Modern Trends in Human Leukemia III - Blog Science Connections

Cellular and Virologieal Studies Direeted to the Pathogenesis 21
Summary and Conclusion
1. Work over the past years and espeeially results of the past few years
indieate that type-C viral or viral related genetie information exists in
humans.
2. We do not know how this information entered humans or whether it
eauses disease, but it is of in te rest that the probes from the viruses used to
deteet this information are from the very same viruses whieh we find ean
affeet growth and differentiation of some human hematopoietie eells.
3. The status of aetual virus isolates from humans, though eneouraging
beeause of similarities of isolates from five different laboratories, remain
very perplexing and so far have not been espeeially informative to human
leukemogenesis.
4. In the near future we hope to clone in baeteria the viral related sequenees
deteeted in human DNA in order to more preeisely determine their ehemieal
and biologie al properties. The HL-60 system mayaiso afford an opportunity
to purify reeeptors for CSF. When CSF and other, perhaps more important,
regulatory faetors are purified, we would like to determine if they
bind differently to leukemie and normal eells.
References
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Fig.5. B-Cell lymphoma of nude mouse induced by injeetion of mouse with cells indueed
to grow by GaLV H .
Cells are human as determined by karyotype analysis. (From: P. Markharn, F. Ruscetti,
Z. Salahuddin. R Gallagher, and R Gallo. in press).