Genome wide association studies in inflammatory myopathy and
Genome wide association studies in inflammatory myopathy and
Genome wide association studies in inflammatory myopathy and
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Methodological Issues <strong>in</strong> Pre-2000<br />
Studies<br />
• Small sample size<br />
• Ethnic heterogeneity<br />
– Caucasian, Jewish & Hispanic patients grouped<br />
together to ga<strong>in</strong> statistical power <strong>in</strong> case:control<br />
comparisons.<br />
• Sub-type heterogeneity<br />
– DM, PM, JDM & IBM pooled to ga<strong>in</strong> statistical power.<br />
– Ab subgroups