Autologous Bone Marrow Transplantation - Blog Science Connections

650 Infections in ABMT
Category
Table 2. Fever in Autologous Bone Marrow Transplantation
No. of Patients
Type
Infection
MDI 20 Septicemias 11
Localized 9
CDI 8 Pneumonias 2
Necrotizing stomatitis 5
Necrotizing stomatitis
and vulvitis 1
PI 14
Total
42 a
"One patient was affected simultaneously by septicemia and urinary tract infection.
Abbreviations: MDI, microbiologically documented infection; CDI, clinically
documented infection; PI, possible infection.
No.
remained unexplained (PI). No doubtful infections were observed. Of MDI,
55% were septicemias and 45% localized infections (4 of 9 urinary tract
infections and 5 of 9 necrotizing stomatitis).
Table 3 shows the MDI-causing pathogens. Gram-positive bacteria
represented 60% of all isolates (14 of 23) and gram-negative, 35% (8 of 23). In
one patient the infectious episode was primarily sustained by a reactivated
Table 3. Microbiologically Documented Infections
in Children Undergoing Autologous Bone Marrow Transplantation
Infection No. of Cases Organism
Septicemias 11 2 S. aureus
1 S. epidermidis
4 Strept. sanguis
1 Strept. mitis
1 E. coli
1 E. coli + Corynebact. spp.
1 E. coli + Haemophilus influenzae
Urinary tract 4 Strept. faecalis
E. coli
E. coli + Strept. faecalis
Proteus spp.
Necrotizing 5 S. aureus
stomatitis
S. aureus
Anaerobic streptococci
Enterobacter cloacae
Herpes simplex virus (reactivation)
Localized 9