Modern - Blog Science Connections

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LSA 2 L 2 Protocoi
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( WOlln.r) Croniol
Irrodiotion
Irrodifltion
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or 198 Au i.th
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Fig. 3. Outline of therapy for study LSA 2 L 2 (WoHner et al.)
Ooys ., 21 35 63
.,.,
91 lOS 119 133 74., 161
i I i I I i I I I I i I i i I I i I I i i-'
W •• b 1 2 3 , 5 6 ., 8 9 10 " 12 13 " 15 16 I., 18 19 20 21 22 23
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above. At this time only preliminary results are
available for these studies. The cumulative
complete remission rate at 2 years is 0.79 for
111 standard risk patients and 0.50 for 58
children with high risk leukemia. Thus far the
outcome has been significantly worse for
patients with leukocyte counts exceeding
100,000 cells/mm 3 (Fig. 6), with mediastinal
masses (Fig. 7), and in children under the age
of 2 and above the age of 10 years (Fig. 8). The
significance of T -cell lymphoblasts and of
initial CNS leukemia could not be calculated.
Cumulali"" complele remission
Cumulalive comp/ele remiuion
r~~~~-lRfSludyY}
Im] ] 1
HR (LSAZ lZ)
o.H.t 0.01
0.2~------4-------~--------4-------~
a+~-----~---~-----~---~
o.z~---~----~----~---~
Cumulalive J"urvival
HR .. high riJ'/( group
lR .. low rir/( roup
Cumulalive sundval
HR - high riJ'/( group
lR • /ow riJ'/( roup
0.11-----";=1
11ft} 9 1 1
LR
0'6r-------~--~.,
o.66t 0. 09
25
ZZ(mf 9 f ~
O.~I----------+----+--- O."f.t 0.0'/ HR
tU
HRfLSAZ l 2 )
02r-----+-----+-----;----~
0.2
2
Years
Fig. 4. Survival and relapse-free survival in childhood
acute lymphocytic leukemia, study IV
J
0
0
Y e
Z
a
r
s
3 +
Fig. 5. Survival and relapse-free survival in childhood
acute lymphocytic leukemia, studies V and
LSA 2 L 2
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