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portive care, inc1uding the use of gastro intestinal tract decontamination, aggressive antibiotic therapy for fever as before, and scrupulous attention to the increased incidence of pneumonia. The use of transtracheal aspiration has made it possible to obtain bacterial isolates and thus potentially influence antibiotic therapy in approximately 50% of the patients with suspected chest infection from whom sputum could not be obtained (Slevin et al.1981). Early analysis of the most re cent Trials (IX, X) suggest that the intensity of the very early therapy is critical to the duration of remission. It is not possible to comment yet on the relevance of "consolidation" therapy, although there is some evidence to support the contention that "early intensification" improves the dura ti on of remission (Bell et al., to be published). The role of maintenance or continuation (philosophically more attractive) therapy has certainly not been established. However, the comparisons made have not all been concurrent nor has identical early therapy been used in all the studies analysed. As in all other reported series, a very c10se correlation between the response to initial therapy and survival has been observed. The obvious corollary of this, namely that overall survival in all studies must now be better than previously since the complete remission rate is so much higher, has yet to be established. There is, however, no doubt that long survival has never been seen in patients in whom the bone marrow is not returned to normal. Extensive analysis of those patients surviving more than 3 years has revealed a wealth of negative correlations between presentation features and survival with only a suspicion that the intensity of the early therapy is important. This is based solelyon the fact that a high proportion of the long survivors were treated in the Trial VIII study and must be tempered by the fact that this is the most recent study, by definition, in which long survivors have occurred. Further long follow up is obviously required. In spite of all these reservations, we believe that these results should be viewed with optimism. Ten years aga the major publications on this subject were only able to record, with justifiable optimism, that it was possible to achieve remission in AML and that it should be treated with curative intent. The data presented here in complete concordance with that of others (Ellison and Glidewell 1979; Keating et al., to be published) show that a significant proportion will live at least 3 years. Exciting experiments with bone marrow transplantation, both in terms of eradication of leukaemia and mismatched grafting, further manipulation of chemotherapy and the design of good c1inical experiments may lead to the speculation of the seventies becoming the reality of the eighties. Acknowledgments The authors are pleased to acknowledge the contribution of the technical and clerical staff of the Departments of Medical Oncology and Haematology and the expert care provided by the nursing and medical staff of Dalziel and Annie Zunz Wards. The manuscript was typed by Miss Jill Davey. References Bell R, Rohatiner AZS, Ford J, Slevin ML, Amess J, Malpas JS, Lister TA (to be published) Short term therapy for acute myelogenous leukaemia - Crowther D, Powles RL, Bateman CJT, Beard MEJ, Gauci CL, Wrigley PFM, Malpas JS, Hamilton Fairley G, Bodley Scott R (1973) Management of adult acute myelogenous leukaemia. Br Med J 1: 131-137 - Ellison RR, Glidewell 0 (1979) Improved survival in adults with acute myelocytic leukaemia. Proc Am Assoc Cancer Res 20: 651 - Gale RP, Cline MJ (1977) High remission-induction rate in acute myeloid leukaemia. Lancet 1 :497-499 - Keating MJ, Smith TC, McCredie KB (to be published) A four year experience with Anthracycline, Cytosine Arabinoside, Vincristine and Prednisone combination chemotherapy in 325 adults with acute leukaemia. Cancer - Lister TA, Whitehouse JMA, Oliver RTD, Bell R, Johnson SAN, Wrigley PFM, Ford JM, Cullen MH, Gregory W, Paxton AM, Malpas JS (1980) Chemotherapy and immunotherapy for acute myelogenous leukaemia. Cancer 46:2142-2148 - Powles RL, Russell J, Lister TA, Oliver RTD, Whitehouse JMA, Malpas JS, Chapuis B, Crowther D, Alexander P (1977) Immunotherapy for acute myelogenous leukaemia. A controlled clinical study 21f2 years after entry of last patient. Br J Cancer 35:265-275 - Priesler H, Browman G, Henderson E, Hryniuk W, Freeman A (1980) Treatment of acute myelocytic leukaemia. Effects of early intensive consolidation. Proc. ASCO 21 :C-493 - Rees JKH, Sandler RM, Challender J, Hayhoe FGJ (1977) Treatment of acute myeloid leukaemia with a tripIe cytotoxic regime: DAT. Br J Cancer 36:770-776 - Rohatiner AZS, LowesLA, Lister TA (1981) Infection in acute myelogenous 43
leukaemia. An analysis of 168 patients. Journal of Hospital Infection, in press - Slevin ML, Lowes A, Bell R, Catto-Smith A, Ford JM, Malpas JS, Lister TA (1981) The role of transtracheal aspiration in the diagnosis of respiratory infection in neutropenic patients with acute Ieukaemia. Leukemia Research 5: 165-168 - Schimpff SC, Green WH, Young VM, Fratner CC, Jepson J, Cusack N (1975) Infection prevention in acute non-Iymphocytic leukaemia. Laminar air flow room reverse isolation with oral non-absorbable antibiotic prophylaxis. Ann Intern Med 82:351-358 44
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Haematology and Blood Transfusion 2
Page 3 and 4:
Dr. Rolf Neth, Universitäts-Kinder
Page 5 and 6: Participants of the Meeting Aaronso
Page 7 and 8: Kurth, R, Friedrich-Miescher-Labora
Page 9 and 10: Wilsede Scholarship Holders (Grante
Page 11 and 12: Preface Gut ist eine Lehrart, wo ma
Page 13 and 14: Personal and scientific discussion
Page 15 and 16: Acknowledgement We should like to t
Page 17 and 18: Wilsede, June 21 1978 Memorial Trib
Page 19 and 20: limiting benign lymphoproliferative
Page 21 and 22: this most unlikely, however (for re
Page 23 and 24: longer subject to the same control
Page 25 and 26: Bregula U, Wiener F, Harris H (1971
Page 27 and 28: fresh lymph node biopsies from ten
Page 29 and 30: Fig. 3. Binucleate mitosis in an ob
Page 31 and 32: y Fig. 4. Schematic diagram of post
Page 33 and 34: than that among patients with Stage
Page 35 and 36: Tests of binding affinity, agglutin
Page 37 and 38: N Engl J Med 297: 963-968 - Green I
Page 39 and 40: Clinical Aspects
Page 41 and 42: "ring chromosome". "Mar" is marker,
Page 43 and 44: 191 chromosomally abnormal patients
Page 45 and 46: tumors of both African and non-Afri
Page 47 and 48: Haematology and Blood Transfusion V
Page 49 and 50: Retrospective group 26/93 evolved l
Page 53 and 54: Treatment
Page 55: advantage in terms of duration of f
Page 59 and 60: 11. Treatment Program Chemotherapy
Page 61 and 62: efractory congestive heart failure
Page 63 and 64: period (Sequence II) was gene rally
Page 65 and 66: children with a multiple drug proto
Page 67 and 68: DAYS 1 5 10 15 20 25 30 35 , I I I
Page 69 and 70: Biologically Drug Outcome fit" sens
Page 71 and 72: may counterbalance the potential be
Page 73 and 74: Ht (0--0) 50 40 30 20 10 0 Platelet
Page 75 and 76: 10 7 ,-----------------------------
Page 77 and 78: 11. Haematological and Biochemical
Page 79 and 80: 0\ 0\ INTERFERON ... 10 3 rl E "'
Page 83 and 84: ("pre-B" phenotype) has been descri
Page 85 and 86: human bone marrow cells exhibit the
Page 87 and 88: 10 9.,0 MBKCC .. .,4 B prot:oool 1'
Page 89 and 90: demann W, Büehner T, Arlin Z, Gee
Page 91 and 92: -...l 00 a-tLDRENS CAt«:ER S TU>Y
Page 93 and 94: prognostic characteristics under in
Page 95 and 96: significantly higher in HR} (14.5%,
Page 97 and 98: normal or elevated immunoglobulin l
Page 99 and 100: References Andreeff M, Darzynkiewic
Page 101 and 102: R GROUP 1 ( 1970 - 1971 ) 17 PTS. R
Page 103 and 104: Table 3. Influence of initial featu
Page 105 and 106: LIJ (f) a.. < -1 LIJ Q: u. 0 >- I-
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Haematology and Blood Transfusion V
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me nt indicated that additional the
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42:2123-2134 - Chessells JM, Cornbl
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Baum et al. 1979). This study was b
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1. 0 '--'1--" 0.9 e: o .- VI VI E C
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e: o e: 1. 0 ,.--...-- 1'"'\ ......
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In conclusion, we can state that th
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Haematology and Blood Transfnsion V
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INDUCTION VCR + PRED + ASNASE (wk 3
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SCHED.INT 1 MTX • ! Adria MTX •
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~ looh---------ooooc>----o---c>----
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Consoll- Irra .tlon t) .tlon Indu
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Highrisk Standard risk Table 1. Cli
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Cumulo/ive comp/el9 remission 1.0 .
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10° 8 = 6 ö 4 Non T Cell .~ :ö
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% SURVIVAL 100 ~ ~II 0 80 60 40 - -
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a) Percentage of donor cell mitoses
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Table 5. Results of bone marrow tra
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...... w N Table 7. Clinical result
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agent had to be added and that in t
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C. Chronic Myelogenous Leukemia The
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Patients with a suitable donor rece
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No. Recurrent Leukaemia Other death
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followed by dialysis against isoton
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HS, HL- Heme >_ 40 0 HS I ;:. =====
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knowing at present. These genes may
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esistance to antifolates. In Vitro
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a DNA probe specific for the gene t
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translocation between chromosomes 9
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Table 1. Subdivision of 1827 Myelo-
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NORMAL CELL ®
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some change of the primary type, in
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F. Transformation of Mouse Bone Mar
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were carried out with 3H-MTX in the
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the lysozyme cDNA prepared from ovi
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et al. 1976). The BJAB cellline in
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dalton bands corresponding to light
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1979). The EBV-carrying cell lines
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producer lines (DAUDI and P3HR-1),
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G, Giovanella B, Westman A, Stehlin
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Dc;bt CT + i J.I9 Raji; 1. i .. 100
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c. Discussion During infectious mon
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C. Nonepisomal Viral DNA We have us
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A 260 3.0 A B 1670 70 N2 2.0 c: E .
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vivo. Nature 260:302-306 - Kirk JTO
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Fig. 1. a Polyacrylamide gelelectro
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1979). The lymphocyte subpopulation
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lysin 0 antigens are found, and mix
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Pope JH (1978) Long-term T cell-med
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Charaeteristie Morphologie maturati
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after TPA-induction (Table 3). The
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PA (1978) Reactivity of a rabbit an
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Blood Monocyte. B lood Monocytes 1-
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and nonhistone proteins can serve a
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The findings of the evaluation of s
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Fig. 3. Tumor grawth of L 428 cells
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Cell biological and Immunological A
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consideration. Sanel (1973) obtaine
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endotoxin serum, were used. A parti
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monocytic leukemia cell line in cul
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B. Isolation, Characterization and
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don al hemopathies generally displa
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nitors. Blood Cells 6:595-607 - Min
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\I) ....I ....I IU Jl 200 r 100 90
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their haemopoietic cells' ability t
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normal normal ALL ALL ALL persons p
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64.5 { V)
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References Biermann E, Neth R, Gros
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ehambers, the growth pattern observ
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References Anderssen LC, 10kinen M,
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REH CELL UNE TO CALLb~Ö ~q~ V.M. c
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the macrophage series in which the
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Table 1. Production of factor depen
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Table 1. Characteristics of the adh
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Fig. 3. A human marrow culture at 6
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300 250 • HYPERPROLIFERATIVE PATT
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Fig. 9. Nonadherent population from
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The cobblestone areas were often no
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L (1976) Induction of colony format
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B. Materials and Methods J. Tissue
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Fig. 2. Ultrastructural appearance
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Page 307 and 308:
Page 309 and 310:
Table 1. Monoclonal antibody reacti
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al. 1979; Janossy et al. 1979) is e
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to which this is an exact replica o
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inger JL (1976) Distribution of la-
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I region antigens were found to be
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have been reported to be present on
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V. FunctionalAssays Assays for PHA
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Functional studies of UCHT1 separat
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40 ,...... (5 L.. C o u 30 .9 ~ .~
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with immunohistochemieal methods (L
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can be dissected by cloning. Utiliz
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Table 1. Origin and marker profile
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Page 339 and 340:
complete identity of gp 100 from no
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Table 1. Reaction of single anti se
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media. Following 24-h incubation, c
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nonleukemic eells (Greaves 1979). L
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Fig. 2. Cytocentrifuged smears of b
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Modification of amino-groups of hum
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disturb this balance in the directi
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The majority of human blood lymphoc
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of the EBV infected B cells. Howeve
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and immunoglobulins. J Immunol 120:
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" K 10 • j ~ ALL RNlL AL wtfh les
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tion akuter Leukämiezellen in "spo
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D. Results and Discussion J. Acute
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selectively responsive to different
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l1J ~ 100 ~ Q. ::) l1J Z 0 ~ z >- .
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Table 2. Growth inhibition of S49 e
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Reverse Infectious ASC/2X1Q6 transc
Page 379 and 380:
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munized animals to 1316 tumor cells
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Page 385 and 386:
Fig. 3. Expression of retroviral gp
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pg70. J Exp Med 143: 151-166 - McGr
Page 389 and 390:
Table 1. Expression of tumor antige
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Virological and Molecularbiological
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Table 1. Oncogenic properties of re
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also Fig. 1). It followed that the
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whether this sequence is related to
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zed in infected cells argue that th
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a specific viral transforming prote
Page 403 and 404:
detect viral RNA as the only charac
Page 405 and 406:
Eisen H (1980) Myeloproliferate vir
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p,60- -34K - 1 2 3 4 Fig. 1. In vit
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.. p - • a'T ... I .t'l Fig. 4. D
Page 411 and 412:
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Fig. 2. Photomicrographs of NY68 in
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DEAE (o(lJmn 'liI GI -2 2 o e s 1
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vity was deterrnined. For endogenou
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pr 180 - - - P 12/15 - A B c D E F
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85,- 66- -27 - -66 40- 27- -1'9 19-
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= 0.5 o E Q. o ILI 0.4 (J) « ILI .
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Table 1. Oncogenic potential of avi
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100 III GI c: o "8 80 > w
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Expt. No. Infecting virus Proportio
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Haematology and Blood 'fransfusion
Page 435 and 436:
sequences, provided its gag portion
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77:3009-3013 - Hu SSF, Moscoviei C,
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RI 2.2 md and Hind III 2.6 md leuke
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Page 443 and 444:
RELATIONSHIP OF ENDOGENOUS AND EXOG
Page 445 and 446:
E ........ E Cl. U E :::l .... Q) (
Page 447 and 448:
References Astrin S (1978) Endogeno
Page 449 and 450:
the same animal were examined (e.g.
Page 451 and 452:
I) 'IQ a \0 - CL -- Fig. 2. Restrie
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~ ..................... ~ Cell 3' 5
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a :Sa,C! + . ~ 111 i' ( " '~ .J. b
Page 457 and 458:
Table 1 Sampie Tissue TS fragment"
Page 459 and 460:
a b Sac I / rep ._-_.-_ K J nl rep
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Haematology and Blood 'fiansfusion
Page 463 and 464:
Osteopetrosis and osteosarcomas occ
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Lymphoma cellline Table 1. T and B
Page 467 and 468:
Table 2. In vivo growth and oneogen
Page 469 and 470:
Page 471 and 472:
Table 1. Transforming aetivity of c
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Table 3. Transformation aetivity of
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- Shoemaker C, Goff S, Gilboa E, Pa
Page 477 and 478:
indieate a shifting of target eell
Page 479 and 480:
Table 2. Expression of Jl and Sourc
Page 481 and 482:
Page 483 and 484:
~ i ,..1---------,,':::::::::::::::
Page 485 and 486:
fragment of pBR322 DNA, a 3.0-kbp S
Page 487 and 488:
Mak TW (1979) Proc Natl Acad Sci US
Page 489 and 490:
Table 1. Transformation of 3T3 cell
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inserts in the genome of rapidly tr
Page 493 and 494:
pulations, it seemed likely that th
Page 495 and 496:
contains antigens which react with
Page 497 and 498:
Page 499 and 500:
le of reacting in sensitive radioim
Page 501 and 502:
Page 503 and 504:
gic approach. In: Hiatt HH, Watson
Page 505 and 506:
12 Eco R [ Fig. 1. Hybridization pa
Page 507 and 508:
Page 509 and 510:
10 - '1~ )( -~ S:! E A U I o 1 2
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Haematology and Blood 'fransfusion
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cultures. These cells did not conta
Page 515 and 516:
indication of malignant T-cells in
Page 517 and 518:
Fig. 3. Thin-section electron micro
Page 519 and 520:
Table 3. Lack of detectable related
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J. HTLV Was Present in the Primary
Page 523 and 524:
specific signals into nonspecific s
Page 525 and 526:
Table 2. Distribution of HTLV-relat
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u 10 ~ 20 ~ :c 30 a 40 o Fig. 1. Ki
Page 529 and 530:
Page 531 and 532:
SSV TrS-gp labeled effectively with
Page 533 and 534:
Page 535 and 536:
60 HFF/SSV cDNA CELL RNAs: 0 HF/SSV
Page 537 and 538:
Antisera a Table 1. Immunofluoresce
Page 539 and 540:
Haematology and Blood 'ftansfusion
Page 541 and 542:
y competition RIA yielded virtually
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SiS'V' gp70: ANTIGEN, ANTI BODY, IM
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type-C virus p30 antigen in cells f
Page 547 and 548:
c. Results The fractionated whole-b
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induced antibodies as well as exper
Page 551 and 552:
- Fig. la-f. Retravirus particles p
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eplication of infecting murine leuk
Page 555 and 556:
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immunodeficiency, multic10nal lymph
Page 559 and 560:
Bovine leukemia --, proteins of 499
Page 561 and 562:
Human T- cell - -, characterization
Page 563 and 564:
RNA -, of tumor virus 439 Rous sarc
Page 565 and 566:
Haematology andBlood Transfusion Su
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