Autologous Bone Marrow Transplantation - Blog Science Connections

46 ABMTin CRI
RESULTS
The AML investigation proposed to study the biologic role of intensification
with CBV and unpurged ABMT by comparing the results with those of a
concurrent nonrandomized control group. We proposed a 3- to 4-year follow-up
period. Once the study began, no additional patients were to be entered. The
results of the 17 patients entered in the CBV program have now been compared
with the control group who, except for the CBV regimen, were treated
identically. The patient characteristics matched in the two groups. The results
are depicted in Figure 3. The Kaplan-Meier plot shows a 75% projected 18-month
t o o
J-t--
90
MAINTENANCE TREATMENT
A^JTO BMT (3/17 RELAPSES)
H CUEMO CONTROL (4/9)
80
lit
i
70
60
Z 50
40
30 •{
20
0 26 52 78 104 130
CR DURATION (WEEKS)
Figure 3. Updated results of CBV (cyclophosphamide, BCNU [carmustine], VP-16-213
[etoposide]) and unpurged autologous bone marrow transplantation in first complete
remission.