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Dimethylsulfoxide (DMSO), differention of human leukemic cells by 215, 268 DNA fragments 479, 496 --, expression 201 - -, mediated gene transfer 171 --, methylation and gene -, RNA hybridization 515, 517 -, tumorvirus447,497,548 -,vkaI197,383,497 Double minutes 153 EBNA3,184 ELISA530 Epigenetic, controll in tumorgenicity 8 Episomes, viral DNA in 198 Epstein-Barrvirus 3,179,207,548 - -, antibodies against 192, 208 --, Buskittlymphoma3, 179, 191 --, cell fusion with 193 --, genom 191 - -, infected cells 192 --, mononuc1eosis infectiosa 4,179,191,207 --, nasopharyngealcarcinoma 179, 191 --, receptor 180 - -, Virus Capsid Antigen of 192 --, X-linked malignant lymphoma 207 Erythrocyte ghosts, loaded with EBNA 185 --, used for microinjection 143, 185 --, usedfortherapy 143 FeLV IFeSV 384, 483, 488, 492 --, anti-sera 492 --, viral nonproducer 492 Flow cytometry of chromosomes 156 FOCMA 484, 488, 492 -, immune response to 485, 490, 492 Friend leukemia virus in haemopoiesis 272, 472 Fujinami sarcoma virus 389 Fusion injection technique 143 Gag see also gene -, gene 386 - - x polyproteins 485, 488 Gene -, aev389 -, amplification 153 -, amv430 -, carcino 5, 9, 393 -, DHFR-I72 -, drugresistance 167 -, EBV see EBV -, env 386, 455 -, episomal viral 197 -, expression and DNA methylation 201 -, fev389 -, gag 386 - -globin 157 -, insertion 167 -, integration 172 -, lysozyme 175 -,maI460 -, mcv389 -, mos460 -,onc386,455,482 -, pol 386, 455 -, retrovirus 383 -, src385 -, transforming 168,171,383,441 Genetic, control in tumorigenicity 8 -, elements 152 -, influence on myelopoiesis 237 -, of leukemogenesis 432 -, structures of viruses 386 -, traits 152 Genom see also gene -,AMV430 -, BALB/c479 -,SFFV472 -, virus 433 Glycophorin A 300, 338 - - in erythroid differentiation 301,340 - - in leukernic cells 340 --, structur238 Graft versus host disease 124, 137,140 ----, pretreatmentwith antisera 124 ----, suppression of 124 Growth-control of T -ce1l363, 504 --, T-Iymphomas363,504 - -factor dependent blood celliines 273 - -inhibition by monoc1onal antibodies 364 -, U 3 region for433 Hematopoietic -, differentiation 325 -- and virus 272 --, glycophorinAin339 -, progenitors 246 -, regulation of 272 -, target cells 417 Herpes virus 197 --, DNA-sequences in lymphoid tumorcelllines 198 Heterogeneous nuc1ear RNA 517 - - - in leukemia 518 HLA-ABCin erythropoeticcells 301 - -DR in leukemic cells 300 - - in erythropoetic cells 301, 340 -, monoc1onal antibodies against 300, 310 HL60-promyelocytic cells 517 Hodgkin's disease 11 --, immunologicaldefectin 16 --,longtermculturesof229 Homogeneously staining regiones 153 Human T -celllymphoma leukemia virus (HTLV) 509 553
Human T- cell - -, characterization by nucleic acid hybridization 515 Hybridcells 181 Hyperthermia, treatment with 146 la-antigen 297 -, expression on Hodgkin celliines 213 --, U-937 cell-surface 219 - in lymphoid cell differentiation 180 Idiotypic-antibodies 343 Immune response --, against antigen loaded erythrocytes ghost 144 - - in Hodgkin 's disease 17 -- in X-linked lymphoproliferative syndrome 210 --, toFOCMA485 Immune system --, adaption to tumor cells 378 --, cloningcells of 294 - -, idiotypic compartments 343 - -, network concept of 343 Immunotherapy of AML 39,54 -, nonspecific 343 Initiation factor in pro tein synthesis 147 Insertion of genes 167 Interferon, activated lymphocytes 346 -, effect oftranslation 148 -, treatment of leukemia 63 Iron, apoferritin in Hodgkin's disease 20 -, binding proteins 20,244 -, ferritin inhibition activity on CFU-MG 244 Isoenzyme in lymphomas 222 Karyotype 151 - in leukemia 27 - in nasopharyngeal carcinomas 195 Killer cells 346, 351 --, isolation by bacteria binding 358 Lactoferrin, inhibition of CSF production by 244 Lectin induced cell killing 362 Leukemia -, ADP-ribosylation in 226 -, associated inhibitory activity (LIA) 242 -, bovine 495 -, cell markers in 355 -, CFU-C in 243,246,252,255 -, chromosom abnormalities in 27, 161 -,CNSI04 -, cytoreduction 73 -, diffusion chamber culture in 62,262,265 -, feline 483 -, genetic factors 237 -, hn RNAin 517 -, human, oncoviruses in 502, 527,530 -, infections 483, 495, 512 -, interferron treatment of 63 - in vitro induction of 272 -, killer cells in 351 -, meningeal 51, 81 -, network concept in 343 -, prognosticfactor in 78,89 -, radiation induced 537 -, T-ceIl5, 70, 90, 506 -, terminale deoxynucleotidyl transferase in 69 -, treatment of 2,22,53,79,88,91,100,108,116 -, treatment with bone marrow transplantation 132, 136,140 --, with high dose thymidin 73 -, viruses 390, 409, 455 -, virus negative 492 Leukemic cell --, antigens, related to C-typ viruses see viral and virus --, cALL-antigen expression in see commonALLantigen --, differentiation of, in culture 62, 262, 265, 268 --, drug sensitivity of 55 - -, killer cells against 348 --, lines see celllines - -, surface marker of 298,355 Leukemogenesis, mechanism of 272 -, genetics of 432 -, promoter insertion model for 444 -, retrovirusin445,512 -, U 3 -regionin435 Long terminal repeat 458, 460 LPS see also lectin -, stimulated lymphocyt cultures 366 Lymphangiogram in Hodgkin's disease 16 Lymphocytes see also B- and T -lymphocytes -, antiidiotypic 343 -, bacteria binding to 355 -, T- 343 Lymphomas -, celllines 198, 323, 377, 505 -, histological types of 318 -, immunological subtypes of 315 -, isoenzymes in 222 -, pathogenesis of 372 -, T -ce1l502 -, TDT -activities in 69 Lymphoreticular neoplasias 14q + markers in 4,31 Lymphotoxicity 345 Lysozyme gene 175 --, expression in macrophages 176 ---in Oviduct 176 Macrophage, expression of lysozyme gene in 176 -, isoenzyme in 222 -, regulation of myelopoiesis by 238 -, synthesis of CSF- and PGE by 239 Meningealleukemia 51 Methotrexate see also chemotherapy 554
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Haematology and Blood Transfusion 2
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Dr. Rolf Neth, Universitäts-Kinder
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Participants of the Meeting Aaronso
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Kurth, R, Friedrich-Miescher-Labora
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Wilsede Scholarship Holders (Grante
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Preface Gut ist eine Lehrart, wo ma
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Personal and scientific discussion
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Acknowledgement We should like to t
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Wilsede, June 21 1978 Memorial Trib
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limiting benign lymphoproliferative
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this most unlikely, however (for re
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longer subject to the same control
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Bregula U, Wiener F, Harris H (1971
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fresh lymph node biopsies from ten
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Fig. 3. Binucleate mitosis in an ob
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y Fig. 4. Schematic diagram of post
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than that among patients with Stage
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Tests of binding affinity, agglutin
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N Engl J Med 297: 963-968 - Green I
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Clinical Aspects
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"ring chromosome". "Mar" is marker,
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191 chromosomally abnormal patients
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tumors of both African and non-Afri
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Haematology and Blood Transfusion V
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Retrospective group 26/93 evolved l
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Treatment
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advantage in terms of duration of f
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leukaemia. An analysis of 168 patie
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11. Treatment Program Chemotherapy
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efractory congestive heart failure
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period (Sequence II) was gene rally
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children with a multiple drug proto
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DAYS 1 5 10 15 20 25 30 35 , I I I
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Biologically Drug Outcome fit" sens
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may counterbalance the potential be
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Ht (0--0) 50 40 30 20 10 0 Platelet
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10 7 ,-----------------------------
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11. Haematological and Biochemical
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0\ 0\ INTERFERON ... 10 3 rl E "'
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("pre-B" phenotype) has been descri
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human bone marrow cells exhibit the
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10 9.,0 MBKCC .. .,4 B prot:oool 1'
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demann W, Büehner T, Arlin Z, Gee
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-...l 00 a-tLDRENS CAt«:ER S TU>Y
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prognostic characteristics under in
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significantly higher in HR} (14.5%,
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normal or elevated immunoglobulin l
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References Andreeff M, Darzynkiewic
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R GROUP 1 ( 1970 - 1971 ) 17 PTS. R
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Table 3. Influence of initial featu
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LIJ (f) a.. < -1 LIJ Q: u. 0 >- I-
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me nt indicated that additional the
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42:2123-2134 - Chessells JM, Cornbl
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Baum et al. 1979). This study was b
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1. 0 '--'1--" 0.9 e: o .- VI VI E C
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e: o e: 1. 0 ,.--...-- 1'"'\ ......
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In conclusion, we can state that th
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Haematology and Blood Transfnsion V
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INDUCTION VCR + PRED + ASNASE (wk 3
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SCHED.INT 1 MTX • ! Adria MTX •
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~ looh---------ooooc>----o---c>----
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Consoll- Irra .tlon t) .tlon Indu
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Highrisk Standard risk Table 1. Cli
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Cumulo/ive comp/el9 remission 1.0 .
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10° 8 = 6 ö 4 Non T Cell .~ :ö
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% SURVIVAL 100 ~ ~II 0 80 60 40 - -
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a) Percentage of donor cell mitoses
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Table 5. Results of bone marrow tra
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...... w N Table 7. Clinical result
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agent had to be added and that in t
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C. Chronic Myelogenous Leukemia The
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Patients with a suitable donor rece
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No. Recurrent Leukaemia Other death
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followed by dialysis against isoton
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HS, HL- Heme >_ 40 0 HS I ;:. =====
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knowing at present. These genes may
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esistance to antifolates. In Vitro
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a DNA probe specific for the gene t
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translocation between chromosomes 9
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Table 1. Subdivision of 1827 Myelo-
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NORMAL CELL ®
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some change of the primary type, in
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F. Transformation of Mouse Bone Mar
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were carried out with 3H-MTX in the
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the lysozyme cDNA prepared from ovi
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et al. 1976). The BJAB cellline in
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dalton bands corresponding to light
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1979). The EBV-carrying cell lines
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producer lines (DAUDI and P3HR-1),
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G, Giovanella B, Westman A, Stehlin
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Dc;bt CT + i J.I9 Raji; 1. i .. 100
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c. Discussion During infectious mon
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C. Nonepisomal Viral DNA We have us
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A 260 3.0 A B 1670 70 N2 2.0 c: E .
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vivo. Nature 260:302-306 - Kirk JTO
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Fig. 1. a Polyacrylamide gelelectro
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1979). The lymphocyte subpopulation
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lysin 0 antigens are found, and mix
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Pope JH (1978) Long-term T cell-med
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Charaeteristie Morphologie maturati
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after TPA-induction (Table 3). The
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PA (1978) Reactivity of a rabbit an
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Blood Monocyte. B lood Monocytes 1-
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and nonhistone proteins can serve a
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The findings of the evaluation of s
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Fig. 3. Tumor grawth of L 428 cells
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Cell biological and Immunological A
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consideration. Sanel (1973) obtaine
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endotoxin serum, were used. A parti
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monocytic leukemia cell line in cul
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B. Isolation, Characterization and
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don al hemopathies generally displa
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nitors. Blood Cells 6:595-607 - Min
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\I) ....I ....I IU Jl 200 r 100 90
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their haemopoietic cells' ability t
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normal normal ALL ALL ALL persons p
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64.5 { V)
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References Biermann E, Neth R, Gros
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ehambers, the growth pattern observ
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References Anderssen LC, 10kinen M,
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REH CELL UNE TO CALLb~Ö ~q~ V.M. c
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the macrophage series in which the
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Table 1. Production of factor depen
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Table 1. Characteristics of the adh
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Fig. 3. A human marrow culture at 6
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300 250 • HYPERPROLIFERATIVE PATT
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Fig. 9. Nonadherent population from
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The cobblestone areas were often no
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L (1976) Induction of colony format
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B. Materials and Methods J. Tissue
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Fig. 2. Ultrastructural appearance
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Table 1. Monoclonal antibody reacti
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al. 1979; Janossy et al. 1979) is e
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to which this is an exact replica o
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inger JL (1976) Distribution of la-
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I region antigens were found to be
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have been reported to be present on
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V. FunctionalAssays Assays for PHA
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Functional studies of UCHT1 separat
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40 ,...... (5 L.. C o u 30 .9 ~ .~
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with immunohistochemieal methods (L
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can be dissected by cloning. Utiliz
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Table 1. Origin and marker profile
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complete identity of gp 100 from no
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Table 1. Reaction of single anti se
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media. Following 24-h incubation, c
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nonleukemic eells (Greaves 1979). L
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Fig. 2. Cytocentrifuged smears of b
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Modification of amino-groups of hum
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disturb this balance in the directi
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The majority of human blood lymphoc
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of the EBV infected B cells. Howeve
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and immunoglobulins. J Immunol 120:
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" K 10 • j ~ ALL RNlL AL wtfh les
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tion akuter Leukämiezellen in "spo
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D. Results and Discussion J. Acute
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selectively responsive to different
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l1J ~ 100 ~ Q. ::) l1J Z 0 ~ z >- .
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Table 2. Growth inhibition of S49 e
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Reverse Infectious ASC/2X1Q6 transc
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munized animals to 1316 tumor cells
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Fig. 3. Expression of retroviral gp
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pg70. J Exp Med 143: 151-166 - McGr
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Table 1. Expression of tumor antige
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Virological and Molecularbiological
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Table 1. Oncogenic properties of re
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also Fig. 1). It followed that the
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whether this sequence is related to
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zed in infected cells argue that th
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a specific viral transforming prote
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detect viral RNA as the only charac
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Eisen H (1980) Myeloproliferate vir
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p,60- -34K - 1 2 3 4 Fig. 1. In vit
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.. p - • a'T ... I .t'l Fig. 4. D
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Fig. 2. Photomicrographs of NY68 in
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DEAE (o(lJmn 'liI GI -2 2 o e s 1
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vity was deterrnined. For endogenou
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pr 180 - - - P 12/15 - A B c D E F
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85,- 66- -27 - -66 40- 27- -1'9 19-
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= 0.5 o E Q. o ILI 0.4 (J) « ILI .
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Table 1. Oncogenic potential of avi
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100 III GI c: o "8 80 > w
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Expt. No. Infecting virus Proportio
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Haematology and Blood 'fransfusion
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sequences, provided its gag portion
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77:3009-3013 - Hu SSF, Moscoviei C,
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RI 2.2 md and Hind III 2.6 md leuke
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RELATIONSHIP OF ENDOGENOUS AND EXOG
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E ........ E Cl. U E :::l .... Q) (
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References Astrin S (1978) Endogeno
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the same animal were examined (e.g.
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I) 'IQ a \0 - CL -- Fig. 2. Restrie
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~ ..................... ~ Cell 3' 5
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a :Sa,C! + . ~ 111 i' ( " '~ .J. b
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Table 1 Sampie Tissue TS fragment"
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a b Sac I / rep ._-_.-_ K J nl rep
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Haematology and Blood 'fiansfusion
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Osteopetrosis and osteosarcomas occ
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Lymphoma cellline Table 1. T and B
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Table 2. In vivo growth and oneogen
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Table 1. Transforming aetivity of c
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Table 3. Transformation aetivity of
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- Shoemaker C, Goff S, Gilboa E, Pa
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indieate a shifting of target eell
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Table 2. Expression of Jl and Sourc
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~ i ,..1---------,,':::::::::::::::
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fragment of pBR322 DNA, a 3.0-kbp S
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Mak TW (1979) Proc Natl Acad Sci US
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Table 1. Transformation of 3T3 cell
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inserts in the genome of rapidly tr
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pulations, it seemed likely that th
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contains antigens which react with
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le of reacting in sensitive radioim
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gic approach. In: Hiatt HH, Watson
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12 Eco R [ Fig. 1. Hybridization pa
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Page 509 and 510: 10 - '1~ )( -~ S:! E A U I o 1 2
Page 511 and 512: Haematology and Blood 'fransfusion
Page 513 and 514: cultures. These cells did not conta
Page 515 and 516: indication of malignant T-cells in
Page 517 and 518: Fig. 3. Thin-section electron micro
Page 519 and 520: Table 3. Lack of detectable related
Page 521 and 522: J. HTLV Was Present in the Primary
Page 523 and 524: specific signals into nonspecific s
Page 525 and 526: Table 2. Distribution of HTLV-relat
Page 527 and 528: u 10 ~ 20 ~ :c 30 a 40 o Fig. 1. Ki
Page 529 and 530: Haematology and Blood Transfusion V
Page 531 and 532: SSV TrS-gp labeled effectively with
Page 535 and 536: 60 HFF/SSV cDNA CELL RNAs: 0 HF/SSV
Page 537 and 538: Antisera a Table 1. Immunofluoresce
Page 539 and 540: Haematology and Blood 'ftansfusion
Page 541 and 542: y competition RIA yielded virtually
Page 543 and 544: SiS'V' gp70: ANTIGEN, ANTI BODY, IM
Page 545 and 546: type-C virus p30 antigen in cells f
Page 547 and 548: c. Results The fractionated whole-b
Page 549 and 550: induced antibodies as well as exper
Page 551 and 552: - Fig. la-f. Retravirus particles p
Page 553 and 554: eplication of infecting murine leuk
Page 557 and 558: immunodeficiency, multic10nal lymph
Page 559: Bovine leukemia --, proteins of 499
Page 563 and 564: RNA -, of tumor virus 439 Rous sarc
Page 565 and 566: Haematology andBlood Transfusion Su
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