Modern - Blog Science Connections

R
GROUP 1 ( 1970 - 1971 ) 17 PTS.
R
R
MUENSTER
WEEKS
I I I I I I I I I I I I I I I I I I I I I I I 1 I I I I I I I I I I I I I I I
o 8 16 24 32 40 48 56 64 72 80 BB 96 104 112 120 12B 136 144 152
R
PROTOCOL I
PRED/VCR REINDUCTION PULSE
~ 6-MP
f223 MTX
rnJl CP
Fig. 1. Outline of study BFM
70/76. PRED, prednisone;
VCR, vincristine, 6-MP, 6-
mercaptopurine; MTX, methotrexate;
CP, cyc1ophosphamide
STANDARD RISK PATIENTS (RISK INDEX = 3 )
81
0 0
liIl
821Jl
~~L::J.
I I I I I I I I I I I I I
0 8 16 24 32 40 48
I PROTOCOL 1 *)
I I : PROTOCOL 11
R : PRED/VCR REINDUCTION PULSE
I I I I I
56 64
~
~
I I I
72 80
6-MP
Fig. 2. Outline of study BFM 76/79. Abbreviations as in Fig. 1
MTX
WEEKS
I I I I I I I I I I I I
88 96 104 112 120 128
*) SAME AS IN lfM 1970ns llIT
CRITERIDN (f [IM; OOSAGE
owao 10 Imf SIIlFACE
( FACTlJ! 1= 2S )
I I I I
I I I I
~~~~
ep 40.0 MG / KG*OAY ) I
ARA-C 3.0 MG / KG*OAY )
MTX 1. T. 0.5 MG / KG*OAY )
6-MP 2.5 MG / KG*OAY )
CNS IRRADIATION
PRED 2.5 MG / KG*OAY )
VCR 0.06 MG / KG*DAY )
OAUNO ( 1. 0 MG / KG*OAY )
L-ASP (200.0 U / KG*OAY )
I I
1111 1111 1111 1111
1 1 1 1
~M
W/ß~ßl
11 I I I I' I I I I I I I I I I I I I I I I I I I I I I I I 11 III I1 I 11 I I I I 11 I 11 I I I 11 I I
B 15 22 29 36 43 50 57
DAYS
Fig. 3. Induction therapy:
Protocol I, PRED, prednisone;
VCR, vincristine;
DA UNO, daunorubicin;
L-ASP, asparaginase; CP, cyc1ophosphamide;
ARA -C, cytarabin
; MT X, methotrexate;
6-MP,6.mercaptopurine
88