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Modern - Blog Science Connections

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1. 0 '--'1--"<br />

0.9<br />

e:<br />

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.-<br />

VI<br />

VI<br />

E<br />

CI><br />

Cl::<br />

e:<br />

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e:<br />

. ē:<br />

'" E<br />

Cl><br />

Cl::<br />

0.8<br />

0.7<br />

0.6<br />

'0 0.5<br />

Standard Risk<br />

(n =351<br />

•<br />

.c<br />

~ 0.4-<br />

o<br />

...<br />

0.. ••••••••••••••••••••••••••••••••••••••••••••••••••<br />

Cl><br />

><br />

High Risk<br />

(n-17)<br />

::l<br />

E<br />

::l<br />

U<br />

0.2<br />

0.1<br />

Months<br />

< Less than 5 patients remaining<br />

after this point<br />

Fig. 2. Duration of complete<br />

remission employing 1DM.<br />

Standard risk and high risk<br />

(see text)<br />

E. Toxicity<br />

The toxicity (Table 2) from the 1DM included:<br />

1. Vomiting occurring in 20/52 patients and<br />

was most pronounced during the first 2-4<br />

h after the institution of 1DM but occasionally<br />

persisted for 24-48 h;<br />

2. Oral ulceration occuring in 20/52 patients<br />

with oral mucositis in 14 and pharyngitis in<br />

six patients. This was mild in 17/20, i.e.,<br />

there were small ulcers which did not<br />

substantially interfere with orlke;<br />

3. Hematologic toxicity occurring in 12 patients<br />

which, however, was minimal in its<br />

Vomiting<br />

(with<br />

administration)<br />

Hematological<br />

WBC<br />

Hgb<br />

Platelets<br />

Mucositis<br />

Pharnygitis<br />

Hepatic<br />

Skin<br />

Renal<br />

20/52<br />

2 (

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