Autologous Bone Marrow Transplantation - Blog Science Connections

ABMTin AML With Monoclonal Antibodies 71
body weight on days -5 and -4, followed by total body irradiation (TBI) (a total
of 1,200 cGy in twice-daily doses of 200 cGy 6 hours apart on days -3,-2, and
-1) delivered with a cobalt-60 source by opposed lateral fields without lung
shielding. On day 0, frozen bone marrow was quickly thawed at 37° C and
administered through a central venous line. All patients received 12 mg of
intrathecal methotrexate before or during ablative therapy.
As Table 1 shows, the patients, nine of them men, ranged in age from 11
to 47 years. Of the two patients who received transplants during early first
relapse, one had extramedullary disease and the other showed 9% marrow
blasts. Patients 2, 3, 8, and 16 were treated at the SCRF and the rest at the
DHMC.
Table 1. Clinical Characteristics of Patients Who Underwent Autologous Bone
Marrow Transplantation
Remission Status at
Patient Age/Gender FAB Harvest ABMT
1 44/M M 3
1st 1st
2 46/M M 2 1st 1st
3 47/M M 2 1st 1st
4 28/F MT 1st Ist-rel"
5 16/F M 2 1st-rel a 1st-rel a
6 20/M M 2 2d 2d
7 36/F M 2 2d 2d
8 24/M M 3
2d 2d
9 44/M M 4 1st 2d
10 32/F M 4 2d 2d
11 28/M M 3
2d 2d
12 44/F M 4 1st 2d
13 44/M M 2 2d 2d
14 11/F M 4 2d 2d
15 44/F M 2 3d 3d
16 27/M M 2 3d 3d
Abbreviations: FAB, French-American-British classification; ABMT, autologous
bone marrow
transplantation.
Bone marrow was harvested from this patient and autologous bone marrow transplantation
performed at the time a breast chloroma was diagnosed. The chloroma was
treated with external beam radiotherapy.
Relapse was diagnosed on the basis of 9% blasts in the bone marrow at the time of
autologous bone marrow transplantation.