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tegy is perhaps still a possibility which should receive further attention. Acknowledgments This investigation was supported by Grant No. 5 R01 CA25250-02 awarded by the National Cancer Institute, U.S. Dept. of Health, Education, and Welfare, in part by Federal funds from the Department of Health, Education and Welfare under contract number N01 CB74144, and by the Swedish Cancer Society. References Ährlund-Richter L, Masucci G, Klein E (1980) Somatic hybrids between a high NK-sensitive lymphoid (Y ACIR) and severallow sesitive sarcoma or L-cell derived mouse lines exhibit low sensitivity. Somatic Cell Genet 6: 89-99 - Augustin AA, Julius MH, Casenza H (1979) Antigen-specific stimulation and trans stimulation of T-cells in long term culture. Eur J Immunol 9: 665-670 - Bakacs T, Klein E, Yefenof E, Gergely P, Steinitz M (1978) Human blood lymphocyte fractionation with special attention to their cytotoxic potential. Z Immunitaetsforsch Immunobiol 154: 121-134 - Becker S, Kiessling R, Lee N, Klein G (1978) Modulation of sensitivity to natural killer cell lysis after in vitro explantation of a mouse lymphoma. J Natl Cancer Inst 61: 1495-1498 - Calleweart DM, Lighbody 11, Kaplan J, Joroszowski J, Peterson WD, Rosemberg JC (1978) Cytotoxicity of human peripheral lymphocytes in cell media ted lympholysis, antibody dependent cell-mediated lympholysis and natural cytotoxicity assay after mixed lymphocyte cultures. J Immunol 121: 81-85 - De Vries JE, Meyerung M, Van Dongren A, Rümke P (1975) The influence of different isolation procedures and the use of target cells from melanoma cell lines and short term cultures on the nonspecific cytotoxic effect of lymphocytes from healthy donors. Int J Cancer 15:391-400 - Enberg RN, Eberle BJ, Williams RC (1974) T and B cells in peripheral blood during infectious mononuc1eosis. J Infect Dis 130: 104-111 - Herberman RB, Holden HT (1978) Natural cell-mediated immunity. Adv Cancer Res 27:305-370 - Jondal M, Spina C, Targan S (1978) Human spontaneous killer cells selective for tumour-derived target cells. Nature 72:62-64 - Kaplan J, Calleweart D (1978) Natural killer cells express human T lymphocyte antigens. J Natl Cancer Inst 60:961-964 - Klein G, Svedmyr E, Jondal M, Persson PO (1975) EBV determined nuclear antigen (EBNA)-positive cells in the peripheral blood of infectious mononucleosis patients. Int J Cancer 17:21-26 - Martin-Chandon MR, Vanky F, Carnaud C, Klein E (1975) "In vitro education" on autologous human sarcoma generates nonspecific killer cells. Int J Cancer 15: 342-350 - Masucci G, Poros A, Seeley JK, Klein E (1980) In vitro generation of K562 killers in human T-Iymphocyte subsets. Cell ImmunoI52:247-254 - Masucci MG, Klein E, Argov S (1980a) Disappearance of the NK effect after explantation of lymphocytes and generation of similar monospecific cytotoxicity correlated to the level of blastogenesis in activated cultures. J Immunol124: 2458-2463 - Masucei MG, Masucei G, Klein E, Berthold W (1980b) Target selectivity of interferon induced human killer lymphocytes related to their Fc receptor expression. Proc Natl Acad Sci USA 77: 3620-3624 - Minato N, Bloom BR, Jones C, Holland J, Reid LM (1979) Mechanism of rejection of virus persistently infected tumor cells by athymic nude mice. J Exp Med 149:1117-1133 - Moss DJ, Rickinson AB, Pope JH (1978) Long term T cell mediated immunity to Epstein Barr virus in man. I. Complete regression of virus-induced transformation in cultures of seropositive donors' lymphocytes. Int J Cancer 22: 662-668 - Ono A Amos DB, Koren HS (1977) Selective cellular natural killing against human leukemic T cells and thymus. Nature 266:546-647 - Poros A, Klein E (1978) Cultivation with K562 cells leads to blastogenesis and increased cytotoxicity with changed properties of the active cells when compared to fresh lymphocytes. Cell Immunol 41 :240-255 - Purtilo DT, Paquin L, DeFlorio D, Virzi F, Sakhuja R (1979) Immunodiagnosis and immunopathogenesis of the X-linked recessive lymphproliferative syndrome. Semin Hematol 16:309-343 - Santoli D, Koprowski H (1979) Mechanism of activation of human natural killer cells against tumor and virus-infected cells. Immunol Rev 44: 125-162 - Sharma B, Odom LF (1979) Generation of killer lymphocytes in vitro against human autologous leukemia cells with leukemia blasts and BCG extract. Cancer Immunol Immunotherp 7: 93-98 - Seeley JK, Golub SH (1978) Studies on cytotoxieity genera ted in human mixed lymphocyte cultures. I. Time course and target spectrum of several distinct concomitant cytotoxic activities. J Immunol 120: 1415-1422 - Stejskal V, Lindberg S, Holm G, Perlman P (1973) Differential cytotoxicity of activated lymphocytes on allogeneic and xenogeneic target cells. 11. Activation by phytohemagglutinin. Cell Immunol 8: 82-92 - Svedmyr EA, Deinhardt F, Klein G (1974) Sensitivity of different target cells to the killing action of peripherallymphocytes stimulated by autologous lymphoblastoid cell lines. Int J Cancer 13 :891-903 -SvedmyrE, JondalM (1975) Cytotoxic effector cells speeific for B cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis. Proc Nat Acad Sei USA 72:1622-1626 - Trinchieri G, Santoli D, Koprowski H (1978) Spontaneous cellmedia ted cytotoxicity in humans: Role of interferon 349
and immunoglobulins. J Immunol 120: 1849-1855 - Vänky F, Argov S (1980a) Human tumor lymphocyte interaction in vitro. VII. Blastogenesis and generation of cytotoxicity against autologous tumor biopsy cells are inhibited by interferon. Int J Cancer 26 :405-411 - Vänky F, Argov S, Einhorn S, Klein E (1980b) Role of alloantigens in natural killing. Allogeneic but not autologous tumor biopsy cells are sensitive for interferon induced cytotoxicity of human blood lymphocytes. J Exp Med 151 : 1151-1165 - Vänky F, Argov S, Klein E (1981) Tumor biopsy cells participating in systems in which cytotoxicity of lymphocytes is generated. Autologous and allogeneic studies. Int J Cancer 27 - Vose BM, Vänky F, Klein E (1977) Lymphocyte cytotoxicity against autologous tumor biopsy cells in humans. Int J Cancer 20:512-519 - Zarling JM, Bach FH (1979) Continuous culture of T cells cytotoxic for autologous human leukemia cells. Nature 280:685-687 - Zarling JM, Raich PC, McKeough M, Bach FH (1976) Generation of cytotoxic lymphocytes in vitro against autologous human leukemia cells. Nature 262:691-693 - Zielske JV, Golub SH (1976) Fetal calf serum induced blastogenic and cytotoxic response of human lymphocytes. Cancer Res 36: 3842-3846 350
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Haematology and Blood Transfusion 2
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Dr. Rolf Neth, Universitäts-Kinder
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Participants of the Meeting Aaronso
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Kurth, R, Friedrich-Miescher-Labora
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Wilsede Scholarship Holders (Grante
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Preface Gut ist eine Lehrart, wo ma
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Personal and scientific discussion
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Acknowledgement We should like to t
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Wilsede, June 21 1978 Memorial Trib
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limiting benign lymphoproliferative
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this most unlikely, however (for re
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longer subject to the same control
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Bregula U, Wiener F, Harris H (1971
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fresh lymph node biopsies from ten
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Fig. 3. Binucleate mitosis in an ob
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y Fig. 4. Schematic diagram of post
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than that among patients with Stage
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Tests of binding affinity, agglutin
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N Engl J Med 297: 963-968 - Green I
Page 39 and 40:
Clinical Aspects
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"ring chromosome". "Mar" is marker,
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191 chromosomally abnormal patients
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tumors of both African and non-Afri
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Haematology and Blood Transfusion V
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Retrospective group 26/93 evolved l
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Treatment
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advantage in terms of duration of f
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leukaemia. An analysis of 168 patie
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11. Treatment Program Chemotherapy
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efractory congestive heart failure
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period (Sequence II) was gene rally
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children with a multiple drug proto
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DAYS 1 5 10 15 20 25 30 35 , I I I
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Biologically Drug Outcome fit" sens
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may counterbalance the potential be
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Ht (0--0) 50 40 30 20 10 0 Platelet
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10 7 ,-----------------------------
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11. Haematological and Biochemical
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0\ 0\ INTERFERON ... 10 3 rl E "'
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("pre-B" phenotype) has been descri
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human bone marrow cells exhibit the
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10 9.,0 MBKCC .. .,4 B prot:oool 1'
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demann W, Büehner T, Arlin Z, Gee
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-...l 00 a-tLDRENS CAt«:ER S TU>Y
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prognostic characteristics under in
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significantly higher in HR} (14.5%,
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normal or elevated immunoglobulin l
Page 99 and 100:
References Andreeff M, Darzynkiewic
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R GROUP 1 ( 1970 - 1971 ) 17 PTS. R
Page 103 and 104:
Table 3. Influence of initial featu
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LIJ (f) a.. < -1 LIJ Q: u. 0 >- I-
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Page 109 and 110:
me nt indicated that additional the
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42:2123-2134 - Chessells JM, Cornbl
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Baum et al. 1979). This study was b
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1. 0 '--'1--" 0.9 e: o .- VI VI E C
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e: o e: 1. 0 ,.--...-- 1'"'\ ......
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In conclusion, we can state that th
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Haematology and Blood Transfnsion V
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INDUCTION VCR + PRED + ASNASE (wk 3
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SCHED.INT 1 MTX • ! Adria MTX •
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~ looh---------ooooc>----o---c>----
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Consoll- Irra .tlon t) .tlon Indu
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Highrisk Standard risk Table 1. Cli
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Cumulo/ive comp/el9 remission 1.0 .
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10° 8 = 6 ö 4 Non T Cell .~ :ö
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% SURVIVAL 100 ~ ~II 0 80 60 40 - -
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a) Percentage of donor cell mitoses
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Table 5. Results of bone marrow tra
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...... w N Table 7. Clinical result
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agent had to be added and that in t
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C. Chronic Myelogenous Leukemia The
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Patients with a suitable donor rece
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No. Recurrent Leukaemia Other death
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followed by dialysis against isoton
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HS, HL- Heme >_ 40 0 HS I ;:. =====
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knowing at present. These genes may
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esistance to antifolates. In Vitro
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a DNA probe specific for the gene t
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translocation between chromosomes 9
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Table 1. Subdivision of 1827 Myelo-
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NORMAL CELL ®
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some change of the primary type, in
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F. Transformation of Mouse Bone Mar
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were carried out with 3H-MTX in the
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the lysozyme cDNA prepared from ovi
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et al. 1976). The BJAB cellline in
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dalton bands corresponding to light
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1979). The EBV-carrying cell lines
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producer lines (DAUDI and P3HR-1),
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G, Giovanella B, Westman A, Stehlin
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Dc;bt CT + i J.I9 Raji; 1. i .. 100
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c. Discussion During infectious mon
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C. Nonepisomal Viral DNA We have us
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A 260 3.0 A B 1670 70 N2 2.0 c: E .
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vivo. Nature 260:302-306 - Kirk JTO
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Fig. 1. a Polyacrylamide gelelectro
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1979). The lymphocyte subpopulation
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lysin 0 antigens are found, and mix
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Pope JH (1978) Long-term T cell-med
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Haematology and Blood Transfnsion V
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Charaeteristie Morphologie maturati
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after TPA-induction (Table 3). The
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PA (1978) Reactivity of a rabbit an
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Blood Monocyte. B lood Monocytes 1-
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and nonhistone proteins can serve a
Page 241 and 242:
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The findings of the evaluation of s
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Fig. 3. Tumor grawth of L 428 cells
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Cell biological and Immunological A
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consideration. Sanel (1973) obtaine
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endotoxin serum, were used. A parti
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monocytic leukemia cell line in cul
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B. Isolation, Characterization and
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don al hemopathies generally displa
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nitors. Blood Cells 6:595-607 - Min
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\I) ....I ....I IU Jl 200 r 100 90
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their haemopoietic cells' ability t
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normal normal ALL ALL ALL persons p
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64.5 { V)
Page 271 and 272:
References Biermann E, Neth R, Gros
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ehambers, the growth pattern observ
Page 275 and 276:
References Anderssen LC, 10kinen M,
Page 277 and 278:
REH CELL UNE TO CALLb~Ö ~q~ V.M. c
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Page 281 and 282:
the macrophage series in which the
Page 283 and 284:
Page 285 and 286:
Table 1. Production of factor depen
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Page 289 and 290:
Table 1. Characteristics of the adh
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Fig. 3. A human marrow culture at 6
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300 250 • HYPERPROLIFERATIVE PATT
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Fig. 9. Nonadherent population from
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The cobblestone areas were often no
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L (1976) Induction of colony format
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B. Materials and Methods J. Tissue
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Fig. 2. Ultrastructural appearance
Page 305 and 306:
Page 307 and 308:
Page 309 and 310: Table 1. Monoclonal antibody reacti
Page 311 and 312: al. 1979; Janossy et al. 1979) is e
Page 313 and 314: to which this is an exact replica o
Page 315 and 316: inger JL (1976) Distribution of la-
Page 317 and 318: I region antigens were found to be
Page 319 and 320: have been reported to be present on
Page 321 and 322: V. FunctionalAssays Assays for PHA
Page 323 and 324: Functional studies of UCHT1 separat
Page 325 and 326: Haematology and Blood Transfusion V
Page 327 and 328: 40 ,...... (5 L.. C o u 30 .9 ~ .~
Page 329 and 330: with immunohistochemieal methods (L
Page 333 and 334: can be dissected by cloning. Utiliz
Page 335 and 336: Table 1. Origin and marker profile
Page 339 and 340: complete identity of gp 100 from no
Page 341 and 342: Table 1. Reaction of single anti se
Page 345 and 346: media. Following 24-h incubation, c
Page 347 and 348: nonleukemic eells (Greaves 1979). L
Page 351 and 352: Fig. 2. Cytocentrifuged smears of b
Page 353 and 354: Modification of amino-groups of hum
Page 355 and 356: disturb this balance in the directi
Page 357 and 358: The majority of human blood lymphoc
Page 359: of the EBV infected B cells. Howeve
Page 363 and 364: " K 10 • j ~ ALL RNlL AL wtfh les
Page 365 and 366: tion akuter Leukämiezellen in "spo
Page 367 and 368: D. Results and Discussion J. Acute
Page 369 and 370: selectively responsive to different
Page 373 and 374: l1J ~ 100 ~ Q. ::) l1J Z 0 ~ z >- .
Page 375 and 376: Table 2. Growth inhibition of S49 e
Page 377 and 378: Reverse Infectious ASC/2X1Q6 transc
Page 381 and 382: munized animals to 1316 tumor cells
Page 383 and 384: Haematology and Blood Transfnsion V
Page 385 and 386: Fig. 3. Expression of retroviral gp
Page 387 and 388: pg70. J Exp Med 143: 151-166 - McGr
Page 389 and 390: Table 1. Expression of tumor antige
Page 391 and 392: Virological and Molecularbiological
Page 393 and 394: Table 1. Oncogenic properties of re
Page 395 and 396: also Fig. 1). It followed that the
Page 397 and 398: whether this sequence is related to
Page 399 and 400: zed in infected cells argue that th
Page 401 and 402: a specific viral transforming prote
Page 403 and 404: detect viral RNA as the only charac
Page 405 and 406: Eisen H (1980) Myeloproliferate vir
Page 407 and 408: p,60- -34K - 1 2 3 4 Fig. 1. In vit
Page 409 and 410: .. p - • a'T ... I .t'l Fig. 4. D
Page 411 and 412:
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Fig. 2. Photomicrographs of NY68 in
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DEAE (o(lJmn 'liI GI -2 2 o e s 1
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vity was deterrnined. For endogenou
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pr 180 - - - P 12/15 - A B c D E F
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85,- 66- -27 - -66 40- 27- -1'9 19-
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= 0.5 o E Q. o ILI 0.4 (J) « ILI .
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Table 1. Oncogenic potential of avi
Page 429 and 430:
100 III GI c: o "8 80 > w
Page 431 and 432:
Expt. No. Infecting virus Proportio
Page 433 and 434:
Haematology and Blood 'fransfusion
Page 435 and 436:
sequences, provided its gag portion
Page 437 and 438:
77:3009-3013 - Hu SSF, Moscoviei C,
Page 439 and 440:
RI 2.2 md and Hind III 2.6 md leuke
Page 441 and 442:
Page 443 and 444:
RELATIONSHIP OF ENDOGENOUS AND EXOG
Page 445 and 446:
E ........ E Cl. U E :::l .... Q) (
Page 447 and 448:
References Astrin S (1978) Endogeno
Page 449 and 450:
the same animal were examined (e.g.
Page 451 and 452:
I) 'IQ a \0 - CL -- Fig. 2. Restrie
Page 453 and 454:
~ ..................... ~ Cell 3' 5
Page 455 and 456:
a :Sa,C! + . ~ 111 i' ( " '~ .J. b
Page 457 and 458:
Table 1 Sampie Tissue TS fragment"
Page 459 and 460:
a b Sac I / rep ._-_.-_ K J nl rep
Page 461 and 462:
Haematology and Blood 'fiansfusion
Page 463 and 464:
Osteopetrosis and osteosarcomas occ
Page 465 and 466:
Lymphoma cellline Table 1. T and B
Page 467 and 468:
Table 2. In vivo growth and oneogen
Page 469 and 470:
Page 471 and 472:
Table 1. Transforming aetivity of c
Page 473 and 474:
Table 3. Transformation aetivity of
Page 475 and 476:
- Shoemaker C, Goff S, Gilboa E, Pa
Page 477 and 478:
indieate a shifting of target eell
Page 479 and 480:
Table 2. Expression of Jl and Sourc
Page 481 and 482:
Page 483 and 484:
~ i ,..1---------,,':::::::::::::::
Page 485 and 486:
fragment of pBR322 DNA, a 3.0-kbp S
Page 487 and 488:
Mak TW (1979) Proc Natl Acad Sci US
Page 489 and 490:
Table 1. Transformation of 3T3 cell
Page 491 and 492:
inserts in the genome of rapidly tr
Page 493 and 494:
pulations, it seemed likely that th
Page 495 and 496:
contains antigens which react with
Page 497 and 498:
Page 499 and 500:
le of reacting in sensitive radioim
Page 501 and 502:
Page 503 and 504:
gic approach. In: Hiatt HH, Watson
Page 505 and 506:
12 Eco R [ Fig. 1. Hybridization pa
Page 507 and 508:
Page 509 and 510:
10 - '1~ )( -~ S:! E A U I o 1 2
Page 511 and 512:
Haematology and Blood 'fransfusion
Page 513 and 514:
cultures. These cells did not conta
Page 515 and 516:
indication of malignant T-cells in
Page 517 and 518:
Fig. 3. Thin-section electron micro
Page 519 and 520:
Table 3. Lack of detectable related
Page 521 and 522:
J. HTLV Was Present in the Primary
Page 523 and 524:
specific signals into nonspecific s
Page 525 and 526:
Table 2. Distribution of HTLV-relat
Page 527 and 528:
u 10 ~ 20 ~ :c 30 a 40 o Fig. 1. Ki
Page 529 and 530:
Page 531 and 532:
SSV TrS-gp labeled effectively with
Page 533 and 534:
Page 535 and 536:
60 HFF/SSV cDNA CELL RNAs: 0 HF/SSV
Page 537 and 538:
Antisera a Table 1. Immunofluoresce
Page 539 and 540:
Haematology and Blood 'ftansfusion
Page 541 and 542:
y competition RIA yielded virtually
Page 543 and 544:
SiS'V' gp70: ANTIGEN, ANTI BODY, IM
Page 545 and 546:
type-C virus p30 antigen in cells f
Page 547 and 548:
c. Results The fractionated whole-b
Page 549 and 550:
induced antibodies as well as exper
Page 551 and 552:
- Fig. la-f. Retravirus particles p
Page 553 and 554:
eplication of infecting murine leuk
Page 555 and 556:
Page 557 and 558:
immunodeficiency, multic10nal lymph
Page 559 and 560:
Bovine leukemia --, proteins of 499
Page 561 and 562:
Human T- cell - -, characterization
Page 563 and 564:
RNA -, of tumor virus 439 Rous sarc
Page 565 and 566:
Haematology andBlood Transfusion Su
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