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Autologous Bone Marrow Transplantat
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Autologous Bone Marrow Transplantat
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To our colleagues, Drs. R. Lee Clar
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via ABMT Autologous Bone Marrow Tra
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X ABMT Pharmacological Manipulation
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XII ABMT C. INTERNATIONAL RANDOMIZE
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xiu ABMT Session IV - Breast Cancer
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xui ABMT Panel Discussion: Session
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xuiii ABMT Effect of Interleukin 2
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Acknowledgments The publication of
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- Page 29 and 30: AML in First Remission 5 performed
- Page 31: AML in First Remission 7 than 50% o
- Page 34 and 35: 10 BAVC + ABMT in Patients With AML
- Page 36 and 37: BAVC + ABMT in Patients With AML in
- Page 38 and 39: 14 BAVC + ABMTin Patients With AML
- Page 40 and 41: 16 Purged ABMT in CR of Acute Leuke
- Page 42 and 43: 18 Purged ABMT in CR of Acute Leuke
- Page 44 and 45: 20 Purged ABMT in CR of Acute Leuke
- Page 46 and 47: 22 Purged ABMT in CR of Acute Leuke
- Page 48 and 49: 24 First-Remission Autograft forAML
- Page 50 and 51: 26 First-Remission Autograft forAML
- Page 52 and 53: 28 First-Remission Autograft forAML
- Page 55 and 56: Autologous Bone Marrow Transplantat
- Page 57: Transplantation in CRI AML 33 DISCU
- Page 60 and 61: 36 ABMT in ALL compared the results
- Page 62 and 63: 38 ABMT in ALL were administered un
- Page 64 and 65: 40 ABMT in ALL CR1 patients receive
- Page 66 and 67: 42 ABMT in ALL 19. Rizzoli V, Mango
- Page 68 and 69: 44 ABMTin CRI program in CR1 is the
- Page 70 and 71: 46 ABMTin CRI RESULTS The AML inves
- Page 73 and 74: Leukemia: First Remission K A. Dick
- Page 75 and 76: Panel Discussion: Session IA 51 DR.
- Page 77: IB. Clinical Studies in Second- or
- Page 81 and 82: ABMT In CR2 57 CR INVERSION: 2/22 -
- Page 83 and 84: Autologous Bone Marrow Transplantat
- Page 85 and 86: ABMT in Acute Nonlymphocytic Leukem
- Page 87 and 88: ABMT in Acute Nonlymphocytic Leukem
- Page 89 and 90: ABMT in Acute Nonlymphocytic Leukem
- Page 91 and 92: ABMT in Acute Nonlymphocytic Leukem
- Page 93 and 94: Transplantation Trial With Marrow T
- Page 95 and 96: ABMTin AML With Monoclonal Antibodi
- Page 97 and 98: ABMT in AML With Monoclonal Antibod
- Page 99 and 100: ABMT in AML With Monoclonal Antibod
- Page 101 and 102: ABMT in AML With Monoclonal Antibod
- Page 103 and 104: Chemopurging of Autologous Bone Mar
- Page 105 and 106: Mafosfamlde Purging in Leukemia 81
- Page 107 and 108: Mafosfamide Purging in Leukemia 83
- Page 109 and 110: Mafosfamide Purging in Leukemia 85
- Page 111: Mafosfamide Purging in Leukemia 87
- Page 114 and 115: 90 ABMT in CR2 Pediatric ALL Immuno
- Page 116 and 117: 92 ABMT in CR2 Pediatric ALL first
- Page 118 and 119: 94 Ex Vivo Marrow Purging with marr
- Page 120 and 121: 96 Ex Vivo Marrow Purging BONE MARR
- Page 122 and 123: 98 Ex Vivo Marrow Purging reflect t
- Page 124 and 125: 700 Conditioning Regimens in AML cy
- Page 126 and 127: 102 Conditioning Regimens in AML Ta
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Double CInpurged Autologous Bone Ma
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Double Unpurged ABMT in Leukemias 1
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Double (Jnpurged ABMT in Leukemias
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Double Autografting as Potential Cu
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Double Autografting in Acute Leukem
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Double Autografting in Acute Leukem
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Double Autografting in Acute Leukem
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Hematopoietic Recovery After Bone M
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Recovery After 4-Hydroperoxycycloph
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Recovery After 4-Hydroperoxycycloph
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126 Panel Discussion: Session IB DR
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128 Panel Discussion: Session IB 18
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IC. Leukemia Purging/Detection of M
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134 Magnetic Separation of Marrow C
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136 Magnetic Separation of Marrow C
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Ol O) < c « .o. >» o T3 c « =5
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M I M ! CM CO CO CO CO LO M M CO CO
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742 Magnetic Separation of Marrow C
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144 Chemopurging leukemic (ALL) pat
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746 Chemopurging isoeffect. On the
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148 Chemopurging Table 4. Ex Vivo P
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750 Chemopurging 5. Kaizer H, Stuar
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152 Merocyanine 540 Marrow Decontam
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754 Merocyanine 540 Marrow Decontam
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756 Merocyanine 540 Marrow Decontam
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758 CALLA-Negatiue Clonogenic B-Cel
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160 CALLA-Negatiue Clonogenic B-Cel
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Acetaldophosphamide—A New Stable
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Acetaldophosphamide Ex Vivo Chemoth
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Acetaldophosphamide Ex Vivo Chemoth
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Acetaldophosphamide Ex Vivo Chemoth
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172 Detecting Residual Disease in B
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174 Detecting Residual Disease in B
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Pharmacological Manipulation to Rev
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Pharmacological Manipulation and Pu
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Pharmacological Manipulation and Pu
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Pharmacological Manipulation and Pu
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Pharmacological Manipulation and Pu
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Transient Restoration of Partial Ph
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CO o o o o o •o c co CD È >•!
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CML Chronic Phase Autografting 193
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Mitoxantrone, Cytarabine, and Melph
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CML Blast Crisis Autografting 197 c
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200 Autografting in Chronic Granulo
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202 Autografting in Chronic Granulo
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Autologous Bone Marrow Transplantat
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IIA. Hodgkin's Disease
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210 ABMTin Hodgkin's Disease Analys
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212 ABMTin Hodgkin's Disease CR n =
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214 ABMTin Hodgkin's Disease Postmo
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216 ABMTin Hodgkin's Disease progno
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218 CBV and ABMT in Hodgkin s Disea
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220 CBV and ABMT in Hodgkin s Disea
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High-Dose Chemotherapy and Autologo
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Chemotherapy andABMT in Hodgkin's D
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Chemotherapy and ABMTin Hodgkin's D
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Chemotherapy andABMTin Hodgkin s Di
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Treating Advanced Hodgkin's Disease
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ABMT for Advanced Hodgkin's Disease
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ABMT for Advanced Hodgkin's Disease
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238 Panel Discussion: Session IIA D
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240 Panel Discussion: Session IIA D
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Recent Results With Salvage Chemoth
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Salvage Chemotherapy for Lymphoma 2
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Salvage Chemotherapy for Lymphoma 2
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250 ABMTin Burkitt's Lymphoma (8-10
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252 ABMT in Burkitt's Lymphoma intr
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254 ABMTin Burkitts Lymphoma Table
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256 ABMT in Burkitt's Lymphoma rela
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258 ABMT in Burkitt's Lymphoma DISC
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260 ABMTin Burkitts Lymphoma restri
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Biology and Therapy of Multiple Mye
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Myeloma Biology and Therapy 265 onl
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Myeloma Biology and Therapy 267 res
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Bone Marrow Transplantation in Rela
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(S E o I 9*1 0 ü 41 O) CD ~ i: O)
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BMT in Relapsed Diffuse Large Cell
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Treatment of Malignant Lymphoma at
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Transplantation for Malignant Lymph
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280 ABMT Timing in Lymphoma produce
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0) O) .2 '55 o c O) o o Q. c o + +
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284 ABMT Timing in Lymphoma ABMT on
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286 ABMT Timing in Lymphoma abdomin
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« "5 a o « £ a> Z aT in O Q « O
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290 ABMT Timing in Lymphoma Role of
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292 ABMT Timing in Lymphoma inducti
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294 ABMT Timing in Lymphoma Clift R
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Treatment Strategies for Advanced A
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Treatment Strategies for NHL 299 Su
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« E BS « oc c 4> E ai O c CD e 0)
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Treatment Strategies for NHL 303 So
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Treatment Strategies for NHL 305 pa
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Non-Hodgkin's Lymphoma S. Gulati an
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Panel Discussion: Session IIB 309 i
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An International Randomized Study o
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Proposed International Adult Lympho
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Proposed International Adult Lympho
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Proposed International Adult Lympho
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Proposed International Adult Lympho
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Proposed International Adult Lympho
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Proposed International Adult Lympho
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Proposed International Adult Lympho
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Proposed International Adult Lympho
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Proposed International Adult Lympho
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Proposed International Adult Lympho
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336 International NHL Trial THEORET
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338 International NHL Trial RELAPSE
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340 International NHL Trial ANALYSI
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342 International NHL Trial The ste
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344 Panel Discussion: Session IIC d
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Chemoimmunoseparation of T Lymphoma
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Chemoimmunoseparation of T Lymphoma
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Using a Liquid Cell Culture Assay t
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Burkitt's Lymphoma Purging Assay 35
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Burkitt's Lymphoma Purging Assay 35
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Burkitt's Lymphoma Purging Assay 35
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Comparative Efficiency of an Immuno
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Purging Methods in Burkitt's Lympho
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Purging Methods in Burkitt's Lympho
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Susceptibility of Lymphoid Malignan
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Leukemia Cell Sensitioity to Immuno
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Leukemia Cell Sensitivity to Immuno
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Lymphoma: Purging and Detecting K.
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III. Neuroblastoma
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376 ABMT for Neuroblastoma TOXICITY
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378 ABMT for Neuroblastoma 100 Befo
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380 ABMTfor Neuroblastoma modificat
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382 ABMTfor Neuroblastoma Naval Med
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384 ABMT in Metastatic Neuroblastom
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386 ABMT in Metastatic Neuroblastom
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388 ABMT in Metastatic Neuroblastom
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390 ABMT in Metastatic Neuroblastom
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High-Dose Therapy and Unpurged Bone
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Unpurged ABMTfor Neuroblastoma 395
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(Jnpurged ABMT for Neuroblastoma 39
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Unpurged ABMT for Neuroblastoma 399
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402 High-Dose Melphalan in Neurobla
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404 High-Dose Melphalan in Neurobla
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Bone Marrow Transplantation in an C
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ABMT in 65 Patients With Neuroblast
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ABMT in 65 Patients With Neuroblast
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ABMT in 65 Patients With Neuroblast
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ABMTin 65 Patients With Neuroblasto
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ABMTin 65 Patients With Neuroblasto
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420 ABMT in Neuroblastoma Group 2
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422 ABMT in Neuroblastoma RESULTS A
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Transplantation for Neuroblastoma U
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Purged Marrow Engraftment in Neurob
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Purged Marrow Engraftment in Neurob
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Purged Marrow Engraftment in Neurob
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s o o o i o i - w n . t t i s T - T
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436 Digital Image Analysis System a
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438 Digital Image Analysis System T
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440 Digital Image Analysis System u
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Eliminating Burkitt's Cells From Ex
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Immunomagnetic Purging ofBurkitt's
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Immunomagnetic Purging ofBurkitt's
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Neuroblastoma T. Philip and C. P. R
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Panel Discussion: Session 111 451 w
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IV. Breast Cancer
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456 High-Dose Chemotherapy and ABMT
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458 High-Dose Chemotherapy and ABMT
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460 High-Dose Chemotherapy and ABMT
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462 High-Dose Chemotherapy and ABMT
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Strategies in the Treatment of Brea
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Treatment Strategies in Breast Canc
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Treatment Strategies in Breast Canc
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Treatment Strategies in Breast Canc
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Treatment Strategies in Breast Canc
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Phase I and II Studies of High-Dose
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a « O 75 o c Ü co s g c .2 — o
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+ O CM CD CM CO CO O O CM O CM CM 8
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High-Dose Chemotherapy and Autologo
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High-Dose Therapy and ABMT in Breas
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Immunodetection of Breast Carcinoma
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Immunodetection of Breast Carcinoma
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490 ABMTfor Breast Cancer initial s
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492 ABMT for Breast Cancer agent gr
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494 ABMT for Breast Cancer approach
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Detection of Occult Breast Cancer C
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Occult Breast Cancer Cells in Marro
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Occult Breast Cancer Cells in Marro
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Breast Cancer E. Frei III and R. Ba
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Panel Discussion: Session IV 505 DR
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V. Lung Cancer
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570 Tumor Cell Detection MATERIAL A
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512 Tumor Cell Detection Table 3. I
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High-Dose Etoposide and Cisplatin W
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Etoposide and Cisplatin for Lung Ca
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Etoposide and Cisplatin for Lung Ca
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Etoposide and Cisplatin for Lung Ca
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524 Panel Discussion: Session V to
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526 Panel Discussion: Session V sma
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VI. Melanoma/Sarcoma/Carcinoma
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532 ABMT in Melanoma chemotherapy a
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534 ABMT in Melanoma Table 2. Effec
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536 ABMT in Melanoma with either si
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538 Panel Discussion: Session VI ca
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540 Panel Discussion: Session VI sa
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Intensive Monochemotherapy With Car
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Carmustine and ABMTfor Malignant Gl
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Carmustine andABMTfor Malignant Gli
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550 High-Dose Carmustine and Transp
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552 High-Dose Carmustine and Transp
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554 High-Dose Carmustine and Transp
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556 High-Dose Carmustine and Transp
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558 High-Dose Therapy of CHS Glioma
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560 High-Dose Therapy of CHS Glioma
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562 High-Dose Therapy of CHS Glioma
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Brain Cancer S. Wolff and G. Herzig
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Panel Discussion: Session VII 567 D
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Intensification Regimens for Autolo
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Clinical Intensification Regimens f
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c « O) o in CM -r 1 •«t 00 i -
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Clinical Intensification Regimens f
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Clinical Intensification Regimens f
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582 Busulfan + Cyclophosphamide in
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Busulfan + Cyclophosphamide in Chil
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586 Busulfan + Cyclophosphamide in
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588 Busulfan + Cyclophosphamide in
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590 Intensive use of Carmustine Pul
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A Phase II Study of a New Cytoreduc
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BEAM: Cytoreductiue Regimen for Lym
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BEAM: Cytoreductiue Regimen for Lym
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BEAM: Cytoreductlue Regimen for Lym
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Total Body Irradiation, High-Dose C
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Total Body Irradiation, Cytarabine,
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New Regimens K. Antman and M. Syman
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IX. Supportive Therapy
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670 Herpesvirus Infections Table 1.
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612 Herpesvirus Infections Table 3.
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Autologous Blood Stem Cell Transpla
- Page 641 and 642:
Peripheral Stem Cell Transplantatio
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Peripheral Stem Cell Transplantatio
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Peripheral Stem Cell Transplantatio
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Peripheral Stem Cell Transplantatio
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a c CO TO O O S E => CO "O CO i- t
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3 w •o « C C o ü ü CD < , o E
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Peripheral Stem Cell Transplantatio
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Peripheral Stem Cell Transplantatio
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Toxic Deaths After Autologous Bone
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Toxic Deaths in ABMT 635 RESULTS Fi
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Toxic Deaths in ABMT 63 7 Patient/
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Infectious Complications of Autolog
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Infectious Complications of ABMT Ta
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Infectious Complications ofABMT 643
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Infectious Complications ofABMT 645
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648 Infections in ABMT MATERIAL AND
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650 Infections in ABMT Category Tab
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652 Infections in ABMT been found,
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654 Antibiotics in Cancer Patients
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656 Antibiotics in Cancer Patients
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The Empiric Use of Amphotericin B f
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Amphotericin B for Neutropenie Feue
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Amphotericin B for Neutropenie Feve
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The Role of Intravenous Immune Glob
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Mg in ABMT 667 broken down; antigen
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The Possible Therapeutic Value of N
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Natural Killer Cells and Transplant
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Natural Killer Cells and Transplant
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676 Transplantation of Circulating
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Transplantation of Circulating Stem
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682 Peripheral Stem Cell Transplant
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684 Peripheral Stem Cell Transplant
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Autologous Transplantation Using Pe
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Peripheral Blood Stem Cell Transpla
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Peripheral Blood Stem Cell Transpla
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Bronchoscopic Examination and Bronc
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Bronchoscopy in Marrow Transplantat
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Effect of Interleukin 2 on T Lympho
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c c 4) "5 Q. Ss •o 3 35 (A U «5
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T Lymphocyte CFU After ABMT 701 Six
- Page 727:
T Lymphocyte CFCJ After ABMT 703 no
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706 Panel Discussion: Session IX se
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Expression of Human Adenosine Deami
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Human ADA in Monkeys 711 to the SAX
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Human ADA in Monkeys 713 4 were nev
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Human ADA in Monkeys 715 tuted marr
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Electric Field-Mediated DNA Transfe
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Electric Field-Mediated DNA Transfe
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Electric Field-Mediated DNA Transfe
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724 Aberrant Gene Expression in AML
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726 Aberrant Gene Expression in AML
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728 Aberrant Gene Expression in AML
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Clonal Detection of Remission by Re
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Clonal Detection of Remission 733 c
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Clonal Detection of Remission 3 735
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XI. Summary
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740 Summary administration of the a
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742 Summary particularly apparent i
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744 Summary limited occurrence of t
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Concluding Remarks Karel A. Dicke I
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Contributors and Participants Zora
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Contributors and Participants 751 M
- Page 777 and 778:
Contributors and Participants 753 A
- Page 779 and 780:
Contributors and Participants 755 R
- Page 781 and 782:
Contributors and Participants 757 M
- Page 783 and 784:
Contributors and Participants Leona
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Contributors and Participants 761 L
- Page 787 and 788:
Contributors and Participants 763 B
- Page 789 and 790:
Contributors and Participants 765 J
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Contributors and Participants 767 L
- Page 793 and 794:
Contributors and Participants 769 B
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Contributors and Participants 771 G
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Contributors and Participants 773 A
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Contributors and Participants 775 L