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Children's Hospital National Medical Center S. Leikin CA 03888 George Washington University, Washington, D.C. Memorial Sloan-Kettering Cancer Center D. R. Miller CA 23742 Cornell University, New York, N.Y. Childrens Hospital of Los Angeles G. Higgins CA 02649 University of Southern California, Los Angeles, California Babies Hospital J. Wolff CA 03526 Columbia University, New York, N.Y. Children's Hospital of Pittsburgh V. Albo CA 07439 University of Pittsburgh, Pittsburgh, Pennsylavania Children's Hospital of Columbus W. Newton CA 03750 Ohio State University, Columbus, Ohio Children's Orthopedic Hospital and Medical R. Chard CA 10382 Center, University of Washington Seattle, Washington University of Wisconsin Hospitals N. Shahidi CA 05436 Madison, Wisconsin University of Minnesota Health <strong>Science</strong>s Center, M. Nesbit CA 97306 Minneapolis, Minnesota Children's Memorial Hospital G. Honig CA 07431 Northwestern University Chicago, Illinois University of Utah Medical Center E. Lahey CA 10198 Salt Lake City. Utah Strong Memorial Hospital M. Klemperer CA 11174 University of Rochester Rochester, New York Children's Hospital D. R. Kmetz University of Louisville, Louisville, Kentucky University of British Columbia, M. Teasdale Vancouver Vancouver, British Columbia Children's Hospital of Philadelphia A. Evans CA 11796 University of Pennsylvania, Philadelphia, Pennsylvania James Whitcomb Riley Hospital for Children R. Baehner CA 14809 Indiana University, Indianapolis, Indiana New Jersey College of Medicine and L. Vitale CA 12637 Dentistry, Newark, New Jersey Harbor General Hospital J. Finklestein CA 14560 University of California Los Angeles, Torrance, California University of California Medical Center A. Ablin CA 17829 San Francisco, California Rainbow Babies and Childrens Hospital S. Gross CA 203020 Case Western Reserve University Cleveland, Ohio University of Texas Health T. Williams <strong>Science</strong>s Center San Antonio, Texas 85
References Andreeff M, Darzynkiewicz Z, Sharpless TK, Clarkson BD, Melamed MR (1980) Discrimination of heman leukemia subtypes by flow cytometric analysis of cellular DNA and RNA. Blood 55 :282-293 - Aur RJA, Simone JV, Verzoza MS, Hustu HD, Barker LF, Pinkel DP, Rivera G, Dahl GV, Wood A, Stagner S, Mason C (1978) Childhood acute Iymphocytic leukemia. Study VIII. Cancer 42:2123-2134 - Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, GralnickNR, Sultan D (French-American-British [FAB] Cooperative Group) (1976) Proposal for the classification of the acute leukemias. Br J Haematol 33 :451-458 - Cox DR Regression models and liefe tables. J R Stat Soc [Br] 34:187-220 - Fahey J, McKelvey EM (1965) Quantitative determination of serum immunoglobulins in antibody agar plates. J Immunol 94: 84-90 - Frei EJ, Sallan SE (1978) Acute lymphoblastie leukemia treatment. Cancer 42: 828-838 - George S, Fernbach K, Vietti T, Sullivan MP, Lane DM, Haggard ME, Berry DH, Lonsdale D, Komp D (1973) Factors influencing survival in pediatric acute leukemia. Cancer 32: 1542-1553 - Haghbin M, Tan CT, Clarkson BD, Mike V, Burchenal J, Murphy ML (1974) Intensive chemotherapy in children with acute lymphoblastic leukemia (L-2 protocol). Cancer 33: 1491-1498 - Haghbin M, Murphy ML, Tan CTC, Clarkson BD, Thaler H, Passe S, Burchenal J (1981) A long-term clinieal follow-up of children with acute lymphoblastie leukemia treated with intensive chemotherapy regimens. Cancer 46:241-252 - Jacquillat C, Weil M, German MF (1974) Combination therapy in 130 patients with acute lymphocytic leukemia. Cancer Res 33: 3284-3289 - Leikin S, Miller DR, Sather H, Albo V, Esber E, Johnson A, Rogentine N, Hammond D (to be published) Immunologie evaluation in the prognosis of acute lymphoblastie leukemia. Blood - Miller DR, Sonley M, Karon M, BreslowN, Hammond D (1974) Additive therapy in the maintenance of remission in acute lymphoblastie leukemia of childhood: the effect of the initial leukocyte count. Cancer 34:508-517 - Miller DR, Leikin S, Albo V, Sather H, Hammond D (to be published) Prognostie significance of lymphoblast morphology (FAB classification) in childhood acute lymphoblastic leukemia. Br J Haematol - Nesbit ME, Coccia PF, Sather HN, Robison LL, Hammond GD (1979) Staging in pediatrie malignancies. In: Proceedings of american cancer society national conference on the care of the child with cancer. American Cancer Society, New York, pp 31-38 - Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35: 1-39 - Robison LL, Sather HN, Coccia PF, Nesbit ME, Hammond GD (1980) Assessment of the interrelationship of prognostie factors in childhood acute Iymphoblastie leukemia: Areport from Childrens Cancer Study Group. Am J Pediatr Hematol Oncol 2:5-14 - SaIIan SE, Ritz J, Pesando J, Geiber R, O'Brien C, Hitchcock S, Coral F, Schlossman SF (1980) CeII surface antigens: Prognostie implications in childhood acute lymphoblastie leukemia. Blood 55: 395-402 - Simone JV, Aur RJA, Hustu HO, Verzosa M, Pinkel D (1975) Combined modality therapy of acute lymphocytic leukemia. Cancer 35 :25-35 - Simone JV (1976) Factors that influence haematological remission duration in acute Iymphocytie leukaemia. Br J Haematol 32:465-472 86
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Haematology and Blood Transfusion 2
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Dr. Rolf Neth, Universitäts-Kinder
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Participants of the Meeting Aaronso
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Kurth, R, Friedrich-Miescher-Labora
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Wilsede Scholarship Holders (Grante
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Preface Gut ist eine Lehrart, wo ma
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Personal and scientific discussion
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Acknowledgement We should like to t
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Wilsede, June 21 1978 Memorial Trib
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limiting benign lymphoproliferative
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this most unlikely, however (for re
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longer subject to the same control
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Bregula U, Wiener F, Harris H (1971
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fresh lymph node biopsies from ten
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Fig. 3. Binucleate mitosis in an ob
Page 31 and 32:
y Fig. 4. Schematic diagram of post
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than that among patients with Stage
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Tests of binding affinity, agglutin
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N Engl J Med 297: 963-968 - Green I
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Clinical Aspects
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"ring chromosome". "Mar" is marker,
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191 chromosomally abnormal patients
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tumors of both African and non-Afri
Page 47 and 48: Haematology and Blood Transfusion V
Page 49 and 50: Retrospective group 26/93 evolved l
Page 53 and 54: Treatment
Page 55 and 56: advantage in terms of duration of f
Page 57 and 58: leukaemia. An analysis of 168 patie
Page 59 and 60: 11. Treatment Program Chemotherapy
Page 61 and 62: efractory congestive heart failure
Page 63 and 64: period (Sequence II) was gene rally
Page 65 and 66: children with a multiple drug proto
Page 67 and 68: DAYS 1 5 10 15 20 25 30 35 , I I I
Page 69 and 70: Biologically Drug Outcome fit" sens
Page 71 and 72: may counterbalance the potential be
Page 73 and 74: Ht (0--0) 50 40 30 20 10 0 Platelet
Page 75 and 76: 10 7 ,-----------------------------
Page 77 and 78: 11. Haematological and Biochemical
Page 79 and 80: 0\ 0\ INTERFERON ... 10 3 rl E "'
Page 83 and 84: ("pre-B" phenotype) has been descri
Page 85 and 86: human bone marrow cells exhibit the
Page 87 and 88: 10 9.,0 MBKCC .. .,4 B prot:oool 1'
Page 89 and 90: demann W, Büehner T, Arlin Z, Gee
Page 91 and 92: -...l 00 a-tLDRENS CAt«:ER S TU>Y
Page 93 and 94: prognostic characteristics under in
Page 95 and 96: significantly higher in HR} (14.5%,
Page 97: normal or elevated immunoglobulin l
Page 101 and 102: R GROUP 1 ( 1970 - 1971 ) 17 PTS. R
Page 103 and 104: Table 3. Influence of initial featu
Page 105 and 106: LIJ (f) a.. < -1 LIJ Q: u. 0 >- I-
Page 109 and 110: me nt indicated that additional the
Page 111 and 112: 42:2123-2134 - Chessells JM, Cornbl
Page 113 and 114: Baum et al. 1979). This study was b
Page 115 and 116: 1. 0 '--'1--" 0.9 e: o .- VI VI E C
Page 117 and 118: e: o e: 1. 0 ,.--...-- 1'"'\ ......
Page 119 and 120: In conclusion, we can state that th
Page 121 and 122: Haematology and Blood Transfnsion V
Page 123 and 124: INDUCTION VCR + PRED + ASNASE (wk 3
Page 125 and 126: SCHED.INT 1 MTX • ! Adria MTX •
Page 127 and 128: ~ looh---------ooooc>----o---c>----
Page 129 and 130: Consoll- Irra .tlon t) .tlon Indu
Page 131 and 132: Highrisk Standard risk Table 1. Cli
Page 133 and 134: Cumulo/ive comp/el9 remission 1.0 .
Page 135 and 136: 10° 8 = 6 ö 4 Non T Cell .~ :ö
Page 139 and 140: % SURVIVAL 100 ~ ~II 0 80 60 40 - -
Page 141 and 142: a) Percentage of donor cell mitoses
Page 143 and 144: Table 5. Results of bone marrow tra
Page 145 and 146: ...... w N Table 7. Clinical result
Page 147 and 148: agent had to be added and that in t
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Haematology and Blood Transfusion V
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C. Chronic Myelogenous Leukemia The
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Patients with a suitable donor rece
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No. Recurrent Leukaemia Other death
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followed by dialysis against isoton
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HS, HL- Heme >_ 40 0 HS I ;:. =====
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knowing at present. These genes may
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esistance to antifolates. In Vitro
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a DNA probe specific for the gene t
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translocation between chromosomes 9
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Table 1. Subdivision of 1827 Myelo-
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NORMAL CELL ®
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some change of the primary type, in
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F. Transformation of Mouse Bone Mar
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were carried out with 3H-MTX in the
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the lysozyme cDNA prepared from ovi
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et al. 1976). The BJAB cellline in
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dalton bands corresponding to light
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1979). The EBV-carrying cell lines
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producer lines (DAUDI and P3HR-1),
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G, Giovanella B, Westman A, Stehlin
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Dc;bt CT + i J.I9 Raji; 1. i .. 100
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c. Discussion During infectious mon
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C. Nonepisomal Viral DNA We have us
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A 260 3.0 A B 1670 70 N2 2.0 c: E .
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vivo. Nature 260:302-306 - Kirk JTO
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Fig. 1. a Polyacrylamide gelelectro
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1979). The lymphocyte subpopulation
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lysin 0 antigens are found, and mix
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Pope JH (1978) Long-term T cell-med
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Haematology and Blood Transfnsion V
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Charaeteristie Morphologie maturati
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after TPA-induction (Table 3). The
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PA (1978) Reactivity of a rabbit an
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Blood Monocyte. B lood Monocytes 1-
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and nonhistone proteins can serve a
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The findings of the evaluation of s
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Fig. 3. Tumor grawth of L 428 cells
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Cell biological and Immunological A
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consideration. Sanel (1973) obtaine
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endotoxin serum, were used. A parti
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monocytic leukemia cell line in cul
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B. Isolation, Characterization and
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don al hemopathies generally displa
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nitors. Blood Cells 6:595-607 - Min
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\I) ....I ....I IU Jl 200 r 100 90
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their haemopoietic cells' ability t
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normal normal ALL ALL ALL persons p
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64.5 { V)
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References Biermann E, Neth R, Gros
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ehambers, the growth pattern observ
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References Anderssen LC, 10kinen M,
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REH CELL UNE TO CALLb~Ö ~q~ V.M. c
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the macrophage series in which the
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Table 1. Production of factor depen
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Table 1. Characteristics of the adh
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Fig. 3. A human marrow culture at 6
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300 250 • HYPERPROLIFERATIVE PATT
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Fig. 9. Nonadherent population from
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The cobblestone areas were often no
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L (1976) Induction of colony format
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B. Materials and Methods J. Tissue
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Fig. 2. Ultrastructural appearance
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Page 307 and 308:
Page 309 and 310:
Table 1. Monoclonal antibody reacti
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al. 1979; Janossy et al. 1979) is e
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to which this is an exact replica o
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inger JL (1976) Distribution of la-
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I region antigens were found to be
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have been reported to be present on
Page 321 and 322:
V. FunctionalAssays Assays for PHA
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Functional studies of UCHT1 separat
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40 ,...... (5 L.. C o u 30 .9 ~ .~
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with immunohistochemieal methods (L
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can be dissected by cloning. Utiliz
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Table 1. Origin and marker profile
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complete identity of gp 100 from no
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Table 1. Reaction of single anti se
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media. Following 24-h incubation, c
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nonleukemic eells (Greaves 1979). L
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Fig. 2. Cytocentrifuged smears of b
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Modification of amino-groups of hum
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disturb this balance in the directi
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The majority of human blood lymphoc
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of the EBV infected B cells. Howeve
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and immunoglobulins. J Immunol 120:
Page 363 and 364:
" K 10 • j ~ ALL RNlL AL wtfh les
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tion akuter Leukämiezellen in "spo
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D. Results and Discussion J. Acute
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selectively responsive to different
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Page 373 and 374:
l1J ~ 100 ~ Q. ::) l1J Z 0 ~ z >- .
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Table 2. Growth inhibition of S49 e
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Reverse Infectious ASC/2X1Q6 transc
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Page 381 and 382:
munized animals to 1316 tumor cells
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Haematology and Blood Transfnsion V
Page 385 and 386:
Fig. 3. Expression of retroviral gp
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pg70. J Exp Med 143: 151-166 - McGr
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Table 1. Expression of tumor antige
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Virological and Molecularbiological
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Table 1. Oncogenic properties of re
Page 395 and 396:
also Fig. 1). It followed that the
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whether this sequence is related to
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zed in infected cells argue that th
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a specific viral transforming prote
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detect viral RNA as the only charac
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Eisen H (1980) Myeloproliferate vir
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p,60- -34K - 1 2 3 4 Fig. 1. In vit
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.. p - • a'T ... I .t'l Fig. 4. D
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Page 413 and 414:
Fig. 2. Photomicrographs of NY68 in
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DEAE (o(lJmn 'liI GI -2 2 o e s 1
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vity was deterrnined. For endogenou
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pr 180 - - - P 12/15 - A B c D E F
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85,- 66- -27 - -66 40- 27- -1'9 19-
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Page 425 and 426:
= 0.5 o E Q. o ILI 0.4 (J) « ILI .
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Table 1. Oncogenic potential of avi
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100 III GI c: o "8 80 > w
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Expt. No. Infecting virus Proportio
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Haematology and Blood 'fransfusion
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sequences, provided its gag portion
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77:3009-3013 - Hu SSF, Moscoviei C,
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RI 2.2 md and Hind III 2.6 md leuke
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Page 443 and 444:
RELATIONSHIP OF ENDOGENOUS AND EXOG
Page 445 and 446:
E ........ E Cl. U E :::l .... Q) (
Page 447 and 448:
References Astrin S (1978) Endogeno
Page 449 and 450:
the same animal were examined (e.g.
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I) 'IQ a \0 - CL -- Fig. 2. Restrie
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~ ..................... ~ Cell 3' 5
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a :Sa,C! + . ~ 111 i' ( " '~ .J. b
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Table 1 Sampie Tissue TS fragment"
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a b Sac I / rep ._-_.-_ K J nl rep
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Haematology and Blood 'fiansfusion
Page 463 and 464:
Osteopetrosis and osteosarcomas occ
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Lymphoma cellline Table 1. T and B
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Table 2. In vivo growth and oneogen
Page 469 and 470:
Page 471 and 472:
Table 1. Transforming aetivity of c
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Table 3. Transformation aetivity of
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- Shoemaker C, Goff S, Gilboa E, Pa
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indieate a shifting of target eell
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Table 2. Expression of Jl and Sourc
Page 481 and 482:
Page 483 and 484:
~ i ,..1---------,,':::::::::::::::
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fragment of pBR322 DNA, a 3.0-kbp S
Page 487 and 488:
Mak TW (1979) Proc Natl Acad Sci US
Page 489 and 490:
Table 1. Transformation of 3T3 cell
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inserts in the genome of rapidly tr
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pulations, it seemed likely that th
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contains antigens which react with
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Page 499 and 500:
le of reacting in sensitive radioim
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Page 503 and 504:
gic approach. In: Hiatt HH, Watson
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12 Eco R [ Fig. 1. Hybridization pa
Page 507 and 508:
Page 509 and 510:
10 - '1~ )( -~ S:! E A U I o 1 2
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Haematology and Blood 'fransfusion
Page 513 and 514:
cultures. These cells did not conta
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indication of malignant T-cells in
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Fig. 3. Thin-section electron micro
Page 519 and 520:
Table 3. Lack of detectable related
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J. HTLV Was Present in the Primary
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specific signals into nonspecific s
Page 525 and 526:
Table 2. Distribution of HTLV-relat
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u 10 ~ 20 ~ :c 30 a 40 o Fig. 1. Ki
Page 529 and 530:
Page 531 and 532:
SSV TrS-gp labeled effectively with
Page 533 and 534:
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60 HFF/SSV cDNA CELL RNAs: 0 HF/SSV
Page 537 and 538:
Antisera a Table 1. Immunofluoresce
Page 539 and 540:
Haematology and Blood 'ftansfusion
Page 541 and 542:
y competition RIA yielded virtually
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SiS'V' gp70: ANTIGEN, ANTI BODY, IM
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type-C virus p30 antigen in cells f
Page 547 and 548:
c. Results The fractionated whole-b
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induced antibodies as well as exper
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- Fig. la-f. Retravirus particles p
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eplication of infecting murine leuk
Page 555 and 556:
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immunodeficiency, multic10nal lymph
Page 559 and 560:
Bovine leukemia --, proteins of 499
Page 561 and 562:
Human T- cell - -, characterization
Page 563 and 564:
RNA -, of tumor virus 439 Rous sarc
Page 565 and 566:
Haematology andBlood Transfusion Su
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