary Sidwick 2 , J. Brian Houston 2 , Rachel Elliott, R. G. Elles, D. W. Ray, J. Shaffer, C. Griffiths,
F. Qasim, I. N. Bruce, W. R. Ollier;
1
Central Manchester & Manchester Children’s University Hospitals, NHS Trust, Manchester,
United Kingdom; 2 University of Manchester, Manchester, United Kingdom
Poster No. 263
VARIATION IN CASE MIX ACROSS WESSEX RHEUMATOLOGY UNITS OVER 10 YEARS
Christopher R. Holroyd, Margaret J. Fletcher, Joanna M. Ledingham;
Rheumatology Department, Queen Alexandra Hospital, Portsmouth, United Kingdom
Poster No. 264
IMPROVED WORK PRODUCTIVITY IN PATIENTS WITH ANKYLOSING SPONDYLITIS
(AS) TREATED WITH ADALIMUMAB: RESULTS FROM THE RHAPSODY TRIAL
Katherine L. Gooch 3 , Martin Rudwaleit 1 , Kyriaki Boki 2 , Mary A. Cifaldi 3 , Robert L. Wong 4 ,
Naijun Chen 3 , Hartmut Kupper 5 ;
1
Charité Universitätsmedizin Berlin, Berlin, Germany; 2 Rheumatology Department,
Sismanoglio Hospital, Athens, Greece; 3 Abbott Laboratories, Abbott Park, IL; 4 Abbott
Laboratories, Parsippany, NJ; 5Abbott GmbH & Co KG, Ludwigshafen, Germany
85

Poster No. 265
Poster No. 266
Poster No. 267
Poster No. 268
Poster No. 269
Poster No. 270
Poster No. 271
Poster No. 272
IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS ADALIMUMAB PLUS MTX
COMBINATION THERAPY DECREASES RESOURCE USE
Mary A. Cifaldi 2 , Ronald F. van Vollenhoven 1 , Saurabh Ray 2 , Chris Bojke 3 , Michael Weisman 4 ;
1
Rheumatology, Karolinska University Hospital, Stockholm, Sweden; 2 Abbott Laboratories,
Abbott Park, IL; 3 Pharmerit International, York, United Kingdom; 4 Cedars-Sinai Medical Center,
Los Angeles, CA
IMPACT OF ADALIMUMAB TREATMENT IN THE WORKPLACE IN PATIENTS WITH RHEUMATOID
ARTHRITIS
Mary A. Cifaldi 4 , Howard Birnbaum 1 , Crystal Pike 1 , Rebecca Kaufman 1 , Matthew Schiller 1 ,
Lizheng Shi 2 , Peter Sun 3 , Saurabh Ray 4 ;
1
Analysis Group, Boston, MA; 2 Tulane University, New Orleans, LA; 3 Kailo Research Group,
Indianapolis, IN; 4 Abbott Laboratories, Abbott Park, IL
SAME QUESTION, DIFFERENT ANSWER: A COMPARISON OF GLOBAL HEALTH
ASSESSMENTS USING VAS SCALES
Mark Harrison 1 , Annalies Boonen 2 , Peter Tugwell 3 , Deborah Symmons 1 ;
1
arc Epidemiology Unit, The University of Manchester, Manchester, United Kingdom; 2 Maastricht
University Medical Centre, Maastricht, Netherlands; 3 Epidemiology & Community Medicine,
University of Ottawa, Ottawa, ON, Canada
COPYING CLINIC LETTERS TO PATIENTS - A PATIENT SURVEY
Sharmistha K. Williams, Christopher R. Kelsey;
Rheumatology, Queens Hospital, Romford, United Kingdom
IMPACT OF RHEUMATOID ARTHRITIS ON WORKING PEOPLE
Abhay Joshi, Elizabeth Price, Lyn Williamson, David Collins;
Rheumatology, Great Western Hospital, Swindon, United Kingdom
WORKING STATUS IN PATIENTS WITH ANKYLOSING SPONDYLITIS RECEIVING ANTI-TNF
THERAPY
Suzanne M.M. Verstappen, Kath D. Watson, Katie McGrother, Deborah P.M. Symmons,
Kimme L. Hyrich, On behalf of the BSR Biologics Register;
arc Epidemiology, the University of Manchester, Manchester, United Kingdom
THE EFFECT OF RHEUMATOID ARTHRITIS (RA) ON JOB LOSS & WORK PRODUCTIVITY.
RESULTS FROM AN INCEPTION COHORT WITH 10YR FOLLOW UP
Adam Young, Peter Prouse, Peter Williams, Joe Devlin, Gouri Koduri, Dor Pattison,
Sue Stafford, Nigel Cox;
ERAS, Rheumatology, City Hospital, St Albans, United Kingdom
THE VALIDITY OF ESTIMATING EQ-5D SCORES FROM THE HAQ AND SF-36
Mark Harrison 1 , Kath Watson 1 , Nick Bansback 2 , Suzanne Verstappen 1 , Deborah Symmons 1 ,
on behalf of the BSRBR 1 ;
1
arc Epidemiology Unit, The University of Manchester, Manchester, United Kingdom;
2
St Paul’s Hospital, Vancouver, BC, Canada
Poster No. 273
IS RA CARE MEETING THE NEEDS OF PATIENTS IN ENGLAND? KEY FINDINGS
FROM A PATIENT SURVEY
Sophie J. Beale 1 , Tesha Cardow 1 , Paul Trueman 1 , Martin Land 2 ;
1
York Health Economics Consortium, University of York, York, United Kingdom; 2 The King’s Fund,
London, United Kingdom
86

Poster No. 274
Poster No. 275
ECONOMIC EVALUATION OF THERAPEUTIC APPROACHES FOR RHEUMATOID
ARTHRITIS: THE CASE FOR SEQUENTIAL ANTI-TNF USE
Mathew Taylor 1 , Carina Righetti 1 , Peter Conway 2 , Maximilian Lebmeier 3 ;
1
York Health Economics Consortium, University of York, York, United Kingdom; 2 Wyeth Europa,
Maidenhead, United Kingdom; 3 Wyeth Pharmaceuticals, Taplow, United Kingdom
THE HIDDEN WORK OF A RHEUMATOLOGY DEPARTMENT: SW THAMES, SURREY
AND SUSSEX REGIONAL SURVEY OF IN-PATIENT RHEUMATOLOGY REFERRALS
Patrick D. Kiely 1 , Piero P. Reynolds 1 , Kay M. Garmston 2 , Vinrod Ravindran 3 ,
Alastair L. Hepburn 4 , Mike Chard 4 , Hugh Jones 5 , Rod Hughes 6 , Martin Ridley 7 ,
Sanjeev Menon 7 , Mark Lloyd 2 ;
1
Rheumatology, St Georges Healthcare NHS Trust, London, United Kingdom; 2 Rheumatology,
Frimley Park Hospital NHS Foundation Trust, Frimley, United Kingdom; 3 Rheumatology,
St Helier University Hospital Trust, Carshalton, United Kingdom; 4 Rheumatology, Worthing and
Southlands Hospital NHS Trust, Worthing, United Kingdom; 5 Rheumatology, Kingston Hospital
NHS Trust, Kingston, United Kingdom; 6 Rheumatology, Ashford and St Peter’s Hospitals NHS
Trust, Kingston, United Kingdom; 7 Rheumatology, The Royal West Sussex NHS Trust,
Chichester, United Kingdom
Poster Viewing Two | Thursday 30 April 2009
Miscellenaous rheumatic disease
Poster No. 276
Poster No. 277
Poster No. 278
Poster No. 279
AN AUDIT OF TB PROPHYLAXIS IN ANTI-TNF TREATED PATIENTS IN SECONDARY CARE
IN EAST LONDON - ARE WE IDENTIFYING THE RIGHT PATIENTS?
Henry Penn, Mandy Greenwood, Margaretta Rooney, Alan J. Hakim, John Lanham,
Simon P. Donnelly, Hasan Tahir;
Rheumatology, Whipps Cross Hospital, London, United Kingdom
CONSIDER HYPOADRENALISM IN PATIENTS WITH FATIGUE AND
RHEUMATIC DISEASE
Dimitra Methiniti, Jennifer Hamilton, Vadivelu Saravanan, Carol Heycock, Clive Kelly;
Rheumatology, QEH, Gateshead, United Kingdom
A ‘HOT JOINT PACK’ IMPROVES THE MANAGEMENT OF THE ACUTE HOT JOINT
Brian F. Menezes, Richard P. Cooke, Cristina Estrach, Nicola J. Goodson,
Robert N. Thompson;
Aintree University Hospitals NHS Foundation Trust, Liverpool, United Kingdom
THE TRANSITION FROM HOSPITAL TO HOME: A QUALITATIVE INVESTIGATION INTO THE
ABILITY OF PATIENTS TO TRANSFER AND MAINTAIN SKILLS LEARNED ON A COMPLEX
REGIONAL PAIN SYNDROME (CRPS) IN-PATIENT PROGRAMME
Karen Rodham 1 , Megan Cockburn 1 , Candy McCabe 2 ;
1
Psychology, University of Bath, Bath, United Kingdom; 2 Rheumatology,
Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom
87

Poster No. 280
ORGAN-SPECIFIC AUTOANTIBODIES BUT NOT ANTI-CCP ARE A FEATURE OF AUTOIMMUNITY
IN DOWN’S SYNDROME
Benjamin A. Fisher 1 , Peter Charles 1 , Karin Lundberg 1 , Kathleen M. Gillespie 2 ,
Richard W. Newton 3 , Patrick J. Venables 1 ;
1
Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom;
2
Diabetes and Metabolism Unit, University Of Bristol, Bristol, United Kingdom; 3 Department of
Paediatric Neurology, Royal Manchester Children’s Hospital, Manchester, United Kingdom
Poster No. 281
Poster No. 282
Poster No. 283
Poster No. 284
Poster No. 285
TOLERABILITY OF COMBINING ANTI-TB PROPHYLAXIS WITH DIFFERENT DMARDS AND
ANTI-TNF AGENTS
Muhammad Haroon, Una Martin, Ciaron Duffy, Joe Devlin;
Department of Rheumatology, Waterford Regional Hospital, Waterford, Ireland
THE USE OF ANTI-TNF THERAPY IN THE TREATMENT OF NINE PATIENTS WITH BEHÇET’S
SYNDROME IN A SINGLE RHEUMATOLOGY TERTIARY REFERRAL CENTRE
Lynne M. Shand 1 , Dorian Haskard 2 ;
1
Rheumatology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United
Kingdom; 2 Eric Bywaters Centre for Vascular Inflammation, Imperial College London, London,
United Kingdom
BILATERAL LIPOMA ARBORESCENS CO-EXISTING WITH PSORIATIC ARTHRITIS RELEASES
TNF-ALPHA AND MATRIX METALLOPROTEINASE 3
Martin E. Perry 1 , Alasdair R. Fraser 2 , Anne Crilly 2 , Jim Reilly 2 , Axel Hueber 2 , Iain B. McInnes 2 ;
1
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, United Kingdom; 2 Division
of Immunology, Infection and Inflammation, Faculty of Medicine, The University of Glasgow,
Glasgow, United Kingdom
Withdrawn
TREATMENT OF CRYOPYRIN ASSOCIATED PERIODIC FEVER SYNDROME WITH A
LONG-ACTING FULLY HUMAN ANTI-IL-1BETA MONOCLONAL ANTIBODY (ACZ885)
Helen Lachmann 1 , Phil Lowe 2 , Mark Offer 1 , Christiane Rordorf 3 , Xavier Gitton 4 , Neha P. Patel 5 ,
Philip N. Hawkins 1 ;
1
Department of Medicine, Royal Free and university College Medical School, London, United
Kingdom; 2 Modelling and Simulation, Novartis, Basel, Switzerland; 3 Translational Medicine,
Novartis, Basel, Switzerland; 4 Clinical Development, Novartis, Basel, Switzerland; 5 Clinical
Development, Novartis, East Hanover, NJ
88

Poster Viewing Three
Friday 01 May 2009
Poster Viewing Three
Fri 01 May 2009

Poster Viewing Three
Friday 01 May 2009, 08.30-10.00
Case reports
Poster No. 286
Poster No. 287
OSTEONECROSIS OF THE ELBOW FOLLOWING BISPHOSPHONATE TREATMENT
Clare S. Bolton 1 , Neil D. McKay 2 , David Coady 2 , Terry Featherstone 3 ;
1
Medical School, Newcastle University, Newcastle, United Kingdom; 2 Rheumatology,
Sunderland Royal Hospital, Sunderland, United Kingdom; 3 Radiology, Sunderland
Royal Hospital, Sunderland, United Kingdom
LANGERHANS CELL HISTIOCYTOSIS PRESENTING AS POLYMYALGIC ONSET OF ANTI-CCP
POSITIVE RHEUMATOID ARTHRITIS
Alison L. Endean 1,2 , Steven A. Young-Min 1 ;
1
Rheumatology, Queen Alexandra Hospital, Portsmouth, United Kingdom; 2 Rheumatology,
Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke, United Kingdom
Poster Viewing Three | Friday 01 May 2009
Poster No. 288
Poster No. 289
Poster No. 290
HYDROXYUREA: A VASCULITIS MIMICK?
Surabhi Wig, Mohammed Akil;
Rheumatology, Royal Hallamshire hospital, Sheffield, United Kingdom
A CASE OF CAT-SCRATCH DISEASE ARTHROPATHY
John D. Pauling, Ellie Korendowych;
Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom
COMPLETE HEART BLOCK IN AN ADULT WITH ANTI-RO ANTIBODIES BUT NO CLINICAL
FEATURES OF SJÖGREN’S SYNDROME
Benjamin J. Wrigley 1 , Tracey E. Toms 2 , Dawn L. Adamson 1 ;
1
Department of Cardiology, University Hospital, Coventry, United Kingdom; 2 Department of
Rheumatology, Russells Hall Hospital, Dudley, United Kingdom
Poster No. 291
Poster No. 292
Poster No. 293
POST SURGICAL WOUND INFLAMMATION - PYODERMA GANGRENOSUM OR
NECROTISING FASCIITIS? A RHEUMATOLOGICAL SOLUTION
Mytheen Jasminsajna, Kuntal Chakravarty;
Rheumatology, Queen’s Hospital,Romford, Essex, United Kingdom
NEISSERIA ELONGATA GLYCOLYTICA SEPTIC ARTHRITIS
Amit k. Saha, Sangita Agarwal, Terence Gibson;
Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
FISHY FINGER: MYCOBACTERIUM KANSASII, A RARE CAUSE OF TENOSYNOVITIS
Judith S. Bubbear 1 , Lynne Shand 2 , Vanessa H. Morris 1 ;
1
Rheumatology Department, University College London Hospital, London, United Kingdom;
2
Rheumatology Department, Hammersmith Hospital, London, United Kingdom
89

Poster No. 294
Poster No. 295
Poster No. 296
Poster No. 297
Poster No. 298
Poster No. 299
Poster No. 300
Poster No. 301
Poster No. 302
A CASE OF POEMS SYNDROME
Piero P. Reynolds, Rodney A. Hughes;
Rheumatology, St. Peters Hospital, Chertsey, United Kingdom
ESSENTIAL THROMBOCYTHAEMIA MIMICKING LARGE VESSEL VASCULITIS
Catherine Gwynne 1 , Marguerite Hill 2 , Stefan Siebert 1 ;
1
Rheumatology, Princess of Wales Hospital, Bridgend, United Kingdom; 2 Neurology, Morriston
Hospital, Swansea, United Kingdom
RHABDOMYOLYSIS PRECIPITATED BY FUCIDIC ACID IN ASSOCIATION WITH LONG-TERM
STATIN THERAPY
Matthew Oates, James Dale, Margaret-Mary Gordon;
Rheumatology, Gartnavel General Hospital, Glasgow, United Kingdom
A KILLER MOCKING BIRD-CASE REPORT
Sangeetha Baskar 1 , George D. Kitas 1 , Rainer Klocke 1 , Michael Cushley 2 , Sixto Batitang 4,
Jeffrey Neilson 3 , Ruth Shave 5 , Karen Douglas 1 ;
1
Rheumatology, Dudley group of hospitals, Dudley, United Kingdom; 2 Respiratory
medicine, Dudley group of hospitals, Dudley, United Kingdom; 3 Haematology, Dudley group of
hospitals, Dudley, United Kingdom; 4 Histopathology, Dudley group of hospitals, Dudley, United
Kingdom; 5 Radiology, Dudley group of hospitals, Dudley, United Kingdom
CLINICAL AND RADIOGRAPHICAL CHARACTERISTICS OF MELORRHOESTOSIS
Marian Chan, Paul B. Wordsworth, Yun Zhang;
Nuffield Department of Orthopaedic Surgery, Botnar Research Centre-University of Oxford,
Oxford, United Kingdom
ADALIMUMAB ASSOCIATED PNEUMONITIS
Gwenan Huws, James Martin, Rhodri Jones;
Rheumatology, Royal Glamorgan Hospital, Llantrisant, United Kingdom
SAFETY OF SEQUENTIAL MONOTHERAPY WITH LEFLUNOMIDE AND RITUXIMAB IN
A TNF ALPHA BLOCKER NAÏVE RHEUMATOID ARTHRITIS PATIENT WITH PREVIOUS
ANTI-RHEUMATIC DRUG INDUCED EPSTEIN BARR VIRUS ASSOCIATED B-CELL LYMPHOMA
Anas Boulemden 1 , Neil McKay 1 , Mike Galloway 2 , Jamal Teir 1 , David Wright 1 ; 1 Rheumatology,
Sunderland Royal Hospital, Sunderland, United Kingdom; 2 Haematology, Sunderland Royal
Hospital, Sunderland, United Kingdom
NECROTISING FASCIITIS - A LIFE-THREATENING COMPLICATION OF ANTI-TNF THERAPY?
Anita Weerakoon 1 , David Rae 2 , Richard Watts1, Suzanne Lane 1 ;
1
Rheumatology, The Ipswich Hospital NHS Trust, Ipswich, United Kingdom; 2 Surgery, The
Ipswich Hospital NHS Trust, Ipswich, United Kingdom
TACROLIMUS- A POTENTIAL THERAPY FOR POLYMYOSITIS?
Lucy E. Waite, Rajan Madhok;
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, United Kingdom
90

Poster No. 303
Poster No. 304
Poster No. 305
IMMUNOTHERAPY-RESPONSIVE AUTOIMMUNE ENCEPHALOPTHY ASSOCIATED WITH
BULLOUS PEMPHIGOID
Anushka Soni 1 , Sarosh R. Irani 2 , Bethan Lang 2 , Robert Mann 3 , Angela Vincent 2 ,
David Collins 1 ;
1
Rheumatology, Great Western Hospital, Swindon, United Kingdom; 2 The Neurosciences
Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United
Kingdom; 3 Dermatology, Great Western Hospital, Swindon, United Kingdom
ACQUIRED HAEMOPHILIA A AND SYSTEMIC LUPUS ERYTHEMATOSUS- A CASE REPORT
Madhura Castelino, Lee-Suan Teh;
Rheumatology, Royal Blackburn Hospital, Blackburn, United Kingdom
RESOLUTION OF SOMATOPARAPHRENIA IN CRPS OCCURS WITH CLINICAL
IMPROVEMENT
Maliha F. Shaikh, Nicholas G. Shenker;
Rheumatology Research Unit, Addenbrooke’s, Cambridge University Hospitals, Cambridge,
United Kingdom
Poster Viewing Three | Friday 01 May 2009
Poster No. 306
Poster No. 307
Poster No. 308
Poster No. 309
Poster No. 310
HEARING IMPROVEMENT IN A FAMILY WITH MUCKLE WELLS SYNDROME TREATED WITH
ANAKINRA
Grainne Murphy 1 , Sinead Harney 1 , Fergus Shanahan 2 , Michael Molloy 1 ;
1
Dept of Rheumatology, Cork University Hospital, Cork, Ireland; 2 Dept of Medicine,
Cork University Hospital, Cork, Ireland
A CASE OF ISOLATED FOCAL ORBITAL MYOSITIS ASSOCIATED WITH NON OCCULAR
DISTANT HERPES ZOSTER
Ziad Estephan 2 , Deepwant Singh 1 , Susana Ramirez-Florez 2 , Sandeep Dahiya 1 ; 1 Department
of Rheumatology, Peterborough and Stamford Hospitals NHS
Foundation Trust, Peterborough, United Kingdom; 2 Department of Ophthalmology,
Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough, United Kingdom
CENTRAL NERVOUS SYSTEM ISCHAEMIA AS THE PRESENTING FEATURE OF
CHURG-STRAUSS SYNDROME (CSS)
Kaushik Sanyal 1 , Karen Walker-Bone 2 ;
1
Rheumatology, Princess Royal Hospital , Haywards Heath, RH16 4EX, Haywards Heath,
United Kingdom; 2 Rheumatology, Brighton & Sussex Medical School, Brighton,
United Kingdom
RITUXIMAB INDUCED REMISSION OF ANCA-ASSOCIATED SCLERITIS: TWO CASE STUDIES
Sarah C. Skeoch 1 , Deborah Symmons 2 , Fiona Carley 3 , Ian Bruce 1,2 ;
1
Rheumatology, Manchester Royal Infirmary, Manchester, United Kingdom; 2 ARC
Epidemiology Unit, University of Manchester, Manchester, United Kingdom; 3 Ophthalmology,
Manchester Royal Eye Hospital, Manchester, United Kingdom
A TEN YEAR HISTORY OF MYCOBACTERIUM MALMOENSE SEPTIC ARTHRITIS OF
THE WRIST
C. Bracewell 1 , N. D. McKay 1 , C. Muwanga 2 , D. Wright 1 ;
1
Rheumatology Department, Sunderland Royal Hospital, Sunderland, United Kingdom;
2
Surgical Department, Sunderland Royal Hospital, Sunderland, United Kingdom
91

Education research
Poster No. 311
I’M GLAD YOU KNOW WHAT THESE ‘VAGUE‘ SYMPTOMS ARE DOC - AN EXPLORATION OF
THE JOURNEY FOR A DIAGNOSIS OF PRIMARY SYSTEMIC VASCULITIS
Janice Mooney 1 , Richard Watts 1 , Fiona Poland 1 , Nicola Spalding 1 , David Scott 2 ;
1
School of Social Sciences, University of East Anglia, Norwich, United Kingdom;
2
Department of Rheumatology, Norfolk & Norwich University Hospital, Norwich, United Kingdom
Poster No. 312
CONCEPT MAPS: A TOOL FOR TEACHING AND ASSESSING MEDICAL STUDENTS
RHEUMATOLOGY?
William R. Tillett 1 , Abigail Samuels 2 , Shane Clarke 1 ;
1
Department of Rheumatology, Weston Area Health Trust, Weston-super-mare, United Kingdom;
2
Gloucestershire Academy, Gloucester Royal Hospital, Gloucester, United Kingdom
Poster No. 313
Poster No. 314
Poster No. 315
Poster No. 316
Poster No. 317
Poster No. 318
A BEHAVIOURAL STUDY OF DISTRACTION AND ATTENTION TO A PAINFUL LASER STIMULUS
IN FIBROMYALGIA, ARTHRITIS AND HEALTHY VOLUNTEERS
Alison Watson, Shawn Morais, Deborah Bentley, Emma Boger, Yvonne Boyle, Bhavna Kulkarni,
Anthony Jones;
Human Pain Research Group, University of Manchester, Manchester, United Kingdom
MUSCULOSKELETAL ULTRASOUND TRAINING SURVEY
Claire Dubois, Sarang Chitale, Robert N. Thompson, Christina Estrach;
Rheumatology, University Hospital Aintree, Liverpool, United Kingdom
MSC IN CLINICAL RHEUMATOLOGY - STUDENT’S PERCEPTIONS OF INFLUENCE ON
FURTHER CAREER
Holly Ennis 1 , Neil Snowden 2 , Deborah Symmons 1 , Terence O’Neill 1 , I. N. Bruce 1 ,
Antony Freemont 1 , Anne Barton 1 , Kimme Hyrich 1 , Ariane Herrick 1 ;
1
University of Manchester, Manchester, United Kingdom; 2 North Manchester General Hospital,
Manchester, United Kingdom
A ONE DAY EXERCISE PROGRAMME: COACHING FOR EXERCISE FOR ANKYLOSING
SPONDYLITIS (COAX-AS)
Lorraine A. McFarland 1 , Sheila Leddington Wright 2 , Jane Tooby 3 , Julie Barlow 1 ;
1
Faculty of Health & Life Sciences, Coventry University, Coventry, United Kingdom;
2
Physiotherapy Department, Coventry University, Coventry, United Kingdom; 3 Physiotherapy
Department, University Hospital Coventry & Warwickshire NHS Trust, Coventry, United Kingdom
Withdrawn
ACCESS TO TRAINING IN MUSCULOSKELETAL ULTRASOUND: A SURVEY OF UK
RHEUMATOLOGY TRAINEES
Toby Garrood 1 , Philip Platt 2 ;
1
Department of Rheumatology, University Hospital Lewisham, London, United Kingdom;
2
Department of Rheumatology, Freeman Hospital, Newcastle-upon-Tyne, United Kingdom
92

Epidemiology
Poster No. 319
Poster No. 320
Poster No. 321
OBESITY APPEARS TO BE ASSOCIATED WITH ANTI-CCP POSITIVE INFLAMMATORY
POLYARTHRITIS: RESULTS FROM AN EARLY ARTHRITIS CLINIC
Jenny Humphreys 2 , Sarang Chitale 2 , Cristina Estrach 2 , Nicola J. Goodson 1 ;
1
Academic Rheumatology dept, Liverpool University, Liverpool, United Kingdom;
2
Rheumatology, Aintree University Hospital, Liverpool, United Kingdom
PREVALENCE OF GOUT IN CENTRAL GREECE
Ioannis Alexiou 1 , Ioannis Anagnostopoulos 1 , Evangelos Davas 1 , Afrodite Papathanasiou 2 ,
Athanasios Koutroumpas 1 , Georgia Barouta 1 , Lazaros I. Sakkas 1 ;
1
Rheumatology, University Hospital of Larissa, Larissa, Greece; 2 Biomathematics,
University Hospital of Larissa, Larissa, Greece
SEASON OF BIRTH AND THE DEVELOPMENT OF THE AUTOANTIBODIES RF AND ANA
Sarah L. Westlake 1 , Karen Jameson 2 , Elaine M. Dennison 2 , Nigel K. Arden 2,3 , Cyrus Cooper 2,3 ,
Christopher J. Edwards 1 ;
1
Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton,
United Kingdom; 2 MRC Epidemiology Resource Centre, University of Southampton,
Southampton, United Kingdom; 3 Musculoskeletal Biomedical Research Unit, University of
Oxford, Oxford, United Kingdom
Poster Viewing Three | Friday 01 May 2009
Poster No. 322
Poster No. 323
Poster No. 324
Poster No. 325
THE OCCURRENCE AND PREDICTORS OF HEART FAILURE IN PATIENT WITH
INFLAMMATORY POLYARTHRITIS
Suet Ying Khong 1 , Tracey Farragher 1 , Jarrod Franklin 1 , Hoda Mirjafari 1 , Diane Bunn 2 ,
Ian Bruce 1 , Deborah Symmons 1 ;
1
arc Epidemiology Unit, The University of Manchester, Manchester, United Kingdom; 2 Norfolk
Arthritis Register, Norfolk and Norwich University Hospital, Norwich, United Kingdom
PRELIMINARY RESULTS FROM THE SPARK SURVEY OF NORTH AMERICAN AND
EUROPEAN CLINICAL PRACTICE: MORE RHEUMATOID ARTHRITIS (RA) OR MORE
SPONDYLOARTHRITIS (SpA)?
A. L. Pangan 5 , M. Dougados 1 , D. van der Hiejde 2 , J. Sieper 3 , P. J. Mease 4 ;
1
Hôpital Cochin and the University of Paris, Paris, France; 2 Leiden University Medical Center,
Leiden, Netherlands; 3 Charité Universitätsmedizin, Berlin, Germany; 4 Swedish Medical Center
and University of Washington, Seattle, WA; 5 Abbott Laboratories, Abbott Park, IL
HYPONATRAEMIA INDEPENDENTLY OF OSTEOPOROSIS IS ASSOCIATED WITH VALIDATED
FRACTURE OCCURRENCE AMONG FEMALE PATIENTS ATTENDING FOR BONE DENSITY
MEASUREMENT
Sinead M. Kinsella 1 , Miriam J. O Sullivan 2 , Michael G. Molloy 2 , Joseph A. Eustace 1 ;
1
Department of Renal Medicine, Cork University Hospital, Cork, Ireland; 2 Department of
Rheumatology,Sports and Exercise Medicine, Cork University Hospital, Cork, Ireland
ONSET AND PERSISTENCE OF DISABLING FOOT PAIN IN COMMUNITY-DWELLING OLDER
ADULTS OVER A THREE-YEAR PERIOD
Edward Roddy, Sara Mottram, Elaine Thomas;
Arthritis Research Campaign National Primary Care Centre, Keele University, Keele,
United Kingdom
93

Poster No. 326
THE PREVALENCE OF RHEUMATOID ARTHRITIS IN RURAL EGYPT:
A WHO-ILAR-COPCORD STUDY
Ahmed Abdel-Nasser 1 , Rawheya Abdel-Tawab 1 , Jehan Mahmoud 1 , Adel Sammy 2 ,
Mahmoud Abdel-Fattah 3 ;
1
Rheumatology, Minia University, Minia, Egypt; 2 Radiology, Minia University, Minia, Egypt;
3
Epidemiology, Minia University, Minia, Egypt
Poster No. 327
Poster No. 328
Poster No. 329
Poster No. 330
PATTERNS OF SELECTED PERIPHERAL JOINT PAINS IN COMMUNITY-DWELLING ADULTS
AGED 50 YEARS AND OVER
George Peat, Elaine Thomas, Krysia Dziedzic, Peter Croft;
Arthritis Research Campaign National Primary Care Centre, Keele University, Keele,
United Kingdom
THE IMPACT OF MUSCULOSKELETAL PAIN ON SEXUAL FUNCTIONING IN MIDDLE AGED AND
ELDERLY EUROPEAN MEN: RESULT FROM THE EUROPEAN MALE AGEING STUDY
Abdelouahid Tajar 1 , Terence W. O’Neill 1 , György Bartfai 2 , Felipe F. Casanueva 3 , Gianni Forti 4 ,
Aleksander Giwercman 5 , Krzysztof Kula 6 , Margus Punab 7 , Dirk Vanderschueren 8 ,
Frederick C. Wu 9 , John McBeth 1 ;
1
ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom;
2
Department of Obstetrics, Gynaecology and Andrology, Albert Szent-Göorgy Medical University,
Szeged, Hungary; 3 Department of Medicine, Santiago de Compostela University, Complejo
Hospitalario Universitario de Santiago (CHUS); CIBER de Fisiopatología Obesidad y Nutricion
(CB06/03), Instituto Salud Carlos III, Santiago de Compostela, Spain; 4 Andrology Unit,
Department of Clinical Physiopathology, University of Florence, Florence, Italy; 5 Scanian
Andrology Centre, Department of Urology, Malmö University Hospital, University of Lund,
Malmö, Sweden; 6 Department of Andrology and Reproductive Endocrinology, Medical University
of Lodz, Lodz, Poland; 7 Andrology Unit, United Laboratories of Tartu University Clinics, Tartu,
Estonia; 8 Department of Andrology and Endocrinology, Catholic University of Leuven, Leuven,
Belgium; 9 Department of Endocrinology, Manchester Royal Infirmary, The University of
Manchester, Manchester, United Kingdom
HAND AND WRIST PROBLEMS IN GENERAL PRACTICE: WHAT IS THE VALUE OF
DIAGNOSTIC INFORMATION FOR PATIENT OUTCOMES?
Marinda N. Spies-Dorgelo 1 , Daniëlle A. van der Windt 2,1 , Pieter A. Prins 3 ,
Bernard M. Uitdehaag 4 , Henriëtte E. van der Horst 1 ;
1
Departement of General Practice, VU university medical center/EMGO-institute, Amsterdam,
Netherlands; 2 Primary Care Musculoskeletal Research Centre, Keele University, Keele, United
Kingdom; 3 Jan van Breemen Institute for rheumatology, Amsterdam, Netherlands; 4 Department
of Neurology, VU university medical center, Amsterdam, Netherlands
PHYSICAL DISABILITY AND PAIN IN A PRIMARY CARE BASED COHORT OF OLDER PEOPLE
WITH INFLAMMATORY AND NON-INFLAMMATORY MUSCULOSKELETAL CONDITIONS
Jon C. Packham, Edward Roddy, Kelvin P. Jordan;
Arthritis Research Campaign National Primary Care Centre, Keele University, Keele,
United Kingdom
94

Rheumatoid arthritis - clinical aspects
Poster No. 331
Poster No. 332
ASSESSMENT OF FALLS RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS IN
THE STANDARD RHEUMATOLOGY PRACTICE: MISSION POSSIBLE
Yasser El Miedany 1 , Deborah Palmer 1 , Mathias Toth 2 ;
1
Rheumatology, Darent Valley Hospital, Dartford, United Kingdom; 2 Geriatrics Department,
Darent Valley Hospital, Dartford, United Kingdom
GENDER DIFFERENCES IN DISEASE ACTIVITY IN EARLY RHEUMATOID ARTHRITIS
R. Martin 1 , M. H. Ma 1 , A. B. Hassell 2 , P. Kiely 3 , D. Walker 4 , D. A. Walsh 5 , R. Williams 6 ,
A. Young 7 , D. L. Scott 1 ;
1
Department of Rheumatology, King’s College School of Medicine, London, United Kingdom;
2
Department of Rheumatology, Hayward Hospital, Stoke-on-Trent, United Kingdom;
3
Department of Rheumatology, St Georges Hospital, London, United Kingdom; 4 Department
of Rheumatology, Freeman Hospital, Newcastle upon Tyne, United Kingdom; 5 Academic
Rheumatology, University of Nottingham, Nottingham, United Kingdom; 6 Department of
Rheumatology, Hereford Hospital, Hereford, United Kingdom; 7 Department of Rheumatology,
City Hospital, St Albans, United Kingdom
Poster Viewing Three | Friday 01 May 2009
Poster No. 333
PLANTAR FOOT PRESSURES ARE NOT RELATED TO DISEASE ACTIVITY IN RHEUMATOID
ARTHRITIS
Anita L. Gay 1 , Catherine J. Bowen 1 , Lindsey Hooper 1 , Christopher J. Edwards 2,3 ,
David Culliford 4 , Nigel K. Arden 5,6 ;
1
School of Health Sciences, University of Southampton, Southampton, United Kingdom;
2
Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton,
United Kingdom; 3 Wellcome Trust Clinical Research Facility, Southampton University
Hospitals NHS Trust, Southampton, United Kingdom; 4 Research Development and Support
Unit, University of Southampton, Southampton, United Kingdom; 5 MRC Epidemiology
Resource Centre, University of Southampton, Southampton, United Kingdom;
6
Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
Poster No. 334
Poster No. 335
Poster No. 336
FATIGUE IS CORRELATED WITH SLEEP DISTURBANCE IN PATIENTS WITH RHEUMATOID
ARTHRITIS (RA)
Penny Storrs, Cai Brockley, Frank McKenna;
Rheumatic Diseases Unit, Trafford NHS Healthcare Trust, Manchester, United Kingdom
CLINICAL AND LABORATORY CHARACTERISTICS OF RHEUMATOID ARTHRITIS IN PATIENTS
WITH AND WITHOUT ANTI-CYCLIC CITRULLINATED PROTEIN ANTIBODIES
Oleg B. Iaremenko 1 , Anna M. Mikitenko 2 ;
1
Rheumatology, National medical university, Kiev, Ukraine; 2 Rheumatology, National medical
university, Kiev, Ukraine
PREDICTORS OF SYNOVITIS AND JOINT DAMAGE AT PRESENTATION TO AN EARLY
ARTHRITIS CLINIC
Jenny A. Watkins 1 , Louise Gartner 2 , Denis Remedios 2 , Jacqueline Andrews 1 ;
1
Rheumatology, Northwick Park Hospital, London, United Kingdom; 2 Radiology, Northwick
Park Hospital, London, United Kingdom
95

Poster No. 337
IMPACT OF ADJUSTING CARDIOVASCULAR RISK SCORES TO KNOWN RISK RATIOS IN
RHEUMATOID ARTHRITIS
Kimberley A. Bailey 2 , Namita Kumar 1 ;
1
Dept of Rheumatology, University Hospital of North Durham, Durham, United Kingdom;
2
Medical School, University of Newcastle, Newcastle-upon-Tyne, United Kingdom
Poster No. 338
ASSESSMENT OF SUBCLINICAL CAROTID ATHEROSCLEROSIS IN RHEUMATOID ARTHRITIS
PATIENTS AND ITS CORRELATION WITH INSULIN RESISTANCE
Nevine M. Fouda 1 , Hanan Abdelaziz 2 , Enas Fouda 3 ;
1
Rheumatology, lecturer in ain shams university, Cairo, Egypt; 2 hanan abdelaziz, ass.prof in
ain shams university, Cairo, Egypt; 3internal medicine, ass.prof in ain shams university,
Cairo, Egypt
Poster No. 339
THE LARGEST ARMA STANDARD OF CARE SURVEY IN INFLAMMATORY ARTHRITIS
Ernest Wong 1 , Elizabeth Price 2 , Lynn Williamson 2 , David Collins 2 ;
1
Rheumatology, Buckinghamshire Hospital NHS Trust, High Wycombe, United Kingdom;
2
Rheumatology, Swindon & Marlborough NHS Trust, Swindon, United Kingdom
Poster No. 340
Poster No. 341
THE USE OF MUSCULOSKELETAL ULTRASOUND TO ASSESS DISEASE ACTIVITY IN
RHEUMATOID ARTHRITIS: A FEASIBILITY EXERCISE
James Dale, Monica Gupta, Duncan Porter;
Rheumatology, Gartnavel General Hospital, Glasgow, United Kingdom
FATIGUE IS AN INDEPENDENT DRIVER OF DISABILITY IN RHEUMATOID ARTHRITIS (RA)
Louise C. Pollard 1 , David L. Scott 1 , Nora Donaldson 2 , Ernest Choy 1 ;
1
Academic Department of Rheumatology, King’s College London, London, United Kingdom;
2
Oral Health Services Research, King’s College London, London, United Kingdom
Poster No. 342
Poster No. 343
HAQ AND GENDER PREDICT REMISSION IN EARLY RA: EXPERIENCE IN THE EARLY
RHEUMATOID ARTHRITIS NETWORK (ERAN)
Margaret H. Ma 1 , David L. Scott 1 , Patrick Kiely 2 , Richard Williams 3 , David Walsh 4 , Adam Young 5 ;
1
Rheumatology, King’s College Hospital, London, United Kingdom; 2 Rheumatology,
St George’s Hospital, London, United Kingdom; 3 Rheumatology, Hereford Hospital, Hereford,
United Kingdom; 4 Academic Rheumatology, University of Nottingham, Nottingham, United
Kingdom; 5 Rheumatology, City Hospital, St Albans, United Kingdom
INVESTIGATION OF THE NATURAL HISTORY OF FOREFOOT BURSITIS DETECTED BY
MUSCULOSKELETAL ULTRASOUND AND PREDICTORS OF ITS CHANGE AFTER ONE YEAR
Catherine J. Bowen 1 , David Culliford 2 , Keith Dewbury 3 , Madeleine Sampson 3 , Jane H. Burridge 1 ,
Christopher J. Edwards 4,5 , Nigel K. Arden 6,7 ;
1
School of Health Sciences, University of Southampton, Southampton, United Kingdom;
2
Research Development and Support Unit, University of Southampton, Southampton, United
Kingdom; 3 Radiology, Southampton University Hospitals Trust, Southampton, United Kingdom;
4
Rheumatology, Southampton University Hospitals Trust, Southampton, United Kingdom;
5
Wellcome Trust Clinical Research Facility, Southampton University Hospitals Trust,
Southampton, United Kingdom; 6 MRC Epidemiology Resource Centre, University of
Southampton, Southampton, United Kingdom; 7 Musculoskeletal Biomedical Research Unit,
University of Oxford, Oxford, United Kingdom
96

Poster No. 344
Poster No. 345
Poster No. 346
CARDIOVASCULAR RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS: WHAT DO OUR
GENERAL PRACTITIONERS THINK?
Eranga Hayes 1 , Jayne Little 1 , Vijay Iyer 2 , Amrit Takhar 3 , Sandeep Dahiya 1 ;
1
Department of Rheumatology, Peterborough and Stamford Hospitals NHS Foundation Trust,
Peterborough, United Kingdom; 2 The Surgery, Hodgson Centre, Werrington, Peterborough,
United Kingdom; 3 Wansford Surgery, Wansford and King’s Cliffe Practice, Peterborough,
United Kingdom
SMOKING ASSOCIATED WITH INCREASED DISEASE ACTIVITY AT PRESENTATION WITH
EARLY INFLAMMATORY POLYARTHRITIS
Sarang Chitale 1,2 , Jenny Humphreys 1 , Cristina Estrach 1 , Robert Thompson 1 ,
Nicola Goodson 1,2 ;
1
Rheumatology, Aintree University Hospital, Liverpool, United Kingdom; 2 Academic
Rheumatology Department, Liverpool University, Liverpool, United Kingdom
BNP LEVELS CORRELATE WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS PATIENTS
WITHOUT HEART DISEASE
David J. Armstrong 1 , Philip V. Gardiner 1 , Maurice J. O’Kane 2 ;
1
Department of Rheumatology, Altnagelvin Hospital, Londonderry, United Kingdom;
Poster Viewing Three | Friday 01 May 2009
2
Department of Biochemistry, Altnagelvin Hospital, Londonderry, United Kingdom
Poster No. 347
CHANGES IN BODY WEIGHT DURING ANTI-TNF THERAPY FOR RHEUMATOID ARTHRITIS
Richard A. Lowdon 1 , Paul Silcocks 2 , Sayka Butt 1 , Greg Summers 1 ;
1
Department of Rheumatology, Derbyshire Royal Infirmary, Derby, United Kingdom; 2 Trent
RDSU, Nottingham, United Kingdom.
Poster No. 348
EARLY INFLAMMATORY ARTHRITIS IS BEST MANAGED IN SPECIALISED CLINICS
Cyndi Goh 1 , Jill Bloxham 1 , Varvara Polydoropoulou 2 , Andrew J. Ostör 1 ;
1
Rheumatology, Addenbrooke’s Hospital, Cambridge, United Kingdom; 2 Centre for Applied
Medical Statistics, University of Cambridge, Cambridge, United Kingdom
Poster No. 349
RHEUMATOID ARTHRITIS (RA): THE ASSESSMENT OF DISEASE ACTIVITY IN
CLINICAL PRACTICE. DOES IT INFLUENCE TREATMENT DECISIONS?
Margaret H. Ma 1,2 , Louise C. Pollard 1 , Gabrielle H. Kingsley 2 , David L. Scott 1 ; 1 Rheumatology,
King’s College Hospital, London, United Kingdom; 2 Rheumatology, University Hospital
Lewisham, London, United Kingdom
Poster No. 350
CXCR3 AND CXCR4 EXPRESSION ON PERIPHERAL BLOOD T-LYMPHOCYTES FROM
PATIENTS WITH RHEUMATOID ARTHRITIS:RELATION TO DISEASE ACTIVITY
Nevine M. Fouda 1 , Eman Kaddah 1 , Sanaa Zaki 2 , Wafaa Zaki 2 ;
1
Rheumatology, lecturer in Ain Shams University, cairo, Egypt; 2 Microbiology and Immunology
Depatments, lecturer in Ain Shams University, Cairo, Egypt
Poster No. 351
DEVELOPMENT AND VALIDATION OF A HEART DISEASE KNOWLEDGE QUESTIONNAIRE
FOR PEOPLE WITH RHEUMATOID ARTHRITIS
Holly John 1 , Gareth J. Treharne 2 , Elizabeth D. Hale 1 , Vasileios Panoulas 1 , Douglas Carroll 3 ,
George Kitas 1 ;
1
Department of Rheumatology, Dudley Group of Hospitals NHS Foundation Trust, Dudley,
United Kingdom; 2 Department of Psychology, University of Otago, Dunedin, New Zealand;
3
School of Sport and Exercise Sciences, University of Birmingham, Birmingham,
United Kingdom
97

Poster No. 352
Poster No. 353
ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVITY CORRELATES WELL
WITH LARSEN RADIOGRAPHIC SCORES IN A CROSS-SECTIONAL COHORT OF PATIENTS
WITH RA BUT TITRE DOES NOT
Helena Robinson 1 , Anahita Rezaei 2 , Karen Walker-Bone 3 ;
1
Rheumatology, Brighton and Sussex University Hospitals, Brighton, United Kingdom; 2 Clinical
Immunology, Brighton and Sussex University Hospitals, Brighton, United Kingdom; 3 Brighton
and Sussex Medical School, Haywards Heath, United Kingdom
FATIGUE IN RHEUMATOID ARTHRITIS (RA), WHAT ARE WE MEASURING?: A FACTOR
ANALYSIS OF FATIGUE INSTRUMENTS
Louise C. Pollard 1 , David L. Scott 1 , Nora Donaldson 2 , Ernest H. Choy 1 ;
1
Academic Department of Rheumatology, King’s College London, London, United Kingdom;
2
Oral Health Services Research, King’s College London, London, United Kingdom
Poster No. 354
THE METABOLIC SYNDROME: A USEFUL CARDIOVASCULAR CONSTRUCT IN EARLY
INFLAMMATORY POLYARTHRITIS?
Hoda Mirjafari 1 , Tracey Farragher 1 , Tarnya Marshall 2 , Diane Bunn 1,2 , Philip Pemberton 3 , Helena
Bodill 4 , Valentine Charlton-Menys 5 , Mark Lunt 1 , Deborah Symmons 1 , Ian Bruce 1 ;
1
ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom; 2 Norfolk &
Norwich University Hospitals, Norwich, United Kingdom; 3 Clinical Research Department,
Manchester Royal Infirmary, Manchester, United Kingdom; 4 Department of Vascular Surgery,
Manchester Royal Infirmary, Manchester, United Kingdom; 5 Cardiovascular Research Group,
Manchester Royal Infirmary, Manchester, United Kingdom
Poster No. 355
Poster No. 356
COMPARISON OF SUBJECTIVE AND OBJECTIVE MEASURES OF SLEEP IN PATIENTS WITH
FIBROMYALGIA AND RHEUMATOID ARTHRITIS
Penny J. Storrs, Cai Brockley, Frank McKenna;
Rheumatic Diseases Unit, Trafford NHS Healthcare Trust, Manchester, United Kingdom
DISEASE ACTIVITY AND FIVE YEAR OUTCOME OF EARLY RHEUMATOID ARTHRITIS
(RA) IN A BIOLOGIC DRUG FREE INCEPTION COHORT
J. Dixey 1 , K. Jayakumar 1 , G. Koduri 1 , P. Williams 1 , S. Norton 2 , D. James 1 , A. Young 1 ;
1
Early Rheumatoid Arthritis Study (ERAS), c/o St Albans City Hospital, St Albans, United
Kingdom; 2 RDS, University of Hertfordshire, Hatfield, United Kingdom
Poster No. 357
Poster No. 358
HOW CAN TNF-BLOCKERS BE STOPPED WITHOUT FLARE? NEEDS EARLY TREATMENT AND
IMMUNOLOGICAL REMISSION
Benazir Saleem, Rekha Parmer, Vincent Goeb, Philip G. Conaghan, Frederique Ponchel,
Paul Emery;
Academic section of musculoskeletal disease, Leeds Institute of Molecular Medicine, Leeds
University, Leeds, United Kingdom
DISCREPANCIES IN CATEGORISING EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS
(RA) PATIENTS BY DAS28(ESR) AND DAS28(CRP): CAN THEY BE REDUCED?
Elizabeth M. Hensor, Paul Emery, Sarah J. Bingham, Philip G. Conaghan, Year Consortium;
Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom
98

Poster No. 359
Poster No. 360
Poster No. 361
THREE_DIMENSIONAL ULTRASOUND IMAGING FOR THE DETECTION AND MONITORING
OF JOINT DAMAGE IN RHEUMATOID ARTHRITIS
Nigel Harris 1 , Jacqueline Shipley 1 , James Thompson 1 , Ashok Bhalla 1 , Graham Robinson 2 ,
David Glew 2 , Francis Duck 2 ;
1
Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom; 2 Royal United
Hospital, Bath, United Kingdom
PERSISTENT MODERATE DAS IS NOT A BENIGN STATE: PROGRESSIVE LOSS OF
FUNCTION OCCURS IN EARLY RA DESPITE STEP-UP DMARD THERAPY
Philip G. Conaghan, Elizabeth M. Hensor, Anne-Maree Keenan, Paul Emery,
Year Consortium;
Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom
THE INFLUENCE OF ANTI-TNF THERAPY UPON CANCER INCIDENCE IN PATIENTS WITH
RHEUMATOID ARTHRITIS (RA) WHO HAVE HAD PRIOR MALIGNANCY: RESULTS FROM
THE BSRBR
Will Dixon, Kath Watson, Mark Lunt, .. BSRBR Control Centre Consortium, Kimme Hyrich,
Deborah Symmons, . on behalf of the BSRBR;
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Poster Viewing Three | Friday 01 May 2009
Poster No. 362
Poster No. 363
Poster No. 364
SECULAR CHANGES IN UK ANTI-TNF PRESCRIBING PATTERNS AND TREATMENT
RESPONSE IN PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS FROM THE BSRBR
Kath Watson, Kimme Hyrich, Mark Lunt, Deborah Symmons, . on behalf of the BSRBR;
arc Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
VITAMIN D DEFICIENCY IS ASSOCIATED WITH SIGNIFICANT DISABILITY IN EARLY
INFLAMMATORY POLYARTHRITIS (IP)
John A. Reynolds 1 , Tracey Farragher 1 , Mark Lunt 1 , Sanjeev Patel 2 , Diane Bunn 1 ,
Deborah Symmons 1 , Ian N. Bruce 1 ;
1
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom; 2 Department
of Medicine & Rheumatology, St Helier University Hospital, Carshalton, United Kingdom
ATHEROGENIC BIOMARKER PROFILES AND THE METABOLIC SYNDROME IN
INFLAMMATORY POLYARTHRITIS: RESULTS FROM THE NORFOLK ARTHRITIS
REGISTER (NOAR)
Hoda Mirjafari 1 , Philip Pemberton 2 , Valentine Charlton-Menys 3 , Tracey Farragher 1 ,
Diane Bunn 1,4 , Tarnya Marshall 4 , Deborah Symmons 1 , Ian Bruce 1 ;
1
ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom;
2
Clinical Research Department, Manchester Royal Infirmary, Manchester, United Kingdom;
3
Cardiovascular Research Group, University of Manchester, Manchester, United Kingdom;
4
Norfolk & Norwich University Hospitals, Norwich, United Kingdom
Poster No. 365
RHEUMATOID ARTHRITIS AND ANTI-TNF THERAPY: DIFFERENT DISEASE ASSESSMENT
NEEDED FOR PATIENTS OF DIFFERENT ETHNIC BACKGROUNDS?
Shabnam Sabah 1 , Sadia Kalsoom 1 , David M. Carruthers 2 , Alison Deeming 2 ;
1
Medical School, University of Birmingham, Birmingham, United Kingdom;
2
Rheumatology, City Hospital, Birmingham, United Kingdom
Poster No. 366
SYSTEMATIC REVIEW OF TIGHT CONTROL REGIMES IN RHEUMATOID ARTHRITIS
Margaret H. Ma 1,2 , Gabrielle H. Kingsley 2 , David L. Scott 1 ;
1
Rheumatology, King’s College Hospital, London, United Kingdom; 2 Rheumatology, University
Hospital Lewisham, London, United Kingdom
99

Poster No. 367
Poster No. 368
CERVICAL SPINE INSTABILITY IN RHEUMATOID ARTHRITIS (RA) IS MORE
COMMON IN PATIENTS UNDERGOING ORTHOPAEDIC SURGERY
B. Ramabhadran, G. Koduri, K. Jayakumar, R. Musa, J. Winfield, P. Williams, A. Young; ERAS,
Rheumatology, ERAS, St Albans City Hospital, St Albans, United Kingdom
LOW DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS (RA) RESULTS IN BETTER CLINICAL
OUTCOMES, BUT RADIOLOGICAL DAMAGE IN HANDS AND FEET CAN STILL PROGRESS
K. Jayakumar 1 , A. Young 1 , J. Dixey 1 , C. Sollymosy 1 , P. Williams 1 , S. Norton 2 ;
1
ERAS, Department of Rheumatology, St Albans City Hospital, St Albans, United Kingdom;
2
RDS, University of Hertfordshire, Hatfield, United Kingdom
Poster No. 369
A HIGH-THROUGHPUT TANSCRIPTOMICS APPROACH TO BIOMARKER DISCOVERY
IN EARLY ARTHRITIS
Arthur G. Pratt 1,2 , Gill Wilson 2 , Daniel C. Swan 3 , David A. Young 1 , Catharien M. Hilkens 1 ,
John D. Isaacs 1,2 ;
1
Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne, United
Kingdom; 2 Musculoskeletal Unit, Freeman Hospital, Newcastle upon Tyne, United Kingdom;
3
Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne, United Kingdom
Poster No. 370
Poster No. 371
Poster No. 372
Poster No. 373
Poster No. 374
POWER DOPPLER ULTRASOUND PREDICTS DEVELOPMENT OF RA IN CCP NEGATIVE
PATIENTS
Jane E. Freeston, Richard J. Wakefield, Philip G. Conaghan, Elizabeth M. Hensor, Paul Emery;
Academic Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom
HOW TO REDUCE THE MORBIDITY AND MORTALITY FROM LOWER RESPIRATORY TRACT
INFECTIONS IN RHEUMATOID ARTHRITIS
Madeleine Housden, Carol Heycock, Jennifer Hamilton, Vadivelu Saravanan, Clive Kelly;
Rheumatology, QEH, Gateshead, United Kingdom
“EXTRA INFORMATION A BIT FURTHER DOWN THE LINE”: RHEUMATOID ARTHRITIS
PATIENTS’ PERCEPTIONS OF DEVELOPING EDUCATIONAL MATERIAL ABOUT THE
CARDIOVASCULAR DISEASE RISK
Holly John 1 , Elizabeth D. Hale 1 , Gareth J. Treharne 2 , Douglas Carroll 3 , George Kitas 1 ;
1
Department of Rheumatology, Dudley Group of Hospitals NHS Foundation Trust, Dudley,
United Kingdom; 2 Department of Psychology, University of Otago, Dunedin, New Zealand;
3
School of Sport and Exercise Sciences, University of Birmingham, Birmingham, United
Kingdom.
OUTCOME MEASURES IN RHEUMATOID ARTHRITIS : PATIENT SELF-REPORT JOINT
TENDERNESS IS RELIABLE AND RESPONSIVE TO CHANGE IN DISEASE ACTIVITY
Yasser El Miedany 1 , Deborah Palmer 1 , Maha El Gaafary 2 ;
1
Rheumatology, Darent Valley Hospital, Dartford, United Kingdom; 2 Community, Environmental
and Occupational Medicine, Ain Shams University, Cairo, Egypt
PREGNANCY OUTCOMES IN PATIENTS RECEIVING ANTI-TNF THERAPY FOR
RHEUMATIC DISEASES: RESULTS FROM THE BSR BIOLOGICS REGISTER
Yvonne King, Kath Watson, . BSR Control Centre Consortium, Deborah Symmons,
Kimme Hyrich, . on behalf of the BSRBR;
arc Epidemiology Unit, University of Manchester, Manchester, United Kingdom
100

Poster No. 375
Poster No. 376
Poster No. 377
A QUESTIONNAIRE BASED ASSESSMENT IS AS EFFECTIVE AS A NURSE-LED CLINIC
IN IDENTIFYING CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH RHEUMATOID
ARTHRITIS
L. J. Smith, A. M. Meadows, Z. Horne, E. Whalley, N. J. Sheehan;
Rheumatology Department, Peterborough & Stamford Hospital NHS Foundation
Trust, Peterborough, United Kingdom
ANTI-CYCLIC CITRULLINATED PEPTIDE (CCP) ANTIBODY TITRE AND DISEASE ACTIVITY IN
RHEUMATOID ARTHRITIS
Sarah J. Evans 1 , Nick Amos 2 , Gill Johnson 1 , Alwyn Lloyd 1 , Margaret M. O’Sullivan 1 ;
1
Rheumatology, Wrexham Maelor Hospital, Wrexham, United Kingdom; 2 Rheumatology,
University Hospital of Wales, Cardiff, United Kingdom
METHOTREXATE REDUCES THE RISK OF CARDIOVASCULAR DISEASE IN PATIENTS WITH
RHEUMATOID ARTHRITIS (RA) - A SYSTEMATIC LITERATURE REVIEW
Sarah Westlake 1 , Alexandra Colebatch 1 , Janis Baird 2 , Ernest Choy 3 , Patrick Kiely 4 , Andrew
Ostor 5 , Mark Quinn 6 , Christopher Edwards 1 ;
1
Southampton General Hospital, Southampton, United Kingdom; 2 MRC Epidemiology
Resource Centre, University of Southampton, Southampton, United Kingdom; 3 Kings College,
London, United Kingdom; 4 St Georges Healthcare NHS Trust, London, United Kingdom;
5
Cambridge University Hospitals, Cambridge, United Kingdom; 6 York Hospital/ Hull York
Poster Viewing Three | Friday 01 May 2009
Medical School, York, United Kingdom
BHPR audit/service delivery
Poster No. 378
Poster No. 379
Poster No. 380
Poster No. 381
EVALUATION OF A RHEUMATOLOGY VOICEMAIL SERVICE
Leena Das 1 , Patricia Eveson 2 , Vivian Weeks 3 , Madelaine Whitlock 4 , Valerie Maddison 5 ;
1
Rheumatology, Southend NHS Foundation Trust, Essex, United Kingdom; 2 Rheumatology,
Southend NHS Foundation Trust, Essex, United Kingdom; 3 Rheumatology, Southend NHS
Foundation Trust, Essex, United Kingdom; 4 Rheumatology, Southend NHS Foundation Trust,
Essex, United Kingdom; 5 Rheumatology, Southend NHS Foundation Trust, Essex, United
Kingdom
THE EXPECTATIONS OF RHEUMATOLOGY DOCTORS AND ALLIED HEALTH
PROFESSIONALS REFERRING PATIENTS TO A NURSE LED CHRONIC MUSCULOSKELETAL
PAIN CLINIC
Sarah Ryan, Cath Thwaites;
Staffordshire Rheumatology Centre, Haywood Hospital, Burslem, Stoke on Trent,
United Kingdom
EVALUATING THE EDUCATION OF PATIENTS WITH NEWLY DIAGNOSED
RHEUMATOID ARTHRITIS
Martin A. Lee;
Rheumatology, Royal Cornwall Hospital, Truro, United Kingdom
DOES A RHEUMATOLOGY ADVICE LINE IMPACT ON PATIENTS TREATMENT?
Eileen A. Taylor 1 , Alan Brooksby 2 ;
1
Rheumatology Department, Norfolk & Norwich University Hospital, Norwich, United
Kingdom; 2 Clinical Audit Department, Norfolk & Norwich University Hospital, Norwich, United
Kingdom
101

Poster No. 382
Poster No. 383
Poster No. 384
Poster No. 385
Poster No. 386
Poster No. 387
Poster No. 388
Poster No. 389
Poster No. 390
Poster No. 391
PATIENT OUTCOMES IN RHEUMATOLOGY PRACTITIONER OUTREACH CLINICS IN NORFOLK
Heather F. Hasthorpe, Corrinne Ellis, Karl Gaffney;
Rheumatology, Norfolk & Norwich University Hospital NHS Foundation Trust., Norwich,
United Kingdom
THE ROLE OF THE INFECTIOUS DISEASES TEAM, RHEUMATOLOGY AND AUDIT IN
MAINTAINING STANDARDS IN THE ACUTE MANAGEMENT OF HOT JOINTS IN A LARGE
DISTRICT GENERAL HOSPITAL
Samah Alimam 1 , Sam T. Douthwaite 1 , Neil Snowden 2 ;
1
Monsall Unit, Dept of Infectious Diseases & Tropical Medicine, North Manchester General
Hospital, Pennine Acute NHS Trust, U.K, Manchester, United Kingdom; 2 Rheumatology Dept,
North Manchester General Hospital, Pennine Acute NHS Trust, U.K, Manchester,
United Kingdom
THE PRACTISE OF SWITCHING ANTI TNF THERAPY. A DISTRICT GENERAL HOSPITAL
EXPERIENCE
Teresa Doherty, Julian Heath, Sathianathan Panthakalam;
Rheumatology, Eastbourne District General Hospital, Eastbourne, United Kingdom
A DISTRICT GENERAL HOSPITAL’S EXPERIENCE OF ANTI TNF THERAPY IN
RHEUMATOID ARTHRITIS
Teresa Doherty, Julian Heath, Fatin Sumner, Andrew Ham, Sathianathan Panthakalam;
Rheumatology, Eastbourne District General Hospital, Eastbourne, United Kingdom
AUDIT - MANAGEMENT OF INFLAMMATORY ARTHRITIS
Madhura Castelino, Wael Sumaya, Lee-Suan Teh;
Rheumatology, Royal Blackburn Hospital, Blackburn, United Kingdom
PATIENT SATISFACTION WITH A NURSE PRESCRIBER LED SUBCUTANEOUS METHOTREXATE
INJECTION SERVICE, FOR PATIENTS WITH INFLAMMATORY ARTHRITIS
Gillian Scott, Janita H. Hayes, Yoke Mei McLoughlin, Frank McKenna;
Rheumatology, Trafford NHS Healthcare Trust, Manchester, United Kingdom
THE MANAGEMENT OF OSTEOARTHRITIS IN A HOSPITAL SETTING
Abdelrazig M. Salih;
Rheumatology Department, Warrington Hospital (NHS), Warrington, United Kingdom
OSTEOPOROSIS SCREENING FOR PATIENTS WITH RHEUMATOID
ARTHRITIS ATTENDING AN ANNUAL REVIEW CLINIC
Tracey A. O’Rourke, Yvonne Hough, Ann Clayton, Adrian Clewes, Mike Lynch, Julie Dawson,
Rikki Abernethy;
Rheumatology Department, St Helens and Knowsley NHS Hospital, St Helens, United Kingdom
COMPLIANCE OF PATIENTS ON DMARDS TO BLOOD MONITORING
Samy Zakout, Mark Pugh, Elaine Healey; Rheumatolgy, St Mary’s Hospital,
Newport, United Kingdom
UTILITY OF SPECIALIST REGISTRAR-RUN URGENT REVIEW CLINICS IN RHEUMATOLOGY
Sangeetha Baskar, Li Koh, Karen Obrenovic, Adrian Pace, Karen Douglas, Nicola Erb,
George D. Kitas, Andrew J. Whallett, Rainer Klocke;
Rheumatology, Dudley group of hospitals, Dudley, United Kingdom
102

Poster No. 392
Poster No. 393
Poster No. 394
Poster No. 395
SURVEY TO DETERMINE PATIENT SATISFACTION WITH PRESCRIBED ORTHOSES AND
FOOTWEAR
Yvonne Hough, Elizabeth Macauley, Ann E. Griffiths, Gemma Abbott, Ian Spencer, Adrian
Clewes, Julie K. Dawson, Mike P. Lynch, Rikki E. Abernethy;
Rheumatology Department, St Helens Hospital, Merseyside, United Kingdom
PATIENTS’ KNOWLEDGE OF AND PREFERENCES FOR HEALTHY FOOD OPTIONS
Madeline O’Neill, Christina Doyle, Patricia Minnock;
Rheumatology Rehabilitation, Our Lady’s Hospice, Dublin, Ireland
COMMUNITY RHEUMATOLOGY? IS THIS THE WAY FORWARD?
Barbara Douglas, Sally Giles, Heather Keating, Tom Sheeran, Tom Price, Venkat Chalam;
Rheumatology, Cannock Chase Hospital, Cannock, United Kingdom
AN OVERVIEW OF INFUSION SERVICE FACILITATION - THE CANNOCK EXPERIENCE
Samantha Roskell, Susan Matthews, Lynda Rogers, Tom Price, Tom Sheeran,
Diarmuid Mulherin, Venkat Chalam;
Rheumatology, Cannock Chase Hospital, Cannock, United Kingdom
Poster Viewing Three | Friday 01 May 2009
Poster No. 396
Poster No. 397
Poster No. 398
Poster No. 399
RELOCATING PAEDIATRIC SERVICES INTO A PAEDIATRIC SETTING - HOW SUCCESSFUL
HAS THIS BEEN?
Anne Trehane, Patricia Cornell, Paul Thompson;
Rheumatology, Poole Hospital NHS Foundation Trust, Poole, United Kingdom
GOUT MANAGEMENT IN SECONDARY CARE: AN AUDIT
Kenneth Baker, Mohammed Bakr, Bara El-Khayat, Malgosia Magliano;
Department of Rheumatology, Stoke Mandeville Hospital, Aylesbury, United Kingdom
SUCCESSFUL CONTINUING PROFESSIONAL DEVELOPMENT OF THE MULTIDISCIPLINARY
TEAM - "WORKING TOGETHER, LEARNING TOGETHER"
Lindsey S. Wilcox, John Halsey, Marwan Bukhari;
Rheumatology, Royal Lancaster Infirmary, Lancaster, United Kingdom
OUTCOMES FROM A COMBINED RHEUMATOLOGY-OBSTETRIC CLINIC
Viral Amin 1 , David Williams 2 , Ian Giles 1 ;
1
Department of Rheumatology, University College London Hospital, London, United Kingdom;
2
Institute of Women’s Health, University College London Hospital, London, United Kingdom
Poster No. 400
AUDIT OF PATIENT AWARENESS OF OSTEOPOROSIS AND ITS RISK FACTORS
Rachael Tan 1 , Madhura Castelino 1 , Robert Wilkinson 2 , Lee-Suan Teh 1 ;
1
Department of Rheumatology, Royal Blackburn Hospital, Blackburn, United Kingdom;
2
Department of Endocrinology, Royal Blackburn Hospital, Blackburn, United Kingdom
Poster No. 401
THE ROLE OF A PHYSIOTHERAPY JOINT INJECTION CLINIC WITHIN A RHEUMATOLOGY
DEPARTMENT
Ann Griffiths 1,2 , Michael Lynch 1 , Adrain Clewes 1 , Julie Dawson 1 , Rikki Abernethy 1 ;
1
Rheumatology Unit, St Helens & Knowsley Teaching Hospitals NHS Trust, St Helens, United
Kingdom; 2 Therapy Service, NHS Knowsley, Knowsley, Liverpool, United Kingdom
103

Poster No. 402
Poster No. 403
Poster No. 404
Poster No. 405
Poster No. 406
Poster No. 407
Poster No. 408
Poster No. 409
Poster No. 410
Poster No. 411
NURSE LED BIOLOGIC CLINICS IN THE CARE OF PATIENTS WITH RHEUMATOID ARTHRITIS
(RA). A DISTRICT GENERAL HOSPITAL (DGH) EXPERIENCE
Teresa Doherty, Julian Heath, Sathianathan Pathakalam;
Rheumatology, Eastbourne District General Hospital, Eastbourne, United Kingdom
AN AUDIT OF MANAGEMENT OF ADULTS WITH HOT SWOLLEN JOINTS PRESENTING
TO SALFORD ROYAL ACCIDENT AND EMERGENCY DEPARTMENT(A&E)
Maryam Shahbaz-Samavi;
Rheumatology, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
SLEEP DISTURBANCE IN PATIENTS WITH RHEUMATOID ARTHRITIS
Penny Storrs, Cai Brockley, Frank McKenna;
Rheumatic Diseases Unit, Trafford NHS Healthcare Trust, Manchester, United Kingdom
IN-HOUSE MANTOUX TESTING IS BETTER FOR PATIENTS
Narabda Kara 1 , Veronica H. Love 1 , Jackie Hewlett 2 , Andrew C. Keat 1 ;
1
Rheumatology, Northwick Park Hospital, Harrow, United Kingdom; 2 Infectious Diseases,
Northwick Park Hospital, Harrow, United Kingdom
IMPACT OF MUSCULOSKELETAL INTERFACE SERVICES AND ‘CHOOSE & BOOK’ ON
REFERRALS TO A RHEUMATOLOGY DEPARTMENT
Deepak Jadon 1 , Emma Clark 2 , Nicola Minaur 1 ;
1
Rheumatology Department, North Bristol NHS Trust, Bristol, United Kingdom; 2 Academic
Rheumatology Department, University of Bristol, Bristol, United Kingdom
THE IMPACT OF PODIATRY INPUT INTO A RHEUMATOLOGY CLINIC
Derek A. Robertshaw 1 , David J. Walker 2 ;
1
Podiatry, Freeman Hospital, Newcastle-on-Tyne, United Kingdom; 2 Musculo-Skeletal Unit,
Freeman Hospital, Newcastle-on-Tyne, United Kingdom
A PILOT STUDY OF THE RA-WIS 2 AS A SCREENING TOOL FOR WORK DISABILITY IN THE
RHEUMATOLOGY CLINIC
Claire Sampson 1 , Jillian Frusher 1 , Anne Meadows 2 , Nicholas Sheehan 2 , Sandeep Dahiya 2 ;
1
Therapy Services, Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough,
United Kingdom; 2 Rheumatology Department, Peterborough and Stamford Hospitals NHS
Foundation Trust, Peterborough, United Kingdom
TELEPHONE REVIEW FOR PATIENTS WITH RHEUMATOID ARTHRITIS - A VIABLE OPTION?
Lindsey M. Hawley, Brian M. Quilty;
Rheumatology, Christchurch Hospital, Christchurch, United Kingdom
PRACTITIONERS CONFIDENCE IN BLOOD TEST REQUESTING IN A MUSCULOSKELETAL
ASSESSMENT SERVICE
Julie Dawson 1,2 , Elaine Hough 2 , Joanne Pates 1 , Treena Chillingworth 2 , Kerry Brookfield 2 ,
Ruth Sephton 2 ;
1
Dept of Rheumatology, St Helens and Knowsley Teaching Hospitals, Merseyside,
United Kingdom; 2 MCAS, Knowsley NHS, Merseyside, United Kingdom
THE PERFECT CARPAL TUNNEL CLINIC
Sophia Mavrommatis, Mary Boland, David Holder, Elliot D. Sorene, Vanessa H. Morris;
University College London Hospitals NHS Foundation Trust, London, United Kingdom
104

Poster No. 412
Poster No. 413
Poster No. 414
MANAGEMENT OF SEPTIC ARTHRITIS AT A UK DISTRICT GENERAL HOSPITAL
Ying-Qiao Wong, Gemma Morgan, Laurel Young;
Rheumatology, Royal Berkshire Hospital, Reading, United Kingdom
THE POOLE RHEUMATOLOGY NEWSLETTER - THE PATIENTS’ PERSPECTIVE
Sue Benjamin, Patricia Cornell, Sarah Wright, Selwyn Richards, Paul Thompson;
Rheumatology, Poole Hospital NHS Foundation Trust, Poole, United Kingdom
A MULTIAGENCY COMPREHENSIVE REHABILITATION PROGRAMME FOR PATIENTS WITH
FIBROMYALGIA
Sophie Taylor 1,2 , Amanda Richards 1 , Abebaw Yohannes 2 ;
1
Therapies Directorate, Royal Liverpool and Broadgreen University Hospitals NHS Trust,
Liverpool, United Kingdom; 2 Physiotherapy Programmes, Faculty of Health, Psychology &
Social Care, Manchester Metropolitan University, Manchester, United Kingdom
Poster No. 415 TELEPHONE ADVICE LINES FOR CHILDREN WITH MUSCULO SKELETAL COMPLAINTS -
ARE THEY AN EFFICIENT USE OF PRACTITIONER TIME?
Anne Trehane, Tricia Cornell, Paul Thompson;
Rheumatology, PooleHospital Foundation Trust, Poole, United Kingdom
Poster Viewing Three | Friday 01 May 2009
BHPR research
Poster No. 416
Poster No. 417
Poster No. 418
Poster No. 419
SLEEP IN RHEUMATOID ARTHITIS: AN INTERVENTION TO IMPROVE SLEEP
QUALITY IN PATIENTS WITH RHEUAMATOID ARTHRITIS
Audrey M. Jolly;
Rheumatology, Derriford Hospital, Derriford Road, Plymouth, United Kingdom
THREE DIMENSIONAL MOTION ANALYSIS OF THE RHEUMATOID PROXIMAL
INTERPHALANGEAL JOINT WITH A SILVER RING SPLINT IN SITU: A MATCHED CASE
STUDY
Zoe Gallos, Jo Adams, Cheryl Metcalf;
School of Health Sciences, University of Southampton, Southampton, United Kingdom
ACCEPTABILITY, CONTENT AND FORMAT FOR A GENERIC EXERCISED-BASED
SELF-MANAGEMENT PROGRAMME FOR CHRONIC ILLNESS
Mike Hurley, Patrick White, Kate Doran, Claire Heppenstall;
King’s College London, London, United Kingdom
THE EFFECT OF LUMBAR STABILISING EXERCISES ON CROSS SECTIONAL AREA OF THE
MULTIFIDUS MUSCLE IN CHRONIC LOW BACK PAIN
Rakesh Kumar 1,2 , Jeanette Thom 1 , Jeremy Jones 1,3 ;
1
School of Sport, Health and Exercise Sciences, Bangor University, Bangor, United Kingdom;
2
Dept of Physiotherapy, North West Wales NHS Trust, Bangor, United Kingdom; 3 Dept of
Rheumatology, North West Wales NHS Trust, Bangor, United Kingdom
Poster No. 420
TRANSLATING THE EDUCATIONAL NEEDS ASESSMENT TOOL FOR RHEUMATOID
ARTHRITIS PATIENTS INTO 4 EUROPEAN LANGUAGES
Claire Hale, Jackie Hill, Mwidimi Ndosi; Academic and Clinical Unit for Musculoskeletal
Nursing, University of Leeds, Leeds, United Kingdom
105

Poster No. 421
Poster No. 422
Poster No. 423
Poster No. 424
Poster No. 425
Poster No. 426
Poster No. 427
Poster No. 428
THE EFFECT OF INDIVIDUAL PHYSIOTHERAPY ON PSYCHOSOCIAL VARIABLES IN SPINAL
PAIN PATIENTS - A PILOT STUDY
Lindsay M. Bearne 1 , Philippa Hartridge 1 , Johan Holte 2 , Emma L. Godfrey 1 ;
1
Division of Applied Biomedical Research, Kings College London, London, United Kingdom;
2
Physiotherapy Department, Kings College Hospital NHS Foundation Trust, London,
United Kingdom
A COMPARISON OF PSYCHOLOGICAL DISTRESS AMONG PEOPLE WITH RHEUMATOID
ARTHRITIS, OSTEOARTHRITIS, MULTIPLE SCLEROSIS AND MYOCARDIAL INFARCTION
Mollie Gilchrist, Andrew P. Turner, Julie H. Barlow, Alison Hipwell;
Applied Research Centre in Health & Lifestyle Interventions, Coventry University, Coventry,
United Kingdom
DELAY IN PRESENTATION TO PRIMARY CARE IN RA PATIENTS OF SOUTH ASIAN ORIGIN
Kanta Kumar 1 , Enid Daley 1 , David M. Carruthers 1 , Deva Situnayake 1 , Caroline Gordon 1 ,
Karl Grindulis 1 , Christopher D. Buckley 2 , Peter Nightingale 3 , Fazal Khattak 1 , Karim Raza 1 ;
1
Department of Rheumatology, Sanwell and West Birmingham Hospitals NHS Trust,
Birmingham, United Kingdom; 2 MRC Centre for Immune Regulation, University of Birmingham,
Birmingham, United Kingdom; 3 Wellcome Trust Clinical Research Facility, Queen Elizabeth
Hospital, Birmingham, United Kingdom;
MEASURING WELL-BEING IN RHEUMATOID ARTHRITIS (RA): THE DEVELOPMENT
OF FIVE WELL-BEING NUMERICAL RATING SCALES (NRS)
Tessa Sanderson 1 , Marianne Morris 2 , Michael Calnan 3 , Pam Richards 4 , Sarah Hewlett 1 ;
1
Academic Rheumatology, University of the West of England, Bristol, United Kingdom; 2 Centre
for Appearances Research, University of the West of England, Bristol, United Kingdom; 3 Centre
for Health Services Research, University of Kent, Canterbury, United Kingdom; 4 Academic
Rheumatology, University of Bristol, Bristol, United Kingdom
HALF OF POSTMENOPAUSAL WOMEN DO NOT FOLLOW RECOMMENDED GUIDELINES ON
DAILY CALCIUM INTAKE
Leigh Morrison, Miranda Cuming, Virginia Gould, Jon Tobias, Emma Clark;
Academic Rheumatology, University of Bristol, Bristol, United Kingdom.
PATIENTS EXPERIENCES OF WEARING THERAPEUTIC FOOTWEAR - A QUALITATIVE
INVESTIGATION
Anita E. Williams 1 , Christopher J. Nester 2 , Michael I. Ravey 3 ;
1
Directorate of podiatry, University of Salford, Salford, United Kingdom; 2 Centre for
Rehabilitation and Human Performance Research, University of Salford, Salford, United
Kingdom; 3 School of Nursing, University of Salford, Salford, United Kingdom.
DO FOOT ORTHOSES AFFECT STABILITY IN PATIENTS WITH RA?
Victoria Cameron 1 , Derek Santos 1 , Adele Osborne 2 ;
1
Queen Margaret University, Edinburgh, United Kingdom; 2 Fife Rheumatic Diseases Unit, Fife,
United Kingdom
THE CLINICAL EFFECTIVENESS OF OFF-THE-SHELF FOOT ORTHOSES ON THE DYNAMICS
OF GAIT IN PATIENTS WITH RA
Victoria Cameron 1 , Derek Santos 1 , Adele Osborne 2 ;
1
Queen Margaret University, Edinburgh, United Kingdom; 2 Fife Rheumatic Diseases Unit, Fife,
United Kingdom
106

Poster No. 429
Poster No. 430
Poster No. 431
A COMPARISON OF PATIENT-INITIATED VERSUS CONVENTIONAL FOLLOW-UP FOR
RHEUMATOID ARTHRITIS
Annette Sands 1 , Nicola Adams 2 ;
1
Occupational Therapy, Wrightington Hospital, Wigan, United Kingdom; 2 Faculty of Medicine
and Health Sciences, University of Nottingham, Nottingham, United Kingdom
QOL SCORES REFLECT DISEASE ACTIVITY BOTH PRE AND POST INITIATION OF
BIOLOGIC THERAPY IN PATIENTS WITH RHEUMATOID AND PSORIATIC ARTHRITIS
Roisin Adams 1 , Chin Teck Ng 2 , Bernadette Lynch 2 , Taj Saber 2 , Eliza Pontiflex 2 , Michael Barry 1 ,
Miriam Molloy 2 , Alexia Grier 2 , Douglas Veale 2 , Barry Bresnihan 2 , Oliver FitzGerald 2 ;
1
National Centre for Pharmacoeconomics, St. James Hospital, Dublin, Ireland;
2
Rheumatology Unit, St.Vincents University Hospital, Dublin, Ireland
IS NURSE-LED CARE EFFECTIVE? A SYSTEMATIC REVIEW OF PHYSICIAN-NURSE
SPECIALIST COMPARISON STUDIES IN RHEUMATOLOGY
Karen Vinall, Mwidimi Ndosi, Jackie Hill;
Academic and Clinical unit for Musculoskeletal Nursing, University of Leeds, Leeds,
United Kingdom
Poster Viewing Three | Friday 01 May 2009
Poster No. 432
PATIENT AND PROFESSIONAL VIEWS OF LONG-TERM MANAGEMENT STRATEGIES FOR
OSTEOARTHRITIS OF THE KNEE: A QUALITATIVE STUDY
Nicola E. Walsh 1 , Kathryn Badlan 1 , Mike V. Hurley 2 ;
1
Faculty of Health and Life Sciences, UWE, Bristol, United Kingdom; 2 Academic
Physiotherapy Department, King’s College, London, United Kingdom
Poster No. 433
CONCURRENT VALIDITY OF HAND-HELD SPHYGMOMANOMETER DYNAMOMETRY FOR
MEASURING THIGH MUSCLE STRENGTHS
Laurence R. Wood, Elaine M. Hay, Julius Sim;
Arthritis Research Campaign National Primary Care Centre, Keele University, Keele,
United Kingdom
Poster No. 434
RCT EXAMINING THE EFFECTS OF EXERCISE FOR PEOPLE WITH RHEUMATOID ARTHRITIS
ON ANTI-TNFα MEDICATION
Angela Reid 1 , Audrey Brady 1 , Tara Cusack 2 , Catherine Blake 2 , Ann-Barbara Mongey 3 ,
Douglas J. Veale 3 , Oliver FitzGerald 3 ;
1
Physiotherapy, Our Lady’s Hospice, Dublin, Ireland; 2 School of Physiotherapy and
Performance Science, University College Dublin, Dublin, Ireland; 3 Rheumatology,
St. Vincent’s University Hospital, Dublin, Ireland
Poster No. 435
EXPERIENCES OF LIVING WITH AND SELF-MANAGING ARTHRITIS: A QUALITATIVE
EXPLORATION FROM PUNJABI SIKH WOMEN’S PERSPECTIVES
Alison Hipwell, Andrew P. Turner, Julie H. Barlow;
Applied Research Centre in Health and Lifestyle Interventions, Coventry University,
Coventry, United Kingdom
Poster No. 436
PARTNERS’ EXPERIENCES OF LIVING WITH RHEUMATOID ARTHRITIS:
"YOUR WHOLE LIFE, YOUR WHOLE WORLD, IT CHANGES"
Lauren E. Matheson, Diana Harcourt, Sarah Hewlett;
Health and Life Sciences, University of the West of England, Bristol, United Kingdom
107

Poster No. 437
“IT’S LIKE TAKING POISON TO KILL POISON BUT I HAVE TO GET BETTER”:
A QUALITATIVE STUDY OF BELIEFS ABOUT MEDICINES IN RA AND SLE PATIENTS
OF SOUTH ASIAN ORIGIN
Kanta Kumar 1 , Caroline Gordon 1 , Robert Barry 1 , Harpal Tiwana 1 , Karen Shaw 5 , Karim Raza 1 ;
1
Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom;
5
University of Birmingham, Birmingham, United Kingdom;
Poster No. 438
DO PERCEPTIONS ABOUT HAND OSTEOARTHRITIS CHANGE OVER AN 18-MONTH PERIOD?
Susan Hill 1 , Elaine Nicholls 1 , Helen Myers 1 , George Peat 1 , Elaine Thomas 1 , Michelle Marshall 1 ,
Danielle van der Windt 1,2 , Krysia Dziedzic 1 ;
1
Arthritis Reseach Campaign National Primary Care Centre, Staffordshire, United Kingdom;
2
EMGO Institute, VU University Medical Center, Amsterdam, Netherlands
Poster No. 439
EDUCATIONAL NEEDS OF PATIENTS WITH 6 RHEUMATIC DISEASES
Mwidimi Ndosi 1 , Jackie Hill 1 , Claire Hale 2 , Bernadette Hardware 3 ;
1
Academic & Clinical Unit for Musculoskeletal Nursing, University of Leeds, Leeds, United
Kingdom; 2 School of Healthcare, University of Leeds, Leeds, United Kingdom; 3 Research &
Development, Barnsley Hospital NHS Foundation Trust, Barnsley, United Kingdom
108

Exhibition Floor Plan
Exhibition Floor Plan

Exhibition Floor Plan
Exhibition Floor Plan | 28 April - 01 May ’09
109

Exhibitor Details
Stand Number Company
A10
Rheumatology/OUP
A11
Alkaptonuria Society
A12
Siemens
A40
Healthcare at Home
A42
Up to Date Inc
A44
Smith and Nephew
A46
The London Lupus Centre
B50
Know about your DAS
B54
Vertec Scientific
C8
Ehlers-Danlos Support Group
C10
Promedics
C12
Genzyme
C13
Medtronic
C14
RCN RF
C15
PRCA
C16
Lupus UK
C17
NRAS
C20/C21 ARMA
C22
BSSA
C23
Arthritis Care
C24
The Scleroderma Society
C25
PSALV
C26
NASS
C27
Fibromyalgia Association
C30
Wyeth
C40
Abbott
C50
Esaote
C9
arc
E20
UCB
E30
Schering-Plough
E40
Servier
E42/E46 BMS
E44
MSD
F20
Napp
F22
Pfizer
F24/F26 Novartis
F30
Roche (Mabthera)
F40
Roche (Bonviva)
F45 Chugai Roche (IL 6)
G20
Goldshield plc
G30/G35 Actelion
G31/G32 Sonosite
G33
Galen
G34
Altacor
G36
TRB Chemedica
G37
Kennedy Institute of Rheumatology
G38
BSR Biologics Register
G39
4S Information Systems Ltd
G40
Proctor & Gamble
G45
Medac
BSR Stand 25th Anniversary exhibition
and BSR/BHPR stand
110
4S Information Systems Ltd (Stand G39)
Kiss goodbye to the frustration of searching for results
and information! Kiss goodbye to filling out forms!
Kiss goodbye to the fear of missing an out-of-line
result! Fall in love with DAWN Rheumatology Clinic
Software and Embrace improved safety, quality and
productivity.
Abbott (Stand C40)
Abbott is a global, broad-based health care company
devoted to discovering new medicines, new
technologies and new ways to manage health. Abbott
scientists are applying innovative monoclonal antibody
technology to discover and develop novel therapies to
treat diseases of the immune system including
rheumatoid arthritis, psoriatic arthritis, ankylosing
spondylitis, Crohn’s disease and psoriasis.
Actelion (Stand G30/G35)
Actelion Pharmaceuticals Ltd is a biopharmaceutical
company headquartered in Allschwil/Basel, Switzerland,
focusing on the discovery, development and
commercialisation of innovative treatments to serve
high unmet medical needs. Please come and visit at
stand G30 and G35 for more information on our
products and clinical data.
Alkaptonuria Society (Stand A11)
Alkaptonuria Society is a charity raising awareness
about the rare genetic disease Alkaptonuria.
Alkaptonuria sufferers are missing an enzyme (HGAO)
and homogentistic acid builds up in the body tissues
where it is toxic. The result is ochronosis, a blue-black
discolouration of the connective tissue. Alkaptonuria is
a debilitating and serious disease that damages bone,
cartilage, blood vessels and other parts of the body.
Altacor (Stand G34)
Altacor is an ophthalmology development company.
The pipeline comprises development and marketed
therapeutic procducts in ocular surface disease, ocular
anti-infectives and glaucoma. Altacor has four Dry Eye
products marketed in the UK, Clinitas (prescription)
and Clinitas range all commercialized through its own
sales and marketing organization. The development
portfolio of prescription products includes novel anti
infectives with broad activity against bacteria,
fungi/yeasts and a low propensity to resistance.

arc (Stand C9)
The Arthritis Research Campaign (arc) is the UK’s
fourth largest medical research charity and the only
charity solely committed to funding high-quality
research into the causes and treatment of all types
of arthritis and musculoskeletal conditions. We rely
entirely on public donations to fund our research and
education programmes, spending over £20m a year
supporting research aimed at improving the lives of
people with arthritis.
ARMA (Stand C20/C21)
The Arthritis and Musculoskeletal Alliance (ARMA)
brings together over 30 member organisations
including support groups, professional societies and
research organisations. Visit our stand to find out
how you can use the Standards of Care and our local
networks to share good practice and improve services
in your area. Also find out more about our members
and policy developments in the musculoskeletal
community.
Arthritis Care (Stand C23)
Come and visit us at Stand C23 and see how
Arthritis Care can enhance the value of your service.
Influencing health policy and services through
campaigning, Providing self management training
courses to help patients manage their condition.
Offering a free confidential helpline to support your
patients throughout their experience of their condition
and providing award winning information enabling
patients to make better use of appointments.
Bristol-Myers Squibb (Stand E42/E46)
Bristol-Myers Squibb is a global pharmaceutical
company whose mission is to extend and enhance
human life. Ranked in the top ten for a number of
products in the R&D pipeline, we are looking forward
to an impressive stream of novel treatments. In the
UK, Bristol-Myers Squibb is one of the largest supplier
of medicines to NHS hospitals.
British Health Professionals in Rheumatology
(Exhibition and Seating Area)
British Health Professionals in Rheumatology (BHPR)
unites and supports members of the multi-disciplinary
team in delivering best quality care which meets the
needs of individuals with musculoskeletal conditions.
We have over 500 members from many professions:
nursing, physiotherapy, occupational therapy, podiatry,
psychology, social work, medicine, pharmacy and
others. Come and visit our stand to learn about
joining our society.
111
British Society for Rheumatology
(Exhibition and Seating Area)
British Society for Rheumatology (BSR) promotes
excellence in the treatment of people with arthritis
and musculoskeletal conditions, and supports those
delivering it. Come and visit our exhibition celebrating
our 25th anniversary; pick up the new draft guidelines
for treatment of RA with biologic therapies and hear
our plans for the new BSR website.
BSR Biologics Register (Stand G38)
The British Society for Rheumatology Biologics
Register (BSRBR) is a prospective observational
cohort study of patients receiving biologic therapy
for rheumatoid arthritis in the UK. In addition, a
comparison cohort of patients receiving DMARD
therapy is also being collected. Data collection is via
the rheumatology team, the patient and the NHS IC.
The primary aim of the study is to monitor the
long-term safety of these therapies in RA.
BSSA (Stand C22)
Sjögren’s Syndrome is an auto immune condition
affecting 3-4% of adults in the UK, Sjögren’s
Syndrome is under diagnosed and may frequently go
untreated. It is a disorder that causes dry eyes and a
dry mouth plus extreme fatigue. The British Sjögren’s
Syndrome Association supports patients and carers,
educates the public and professionals and raises
funds for research into this disabling condition.
Chugai (Stand F45)
Chugai’s mission is to dedicate itself to adding
exceptional value through the creation of innovative
medical products and services for the benefit of the
medical community and human health around the
world.
Ehlers-Danlos Support Group (Stand C8)
Ehlers-Danlos Syndrome is the name given to a
group of inherited disorders of connective tissue. It is
characterised by abnormalities of skin, ligaments and
internal organs. Joints are unstable and hypermobile
and chronic joint and limb pain is common. The
Ehlers-Danlos Support Group aims to provide
information, advice and support for people with
Ehlers-Danlos Syndrome and their families.
Exhibition Floor Plan | 28 April - 01 May ’09

Esoate (Stand C50)
Visit the Esaote stand to discuss the exciting
opportunities that the latest generation of Ultrasound
scanners can offer your Rheumatology practice.
Showcasing will be the revolutionary portable
ultrasound scanner the MyLab25Gold; as well as a
must see for Rheumatology ‘09 the first showing of
Esaote’s state-of-the-art advanced MyLab70XVG
Virtual Navigator fusion imaging system.
Come and visit us and be innovated!
Fibromyalgia Association (Stand C27)
Fibromyalgia Association UK (FMA UK) is the national
charity supporting those with fibromyalgia, their
families and carers by:
• Providing information and support.
• Promoting awareness among health professionals,
the general public, and government.
• Lobbying for effective and available treatment.
• Facilitating the networking of those with
fibromyalgia.
• Encouraging self help.
Galen Limited (Stand G33)
Galen Limited is a privately owned pharmaceutical
company that promotes branded and generic
prescription medicines in the UK and Ireland. Galen’s
objective is to improve the healthcare of patients by
providing innovative products and developing
joint-working relationships with healthcare
professionals. Visit the Galen stand for more
information on the company and its interest in
osteoporosis. We look forward to meeting you!
Genzyme (Stand C12)
4620 Kingsgate
Cascade Way
Oxford Business Park South
OX4 2SU
www.genzyme.com
Goldshield Plc (Stand G20)
NLA Tower, 12th Floor
12-16 Addiscombe Road
Croydon
Surrey
CR0 0XT
www.goldshieldplc.com
Healthcare at Home (Stand A40)
Healthcare at Home are the UK’s leading provider of
high-tech home healthcare and speciality pharmacy
services, covering numerous disease areas. We also
deliver innovative services on-site throughout the NHS
and independent sector.
Our 750 staff include over 400 highly skilled and experienced
nurses. Operating from 24 locations throughout
the UK, our unrivalled infrastructure keeps us close to
over 70,000 patients 24 hours a day, 365 days a year.
Kennedy Institute of Rheumatology (Stand G37)
The Kennedy Institute of Rheumatology is part of
Imperial College London, and supports both clinical and
non-clinical scientists working on the pathogenesis and
treatment of rheumatological disease. Research
projects range from clinical trials to basic matrix
biochemistry and immunology. This integrated
approach allows for successful translational research
as well as providing an ideal environment for training
and fostering the development of academic clinicians.
Know about your DAS (Stand B50)
The stand launches the new National Rheumatoid
Arthritis Society (NRAS) booklet, ‘Know About Your
DAS’. The DAS booklet is designed to educate and
provide an overview of DAS to patients with rheumatoid
arthritis and to enable patients to track their DAS and
feel better informed about their disease. The stand
is sponsored by Roche Products Ltd in collaboration
with NRAS.
The stand will be used for:
• Distribution of DAS booklets
• BSR attendees to discuss the assessment of
DAS with other healthcare professionals
The London Lupus Centre (Stand A46)
(www.thelondonlupuscentre.com)
This International Centre is aimed at the diagnosis and
management of patients with lupus, Hughes Syndrome
and related rheumatic disorders.
The Centre comprises nine Consultant Rheumatologists
and is supported by the multi-specialist facilities
available at London Bridge Hospital.
For further information:
Tel: +44 (0)20 7234 2155
Fax: +44 (0)20 7234 2462
Email: londonlupuscentre@hcahealthcare.co.uk
112

Lupus UK (Stand C16)
LUPUS UK is the only national charity for patients with
lupus offering support through our voluntary network
of over 25 Regional Groups. Our priorities are to
increase lupus awareness amongst the public and the
medical profession, provide support to our members,
and raise funds towards research and Lupus Nurses.
Tel: 01708 731251 (24 hour answerphone)
website www.lupusuk.org.uk
Medac UK (Stand G45)
Metoject® - a fresh new blend of experience and
innovation in the treatment of rheumatoid arthritis.
Our new, improved methotrexate syringe has been
developed as the result of feedback from prescribers
and end users. Come to the Medac stand to learn
more about new improved Metoject.
Medtronic (Stand C13)
Medtronic is the global leader in medical technology -
alleviating pain, restoring health, and extending life
for millions of people around the world.
Spinal and Biologics is Medtronic’s second largest
business. Our market leadership is largely a result of
our innovation: we’re developing many of the new
standards of care in spinal and musculoskeletal
therapies. We collaborate with world-renowned
surgeons and researchers to offer state-of-the-art
therapies for spinal, neurological and orthopaedic
conditions. www.medtronic.co.uk
MSD (Stand E44)
Merck Sharp and Dohme Limited (MSD) is the
subsidiary of Merck & Co., Inc., of Whitehouse
Station, New Jersey, USA, a leading research-based
pharmaceutical company that discovers, develops,
manufactures and markets a wide range of innovative
pharmaceutical products to improve human health.
Napp Pharmaceuticals (Stand F20)
Napp Pharmaceuticals Limited is renowned as a
leader in pain control with a reputation for expertise
in novel formulations and an impressive list of
pioneering products to help individuals fight the
burden of chronic pain.
NASS (Stand C26)
The National Ankylosing Spondylitis Society (NASS)
was founded over 30 years ago to provide support
and advice for patients and their families. NASS works
to raise awareness of AS and provides a website,
publications and information as well as running a
branch network of around 95 branches throughout
the UK offering regular supervised exercise sessions.
NASS members also participate in ongoing genetic
research into the disease. www.nass.co.uk
Novartis (Stand F24/F26)
Novartis is a company committed to the discovery and
development of medicines in areas of unmet clinical
need. The therapeutic areas that Novartis works in
include cardiovascular and metabolism, neuroscience,
respiratory, arthritis, bone, infectious diseases,
transplantation and immunology and oncology.
Our product pipeline is one of the strongest in the
pharmaceutical industry and in the UK alone we
spend around £1 million per week on research and
development.
NRAS (Stand C17)
NRAS is the only patient-led UK charity focusing on
people with Rheumatoid Arthritis, their families and
carers. We aim to help these groups by:-
• providing information and support
• facilitating networking and encouraging self-help
• raising public and government awareness
• campaigning for more funding and better use of
existing resources
Pfizer (Stand F22)
Pfizer Inc., founded in 1849, is dedicated to better
health and greater access to health care for people
and their valued animals. Every day, colleagues in
more than 150 countries work to discover, develop,
manufacture and deliver quality, safe and effective
prescription medicines to patients.
In the UK, Pfizer has its European R&D headquarters
at Sandwich and its UK business headquarters in
Surrey, and is the major supplier of medicines to the
NHS. Pfizer’s annual UK R&D investment is more
than £550 million – more than £10 million a week.
Exhibition Floor Plan | 28 April - 01 May ’09
PRCA (Stand C15)
The PRCA is an independent group working towards
excellence in the care of rheumatic foot disorders
through education and research.
www.prcassoc.org.uk
113

Procter & Gamble Pharmaceuticals (Stand G40)
Procter & Gamble has a rich heritage in health care
that extends back more than 150 years. Then and
now, P&G is driven by our mission to improve the lives
of people around the world every day. P&G’s health
care products include prescription medicines,
over-the-counter medications and oral care products.
P&G began developing and marketing prescription products
in the late-1960s.
Promedics (Stand C10)
Promedics are a UK manufacturer and supplier of
an extensive range of splints and supports for all
conditions and all areas of the body. We have over 25
years experience of dealing with the health service and
in particular Rhematology. We look forward to
welcoming you to our stand.
PSALV (Stand C25)
PSALV, PSORIASIS SCOTLAND ARTHRITIS LINK
VOLUNTEERS.
The only Scottish charity for all with skin psoriasis,
and associated inflammatory arthritis- PsA. PSALV is
a national Scottish charity with expert advisers, and a
small grant from the Scottish Government.
We aim to raise awareness of these debilitating
misunderstood diseases. We provide literature for
enquirers and clinics, hold open info meetings with
specialists, campaign and lobby at Holyrood.
RCN RF (Stand C14)
The Royal College of Nursing Rheumatology Forum
exists to give support to nurses involved in the care of
rheumatology patients. Currently membership stands
at over 1200 nurses who have voiced an interest in
rheumatology issues. The stand will be open during the
break times and staffed by members of the committee,
please drop by and say hello to us.
Rheumatology/OUP (Stand A10)
Oxford University Press publishes some of most
respected medical books and journals in the world
including the Oxford Textbook of Rheumatology and
Rheumatology which is published on behalf of the
British Society for Rheumatology. Visit our stand to
discover more about our quality products, and to pick
up a free copy of the journal.
Roche (F30, F40 and F45)
Roche aims to improve people’s health and quality of
life with innovative products and services for the early
detection, prevention, diagnosis and treatment of
disease. Part of one of the world’s leading healthcare
groups, Roche in the UK employs nearly 2,000 people
in pharmaceuticals and diagnostics. Globally Roche is
the leader in diagnostics, and a major supplier of
medicines for the treatment of cancer, transplantation,
virology, bone and rheumatology, obesity and renal
anaemia.
Schering-Plough (Stand E30)
Schering-Plough is an innovation-driven,
science-centered global health care company. Through
its own biopharmaceutical research and
collaborations with partners, Schering-Plough creates
therapies that help save and improve lives around the
world. The company applies its research-anddevelopment
platform to human prescription and
consumer products as well as to animal health
products.
Servier Laboratories (Stand E40)
Servier Laboratories is the UK subsidiary of The Servier
Research Group, the leading independent French
research based pharmaceutical company. The key
franchises of the Servier Research Group are rheumatology,
cardiovascular disease, diabetes, Central
Nervous System and oncology. Servier regularly invests
more than 25% of its annual turnover into research,
discovering and delivering therapeutic innovations to
patients through their healthcare professionals.
Siemens (Stand A12)
In line with Siemens reputation for innovation we will
be showcasing the new ACUSON X300 PE ultrasound
system. The X300 PE is an ultra-compact,
performance-oriented system designed for clinical
efficiency. With an operator-friendly console that helps
to reduce arm and hand movement and its small,
lightweight transducers, the X300 PE system takes
the pain and pressure out of routine scanning.
See us at stand A12 for more details.
114

Smith & Nephew (Stand A44)
Smith & Nephew will be presenting advanced
DUROLANE scientific information at stand A44
A collection of recently presented pre-clinical studies
show how the DUROLANE NASHA formulation
improves intra-articular residence time, resistance to
degradation and exhibits prolonged anti-nociceptive
behaviour compared with standard HA.
We are pleased to support BSR and look forward to
meeting you in Glasgow.
Sonosite (Stand G31/G32)
SonoSite is the world leader and specialist in
hand-carried ultrasound. All SonoSite systems are
drop-tested to 1 metre and come with a fluid resistant
membrane for ease of cleaning along with the
company’s 5-year warranty to deliver the lowest cost
of ownership in point-of-care medicine.
Visit stand G31 and G32 to see the very latest is
hand-carried ultrasound.
The Scleroderma Society (Stand C24)
A registered charity that has been supporting people
with scleroderma for over 25 years.
The society aims are to:
• Support people with scleroderma
• Increase awareness of scleroderma
• Fund scientific and medical research in
scleroderma
On this stand you will find our range of information
leaflets covering many ways in which people can be
affected by scleroderma.
TRB Chemedica (Stand G36)
Viscoseal enhances post arthroscopy recovery by
replacing lost synovial fluid. Ostenil treats osteoarthritis
in large joints. Ostenil mini treats osteoarthitis in small
joints such as the fingers, toes and shoulder. All TRB
products are non animal derived medical devices.
Samples can be supplied at the stand.
UpToDate (Stand A42)
UpToDate is a dynamic, electronic resource providing
evidence-based, synthesized medical information.
It is written and peer-reviewed by leading doctors
worldwide, and is designed to anticipate questions
and support clinical decision-making across thousands
of Topics in 14 clinical specialties. A recent
survey indicated that 98% of UK doctors with access
to UpToDate, during a one-year pilot trial at 18 major
teaching trusts, were satisfied or very satisfied with it
as a clinical resource.
Vertec Scientific (Stand B54)
Vertec Scientific would like to welcome you to the
BSR. We are the UK distributors for Hologic Dexa
Scanners, which have been the system of choice in
the diagnosis of Osteoporosis for over 20 years.
We will also be showing Ultrasonix, a dedicated
Ultrasound scanner for the MSK and Rheumatology
environment as well as ONI the world’s first dedicated
1.5T High Field MRI for extremities.
Wyeth (Stand C30)
Wyeth welcomes all BSR delegates to Glasgow
and invites you to visit us at our stand.
Wyeth is one of the UK’s leading pharmaceutical
companies with a significant commitment to clinical
research. Wyeth is committed to working in
partnership with Government, healthcare
professionals and patient support organisations to
continue to enhance the quality of life for as many
people as possible.
Worldwide, the company focuses on finding
groundbreaking medical therapies, and has a broad
portfolio of leading products across a wide range of
therapy areas, including rheumatological disease.
Exhibition Floor Plan | 28 April - 01 May ’09
UCB (Stand E20)
UCB, headquartered in Brussels, Belgium is a
biopharmaceutical company dedicated to the
research, development and commercialisation of
innovative medicines with a focus on the fields of
central nervous system and immunology disorders.
Employing more than 10,000 people in over 40
countries, UCB produced revenue of 3.6 billion
euro in 2008.
115

Abstract Reviewers
The BSR Heberden Committee was expanded substantially for the purpose of abstract assessment to
ensure that all abstracts were peer reviewed, blind by at least three reviewers. The Heberden Committee
is extremely grateful for the assistance of everyone that gave up their time to review abstracts, and
acknowledges accordingly:
Prof Hill Gaston Heberden Committee Dr Ross Wilkie Heberden Committee
Dr Richard Watts Heberden Committee Dr Andrew Keat Heberden Committee
Prof Chris Denton Heberden Committee Dr Hector Chinoy Heberden Committee
Dr Elizabeth Price Heberden Committee Dr Clive Ryder Heberden Committee
Prof Alex MacGregor Heberden Committee Prof David Sansom Heberden Committee
Dr Chetan Mukhtyar Heberden Committee
Dr David Abraham
Dr Simon Allard
Prof Nigel Arden
Dr John Axford
Dr Andrew Bamji
Dr Ashok Bhalla
Dr Fraser Birrell
Prof Fionula Brennan
Prof Matt Brown
Dr Mya Buch
Prof Chris Buckley
Dr Robin Butler
Dr Geraldine Cambridge
Prof Tim Cawston
Prof Kuntal Chakravarty
Prof Yuti Chernajovsky
Dr Ernest Choy
Prof Ian Clark
Dr Gavin Cleary
Dr Andy Cope
Mrs Trish Cornell
Dr Bhaskar Dasgupta
Dr Peter Dawes
Dr Chris Deighton
Dr Karen Douglas
Dr Michael Ehrenstein
Dr Ian Giles
Mr Stewert Glaspole
Dr Nicola Goodson
Dr Alan Hakim
Ms Alison Hammond
Dr Inam Haq
Prof Dorian Haskard
Mrs Lindsey Hawley
Prof Elaine Hay
Dr Ariane Herrick
Dr Rod Hughes
Ms Keri Hutchinson
Dr Charles Hutton
Prof John Isaacs
Dr Ali Jawad
Dr Rachel Jeffery
Dr Adrian Jones
Dr Jeremy Jones
Dr Sharon Jones
Dr Karen Jubb
Dr Lesley Kay
Dr George Kitas
Dr Rainer Klocke
Dr Thomas Lawson
Dr Alison Leak
Dr Raashid Luqmani
Prof Peter Maddison
Dr Janet McDonagh
Prof Dennis McGonagle
Dr Julie McHale
Dr Adrian Pace
Dr Lazlo Pazmany
Prof Frederique Ponchel
Dr Anisur Rahman
Dr Karim Raza
Dr Anthony Redmond
Prof David Reid
Dr Shirley Rigby
Dr Graham Riley
Prof Drew Rowan
Dr Andrew Russel
Ms Sarah Ryan
Dr Ash Samanta
Dr Dagmar Scheel-Toellner
Dr Preeti Shah
Dr Nick Shenker
Dr Paul Thompson
Dr Robert Thompson
Dr Jon Tobias
Dr Gareth Treharne
Prof Patrick Venables
Dr Tonia Vincent
Dr Lyn Williamson
Dr Gerry Wilson
116

Switching to MabThera can offer your
patients a passport to get away
Dear Doctor,
Following my treatment I am travelling again.
Exploring San Francisco on foot, despite the
hills – I just step onto a tram and whizz
through the streets!
I remember when I came here with my
college friend, many years have passed but it’s
great that I can still enjoy this city.
Thanks
Mary Gibson
MabThera in combination with methotrexate, provides
sustained efficacy 1 with unprecedented treatment
intervals of 6-12 months in severe active RA patients
with an inadequate response to anti-TNF therapy. 2
B SELECTIVE • B EFFECTIVE
PRESCRIBING INFORMATION MABTHERA ® (rituximab) in
Rheumatoid Arthritis: Please refer to MabThera SPC for full
prescribing information. Indication: MabThera, in combination
with methotrexate, for the treatment of adult patients with severe
active rheumatoid arthritis who have had an inadequate response
or intolerance to other DMARDs including one or more TNF inhibitor
therapies. Dosage and Administration: A course of MabThera
consists of two infusions: 1000mg by iv infusion followed by a
second 1000mg iv infusion two weeks later. Administer through a
dedicated line, with full resuscitation facilities immediately available.
Premedication should be given. Monitor for onset of cytokine
release syndrome. Severe reactions e.g. severe dyspnoea,
bronchospasm or hypoxia require immediate interruption of
infusion. First Infusion: Recommended initial infusion rate is
50mg/hr. Second Infusion: Initial rate of 100mg/hr. Dose
adjustments: No dose adjustment is required in elderly patients.
Contraindications: Hypersensitivity to this product or to murine
proteins; active, severe infections; severe heart failure (NYHA Class
IV) or severe, uncontrolled cardiac disease. Precautions: Infusion
reactions: Anaphylactic and other hypersensitivity reactions.
Premedication with iv glucocorticoid is recommended. Treatments
for hypersensitivity reactions should be immediately available.
Presence of HACA may be associated with worsening infusion
reactions. Consider carefully patients with cardiac history and
monitor during administration. Hypotension may occur, consider
withholding antihypertensive medications. Infections: Do not give to
patients with an active and/or severe infection, or severely
immunocompromised patients. Exercise caution in patients with
recurring/chronic infections. Treat and evaluate promptly and
appropriately. Use of MabThera may be associated with an
increased risk of Progressive Multifocal Leukoencephalopathy
(PML). Immunisation: Safety or efficacy of vaccination – consult SPC.
Concomitant/sequential use of other DMARDs: Initial data suggest
that the rate of clinically relevant infection is unchanged.
Malignancy: Limited experience in RA patients cannot exclude a
possible risk for the development of solid tumours. Drug
Interactions: Limited data on drug interactions. Co-administration
with methotrexate had no effect on the pharmacokinetics of
MabThera. Pregnancy and Lactation: Women should not become
pregnant, and should not breastfeed during, and for 12 months
following, treatment. Contraception should be used during, and for
12 months following, treatment. Undesirable effects: Common
adverse reactions: infusion reactions (hypertension, nausea, rash,
pyrexia, pruritis, urticaria, rhinitis, throat irritation, hot flush,
hypotension, chills). Infection (UTI, URTI, any infection). Other:
dyspepsia, hypercholesterolaemia, arthralgia/musculo skeletal pain,
osteoarthritis, parasthesia, migraine. Medically significant events:
Acute infusion reactions, incidence of clinically significant infection,
some of which were fatal, was 0.05 per patient year. Very rare cases
of PML have been reported. Serious cardiac events reported equally
in 2% of MabThera and placebo treated patients. Other: generalised
oedema, bronchospasm, wheezing, laryngeal oedema, angio -
neurotic oedema, generalized pruritis, anaphylaxis, anaphylactoid
reaction. Prescriber should consult SPC for full details of side-effects.
Legal category: POM. Presentations and Basic NHS Costs:
100mg of rituximab in 10ml (10mg/ml) pack of 2 vials: £349.25,
500mg of rituximab in 50ml (10mg/ml) pack of 1 vial: £873.15.
Marketing Authorisation Numbers: EU/1/98/067/001 (100mg),
EU/1/98/067/002 (500mg). Marketing Authorisation Holder:
Roche Registration Limited, 6 Falcon Way, Welwyn Garden City,
Herts AL7 1TW. MABTHERA is a registered trade
mark. MEDI00038 Date of Preparation: January
2009. References: 1. Cohen SB et al. Arthritis
Rheum 2006; 54(9): 2793-2806. 2. MabThera SmPC.
Adverse events should be reported.
Reporting forms and information can be found at
www.yellowcard.gov.uk. Adverse events should also
be reported to Roche Products Ltd. Please contact
Roche Drug Safety Centre on: 01707 367554.
MABR00114f Date of preparation: March 2009.

1
2,3
4
References:
1. Madhok R, Crilly A, Watson J, Capell HA. Serum interleukin 6 levels in rheumatoid arthritis: correlations with
clinical and laboratory indices of disease activity. Ann Rheum Dis. 1993;52:232-234. 2. Naka T, Nishimoto N,
Kishimoto T. The paradigm of IL-6: from basic science to medicine. Arthritis Res. 2002;4(suppl 3):S233-S242.
3. Rose-John S, Scheller J, Elson G, Jones SA. Interleukin-6 biology is coordinated by membrane-bound
and soluble receptors: role in inflammation and cancer. J Leukoc Biol. 2006;80:227-236. 4. Choy E. Inhibiting
interleukin-6 in rheumatoid arthritis. Curr Rheumatol Rep. 2008; 10: 413-417.
Date of preparation: March 2009. ACTE00201a