Autologous Bone Marrow Transplantation - Blog Science Connections

T Lymphocyte CFCJ After ABMT 703
notably CMV, are common after transplantation. They induce T8 +
proliferation and T4/T8 ratio inversion (5,6). Nevertheless, 1L2 effects on T
lymphocyte-colony formation were independent of CMV status, and thus viral
infections cannot provide the sole explanation for the T lymphocyte
abnormalities summarized previously. Conditioning chemotherapy with
cyclophosphamide and melphalan used before transplantation can alter the
lymphocytic microenvironment (7). Finally, transplanted T cells and their
precursors may present quantitative or qualitative defects. It has been shown
that after both allogeneic and autologous transplantation, T lymphocytes
have a defect in IL2 production, but in liquid culture with mitogens (OKT3,
PHA), T lymphocyte-proliferation capacity can be restored by exogenous IL2
(8).
This is consistent with our finding that, after ABMT, T lymphocyte
colony-formation capacity was decreased but can be restored by adding rlL2.
In light of these results, the clinical assessment of the effects 1L2 administration
has on immunologic reconstitution in autografted patients would appear
logical.
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