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656 Antibiotics in Cancer Patients with a broad antimicrobial spectrum including most gram-positive and gramnegative organisms (21 ). They have the added advantage of being available for oral administration since they are well absorbed from the gastrointestinal tract. They have not yet been fully evaluated in neutropenic patients, but if found to be effective, could result in considerable reduction in the costs associated with antibiotic therapy. SUMMARY Many therapeutic options are available for the management of infections in neutropenic patients. No single approach can be considered universally applicable since, very often, local factors (different microflora and resistance patterns) are quite variable in different institutions. Newer agents, which are potentially more potent and less toxic, might improve the overall clinical outcome of neutropenic patients in the near future. The emergence of resistant organisms may limit the usefulness of some of these newer agents. Therefore, greater efforts need to be directed toward the prevention of infectious complications in neutropenic patients. 1. Brown WE. Am J Med 1984;76:421. REFERENCES 2. BodeyGP. Arch Intern Med 1984;144:1845. 3. Klastersky J, Hensgens C, Debusscher L. Antimicrob Agents Chemother 1975;7:640. 4. DeJongh CA, Wade JC, Schimpff SC, Newman KA, Finley RS, Salvatore PC, Moody MR, Standiford HC, Fortner CL, Wiernik PH. Am J Med 1982;73:89. 5. Lau WK, Young LS, Black RE, Winston DJ, Linne SR, Weinstein RF, Hewitt WL. Am J Med 1977;62:959. 6. Lawson RD, Gentry LO, Bodey GP, Keating MJ, Smith TL. Am J Med Sci 1984;287:16. 7. Dejace P, Klastersky J. Am J Med 1986;80(Suppl B):29. 8. BodeyGP. Arch Intern Med 1985:145:1964. 9. Wade JC, Schimpff SC, Newman CA, Fortner CL, Standiford HC, Wiernik PH. Am J Med 1981:71:983. 10. Fainstein V, Elting L, Pitlik S, Hortobagyi G, Keating M, Bodey GP. Am J Med 1985;79(SupplB):62. 11. Winston DJ, Barnes RC, Ho WG, Young LS, Champlin RE, Gale RP. Am J Med 1984;77:442. 12. Fainstein V, Bodey GP, Bolivar R, Elting L, McCredie KB, Keating MJ. Arch Intern Med 1984:144:1766. 13. Bolivar R, Fainstein V, Elting L, BodeyGP. Rev Infect Dis 1983;5:sl81. 14. Karp JE, Dick JD, Angelopulos C, Charache P, Green L, Burke PJ, Saral R. Am J Med 1986:81:237. 15. Jones PG, Rolston KV1, Fainstein V, Elting L, Walters RS, Bodey GP. Am J Med 1986;81:243. 16. Keating MJ, Lawson R, Grose W, Bodey GP. Arch Intern Med 1981 ;141:926. 17. Piccart M, Klastersky J, Meunier F, Lagast H, Van Laethem Y, Weerts D. Antimicrob Agents Chemother 1984;26:870. 18. Fainstein V, Bodey GP, Elting L, Bolivar R, Keating MJ, McCredie KB, Valdivieso M. J Antimicrob Chemother 1983;12(Suppl A):101.
Antibiotics in Cancer Patients 657 19. Pizzo PA, Hathorn JW, Hiemenz J, Browne M, Commers J, Cotton D, Cress J, Longo D, Marshall D, McKnight J, Rubin M, Skelton J, Thaler M, Wesley R. N Engl J Med 1986:315:552. 20. Bodey GP, Alvarez ME, Jones PG, Rolston KVI, Steelhammer L, Fainstein V. Antimicrob Agents Chemother 1986;30:211. 21. King A, Shannon K, Phillips 1. J Antimicrob Chemother 1985:15:551.
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Autologous Bone Marrow Transplantat
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To our colleagues, Drs. R. Lee Clar
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via ABMT Autologous Bone Marrow Tra
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X ABMT Pharmacological Manipulation
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XII ABMT C. INTERNATIONAL RANDOMIZE
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xiu ABMT Session IV - Breast Cancer
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xui ABMT Panel Discussion: Session
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xuiii ABMT Effect of Interleukin 2
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Acknowledgments The publication of
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AML in First Remission 5 performed
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AML in First Remission 7 than 50% o
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10 BAVC + ABMT in Patients With AML
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BAVC + ABMT in Patients With AML in
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14 BAVC + ABMTin Patients With AML
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16 Purged ABMT in CR of Acute Leuke
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24 First-Remission Autograft forAML
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Transplantation in CRI AML 33 DISCU
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36 ABMT in ALL compared the results
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38 ABMT in ALL were administered un
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40 ABMT in ALL CR1 patients receive
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42 ABMT in ALL 19. Rizzoli V, Mango
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44 ABMTin CRI program in CR1 is the
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46 ABMTin CRI RESULTS The AML inves
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Leukemia: First Remission K A. Dick
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Panel Discussion: Session IA 51 DR.
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IB. Clinical Studies in Second- or
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56 ABMTIn CR2 RESULTS OF VARIOUS TR
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58 ABMTIn CR2 antibodies; for non-T
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60 ABMT in Acute Nonlymphocytic Leu
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70 ABMT in AML With Monoclonal Anti
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80 Mafosfamide Purging in Leukemia
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ABMT in CR2 Pediatric ALL 91 follow
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Ex Vivo Use of Monoclonal Antibodie
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Ex Vivo Marrow Purging 95 Table 1.
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De Viuo Marrow Purging 97 WBC-f- AN
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Conditioning Regimens Before Bone M
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Conditioning Regimens in AML 101 Le
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Conditioning Regimens in AML 103 co
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106 Double (Jnpurged ABMT in Leukem
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108 Double Unpurged ABMT in Leukemi
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770 Double (Jnpurged ABMT in Leukem
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7/2 Double Autografting in Acute Le
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114 Double Autografting in Acute Le
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120 Recovery After 4-Hydroperoxycyc
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122 Recovery After 4-Hydroperoxycyc
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Panel Discussion: Session IB 127 di
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Panel Discussion: Session IB 129 tu
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Magnetic Affinity Colloid Eliminati
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Magnetic Separation of Marrow Cells
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*r r- r» u. >>• O S ^ CO ai a> C
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4-Hydroperoxycyclophosphamide and V
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Chemopurging 145 incubation, the ce
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Chemopurging 147 To date, four pati
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Chemopurging 149 4-HC + VCR IC75 AM
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Decontaminating Bone Marrow With Me
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Merocyanine 540 Marrow Decontaminat
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Merocyanine 540 Marrow Decontaminat
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CALLA-Negative Clonogenic Cultures
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CALLA-Negatiœ Clonogenic BCell ALL
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CALLA-Negative Clonogenic BCell ALL
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164 Acetaldophosphamide Ex Vivo Che
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766 Acetaldophosphamide Ex Vivo Che
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168 Acetaldophosphamide Ex Viuo Che
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Detecting Residual Disease in Bone
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178 Pharmacological Manipulation an
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ID. Chronic Myelogenous Leukemia
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190 CML Chronic Phase Autografting
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196 CML Blast Crisis Autografting e
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Autologous Transplantation of Phila
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Autografting in Chronic Granulocyti
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Autografting in Chronic Granulocyti
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206 Panel Discussion: Session ID DR
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Natural History of Relapsed Hodgkin
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ABMT in Hodgkin's Disease 211 50%.
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ABMTin Hodgkin, 's Disease 213 (62%
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ABMT in Hodgkin's Disease 215 LLLLL
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Updated Results of CBV and Autologo
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CBV and ABMT in Hodgkin's Disease 2
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CBV and ABMT in Hodgkin 's Disease
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224 Chemotherapy and ABMT in Hodgki
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226 Chemotherapy and ABMTin Hodgkin
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232 ABMT for Advanced Hodgkin's Dis
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234 ABMTfor Advanced Hodgkin's Dise
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Hodgkin's Disease J. O. Armitage an
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Panel Discussion: Session IIA 239 D
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IIB. Non-Hodgkin's Lymphoma
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244 Salvage Chemotherapy for Lympho
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246 Salvage Chemotherapy for Lympho
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ABMT in Burkitt's Lymphoma 251 Tabl
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ABMT in Burkitt's Lymphoma 253 medi
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ABMT in Burkitt's Lymphoma 255 Heal
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ABMT in Burkitt's Lymphoma 257 •
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ABMT in Burkitt's Lymphoma 259 init
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ABMT in Burkitt's Lymphoma 261 11.
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264 Myeloma Biology and Therapy hig
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266 Myeloma Biology and Therapy mon
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265 Myeloma Biology and Therapy 5.
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270 BMT in Relapsed Diffuse Large C
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276 Transplantation for Malignant L
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Optimum Timing of Autologous Bone M
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ABMT Timing in Lymphoma 281 PATIENT
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3 o + + + + o LO T— T— LO co Tf
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ABMT Timing in Lymphoma 285 RESULTS
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co co I I I I I I I I I I 2 2 2 CD
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ABMT Timing in Lymphoma 289 Median
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ABMT Timing in Lymphoma 291 in a mi
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ABMT Timing in Lymphoma 293 Develop
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ABMT Timing in Lymphoma 295 53. Sto
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298 Treatment Strategies for NHL PA
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300 Treatment Strategies for NHL 10
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302 Treatment Strategies for NHL 2)
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304 Treatment Strategies for NHL al
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306 Treatment Strategies for NHL 31
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308 Panel Discussion: Session IIB m
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IIC. International Randomized Study
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314 Proposed International Adult Ly
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International Randomized Trial in N
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International NHL Trial 337 dispari
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International NHL Trial 339 cannot
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International NHL Trial 341 ORGANIZ
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Lymphoma T. Philip and G. Spitzer,
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IID. Purging and Detection
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348 Chemoimmunoseparation of T Lymp
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350 Chemoimmunoseparation of T Lymp
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352 Burkitt's Lymphoma Purging Assa
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354 Burkitts Lymphoma Purging Assay
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356 Burkitt's Lymphoma Purging Assa
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358 Burkitts Lymphoma Purging Assay
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360 Purging Methods in Burkitt's Ly
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366 Leukemia Cell Sensitivity to Im
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368 Leukemia Cell Sensitivity to Im
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370 Leukemia Cell Sensitiuity to Im
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372 Panel Discussion: Session IID D
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ABMTfor Neuroblastoma 377 sedimenta
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ABMT for Neuroblastoma 379 EX VIVO
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ABMTfor Neuroblastoma 381 PATIENTS
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Repeated High-Dose Chemotherapy Fol
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ABMT in Metastatic Neuroblastoma 38
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ABMT in Metastatic neuroblastoma 39
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394 Clnpurged ABMTfor Neuroblastoma
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396 Unpurged ABMTfor Neuroblastoma
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398 Unpurged ABMTfor Neuroblastoma
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ENSG 1—Randomized Study of High-D
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High-Dose Melphalan in Neuroblastom
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High-Dose Melphalan in Neuroblastom
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408 ABMTin 65 Patients With Neurobl
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410 ABMT in 65 Patients With. Neuro
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416 ABMTin 65 Patients With neurobl
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A Single Institution's Experience o
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ABMT in Neuroblastoma 421 procedure
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ABMT in Neuroblastoma 423 therapies
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426 Purged Marrow Engraftment in Ne
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Digital Image Analysis System for D
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Digital Image Analysis System 435 d
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Digital Image Analysis System 437 c
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Digital Image Analysis System 439 C
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Digital Image Analysis System 441 1
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444 Immune-magnetic Purging ofBurki
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450 Panel Discussion: Session III W
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452 Panel Discussion: Session III e
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High-Dose Chemotherapy Intensificat
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High-Dose Chemotherapy and ABMT in
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466 Treatment Strategies in Breast
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10 CO 0) I- m c o a. a. 3 W ? o k_
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476 Phase I and II Studies of Alkyl
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482 High-Dose Therapy and ABMT in B
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484 High-Dose Therapy and ABMT in B
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486 Immunodetection of Breast Carci
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ABMTfor Breast Cancer 491 only adju
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ABMT for Breast Cancer 493 Table 3.
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ABMTfor Breast Cancer 495 4. Eder J
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498 Occult Breast Cancer Cells in M
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504 Panel Discussion: Session IV DR
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506 Panel Discussion: Session IV a
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Detection of Bone Marrow Metastases
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Tumor Cell Detection 511 Two separa
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Tumor Cell Detection 513 immunofluo
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516 Etoposide and Cisplatin for Lun
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Lung Cancer G. Spitzer and H. Lazar
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Panel Discussion: Session V 525 com
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Panel Discussion: Session V 527 col
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Treatment of Advanced Melanoma With
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ABMT in Melanoma 533 Table 1. Three
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ABMT in Melanoma 535 mg/m 2 ). The
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Melanoma/ Sarcoma/ Carcinoma R. Ben
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Panel Discussion: Session VI 539 re
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VII. Brain Cancer
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544 Carmustine and ABMT for Maligna
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546 Carmustine and ABMTfor Malignan
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Pilot Study of High-Dose Carmustine
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High-Dose Carmustine and Transplant
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High-Dose Chemotherapy With Autolog
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High-Dose Therapy of CNS Gliomas Ta
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High-Dose Therapy of CHS Gliomas 56
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High-Dose Therapy of CHS Gliomas 56
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566 Panel Discussion: Session VII A
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VIII. New Regimens
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572 Clinical Intensification Regime
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574 Clinical Intensification Regime
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Clinical Intensification Regimens f
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Clinical Intensification Regimens f
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High-Dose Busulfan and Cyclophospha
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Busulfan + Cyclophosphamide in Chil
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The Intensive Use of Carmustine Wit
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Intensive Use ofCarmustine 591 6. P
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594 BEAM: Cytoreductive Regimen for
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596 BEAM: Cytoreductiue Regimen for
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602 Total Body Irradiation, Cytarab
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604 Total Body Irradiation, Cytarab
Page 630 and 631: 606 Panel Discussion: Session VIII
Page 633 and 634: Herpesvirus Infections After Autolo
Page 635 and 636: Herpesvirus Infections 611 Table 2.
Page 637: Herpesvirus Infections 613 contrast
Page 640 and 641: 616 Peripheral Stem Cell Transplant
Page 644 and 645: CO ^ CO COi-t'ycOi-T-CO O E « to T
Page 648 and 649: fc CD rr ^ O < c E + o — ce S O O
Page 650 and 651: o E ra o CD .Q Û ra co CL o E o 15
Page 658 and 659: 634 Toxic Deaths in ABMT PATIENTS A
Page 660 and 661: 636 Toxic Deaths in ABMT Table 2. D
Page 662 and 663: 638 Toxic Deaths in ABMT defined an
Page 664 and 665: 640 Infectious Complications ofABMT
Page 671 and 672: Infectious Complications of Autolog
Page 673 and 674: Infections in ABMT 649 Table 1. ABM
Page 675 and 676: Infections in ABMT 651 herpes simpl
Page 677 and 678: Newer Antibiotic Regimens in Cancer
Page 679: Antibiotics in Cancer Patients 655
Page 684 and 685: 660 Amphotericin B for Neutropenic
Page 686 and 687: 662 Amphotericin B for Neutropenie
Page 688 and 689: 664 Amphotericin B for Neutropenie
Page 690 and 691: 666 IVIg in ABMT in autologous tran
Page 692 and 693: 668 IVlg in ABMT 25. Neiman PE, Ree
Page 694 and 695: 670 Natural Killer Cells and Transp
Page 696 and 697: 672 Natural Killer Cells and Transp
Page 699 and 700: Autologous Transplantation of Circu
Page 702 and 703: 678 Transplantation of Circulating
Page 705 and 706: Restoration of Hematopoietic Functi
Page 707 and 708: Peripheral Stem Cell Transplants 68
Page 709: Peripheral Stem Cell Transplants 68
Page 712 and 713: 688 Peripheral Blood Stem Cell Tran
Page 718 and 719: 694 Bronchoscopy in Marrow Transpla
Page 720 and 721: 696 Bronchoscopy in Marrow Transpla
Page 722 and 723: 698 T Lymphocyte CFU After ABMT cer
Page 724 and 725: 700 T Lymphocyte CFCI After ABMT RE
Page 726 and 727: 702 T Lymphocyte CFU After ABMT CMV
Page 729 and 730: Supportive Therapy H. Vriesendorp a
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X. Molecular Biology
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770 Human ADA in Monkeys years in a
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7/2 Human ADA in Monkeys supernatan
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714 Human ADA in Monkeys Number of
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776 Human ADA in Monkeys primate ma
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718 Electric Field-Mediated DMA Tra
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720 Electric Field-Mediated DNA Tra
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Aberrant Gene Expression in Acute M
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+ z + + + les •ras a z E i ü (0
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Aberrant Gene Expression in AML 727
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Aberrant Gene Expression in AML 729
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732 Clonal Detection of Remission p
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734 Clonal Detection of Remission K
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736 Clonal Detection of Remission 3
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Summary D. W. van Bekkum Attempts t
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Summary 741 T cell-depleted bone ma
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Summary 743 hybridization technique
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Summary 745 GENETIC THERAPY The las
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748 Concluding Remarks time of the
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750 Contributors and Participants F
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754 Contributors and Participants P
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756 Contributors and Participants A
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758 Contributors and Participants P
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762 Contributors and Participants H
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764 Contributors and Participants A
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766 Contributors and Participants G
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770 Contributors and Participants S
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772 Contributors and Participants C
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776 Contributors and Participants D
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