van den Engh, G., Radiobiological Institute 151 Lange Kleiweg, Rijswijk, The Netherlands Erfle, V., Gesellschaft für Strahlen- und Umweltschäden, Ingolstädter Landstraße 1,8042 Neuherberg, West-Germany Erikson, Eleanor, Health <strong>Science</strong>s Center, University of Colorado, 4200 East Ninth Avenue, Denver, CO 80262, USA Essex, M., Dept. Microbiology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA Evans, L., Dept. Molecular Biology, WendeIl M. Stanley Hall, University of California, Berkeley, CA 92720, USA Feldman, M., The Weizmann Institute of <strong>Science</strong>, P.O. Box 26, Rehovot 76 100, Israel Fleckenstein, B., Institut für Klinische Virologie, Loschgestraße 7, 8520 Erlangen, West-Germany Forbes, Penelope, Chester Beatty Research Institute, Clifton Avenue, Belmont, Sutton, Surrey SM2 5PX, u.K. Frei III, E., Sidney Farber Cancer Institute, 44, Binney Street, Boston, MA 02115, USA Friis, R R, Institut für Virologie, Justus-Liebig-Universität, Frankfurter Straße 107,6300 Gießen, West-Germany Furusawa, M., Dept. Biology, Osaka City University, Sugimoto-Cho, Sumiyoshi Ku, Osaka 558, Japan Gallo, R c., National Cancer Institute, Bethesda, MD 20014, USA Gartner, Suzanne, Dept. Radiology, Cancer Biology Research Laboratory, Stanford University Medical Center, Stanford, CA 94305, USA Georgii, A., Medizinische Hochschule Hannover, Pathologisches Institut, Karl Wiehert-Allee 9, 3000 Hannover-Kleefeld, West-Germany Godal, T., Norsk Hydro's Institute for Cancer Research, Montebello, Oslo 3, Norway Graf, T., Institut für Virusforschung, Im Neuenheimer Feld 280, 6900 Heidelberg 1, West-Germany Greaves, M. F., Imperial Cancer Research Fund Laboratories, P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX, U.K. Greenberger, J. S., Dept. Radiation Therapy, Harvard Medical School, 44, Binney Street, Boston, MA 02115, USA Hardesty, B., Dept. Chemistry, The Clayton Foundation Biochemical Institute, University of Texas, Austin, TX 78712, USA Hausen, H. zur, Institut für Virologie im Zentrum für Hygiene, Hermann-Herder Straße 11, 7800 Freiburg i. Br., West-Germany Hayward, W., RockefeIler University, 1230 Y ork Avenue, New Y ork, NY 10021, USA Hehlmann, R, Institut für Biologie, Ingolstädter Landstraße 1,8042 Neuherberg, West-Germany Helm, K. von der, Max v. Pettenkofer-Institut, Pettenkoferstraße 9a, 8000 München 2, West-Germany Hengartner, H., Experimentelle Pathologie, Universität Zürich, Schmelzbergstraße 12, 8091 Zürich, Switzerland Hölzer, D., Zentrum für Innere Medizin und Kinderheilkunde, Universität Ulm, Steinhövelstraße 9, 7900 Ulm, West-Germany Kabiseh, H., Universitäts-Kinderklinik, Abt. für Hämatologie und Onkologie, Martinistr. 52, 2000 Hamburg 20, West-Germany Kaplan, H. S., Dept. Radiology, Cancer Biology Research Laboratory, Stanford University Medical School, Stanford, CA 94305, USA Kettmann, R, Faculte des <strong>Science</strong>s Agronomiques de l'Etat, Chaire de Zootechnie, Gembloux, Belgium Klein, Eva, Dept.Tumor Biology, Karolinska Institutet, 104 Stockholm 60, Sweden Klein, G., Dept. Tumor Biology, KarolinskaInstitutet, 104 Stockholm 60, Sweden Kirsten, W. H., Dept. Pathology, University of Chicago, 950 East 50th Street, Chicago, IL 60637, USA Kramer, Gisela, Dept. Chemistry, The Clayton Foundation Biochemical Institute, University of Texas, Austin, TX 78712, USA XVI
Kurth, R, Friedrich-Miescher-Laboratorium der Max-Planck-Gesellschaft, Spemannstraße 37-39, 7400 Tübingen, West-Germany Lajtha, L. G., Christie Hospital & Holt Radium Institute, Paterson Laboratories, Manchester M20 9BX, U.K Lau, Barbara, Gesellschaft für Strahlen- und Umweltforschung mbH, Abteilung Experimentelle Hämatologie und Immunologie, Landwehrstraße 61, 8000 München 15, West-Germany Levan, G., Genetiska Institutionen, Göteborgs Universitet, Stigbergsliden 14, 41463 Göteborg, Sweden Linemeyer, D. L., National Cancer Institute, Bethesda, MD 20014, USA Lister, A., Dept. Medical Oncology, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, U.K Löliger, H.-Ch., Institut für Kleintierzucht, Dörnbergstraße 25-27, 3100 Celle, West-Germany Mannweiler, K, Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Martinistraße 52, 2000 Hamburg 20, West-Germany Mayer, R, Sidney Farber Cancer Institute, 44, Binney Street, Boston, MA 02115, USA McCredie, K B., Leukemia Service, M. D. Anderson Hospital, 6723 Bertner Avenue, Houston, TX 77030, USA McGrath, M., Dept. Pathology, Stanford UniversityMedical Center, Stanford, CA 94305, USA Mercola, Karen, Dept. Medicine, University of California, Los Angeles, CA 90024, USA Mertelsmann, R, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA Messner, H., The Ontario Cancer Institute, 5000 Sherbourne Street, Toronto, Ontario M4X, 1K9, Canada Milleck, J., Zentralinstitut für Krebsforschung, Lindenbergerweg 80, 115 Berlin Buch, GDR Miller, D. R., Memorial Sloan-Kettering Cancer Center, 1275 YorkAvenue, New York, NY 10021, USA Minowada, J., Roswell Park Memorial Institute, 666 Elm Street, Buffalo, NY 14263, USA Mitchison, N. A., Tumor Immunolgy Unit, University College London, Gower Street, London WC1E 6BT, U.K Mölling, Karin, Max-Planck-Institut für Molekulare Genetik, Ihnestraße 63-73, 1000 Berlin 33, West-Germany Moloney, W. c., Peter Bent Brigham Hospital, Hematology Division, 721 Huntington Avenue, Boston, MA 02115, USA Moore, M. A. S., Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA Munk, K, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 6900 Heidelberg, West-Germany Neth, R, Universitäts-Kinderklinik Hamburg-Eppendorf, Martinistraße 52, 2000 Hamburg 20, West-Germany Newman, R, Imperial Cancer Research Fund Laboratories, P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX, U.K. Nilsson, K, The Wallenberg Laboratory, Box 562, University of Uppsala, 75122 Uppsala, Sweden Nooter, K, Radiobiological Institute, 151 Lange Kleiweg, Rijswijk, The Netherlands Pragnell, 1., Beaton Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland Preisler, H., Roswell Park Memorial Institute, 666 Elm Street, Buffalo, NY 14263, USA Purtilo, D. T., Dept. Pathology, University of Massachusetts Medical Center, Worcester, MA 01605, USA Radzun, H. J., Klinikum der Christian-Albrechts-Universität Kiel, Institut für Pathologie, Hospitalstraße 42, 2300 Kiel, West-Germany XVII
- Page 1 and 2: Haematology and Blood Transfusion 2
- Page 3 and 4: Dr. Rolf Neth, Universitäts-Kinder
- Page 5: Participants of the Meeting Aaronso
- Page 9 and 10: Wilsede Scholarship Holders (Grante
- Page 11 and 12: Preface Gut ist eine Lehrart, wo ma
- Page 13 and 14: Personal and scientific discussion
- Page 15 and 16: Acknowledgement We should like to t
- Page 17 and 18: Wilsede, June 21 1978 Memorial Trib
- Page 19 and 20: limiting benign lymphoproliferative
- Page 21 and 22: this most unlikely, however (for re
- Page 23 and 24: longer subject to the same control
- Page 25 and 26: Bregula U, Wiener F, Harris H (1971
- Page 27 and 28: fresh lymph node biopsies from ten
- Page 29 and 30: Fig. 3. Binucleate mitosis in an ob
- Page 31 and 32: y Fig. 4. Schematic diagram of post
- Page 33 and 34: than that among patients with Stage
- Page 35 and 36: Tests of binding affinity, agglutin
- Page 37 and 38: N Engl J Med 297: 963-968 - Green I
- Page 39 and 40: Clinical Aspects
- Page 41 and 42: "ring chromosome". "Mar" is marker,
- Page 43 and 44: 191 chromosomally abnormal patients
- Page 45 and 46: tumors of both African and non-Afri
- Page 47 and 48: Haematology and Blood Transfusion V
- Page 49 and 50: Retrospective group 26/93 evolved l
- Page 51 and 52: Haematology and Blood Transfusion V
- Page 53 and 54: Treatment
- Page 55 and 56: advantage in terms of duration of f
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leukaemia. An analysis of 168 patie
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11. Treatment Program Chemotherapy
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efractory congestive heart failure
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period (Sequence II) was gene rally
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children with a multiple drug proto
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DAYS 1 5 10 15 20 25 30 35 , I I I
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Biologically Drug Outcome fit" sens
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may counterbalance the potential be
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Ht (0--0) 50 40 30 20 10 0 Platelet
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10 7 ,-----------------------------
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11. Haematological and Biochemical
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0\ 0\ INTERFERON ... 10 3 rl E "'
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Haematology and Blood Transfusion V
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("pre-B" phenotype) has been descri
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human bone marrow cells exhibit the
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10 9.,0 MBKCC .. .,4 B prot:oool 1'
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demann W, Büehner T, Arlin Z, Gee
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-...l 00 a-tLDRENS CAt«:ER S TU>Y
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prognostic characteristics under in
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significantly higher in HR} (14.5%,
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normal or elevated immunoglobulin l
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References Andreeff M, Darzynkiewic
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R GROUP 1 ( 1970 - 1971 ) 17 PTS. R
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Table 3. Influence of initial featu
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LIJ (f) a.. < -1 LIJ Q: u. 0 >- I-
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Haematology and Blood Transfusion V
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me nt indicated that additional the
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42:2123-2134 - Chessells JM, Cornbl
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Baum et al. 1979). This study was b
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1. 0 '--'1--" 0.9 e: o .- VI VI E C
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e: o e: 1. 0 ,.--...-- 1'"'\ ......
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In conclusion, we can state that th
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Haematology and Blood Transfnsion V
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INDUCTION VCR + PRED + ASNASE (wk 3
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SCHED.INT 1 MTX • ! Adria MTX •
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~ looh---------ooooc>----o---c>----
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Consoll- Irra .tlon t) .tlon Indu
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Highrisk Standard risk Table 1. Cli
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Cumulo/ive comp/el9 remission 1.0 .
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10° 8 = 6 ö 4 Non T Cell .~ :ö
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Haematology and Blood Transfusion V
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% SURVIVAL 100 ~ ~II 0 80 60 40 - -
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a) Percentage of donor cell mitoses
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Table 5. Results of bone marrow tra
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...... w N Table 7. Clinical result
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agent had to be added and that in t
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Haematology and Blood Transfusion V
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C. Chronic Myelogenous Leukemia The
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Patients with a suitable donor rece
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No. Recurrent Leukaemia Other death
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followed by dialysis against isoton
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Haematology and Blood Transfusion V
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HS, HL- Heme >_ 40 0 HS I ;:. =====
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Haematology and Blood Transfusion V
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knowing at present. These genes may
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esistance to antifolates. In Vitro
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a DNA probe specific for the gene t
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translocation between chromosomes 9
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Table 1. Subdivision of 1827 Myelo-
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NORMAL CELL ®
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some change of the primary type, in
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Haematology and Blood Transfusion V
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F. Transformation of Mouse Bone Mar
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Haematology and Blood Transfusion V
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were carried out with 3H-MTX in the
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Haematology and Blood Transfusion V
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the lysozyme cDNA prepared from ovi
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Haematology and Blood Transfusion V
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et al. 1976). The BJAB cellline in
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dalton bands corresponding to light
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1979). The EBV-carrying cell lines
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producer lines (DAUDI and P3HR-1),
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G, Giovanella B, Westman A, Stehlin
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Haematology and Blood Transfusion V
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Dc;bt CT + i J.I9 Raji; 1. i .. 100
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c. Discussion During infectious mon
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Haematology and Blood Transfusion V
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C. Nonepisomal Viral DNA We have us
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A 260 3.0 A B 1670 70 N2 2.0 c: E .
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vivo. Nature 260:302-306 - Kirk JTO
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Fig. 1. a Polyacrylamide gelelectro
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Haematology and Blood Transfusion V
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1979). The lymphocyte subpopulation
- Page 223 and 224:
lysin 0 antigens are found, and mix
- Page 225 and 226:
Pope JH (1978) Long-term T cell-med
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Haematology and Blood Transfnsion V
- Page 229 and 230:
Charaeteristie Morphologie maturati
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after TPA-induction (Table 3). The
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PA (1978) Reactivity of a rabbit an
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Blood Monocyte. B lood Monocytes 1-
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Haematology and Blood Transfusion V
- Page 239 and 240:
and nonhistone proteins can serve a
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Haematology and Blood Transfusion V
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The findings of the evaluation of s
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Fig. 3. Tumor grawth of L 428 cells
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Cell biological and Immunological A
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consideration. Sanel (1973) obtaine
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endotoxin serum, were used. A parti
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monocytic leukemia cell line in cul
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B. Isolation, Characterization and
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Haematology and Blood Transfusion V
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don al hemopathies generally displa
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nitors. Blood Cells 6:595-607 - Min
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\I) ....I ....I IU Jl 200 r 100 90
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their haemopoietic cells' ability t
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normal normal ALL ALL ALL persons p
- Page 269 and 270:
64.5 { V)
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References Biermann E, Neth R, Gros
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ehambers, the growth pattern observ
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References Anderssen LC, 10kinen M,
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REH CELL UNE TO CALLb~Ö ~q~ V.M. c
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Haematology and Blood Transfusion V
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the macrophage series in which the
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Haematology and Blood Transfusion V
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Table 1. Production of factor depen
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Haematology and Blood Transfusion V
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Table 1. Characteristics of the adh
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Fig. 3. A human marrow culture at 6
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300 250 • HYPERPROLIFERATIVE PATT
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Fig. 9. Nonadherent population from
- Page 297 and 298:
The cobblestone areas were often no
- Page 299 and 300:
L (1976) Induction of colony format
- Page 301 and 302:
B. Materials and Methods J. Tissue
- Page 303 and 304:
Fig. 2. Ultrastructural appearance
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Haematology and Blood Transfusion V
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Haematology and Blood Transfusion V
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Table 1. Monoclonal antibody reacti
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al. 1979; Janossy et al. 1979) is e
- Page 313 and 314:
to which this is an exact replica o
- Page 315 and 316:
inger JL (1976) Distribution of la-
- Page 317 and 318:
I region antigens were found to be
- Page 319 and 320:
have been reported to be present on
- Page 321 and 322:
V. FunctionalAssays Assays for PHA
- Page 323 and 324:
Functional studies of UCHT1 separat
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Haematology and Blood Transfusion V
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40 ,...... (5 L.. C o u 30 .9 ~ .~
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with immunohistochemieal methods (L
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Haematology and Blood Transfusion V
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can be dissected by cloning. Utiliz
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Table 1. Origin and marker profile
- Page 337 and 338:
Haematology and Blood Transfusion V
- Page 339 and 340:
complete identity of gp 100 from no
- Page 341 and 342:
Table 1. Reaction of single anti se
- Page 343 and 344:
Haematology and Blood Transfusion V
- Page 345 and 346:
media. Following 24-h incubation, c
- Page 347 and 348:
nonleukemic eells (Greaves 1979). L
- Page 349 and 350:
Haematology and Blood Transfusion V
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Fig. 2. Cytocentrifuged smears of b
- Page 353 and 354:
Modification of amino-groups of hum
- Page 355 and 356:
disturb this balance in the directi
- Page 357 and 358:
The majority of human blood lymphoc
- Page 359 and 360:
of the EBV infected B cells. Howeve
- Page 361 and 362:
and immunoglobulins. J Immunol 120:
- Page 363 and 364:
" K 10 • j ~ ALL RNlL AL wtfh les
- Page 365 and 366:
tion akuter Leukämiezellen in "spo
- Page 367 and 368:
D. Results and Discussion J. Acute
- Page 369 and 370:
selectively responsive to different
- Page 371 and 372:
Haematology and Blood Transfusion V
- Page 373 and 374:
l1J ~ 100 ~ Q. ::) l1J Z 0 ~ z >- .
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Table 2. Growth inhibition of S49 e
- Page 377 and 378:
Reverse Infectious ASC/2X1Q6 transc
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Haematology and Blood Transfusion V
- Page 381 and 382:
munized animals to 1316 tumor cells
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Haematology and Blood Transfnsion V
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Fig. 3. Expression of retroviral gp
- Page 387 and 388:
pg70. J Exp Med 143: 151-166 - McGr
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Table 1. Expression of tumor antige
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Virological and Molecularbiological
- Page 393 and 394:
Table 1. Oncogenic properties of re
- Page 395 and 396:
also Fig. 1). It followed that the
- Page 397 and 398:
whether this sequence is related to
- Page 399 and 400:
zed in infected cells argue that th
- Page 401 and 402:
a specific viral transforming prote
- Page 403 and 404:
detect viral RNA as the only charac
- Page 405 and 406:
Eisen H (1980) Myeloproliferate vir
- Page 407 and 408:
p,60- -34K - 1 2 3 4 Fig. 1. In vit
- Page 409 and 410:
.. p - • a'T ... I .t'l Fig. 4. D
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Haematology and Blood Transfusion V
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Fig. 2. Photomicrographs of NY68 in
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DEAE (o(lJmn 'liI GI -2 2 o e s 1
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vity was deterrnined. For endogenou
- Page 419 and 420:
pr 180 - - - P 12/15 - A B c D E F
- Page 421 and 422:
85,- 66- -27 - -66 40- 27- -1'9 19-
- Page 423 and 424:
Haematology and Blood Transfusion V
- Page 425 and 426:
= 0.5 o E Q. o ILI 0.4 (J) « ILI .
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Table 1. Oncogenic potential of avi
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100 III GI c: o "8 80 > w
- Page 431 and 432:
Expt. No. Infecting virus Proportio
- Page 433 and 434:
Haematology and Blood 'fransfusion
- Page 435 and 436:
sequences, provided its gag portion
- Page 437 and 438:
77:3009-3013 - Hu SSF, Moscoviei C,
- Page 439 and 440:
RI 2.2 md and Hind III 2.6 md leuke
- Page 441 and 442:
Haematology and Blood Transfusion V
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RELATIONSHIP OF ENDOGENOUS AND EXOG
- Page 445 and 446:
E ........ E Cl. U E :::l .... Q) (
- Page 447 and 448:
References Astrin S (1978) Endogeno
- Page 449 and 450:
the same animal were examined (e.g.
- Page 451 and 452:
I) 'IQ a \0 - CL -- Fig. 2. Restrie
- Page 453 and 454:
~ ..................... ~ Cell 3' 5
- Page 455 and 456:
a :Sa,C! + . ~ 111 i' ( " '~ .J. b
- Page 457 and 458:
Table 1 Sampie Tissue TS fragment"
- Page 459 and 460:
a b Sac I / rep ._-_.-_ K J nl rep
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Haematology and Blood 'fiansfusion
- Page 463 and 464:
Osteopetrosis and osteosarcomas occ
- Page 465 and 466:
Lymphoma cellline Table 1. T and B
- Page 467 and 468:
Table 2. In vivo growth and oneogen
- Page 469 and 470:
Haematology and Blood Transfusion V
- Page 471 and 472:
Table 1. Transforming aetivity of c
- Page 473 and 474:
Table 3. Transformation aetivity of
- Page 475 and 476:
- Shoemaker C, Goff S, Gilboa E, Pa
- Page 477 and 478:
indieate a shifting of target eell
- Page 479 and 480:
Table 2. Expression of Jl and Sourc
- Page 481 and 482:
Haematology and Blood Transfusion V
- Page 483 and 484:
~ i ,..1---------,,':::::::::::::::
- Page 485 and 486:
fragment of pBR322 DNA, a 3.0-kbp S
- Page 487 and 488:
Mak TW (1979) Proc Natl Acad Sci US
- Page 489 and 490:
Table 1. Transformation of 3T3 cell
- Page 491 and 492:
inserts in the genome of rapidly tr
- Page 493 and 494:
pulations, it seemed likely that th
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contains antigens which react with
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Haematology and Blood Transfusion V
- Page 499 and 500:
le of reacting in sensitive radioim
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Haematology and Blood Transfusion V
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gic approach. In: Hiatt HH, Watson
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12 Eco R [ Fig. 1. Hybridization pa
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Haematology and Blood Transfusion V
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10 - '1~ )( -~ S:! E A U I o 1 2
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Haematology and Blood 'fransfusion
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cultures. These cells did not conta
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indication of malignant T-cells in
- Page 517 and 518:
Fig. 3. Thin-section electron micro
- Page 519 and 520:
Table 3. Lack of detectable related
- Page 521 and 522:
J. HTLV Was Present in the Primary
- Page 523 and 524:
specific signals into nonspecific s
- Page 525 and 526:
Table 2. Distribution of HTLV-relat
- Page 527 and 528:
u 10 ~ 20 ~ :c 30 a 40 o Fig. 1. Ki
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Haematology and Blood Transfusion V
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SSV TrS-gp labeled effectively with
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Haematology and Blood Transfusion V
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60 HFF/SSV cDNA CELL RNAs: 0 HF/SSV
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Antisera a Table 1. Immunofluoresce
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Haematology and Blood 'ftansfusion
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y competition RIA yielded virtually
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SiS'V' gp70: ANTIGEN, ANTI BODY, IM
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type-C virus p30 antigen in cells f
- Page 547 and 548:
c. Results The fractionated whole-b
- Page 549 and 550:
induced antibodies as well as exper
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- Fig. la-f. Retravirus particles p
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eplication of infecting murine leuk
- Page 555 and 556:
Haematology and Blood Transfusion V
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immunodeficiency, multic10nal lymph
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Bovine leukemia --, proteins of 499
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Human T- cell - -, characterization
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RNA -, of tumor virus 439 Rous sarc
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Haematology andBlood Transfusion Su