Genome wide association studies in inflammatory myopathy and

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Next Steps • Immunochip analysis currently being undertaken in DM. • Generate larger cohorts for DM, PM and the rarer MSAassociated IIM subgroups. • So, recruit, recruit, recruit!!! 26
Total number of participants recruited each year Yearly accrual figures since AOMIC began in 2000, became UK MYONET in 2008/9 (current recruitment total 922) 250 200 150 100 50 0 1 2 3 4 5 6 7 8 9 10 11 12 Years
Page 1 and 2: IIM GWAS reveals genetic risk facto
Page 3 and 4: Polymyositis Dermatomyositis Idiopa
Page 5 and 6: Early genetics - HLA region
Page 7 and 8: Classification of myositis accordin
Page 9 and 10: UK-Adult Onset Myositis Immunogenet
Page 11 and 12: log OR & 95% confidence interval HL
Page 13 and 14: Myositis-specific autoantibodies My
Page 15 and 16: Dermatomyositis (DM) • Myositis w
Page 17 and 18: GWAS approaches 1 • MYOGEN (UK/EU
Page 19 and 20: Covariate 2 Multidimensional scalin
Page 21 and 22: Populations Studied Cases Controls
Page 23 and 24: Published GWAS loci for AID - Assoc
Page 25: • The first GWAS in DM confirmed
Page 29: • Hector Chinoy - Musculoskeletal

Genome wide association studies in inflammatory myopathy and

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