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York, pp 7-24 - Gallo RC, Reitz MS (1976) Molecular probes for tumor viruses in human cancer. Int Rev Exp Pathol16: 1-58 - Gallo RC, Gallagher RE, Miller NR, Mondal H, Saxinger WC, Mayer RJ, Smith RG, Gillespie DH (1975) Relationships between components in primate RNA tumorviruses and in the cytoplasm of human leukemic cells: Implications to leukemogenesis. Cold Spring Harbor Symp Quant Bio139: 933-961 - Gazdar AF, Carney DN, Bunn PA, Russell EF, Jaffe ES, Schechter GP, Guccion JG (1980) Mitogen requirements for the in vitro propagation of cutaneous T cell lymphomas. Blood 55 :409-417 - Gillis S, Baker PE, Union NA, Smith KA (1979) The in vitro generation and sustained culture of nude mouse cytolytic T -lymphocytes. J Exp Med 149: 1460-1466 - Gupta S, Good RA (1980) Markers of human lymphocyte subpopulations in primary immunodefieiency and lymphoproliferate disorders. Semin Hematol 17: 1-29 - Guroff MR, Gallo RC (1977) Serologieal analysis of cellular and viral DNA polymerases by an antiserum to DNA polymerase I-l of human lymphoblasts. Biochemistry 16:2874-2880 - Guroff MR, Gallo RC (1979) Type-specific binding antibody to baboon endogenous virus (M7) reverse transcriptase. J Gen Virol 43: 1-6 - Haran-Ghera N (1980) Pathogenesis of murine leukemia. In: Klein G (ed) Viral oncology. Raven, New York, pp 161-185 - Jaffe ES, Shevach EM, Sussman EH (1975) Membrane receptor sites for the identification of lymphoreticular cells in benign and malignant conditions. Br J Cancer 31: 107-120 (Suppl)-Kalyanaraman VS, Sarngadharan MG, Poiesz B, Ruscetti FW, Gallo RC (to be published) Immunological properties of a type-C retrovirus isolated from cultured human T-Iymphoma cells and comparison to other mammalian retroviruses. - Kaplan HS, Goodenow RS, Epstein AL, Gartner S, Decleve A, RosenthaI PN (1977) Isolation of type-C RNA virus from an established human histiocytie lymphoma cell line. Proc Natl Acad Sci USA 74:2564-2568 - Klein G (1980) Viral Oncology. Raven, NewYork-Larsson EL, Iscove NN, Coutinko A (1980) Two distinct factors are required for induction of T -cell growth. Nature 283:664-666 - Lutzner M, Edelson R, Schein P, Green I, Kirkpatrick C, Ahmd A (1975) Cutaneous T -cell lymphomas: The Sezary syndrome, mycosis fungoides and related disorders. Ann Intern Med 83:534-552 - Mier JW, Gallo RC (1980) Purification and some characteristies of human T-cell growth factor (TCGF) from PHA-stimulated lymphocyte conditioned media. Proc Natl Acad Sci USA 77:6134-6138 - Mondal H, Gallagher RE, Gallo RC (1975) RNA-directed DNA polymerase from human leukemic blood cells and from primate type-C virus producing cells: High and low molecular weight forms with variant biochemical and immunological properties. Proc Natl Acad Sci USA 72:1194-1198 - Morgan DA, Ruscetti FW, Gallo RC (1976) Selective in vitro growth of T-lymphocytes from normal human bone marrows. Seience 193: 1007-1008 - Nelson J, Yeong J, Levy J (1978) Normal human placentas contain RNA-directed DNA polymerase activity like that in viruses. Proc N atl Acad Sei USA 75: 6263-6267 - Nilsson K, Ponten J (1975) Classification and biologie nature of established human hematopoietie cell lines. Int J Cancer 15:321-341 - Nooter K, Aarssen AM, Bentvelzen P, d'Groot FG (1975) Isolation of an infectious C-type oncornavirus from human leukernie bone marrow cells. Nature 256: 595-597 - 01- son C (1979) Progress for control of bovine leukosis. Practitioner 14: 115-120 - Oppenheim JJ, Mizel SB, Meltzer MS (1979) Biologieal effects of lymphocyte and macrophage-derived mitogenie "amplication" factors. In: Cohen S, Peck E, Oppenheim JJ (eds) Biology of the Lymphokines. Academic, New York, pp 291-323 - Panem S, Prochownik EV, Reale FR, Kirsten WH (1975) Isolation of C-type virions from a normal human fibroblast strain. Seience 189:297-299 - Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC (to be published a) Isolation of type-C retrovirus partieIes from cultured and fresh lymphocytes of a patient with cutaneous T -celllymphoma. Proc N atl Acad Sei USA - Poiesz BJ, Ruscetti FW, Mier JW, Wopds AM, Gallo RC (1980) T cell lines established from human T-Iymphocytic neoplasias by direct response to T-cell growth factor. Proc Natl Acad Sci USA 77:6815-6819 - Poiesz BJ, Ruscetti FW, Reitz MS, Kalyanaraman VS, Gallo RC (1980) Evidence for nucleic acids and antigens of a new type-C retrovirus (HTLV) in primary ulcultured cells of a patient with Sezary T -cell leukemia and isolation of the virus. Proc Natl Acad Sci USA 77:7415-7419 - Reitz MS JR, Poiesz BJ, Ruscetti FW, Gallo RC (1981) Characterization and distribution of nucleic acid sequences of a novel type-C retrovirus isolated from neoplastic human T -lymphocytes. Proc Natl Acad Sci USA 78: 1887-1891 - Rho HM, Poiesz B, Ruscetti FW, Gallo RC (to be published) Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T -cell lymphoma cell line. - Ruscetti FW, Gallo RC (1981) Human T-lymphocyte growth factor: Regulation of growth and function of T-lymphocytes. Blood (Ed. Review) 57:379-394 -Ruscetti FW, MorganDA, Gallo RC (1977) Functional and morphologieal characterization of human T cells continuously grown in vitro. J Immunol 119: 131-138 - Sarngadharan MG, Robert-Guroff M, Gallo RC (1978) DNA polymerases of normal and neoplastie mammalian cells. Biochim Biophys Acta 516:419-487 - Saxon A, Stevens RH, Golde DW (1978) T-lymphocytic variant of hairy cell leukemia. Ann Intern Med 88:323-326 - Schidlovsky G (1977) Structure of RNA tumor viruses. In: Gallo RC (ed) Recent advances in cancer research: Cell biology, molecular biology and tumor virology, Vol I. CRC, Cleveland Ohio, pp 189-245 - Schreier MH, Tees R (1980) Clonal induction of helper T cells: Conversion of 513
specific signals into nonspecific signals. Int Arch AIlergy Appl Immuno161 :227-231-SchreierMH, Iscove NN, Tees R, Aardon L, von Boehmer H (to be published) Clones of killer and helper T cells: Growth requirements, specificity and retention of functions in long-term culture. Immunol Rev - Schwarce WW (1975) T cell origin of acid-phosphatase positive lymphoblasts. Lancet 2: 1264-1266 - Smith KA (to be published) T -cell growth factor. Immunol Rev - Smith RG, AbreIl JW, Lewis BJ, Gallo RC (1975) Serological analysis of human deoxyribonucleic acid polymerases. J Biol Chem 250: 1702-1709 - Smith KA, Lachman LB, Oppenheim JJ, Favata MF (1980) The functional relationship of the interleukernias. J Exp Med 151: 1551-1555 - Todaro GJ, Gallo RC (1973) Immunological relationship of DNA polymerase from human acute leukaemia cells and primate and mouse leukaemia virus reverse transcriptase. Nature 244:206-209 514
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Haematology and Blood Transfusion 2
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Dr. Rolf Neth, Universitäts-Kinder
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Participants of the Meeting Aaronso
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Kurth, R, Friedrich-Miescher-Labora
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Wilsede Scholarship Holders (Grante
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Preface Gut ist eine Lehrart, wo ma
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Personal and scientific discussion
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Acknowledgement We should like to t
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Wilsede, June 21 1978 Memorial Trib
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limiting benign lymphoproliferative
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this most unlikely, however (for re
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longer subject to the same control
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Bregula U, Wiener F, Harris H (1971
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fresh lymph node biopsies from ten
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Fig. 3. Binucleate mitosis in an ob
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y Fig. 4. Schematic diagram of post
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than that among patients with Stage
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Tests of binding affinity, agglutin
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N Engl J Med 297: 963-968 - Green I
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Clinical Aspects
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"ring chromosome". "Mar" is marker,
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191 chromosomally abnormal patients
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tumors of both African and non-Afri
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Haematology and Blood Transfusion V
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Retrospective group 26/93 evolved l
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Treatment
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advantage in terms of duration of f
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leukaemia. An analysis of 168 patie
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11. Treatment Program Chemotherapy
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efractory congestive heart failure
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period (Sequence II) was gene rally
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children with a multiple drug proto
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DAYS 1 5 10 15 20 25 30 35 , I I I
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Biologically Drug Outcome fit" sens
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may counterbalance the potential be
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Ht (0--0) 50 40 30 20 10 0 Platelet
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10 7 ,-----------------------------
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11. Haematological and Biochemical
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0\ 0\ INTERFERON ... 10 3 rl E "'
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("pre-B" phenotype) has been descri
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human bone marrow cells exhibit the
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10 9.,0 MBKCC .. .,4 B prot:oool 1'
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demann W, Büehner T, Arlin Z, Gee
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-...l 00 a-tLDRENS CAt«:ER S TU>Y
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prognostic characteristics under in
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significantly higher in HR} (14.5%,
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normal or elevated immunoglobulin l
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References Andreeff M, Darzynkiewic
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R GROUP 1 ( 1970 - 1971 ) 17 PTS. R
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Table 3. Influence of initial featu
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LIJ (f) a.. < -1 LIJ Q: u. 0 >- I-
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me nt indicated that additional the
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42:2123-2134 - Chessells JM, Cornbl
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Baum et al. 1979). This study was b
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1. 0 '--'1--" 0.9 e: o .- VI VI E C
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e: o e: 1. 0 ,.--...-- 1'"'\ ......
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In conclusion, we can state that th
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Haematology and Blood Transfnsion V
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INDUCTION VCR + PRED + ASNASE (wk 3
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SCHED.INT 1 MTX • ! Adria MTX •
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~ looh---------ooooc>----o---c>----
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Consoll- Irra .tlon t) .tlon Indu
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Highrisk Standard risk Table 1. Cli
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Cumulo/ive comp/el9 remission 1.0 .
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10° 8 = 6 ö 4 Non T Cell .~ :ö
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% SURVIVAL 100 ~ ~II 0 80 60 40 - -
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a) Percentage of donor cell mitoses
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Table 5. Results of bone marrow tra
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...... w N Table 7. Clinical result
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agent had to be added and that in t
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C. Chronic Myelogenous Leukemia The
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Patients with a suitable donor rece
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No. Recurrent Leukaemia Other death
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followed by dialysis against isoton
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HS, HL- Heme >_ 40 0 HS I ;:. =====
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knowing at present. These genes may
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esistance to antifolates. In Vitro
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a DNA probe specific for the gene t
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translocation between chromosomes 9
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Table 1. Subdivision of 1827 Myelo-
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NORMAL CELL ®
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some change of the primary type, in
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F. Transformation of Mouse Bone Mar
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were carried out with 3H-MTX in the
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the lysozyme cDNA prepared from ovi
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et al. 1976). The BJAB cellline in
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dalton bands corresponding to light
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1979). The EBV-carrying cell lines
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producer lines (DAUDI and P3HR-1),
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G, Giovanella B, Westman A, Stehlin
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Dc;bt CT + i J.I9 Raji; 1. i .. 100
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c. Discussion During infectious mon
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C. Nonepisomal Viral DNA We have us
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A 260 3.0 A B 1670 70 N2 2.0 c: E .
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vivo. Nature 260:302-306 - Kirk JTO
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Fig. 1. a Polyacrylamide gelelectro
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1979). The lymphocyte subpopulation
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lysin 0 antigens are found, and mix
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Pope JH (1978) Long-term T cell-med
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Charaeteristie Morphologie maturati
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after TPA-induction (Table 3). The
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PA (1978) Reactivity of a rabbit an
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Blood Monocyte. B lood Monocytes 1-
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and nonhistone proteins can serve a
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The findings of the evaluation of s
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Fig. 3. Tumor grawth of L 428 cells
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Cell biological and Immunological A
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consideration. Sanel (1973) obtaine
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endotoxin serum, were used. A parti
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monocytic leukemia cell line in cul
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B. Isolation, Characterization and
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don al hemopathies generally displa
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nitors. Blood Cells 6:595-607 - Min
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\I) ....I ....I IU Jl 200 r 100 90
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their haemopoietic cells' ability t
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normal normal ALL ALL ALL persons p
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64.5 { V)
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References Biermann E, Neth R, Gros
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ehambers, the growth pattern observ
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References Anderssen LC, 10kinen M,
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REH CELL UNE TO CALLb~Ö ~q~ V.M. c
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the macrophage series in which the
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Table 1. Production of factor depen
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Table 1. Characteristics of the adh
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Fig. 3. A human marrow culture at 6
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300 250 • HYPERPROLIFERATIVE PATT
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Fig. 9. Nonadherent population from
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The cobblestone areas were often no
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L (1976) Induction of colony format
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B. Materials and Methods J. Tissue
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Fig. 2. Ultrastructural appearance
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Page 307 and 308:
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Table 1. Monoclonal antibody reacti
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al. 1979; Janossy et al. 1979) is e
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to which this is an exact replica o
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inger JL (1976) Distribution of la-
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I region antigens were found to be
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have been reported to be present on
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V. FunctionalAssays Assays for PHA
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Functional studies of UCHT1 separat
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40 ,...... (5 L.. C o u 30 .9 ~ .~
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with immunohistochemieal methods (L
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can be dissected by cloning. Utiliz
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Table 1. Origin and marker profile
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complete identity of gp 100 from no
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Table 1. Reaction of single anti se
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media. Following 24-h incubation, c
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nonleukemic eells (Greaves 1979). L
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Fig. 2. Cytocentrifuged smears of b
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Modification of amino-groups of hum
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disturb this balance in the directi
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The majority of human blood lymphoc
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of the EBV infected B cells. Howeve
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and immunoglobulins. J Immunol 120:
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" K 10 • j ~ ALL RNlL AL wtfh les
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tion akuter Leukämiezellen in "spo
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D. Results and Discussion J. Acute
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selectively responsive to different
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l1J ~ 100 ~ Q. ::) l1J Z 0 ~ z >- .
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Table 2. Growth inhibition of S49 e
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Reverse Infectious ASC/2X1Q6 transc
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munized animals to 1316 tumor cells
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Fig. 3. Expression of retroviral gp
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pg70. J Exp Med 143: 151-166 - McGr
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Table 1. Expression of tumor antige
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Virological and Molecularbiological
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Table 1. Oncogenic properties of re
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also Fig. 1). It followed that the
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whether this sequence is related to
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zed in infected cells argue that th
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a specific viral transforming prote
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detect viral RNA as the only charac
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Eisen H (1980) Myeloproliferate vir
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p,60- -34K - 1 2 3 4 Fig. 1. In vit
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.. p - • a'T ... I .t'l Fig. 4. D
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Fig. 2. Photomicrographs of NY68 in
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DEAE (o(lJmn 'liI GI -2 2 o e s 1
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vity was deterrnined. For endogenou
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pr 180 - - - P 12/15 - A B c D E F
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85,- 66- -27 - -66 40- 27- -1'9 19-
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= 0.5 o E Q. o ILI 0.4 (J) « ILI .
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Table 1. Oncogenic potential of avi
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100 III GI c: o "8 80 > w
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Expt. No. Infecting virus Proportio
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Haematology and Blood 'fransfusion
Page 435 and 436:
sequences, provided its gag portion
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77:3009-3013 - Hu SSF, Moscoviei C,
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RI 2.2 md and Hind III 2.6 md leuke
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RELATIONSHIP OF ENDOGENOUS AND EXOG
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E ........ E Cl. U E :::l .... Q) (
Page 447 and 448:
References Astrin S (1978) Endogeno
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the same animal were examined (e.g.
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I) 'IQ a \0 - CL -- Fig. 2. Restrie
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~ ..................... ~ Cell 3' 5
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a :Sa,C! + . ~ 111 i' ( " '~ .J. b
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Table 1 Sampie Tissue TS fragment"
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a b Sac I / rep ._-_.-_ K J nl rep
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Haematology and Blood 'fiansfusion
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Osteopetrosis and osteosarcomas occ
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Lymphoma cellline Table 1. T and B
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Table 2. In vivo growth and oneogen
Page 469 and 470:
Page 471 and 472: Table 1. Transforming aetivity of c
Page 473 and 474: Table 3. Transformation aetivity of
Page 475 and 476: - Shoemaker C, Goff S, Gilboa E, Pa
Page 477 and 478: indieate a shifting of target eell
Page 479 and 480: Table 2. Expression of Jl and Sourc
Page 481 and 482: Haematology and Blood Transfusion V
Page 483 and 484: ~ i ,..1---------,,':::::::::::::::
Page 485 and 486: fragment of pBR322 DNA, a 3.0-kbp S
Page 487 and 488: Mak TW (1979) Proc Natl Acad Sci US
Page 489 and 490: Table 1. Transformation of 3T3 cell
Page 491 and 492: inserts in the genome of rapidly tr
Page 493 and 494: pulations, it seemed likely that th
Page 495 and 496: contains antigens which react with
Page 499 and 500: le of reacting in sensitive radioim
Page 503 and 504: gic approach. In: Hiatt HH, Watson
Page 505 and 506: 12 Eco R [ Fig. 1. Hybridization pa
Page 509 and 510: 10 - '1~ )( -~ S:! E A U I o 1 2
Page 511 and 512: Haematology and Blood 'fransfusion
Page 513 and 514: cultures. These cells did not conta
Page 515 and 516: indication of malignant T-cells in
Page 517 and 518: Fig. 3. Thin-section electron micro
Page 519 and 520: Table 3. Lack of detectable related
Page 521: J. HTLV Was Present in the Primary
Page 525 and 526: Table 2. Distribution of HTLV-relat
Page 527 and 528: u 10 ~ 20 ~ :c 30 a 40 o Fig. 1. Ki
Page 531 and 532: SSV TrS-gp labeled effectively with
Page 535 and 536: 60 HFF/SSV cDNA CELL RNAs: 0 HF/SSV
Page 537 and 538: Antisera a Table 1. Immunofluoresce
Page 539 and 540: Haematology and Blood 'ftansfusion
Page 541 and 542: y competition RIA yielded virtually
Page 543 and 544: SiS'V' gp70: ANTIGEN, ANTI BODY, IM
Page 545 and 546: type-C virus p30 antigen in cells f
Page 547 and 548: c. Results The fractionated whole-b
Page 549 and 550: induced antibodies as well as exper
Page 551 and 552: - Fig. la-f. Retravirus particles p
Page 553 and 554: eplication of infecting murine leuk
Page 557 and 558: immunodeficiency, multic10nal lymph
Page 559 and 560: Bovine leukemia --, proteins of 499
Page 561 and 562: Human T- cell - -, characterization
Page 563 and 564: RNA -, of tumor virus 439 Rous sarc
Page 565 and 566: Haematology andBlood Transfusion Su
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