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Number of patients 111 58
Early deaths 4 9
Complete remission 102 44
Number of relapses 12 12
Marrow 7 7
Marrow+CNS 0 0
CNS 4 4
Testes 1 1
Remission deaths 2 2
Table 2. Clinical course in
StudyV LSA 2 L 2 (WoIIner) study V and LSA 2 L 2
Standard risk (Highrisk (1978-1979)
patients)
patients)
Cumulative complete
remission O.79±O.O6 O.50±O.12
used in study IV did not prove to be more
effective when important features such as
leukocyte count over 100,000 cells/mm 3 , mediastinal
mass, or age under 2 or over 10 years
were present. Since different criteria were used
to define high risk patients in studies IV and
LSA 2 L 2 , results cannot be readily compared
among both treatment groups. Current information,
however, favors the results attained in
the LSA 2 Lz study when single factors are
comparatively analyzed, i.e., mediastinal mass,
leukocyte count up to 100,000 cells/mm 3 , and
acid phosphat ase re action by lymphoblasts.
For patients with leukocyte counts over
ClImll/ative comp/ele remi.uion
1.0 ~
aB ~
rlf!!;'
I-
(11 ~
~
atoll!!...
~2(1J
-, - 1. Hediaslinal mass
TSr1} --- 2. Wi/lloul medlast/nul m(/S's
16m
----.. C. R. • Comp/ele rl'lfIifJ'Kn
I
12 (1J
E.b . .. Early dM/li
li!L
t!~!! __
J!1L
.,
I
I
I
I
I Gm
c ___________
0.55
Nr. p!!!ien/s
C.R. E.D.
15" 3
28 6
0.+ ~
I-
3m
0.37
a1 I-
o o
I I I I I I I I I J I I
2 3
Y e arS'
Fig. 7. Relationship of mediastinal mass to relapse-free survival in childhood acute Iymphocytic leukemia,
study LSA 2 L 2
119