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emic 'lymphoid' cells. Leuk Res 4: 15-32 - Greaves MF, Janossy G, Francis GE, Minowada J (1978) Membrane phenotypes of human leukemic cells and leukemic celliines. Clinical correlates and biological implications. In: Differentiation of normal and neoplastic hematopoietic eells. Cold Spring Harbor Laboratory, New York, pp 823-841- Greaves MF, Verbi W, Vogler L, Cooper M, Ellis R, Ganeshaguru K, Hoffbrand V, Janossy G, Bollum FJ: Antigenie and enzymatic phenotypes of the pre-B subclass of acute lymphoblastic leukaemia. Leuk Res 3:353-362 - Greaves MF, Verbi W, Kemshead J, Kennett R (1980) A monoc1onal antibody identifying a eell surface antigen shared by common acute lymphoblastie leukemias and B lineage cells. Blood 56: 1141-1144 - Hakomori S (1975) Structure and organization of eell surface glyeolipids: dependency on cell growth and malignant transformation. Bioehim Biophys Acta 417 : 55-89 - J anossy G, Greaves MF, Sutherland R, Durrant J, Lewis C (1977) Comparative analysis of membrane phenotypes in aeute lymphoid leukaemia and in lymphoid blast crisis of ehronic myeloid leukaemia. Leuk Res 1:289-300 - Janossy G, Franeis GE, Capellaro D, Goldstone AH, Greaves MF (1978a) Cell sorter analysis of leukaemia-associated antigens on human myeloid precursors. Nature 276: 176-178 - Janossy G, Goldstone AH, Capellaro D, Greaves MF, Kulenkampff J, Pippard M, Welsh K (1978b) Differentiation linked expression of p28,33 (Ia-like) struetures on human leukaemic cells. Br J Haematol 37:391-402 - Janossy G, Bollum F, Bradstoek K, Rapson N, Greaves MF (1979) Terminal deoxynuc1eotidyl transfer ase positive human bone marrow cells exhibit the antigenie phenotype of common acute lymphoblastic leukaemia. J Immunol 123:1525-1529 - Kabisch H, Arndt R, Becker W-M, Thiele H-G, Landbeek G (1979) Serological deteetion and partial eharacterization of the eommon-ALL-cell associated antigen in the serum of cALL-patients. Leuk Res 3:83-91 - Kennett RH, Gilbert F (1979) Hybrid myelomas producing antibodies against a human neuroblastoma antigen present on fetal brain. Seienee 203: 1120-1121 - Kersey JH, LeBien TW, Abramson CS, Newman R, Sutherland R, Greaves M (to be published) gp24: a human hemopoietie progenitor and aeute lymphoblastic leukemia-associated cell surfaee structure identified with monoc1onal antibody. J Exp Med 153:726-731 - Koeffler HP, Niskanen E, Cline M, Billing R, Golde D (1979) Human myeloid precursors forming colonies in diffusion chambers expresses the Ia-like antigen. Blood 54: 1188-1191-Kung PC, Goldstein G, Reinherz EL, Schlossman SF (1979) Monoclonal antibodies defining destinctive human T cell surfaee antigens. Seience 206: 347-349 - LeBien TW,. Hurwitz RL, Kersey JH (1979) CharaeterizatioQ ofaxenoantiserum produeed against three molar KC1-solubilized antigens obtained from a non-T, non-B (pre-B) acute lymphoblastie leukemia cellline. J ImmunoI122:82-88-Levy R (to be published) In: Cell markers and acute leukaemia. Cancer Treat Rep - Marchesi VT (ed) (1976) Membranes and neoplasia. Prog Clin Biol Res 9 - McDevitt HO (1978) Ia antigens and Ir genes. Aeademic Press, London New York - MeMichael AJ, Pilch JR, Galfre G, Mason DY, FabreJW, Milstein C (1979) A human thymocyte antigen defined by a hybrid myeloma monoc1onal antibody. Eur J Immunol 9:205-210 - Moller G (ed) (1976) Transplant Rev 30 - Moore MAS, Broxmeyer HE, Sheridan APC, Meyers PA, J aeobsen N, Winehester RC (1980) Continuous human bone marrow culture: Ia antigen eharaeterization of probable pluripotential stern cells. Blood 55: 682-690 - Netzel B, Rodt H, Lau B, Thiel E, Haas RJ, Dörmer P, Thierfelder S (1978) Transplantation of syngeneie bone marrow ineubated with leukoeyte antibodies. 11. Cytotoxic activity of anti-cALL globulin on leukemic eells and normal hemopoietie preeursor eells in Man. Transplantation 26: 157-161 - Newman RA, Sutherland R, Greaves MF (1981) The bioehemical charaeterization of a cell surfaee antigen assoeiated with acute lymphoblastic leukemia and lymphocyte precursors J Immunol, in press - Pesando JM, Ritz J, Lazarus H, Baseman Costello S, Sallan S, Schlossman SF (1979) leukemia-assoeiated antigens in ALL. Blood 54: 1240-1248 - Pesando JM, Ritz J, Levine H, Terhorst C, Lazarus H, Sehlossman SF (1980) Human leukemia-assoeiated antigen: Relation to a family of surface glycoproteins. J Immunol 124:2794-2799 - Potter VR (1978) Phenotypic diversity in experimental hepatomas: the eoneept of partially bloeked ontogeny. Br J Cancer 38: 1-23 - Reinherz EL, Kung PC, Goldstein G, Schlossman SF (1979a) Separation of functional subsets of human T cells by a monoc1onal antibody. Proe Natl Aead Sei USA 76:4061-4065 - Reinherz EL, Kung PC, Goldstein G, Schlossman SF (1979b) A monoc1onal antibody with seleetive reactivity with functionally mature human thymoeytes and all peripheral human T cells. J Immunol 123:1312-1317 - Reinherz EL, Kung PC, Goldstein G, Levey RH, Sehlossman SF (1980) Discrete stages of human intrathymic differentiation: Analysis of normal thymoeytes and leukemic lymphoblasts of T lineage. Proc Natl Aead Sei USA 77: 1588-1592 - Ritz J, Pesando JM, Notis-MeConarty J, Lazarus H, Sehlossman SF (1980) A monoc10nal antibody to human aeute lymphoblastic leukaemia antigen. Nature 283:583-585 -RobinsonJ, Sieff C, Delia D, Edwards P, Greaves M (1981) Expression of cell surfaee HLA-DR, HLA-ABC and glyeophorin during erythroid differentiation. Nature 289:68-71- Ross GD, Jarowski GI, Rabellino EM, Winchester RJ (1978) The sequential appearance of Ia-like antigens and two different eomplement receptors during the matura ti on of human neutrophils. J Exp Med 147:730-744 - Rowley JD (1978) Chromosomes in leukaemia and lymphoma. Semin Haematol 15:301-319 - Schlossman SF, Chess L, Humphreys RE, Strom- 303
inger JL (1976) Distribution of la-like moleeules on the surface of normal and leukemic human cells. Proc Natl Acad Sei USA 73: 1288-1292 - Shumak KH, Rachkewich RA, Greaves MF (1975) land i antigens on normal human T and B lymphocytes and on lymphocytes from patients with chronic lymphocytic leukaemia. Clin Immunol ImmunopathoI4:241-247 - Sutherland R, Smart J, NiaudetP, Greaves MF (1978) Acute lymphoblastic leukaemia associated antigen. II. Isolation and partial characterisation. Leuk Res 2: 115-126 - Vogler LB, Crist WM, Bockman DE, Pearl ER, Lawton AR, Cooper MD (1978) Pre-B cell leukemia. N Engl J Med 298:872-878 - Wallach DFH(ed) (1978) Membrane anomalies of tumor cells. Karger, Basel- Winchester RJ, Ross GD, Jarowski CI, Wang CY, Halper J, Broxmeyer HE (1977) Expression of la-like antigen molecules on human granulocytes during early phases of differentiation. Proc Natl Acad Sei USA 74:4012-4016 - Winchester RJ, Meyers PA, Broxmeyer HE, Wang CY, Moore MAS, Kunkel HG (1978) Inhibition of human erythropoietic colony formation in culture by treatment with la antisera. J Exp Med 148:613-618 304
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Haematology and Blood Transfusion 2
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Dr. Rolf Neth, Universitäts-Kinder
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Participants of the Meeting Aaronso
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Kurth, R, Friedrich-Miescher-Labora
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Wilsede Scholarship Holders (Grante
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Preface Gut ist eine Lehrart, wo ma
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Personal and scientific discussion
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Acknowledgement We should like to t
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Wilsede, June 21 1978 Memorial Trib
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limiting benign lymphoproliferative
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this most unlikely, however (for re
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longer subject to the same control
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Bregula U, Wiener F, Harris H (1971
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fresh lymph node biopsies from ten
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Fig. 3. Binucleate mitosis in an ob
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y Fig. 4. Schematic diagram of post
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than that among patients with Stage
Page 35 and 36:
Tests of binding affinity, agglutin
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N Engl J Med 297: 963-968 - Green I
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Clinical Aspects
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"ring chromosome". "Mar" is marker,
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191 chromosomally abnormal patients
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tumors of both African and non-Afri
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Haematology and Blood Transfusion V
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Retrospective group 26/93 evolved l
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Page 53 and 54:
Treatment
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advantage in terms of duration of f
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leukaemia. An analysis of 168 patie
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11. Treatment Program Chemotherapy
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efractory congestive heart failure
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period (Sequence II) was gene rally
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children with a multiple drug proto
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DAYS 1 5 10 15 20 25 30 35 , I I I
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Biologically Drug Outcome fit" sens
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may counterbalance the potential be
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Ht (0--0) 50 40 30 20 10 0 Platelet
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10 7 ,-----------------------------
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11. Haematological and Biochemical
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0\ 0\ INTERFERON ... 10 3 rl E "'
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("pre-B" phenotype) has been descri
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human bone marrow cells exhibit the
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10 9.,0 MBKCC .. .,4 B prot:oool 1'
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demann W, Büehner T, Arlin Z, Gee
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-...l 00 a-tLDRENS CAt«:ER S TU>Y
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prognostic characteristics under in
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significantly higher in HR} (14.5%,
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normal or elevated immunoglobulin l
Page 99 and 100:
References Andreeff M, Darzynkiewic
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R GROUP 1 ( 1970 - 1971 ) 17 PTS. R
Page 103 and 104:
Table 3. Influence of initial featu
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LIJ (f) a.. < -1 LIJ Q: u. 0 >- I-
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Page 109 and 110:
me nt indicated that additional the
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42:2123-2134 - Chessells JM, Cornbl
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Baum et al. 1979). This study was b
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1. 0 '--'1--" 0.9 e: o .- VI VI E C
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e: o e: 1. 0 ,.--...-- 1'"'\ ......
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In conclusion, we can state that th
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Haematology and Blood Transfnsion V
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INDUCTION VCR + PRED + ASNASE (wk 3
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SCHED.INT 1 MTX • ! Adria MTX •
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~ looh---------ooooc>----o---c>----
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Consoll- Irra .tlon t) .tlon Indu
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Highrisk Standard risk Table 1. Cli
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Cumulo/ive comp/el9 remission 1.0 .
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10° 8 = 6 ö 4 Non T Cell .~ :ö
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% SURVIVAL 100 ~ ~II 0 80 60 40 - -
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a) Percentage of donor cell mitoses
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Table 5. Results of bone marrow tra
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...... w N Table 7. Clinical result
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agent had to be added and that in t
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C. Chronic Myelogenous Leukemia The
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Patients with a suitable donor rece
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No. Recurrent Leukaemia Other death
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followed by dialysis against isoton
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HS, HL- Heme >_ 40 0 HS I ;:. =====
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knowing at present. These genes may
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esistance to antifolates. In Vitro
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a DNA probe specific for the gene t
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translocation between chromosomes 9
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Table 1. Subdivision of 1827 Myelo-
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NORMAL CELL ®
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some change of the primary type, in
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F. Transformation of Mouse Bone Mar
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were carried out with 3H-MTX in the
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the lysozyme cDNA prepared from ovi
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et al. 1976). The BJAB cellline in
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dalton bands corresponding to light
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1979). The EBV-carrying cell lines
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producer lines (DAUDI and P3HR-1),
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G, Giovanella B, Westman A, Stehlin
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Page 205 and 206:
Dc;bt CT + i J.I9 Raji; 1. i .. 100
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c. Discussion During infectious mon
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C. Nonepisomal Viral DNA We have us
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A 260 3.0 A B 1670 70 N2 2.0 c: E .
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vivo. Nature 260:302-306 - Kirk JTO
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Fig. 1. a Polyacrylamide gelelectro
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1979). The lymphocyte subpopulation
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lysin 0 antigens are found, and mix
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Pope JH (1978) Long-term T cell-med
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Charaeteristie Morphologie maturati
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after TPA-induction (Table 3). The
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PA (1978) Reactivity of a rabbit an
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Blood Monocyte. B lood Monocytes 1-
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and nonhistone proteins can serve a
Page 241 and 242:
Page 243 and 244:
The findings of the evaluation of s
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Fig. 3. Tumor grawth of L 428 cells
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Cell biological and Immunological A
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consideration. Sanel (1973) obtaine
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endotoxin serum, were used. A parti
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monocytic leukemia cell line in cul
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B. Isolation, Characterization and
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don al hemopathies generally displa
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nitors. Blood Cells 6:595-607 - Min
Page 263 and 264: \I) ....I ....I IU Jl 200 r 100 90
Page 265 and 266: their haemopoietic cells' ability t
Page 267 and 268: normal normal ALL ALL ALL persons p
Page 269 and 270: 64.5 { V)
Page 271 and 272: References Biermann E, Neth R, Gros
Page 273 and 274: ehambers, the growth pattern observ
Page 275 and 276: References Anderssen LC, 10kinen M,
Page 277 and 278: REH CELL UNE TO CALLb~Ö ~q~ V.M. c
Page 279 and 280: Haematology and Blood Transfusion V
Page 281 and 282: the macrophage series in which the
Page 285 and 286: Table 1. Production of factor depen
Page 289 and 290: Table 1. Characteristics of the adh
Page 291 and 292: Fig. 3. A human marrow culture at 6
Page 293 and 294: 300 250 • HYPERPROLIFERATIVE PATT
Page 295 and 296: Fig. 9. Nonadherent population from
Page 297 and 298: The cobblestone areas were often no
Page 299 and 300: L (1976) Induction of colony format
Page 301 and 302: B. Materials and Methods J. Tissue
Page 303 and 304: Fig. 2. Ultrastructural appearance
Page 309 and 310: Table 1. Monoclonal antibody reacti
Page 311 and 312: al. 1979; Janossy et al. 1979) is e
Page 313: to which this is an exact replica o
Page 317 and 318: I region antigens were found to be
Page 319 and 320: have been reported to be present on
Page 321 and 322: V. FunctionalAssays Assays for PHA
Page 323 and 324: Functional studies of UCHT1 separat
Page 327 and 328: 40 ,...... (5 L.. C o u 30 .9 ~ .~
Page 329 and 330: with immunohistochemieal methods (L
Page 333 and 334: can be dissected by cloning. Utiliz
Page 335 and 336: Table 1. Origin and marker profile
Page 339 and 340: complete identity of gp 100 from no
Page 341 and 342: Table 1. Reaction of single anti se
Page 345 and 346: media. Following 24-h incubation, c
Page 347 and 348: nonleukemic eells (Greaves 1979). L
Page 351 and 352: Fig. 2. Cytocentrifuged smears of b
Page 353 and 354: Modification of amino-groups of hum
Page 355 and 356: disturb this balance in the directi
Page 357 and 358: The majority of human blood lymphoc
Page 359 and 360: of the EBV infected B cells. Howeve
Page 361 and 362: and immunoglobulins. J Immunol 120:
Page 363 and 364: " K 10 • j ~ ALL RNlL AL wtfh les
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tion akuter Leukämiezellen in "spo
Page 367 and 368:
D. Results and Discussion J. Acute
Page 369 and 370:
selectively responsive to different
Page 371 and 372:
Page 373 and 374:
l1J ~ 100 ~ Q. ::) l1J Z 0 ~ z >- .
Page 375 and 376:
Table 2. Growth inhibition of S49 e
Page 377 and 378:
Reverse Infectious ASC/2X1Q6 transc
Page 379 and 380:
Page 381 and 382:
munized animals to 1316 tumor cells
Page 383 and 384:
Page 385 and 386:
Fig. 3. Expression of retroviral gp
Page 387 and 388:
pg70. J Exp Med 143: 151-166 - McGr
Page 389 and 390:
Table 1. Expression of tumor antige
Page 391 and 392:
Virological and Molecularbiological
Page 393 and 394:
Table 1. Oncogenic properties of re
Page 395 and 396:
also Fig. 1). It followed that the
Page 397 and 398:
whether this sequence is related to
Page 399 and 400:
zed in infected cells argue that th
Page 401 and 402:
a specific viral transforming prote
Page 403 and 404:
detect viral RNA as the only charac
Page 405 and 406:
Eisen H (1980) Myeloproliferate vir
Page 407 and 408:
p,60- -34K - 1 2 3 4 Fig. 1. In vit
Page 409 and 410:
.. p - • a'T ... I .t'l Fig. 4. D
Page 411 and 412:
Page 413 and 414:
Fig. 2. Photomicrographs of NY68 in
Page 415 and 416:
DEAE (o(lJmn 'liI GI -2 2 o e s 1
Page 417 and 418:
vity was deterrnined. For endogenou
Page 419 and 420:
pr 180 - - - P 12/15 - A B c D E F
Page 421 and 422:
85,- 66- -27 - -66 40- 27- -1'9 19-
Page 423 and 424:
Page 425 and 426:
= 0.5 o E Q. o ILI 0.4 (J) « ILI .
Page 427 and 428:
Table 1. Oncogenic potential of avi
Page 429 and 430:
100 III GI c: o "8 80 > w
Page 431 and 432:
Expt. No. Infecting virus Proportio
Page 433 and 434:
Haematology and Blood 'fransfusion
Page 435 and 436:
sequences, provided its gag portion
Page 437 and 438:
77:3009-3013 - Hu SSF, Moscoviei C,
Page 439 and 440:
RI 2.2 md and Hind III 2.6 md leuke
Page 441 and 442:
Page 443 and 444:
RELATIONSHIP OF ENDOGENOUS AND EXOG
Page 445 and 446:
E ........ E Cl. U E :::l .... Q) (
Page 447 and 448:
References Astrin S (1978) Endogeno
Page 449 and 450:
the same animal were examined (e.g.
Page 451 and 452:
I) 'IQ a \0 - CL -- Fig. 2. Restrie
Page 453 and 454:
~ ..................... ~ Cell 3' 5
Page 455 and 456:
a :Sa,C! + . ~ 111 i' ( " '~ .J. b
Page 457 and 458:
Table 1 Sampie Tissue TS fragment"
Page 459 and 460:
a b Sac I / rep ._-_.-_ K J nl rep
Page 461 and 462:
Haematology and Blood 'fiansfusion
Page 463 and 464:
Osteopetrosis and osteosarcomas occ
Page 465 and 466:
Lymphoma cellline Table 1. T and B
Page 467 and 468:
Table 2. In vivo growth and oneogen
Page 469 and 470:
Page 471 and 472:
Table 1. Transforming aetivity of c
Page 473 and 474:
Table 3. Transformation aetivity of
Page 475 and 476:
- Shoemaker C, Goff S, Gilboa E, Pa
Page 477 and 478:
indieate a shifting of target eell
Page 479 and 480:
Table 2. Expression of Jl and Sourc
Page 481 and 482:
Page 483 and 484:
~ i ,..1---------,,':::::::::::::::
Page 485 and 486:
fragment of pBR322 DNA, a 3.0-kbp S
Page 487 and 488:
Mak TW (1979) Proc Natl Acad Sci US
Page 489 and 490:
Table 1. Transformation of 3T3 cell
Page 491 and 492:
inserts in the genome of rapidly tr
Page 493 and 494:
pulations, it seemed likely that th
Page 495 and 496:
contains antigens which react with
Page 497 and 498:
Page 499 and 500:
le of reacting in sensitive radioim
Page 501 and 502:
Page 503 and 504:
gic approach. In: Hiatt HH, Watson
Page 505 and 506:
12 Eco R [ Fig. 1. Hybridization pa
Page 507 and 508:
Page 509 and 510:
10 - '1~ )( -~ S:! E A U I o 1 2
Page 511 and 512:
Haematology and Blood 'fransfusion
Page 513 and 514:
cultures. These cells did not conta
Page 515 and 516:
indication of malignant T-cells in
Page 517 and 518:
Fig. 3. Thin-section electron micro
Page 519 and 520:
Table 3. Lack of detectable related
Page 521 and 522:
J. HTLV Was Present in the Primary
Page 523 and 524:
specific signals into nonspecific s
Page 525 and 526:
Table 2. Distribution of HTLV-relat
Page 527 and 528:
u 10 ~ 20 ~ :c 30 a 40 o Fig. 1. Ki
Page 529 and 530:
Page 531 and 532:
SSV TrS-gp labeled effectively with
Page 533 and 534:
Page 535 and 536:
60 HFF/SSV cDNA CELL RNAs: 0 HF/SSV
Page 537 and 538:
Antisera a Table 1. Immunofluoresce
Page 539 and 540:
Haematology and Blood 'ftansfusion
Page 541 and 542:
y competition RIA yielded virtually
Page 543 and 544:
SiS'V' gp70: ANTIGEN, ANTI BODY, IM
Page 545 and 546:
type-C virus p30 antigen in cells f
Page 547 and 548:
c. Results The fractionated whole-b
Page 549 and 550:
induced antibodies as well as exper
Page 551 and 552:
- Fig. la-f. Retravirus particles p
Page 553 and 554:
eplication of infecting murine leuk
Page 555 and 556:
Page 557 and 558:
immunodeficiency, multic10nal lymph
Page 559 and 560:
Bovine leukemia --, proteins of 499
Page 561 and 562:
Human T- cell - -, characterization
Page 563 and 564:
RNA -, of tumor virus 439 Rous sarc
Page 565 and 566:
Haematology andBlood Transfusion Su
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