Genome wide association studies in inflammatory myopathy and

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Background • IIM rema<strong>in</strong> a therapeutic challenge – 1) Often refractory 2) Disease mechanisms poorly understood • Mechanistic research difficult, as IIM so rare: ~ 1 new case per UK rheumatologist every 4-5 yrs.
Early genetics - HLA region
Page 1 and 2: IIM GWAS reveals genetic risk facto
Page 3: Polymyositis Dermatomyositis Idiopa
Page 7 and 8: Classification of myositis accordin
Page 9 and 10: UK-Adult Onset Myositis Immunogenet
Page 11 and 12: log OR & 95% confidence interval HL
Page 13 and 14: Myositis-specific autoantibodies My
Page 15 and 16: Dermatomyositis (DM) • Myositis w
Page 17 and 18: GWAS approaches 1 • MYOGEN (UK/EU
Page 19 and 20: Covariate 2 Multidimensional scalin
Page 21 and 22: Populations Studied Cases Controls
Page 23 and 24: Published GWAS loci for AID - Assoc
Page 25 and 26: • The first GWAS in DM confirmed
Page 27 and 28: Total number of participants recrui
Page 29: • Hector Chinoy - Musculoskeletal

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