Autologous Bone Marrow Transplantation - Blog Science Connections

ABMT in AML With Monoclonal Antibodies 75
and recovery was generally greater than or equal to 90%. An average of 50% of
CFOs-GM was lost during MAb treatment. No significant depletion of erythroid
or mixed erythroid/myeloid colonies was noted (data not shown).
Disease-free and overall survival data are shown in Table 4 and Figures 1
and 2. Ten of the 16 patients who underwent transplantation are surviving; 7
of the 16 are surviving continuously disease free. Three patients have died in
remission, two from subarachnoid hemorrhage secondary to thrombocytopenia
(patients 10 and 13) and one from respiratory infection (patient 5). Six
of the 13 patients (46%) who underwent transplantation later than in CR1
(patients 4, 6, 9, 12, 14, 16) experienced relapses, as did three of the four
patients with FAB M 4
disease (Table 1). In three of the six patients who
relapsed, third CR (CR3) was successfully induced with mitoxantrone (two
1.0
0.8
0.6