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Fig. 1. NK and K cell activities (%
specific slCr-release) of mononuc1ear
blood leukocytes, (PBL) or bone marrow
(BM) cells. a acute non treated leukemia
patients; b patients in a remission phase
and hematologically healthy children .
ALL, acute lymphoblastic leukemia;
ANLL, acute nonlymphoblastic leukemia;
AL, acute leukemia
least two patients, because their killer cell
activities increased in a later remission phase.
With remission patients (Figs. 1b and 2) the
K cell activity was somewhat lower compared
with normal donors. Greater differences appeared
in NK cell activity. The patients und ergoing
chemotherapy had a lower activity than
remission patients without therapy or contral
donors. This finding suggests that chemotherapy
has astranger effect on NK cell activity than
on K cell activity.
When comparing the PBL and bone marrow
cells of individual hematologically healthy
donors, in part coinciding killer cell activities
were found, the coincidence being better on
the K cellievel than on the NK cellievel. That
PBL and BM cells stern from different sources
is revealed by the proportions of E rosette
forming cells: PBL: 52%+9% (64 donors)
and BM cells: 19%+8% (six donors). With
leukemia patients there occurred greater differences
in the killer cell activity between PBL
and BM cells. Differences were also observable
when comparing the NK and K cell
activities with each other, which indicates
selective inhibition of NK or K cell receptors.
But it could also be a hint to the presence of
different NK and K cell populations.
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