Autologous Bone Marrow Transplantation - Blog Science Connections

Mg in ABMT 667
broken down; antigenically intact Ig appears in the stool (42). In one pilot
study, six patients given oral globulin following ABMT suffered from no
bacteremia, diarrhea, or enteritis (43).
Today, more cytotoxic regimens are being used with ABMT, and more ex
vivo marrow manipulation is being done prior to transplant. Therefore,
immunologic and physical barriers to infections may become severely compromised.
FVIg can play a role in suppressing bacterial infections, whether
systemic or in the intestinal tract. Therefore studies with large numbers of
patients are still needed to define whether Mg, administered intravenously,
orally, or by both routes, may indeed have a role in preventing the
complications of ABMT.
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