Genome wide association studies in inflammatory myopathy and
Genome wide association studies in inflammatory myopathy and
Genome wide association studies in inflammatory myopathy and
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GWAS approaches 1<br />
• MYOGEN (UK/EU/US), an <strong>in</strong>ternational myositis<br />
genetics consortium established to study the genetics of<br />
myositis.<br />
• Objectives of the first MYOGEN study were to identify<br />
new genetic risk or protective factors for DM, <strong>and</strong> to<br />
assess possible genetic overlaps with other AID.<br />
• GWAS performed on subjects of European ancestry<br />
meet<strong>in</strong>g probable or def<strong>in</strong>ite Bohan <strong>and</strong> Peter criteria for<br />
DM, us<strong>in</strong>g Illum<strong>in</strong>a platforms.<br />
• Subjects studied were 1178 DM cases (705 with adult<br />
DM <strong>and</strong> 473 with juvenile DM) who were compared to<br />
4724 geographically- <strong>and</strong> race-matched controls.
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