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632 Peripheral Stem Cell Transplantation 18. Kessinger A, Armitage JO, Landmark JD, Weisenburger DD. Exp Hematol 1986;14:192. 19. Stiff PJ, Koester AR, Lanzotti VJ. Exp Hematol 1986;14:465. 20. To LB, Dyson PG, Juttner CA. Lancet 1986;2:404. 21. Korbling M, Fliedner TM, Pflieger H. Scand J Haematol 1980;24:22. 22. Jagannath S, Dicke KA, Armitage JO, Cabanillas FF, Horwitz U, Vellekoop L, Zander AR, SpitzerG. Ann Intern Med 1986;104:163. 23. Fauser AA, Messner HA. Blood 1979;53:1023. 24. Ash RC, DetrickRA, Zanjani ED. Blood 1981;58:309. 25. Richman CM, Weiner RS, Yankee RA. Blood 1976;47:1031. 26. To LB, Haylock DM, Kimber RJ, Juttner CA. Br J Haematol 1984;58:399. 27. Bernard PH, Reiffers J, Vezon G, Sarrat A, Marit G, David B, Broustet A. Br J Haematol 1985;61:577. 28. Geissler K, Hinterberger W, Lechner K. Br J Haematol 1986;62:596. 29. Tilly H, Vannier JP, Bastit D, Monconduit M, Piguet H. Leuk Res 1986;10:353. 30. Nothdurft W, Fliedner TM, Calvo W, Flad HD, Huget R, Korbling M, Krumbacher-von Loringhofen K, Ross WM, Schnappauf HP, Steinbach I. Scand J Haematol 1978;21:115. 31. Haen M, Gilli G, Nothdurft W, Fliedner TM. Exp Hematol 1980;8(Suppl 7):26. 32. Haen M, Grilli G, Fliedner TM. Blut 1982;45:213. 33. Raghavachar A, Prummer O, Fliedner TM. Exp Hematol 1984:12:439. 34. Raghavachar A, Prummer O, Fliedner TM, Steinbach KH. Exp Hematol 1983;11:996. 35. Vos O, Buurman WA, Ploemacher RE. Cell Tissue Kinet 1972;5:467. 36. Cline MJ, Golde DW. Exp Hematol 1977;5:186. 37. Zander AR, Templeton J, Gray KN, Spitzer G, Verma DS, Dicke KA. Biomed Pharmacother 1984:38:107. 38. Ross WM, Calvo S, Fliedner TM, Korbling M, Nothdurft W. Exp Hematol 1977;5:13. 39. Ross WM, Korbling M, Nothdurft W, Fliedner TM. Proc Soc Exp Biol Med 1978:157:301. 40. Morra L, Ponassi A, Parodi GB, Caristo G, Bruzzi P, Sacchetti C. Biomedicine 1981:35:87. 41. Lasky LC, Ascensao J, McCullough J, Zanjani ED. Br J Haematol 1983:55:615. 42. Barrett AJ, Longhurst P, Sneath P, Watson JG. Exp Hematol 1978:6:590.
Toxic Deaths After Autologous Bone Marrow Transplantations: Rate and Etiology Eric Bouffet, Pierre Biron, Didier Frappaz, and Thierry Philip Toxic deaths are the major problem after bone marrow transplantation. The toxic death rate reported in the world literature after autologous bone marrow transplantation (ABMT) is in the range of 8-20%. It seems not to be related to the specific disease, i.e., it is 21% in lymphoma (1,2) and Hodgkin's disease (3), 20% in neuroblastoma (seeT. Philip et ai, "Bone Marrow Transplantation in an Unselected Group of 65 Patients With Stage IV Neuroblastoma," in this volume), 12% in acute myeloid leukemia (4) and Burkitt's lymphoma (see T. Philip et ai, "Autologous Bone Marrow Transplantation in Burkitt's Lymphoma: 50 Cases in the Lyons Protocol," in this volume), 10% in Hodgkin's disease (5), and as low as 8% in breast cancer (6). However, despite controversy ( 1 ), a slightly but not significantly higher toxic death rate seems to be related to regimens incorporating total body irradiation (TBI) (Philip, unpublished data). Our primary objectives in this retrospective study were to determine the toxic death rate in a group of 103 patients after ABMT and also to try to correlate status before ABMT with fatal complications. A secondary objective was to separate toxic deaths into early (i.e., before day 30 post-ABMT) and delayed (30-100 days post-ABMT) occurrences. 633
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Autologous Bone Marrow Transplantat
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To our colleagues, Drs. R. Lee Clar
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via ABMT Autologous Bone Marrow Tra
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X ABMT Pharmacological Manipulation
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XII ABMT C. INTERNATIONAL RANDOMIZE
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xiu ABMT Session IV - Breast Cancer
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xui ABMT Panel Discussion: Session
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xuiii ABMT Effect of Interleukin 2
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Acknowledgments The publication of
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AML in First Remission 5 performed
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AML in First Remission 7 than 50% o
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10 BAVC + ABMT in Patients With AML
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BAVC + ABMT in Patients With AML in
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14 BAVC + ABMTin Patients With AML
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16 Purged ABMT in CR of Acute Leuke
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24 First-Remission Autograft forAML
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Transplantation in CRI AML 33 DISCU
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36 ABMT in ALL compared the results
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38 ABMT in ALL were administered un
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40 ABMT in ALL CR1 patients receive
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42 ABMT in ALL 19. Rizzoli V, Mango
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44 ABMTin CRI program in CR1 is the
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46 ABMTin CRI RESULTS The AML inves
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Leukemia: First Remission K A. Dick
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Panel Discussion: Session IA 51 DR.
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IB. Clinical Studies in Second- or
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56 ABMTIn CR2 RESULTS OF VARIOUS TR
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58 ABMTIn CR2 antibodies; for non-T
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60 ABMT in Acute Nonlymphocytic Leu
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70 ABMT in AML With Monoclonal Anti
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80 Mafosfamide Purging in Leukemia
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ABMT in CR2 Pediatric ALL 91 follow
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Ex Vivo Use of Monoclonal Antibodie
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Ex Vivo Marrow Purging 95 Table 1.
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De Viuo Marrow Purging 97 WBC-f- AN
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Conditioning Regimens Before Bone M
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Conditioning Regimens in AML 101 Le
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Conditioning Regimens in AML 103 co
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106 Double (Jnpurged ABMT in Leukem
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108 Double Unpurged ABMT in Leukemi
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770 Double (Jnpurged ABMT in Leukem
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7/2 Double Autografting in Acute Le
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114 Double Autografting in Acute Le
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120 Recovery After 4-Hydroperoxycyc
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122 Recovery After 4-Hydroperoxycyc
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Panel Discussion: Session IB 127 di
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Panel Discussion: Session IB 129 tu
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Magnetic Affinity Colloid Eliminati
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Magnetic Separation of Marrow Cells
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*r r- r» u. >>• O S ^ CO ai a> C
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4-Hydroperoxycyclophosphamide and V
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Chemopurging 145 incubation, the ce
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Chemopurging 147 To date, four pati
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Chemopurging 149 4-HC + VCR IC75 AM
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Decontaminating Bone Marrow With Me
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Merocyanine 540 Marrow Decontaminat
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Merocyanine 540 Marrow Decontaminat
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CALLA-Negative Clonogenic Cultures
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CALLA-Negatiœ Clonogenic BCell ALL
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CALLA-Negative Clonogenic BCell ALL
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164 Acetaldophosphamide Ex Vivo Che
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766 Acetaldophosphamide Ex Vivo Che
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168 Acetaldophosphamide Ex Viuo Che
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Detecting Residual Disease in Bone
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178 Pharmacological Manipulation an
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ID. Chronic Myelogenous Leukemia
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190 CML Chronic Phase Autografting
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196 CML Blast Crisis Autografting e
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Autologous Transplantation of Phila
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Autografting in Chronic Granulocyti
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Autografting in Chronic Granulocyti
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206 Panel Discussion: Session ID DR
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Natural History of Relapsed Hodgkin
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ABMT in Hodgkin's Disease 211 50%.
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ABMTin Hodgkin, 's Disease 213 (62%
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ABMT in Hodgkin's Disease 215 LLLLL
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Updated Results of CBV and Autologo
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CBV and ABMT in Hodgkin's Disease 2
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CBV and ABMT in Hodgkin 's Disease
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224 Chemotherapy and ABMT in Hodgki
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226 Chemotherapy and ABMTin Hodgkin
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232 ABMT for Advanced Hodgkin's Dis
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234 ABMTfor Advanced Hodgkin's Dise
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Hodgkin's Disease J. O. Armitage an
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Panel Discussion: Session IIA 239 D
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IIB. Non-Hodgkin's Lymphoma
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244 Salvage Chemotherapy for Lympho
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246 Salvage Chemotherapy for Lympho
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ABMT in Burkitt's Lymphoma 251 Tabl
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ABMT in Burkitt's Lymphoma 253 medi
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ABMT in Burkitt's Lymphoma 255 Heal
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ABMT in Burkitt's Lymphoma 257 •
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ABMT in Burkitt's Lymphoma 259 init
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ABMT in Burkitt's Lymphoma 261 11.
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264 Myeloma Biology and Therapy hig
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266 Myeloma Biology and Therapy mon
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265 Myeloma Biology and Therapy 5.
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270 BMT in Relapsed Diffuse Large C
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276 Transplantation for Malignant L
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Optimum Timing of Autologous Bone M
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ABMT Timing in Lymphoma 281 PATIENT
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3 o + + + + o LO T— T— LO co Tf
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ABMT Timing in Lymphoma 285 RESULTS
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co co I I I I I I I I I I 2 2 2 CD
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ABMT Timing in Lymphoma 289 Median
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ABMT Timing in Lymphoma 291 in a mi
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ABMT Timing in Lymphoma 293 Develop
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ABMT Timing in Lymphoma 295 53. Sto
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298 Treatment Strategies for NHL PA
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300 Treatment Strategies for NHL 10
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302 Treatment Strategies for NHL 2)
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304 Treatment Strategies for NHL al
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306 Treatment Strategies for NHL 31
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308 Panel Discussion: Session IIB m
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IIC. International Randomized Study
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314 Proposed International Adult Ly
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International Randomized Trial in N
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International NHL Trial 337 dispari
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International NHL Trial 339 cannot
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International NHL Trial 341 ORGANIZ
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Lymphoma T. Philip and G. Spitzer,
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IID. Purging and Detection
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348 Chemoimmunoseparation of T Lymp
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350 Chemoimmunoseparation of T Lymp
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352 Burkitt's Lymphoma Purging Assa
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354 Burkitts Lymphoma Purging Assay
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356 Burkitt's Lymphoma Purging Assa
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358 Burkitts Lymphoma Purging Assay
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360 Purging Methods in Burkitt's Ly
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366 Leukemia Cell Sensitivity to Im
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368 Leukemia Cell Sensitivity to Im
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370 Leukemia Cell Sensitiuity to Im
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372 Panel Discussion: Session IID D
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ABMTfor Neuroblastoma 377 sedimenta
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ABMT for Neuroblastoma 379 EX VIVO
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ABMTfor Neuroblastoma 381 PATIENTS
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Repeated High-Dose Chemotherapy Fol
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ABMT in Metastatic Neuroblastoma 38
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ABMT in Metastatic neuroblastoma 39
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394 Clnpurged ABMTfor Neuroblastoma
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396 Unpurged ABMTfor Neuroblastoma
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398 Unpurged ABMTfor Neuroblastoma
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ENSG 1—Randomized Study of High-D
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High-Dose Melphalan in Neuroblastom
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High-Dose Melphalan in Neuroblastom
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408 ABMTin 65 Patients With Neurobl
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410 ABMT in 65 Patients With. Neuro
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416 ABMTin 65 Patients With neurobl
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A Single Institution's Experience o
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ABMT in Neuroblastoma 421 procedure
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ABMT in Neuroblastoma 423 therapies
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426 Purged Marrow Engraftment in Ne
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Digital Image Analysis System for D
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Digital Image Analysis System 435 d
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Digital Image Analysis System 437 c
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Digital Image Analysis System 439 C
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Digital Image Analysis System 441 1
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444 Immune-magnetic Purging ofBurki
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450 Panel Discussion: Session III W
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452 Panel Discussion: Session III e
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High-Dose Chemotherapy Intensificat
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High-Dose Chemotherapy and ABMT in
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466 Treatment Strategies in Breast
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10 CO 0) I- m c o a. a. 3 W ? o k_
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476 Phase I and II Studies of Alkyl
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482 High-Dose Therapy and ABMT in B
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484 High-Dose Therapy and ABMT in B
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486 Immunodetection of Breast Carci
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ABMTfor Breast Cancer 491 only adju
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ABMT for Breast Cancer 493 Table 3.
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ABMTfor Breast Cancer 495 4. Eder J
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498 Occult Breast Cancer Cells in M
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504 Panel Discussion: Session IV DR
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506 Panel Discussion: Session IV a
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Detection of Bone Marrow Metastases
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Tumor Cell Detection 511 Two separa
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Tumor Cell Detection 513 immunofluo
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516 Etoposide and Cisplatin for Lun
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Lung Cancer G. Spitzer and H. Lazar
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Panel Discussion: Session V 525 com
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Panel Discussion: Session V 527 col
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Treatment of Advanced Melanoma With
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ABMT in Melanoma 533 Table 1. Three
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ABMT in Melanoma 535 mg/m 2 ). The
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Melanoma/ Sarcoma/ Carcinoma R. Ben
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Panel Discussion: Session VI 539 re
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VII. Brain Cancer
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544 Carmustine and ABMT for Maligna
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546 Carmustine and ABMTfor Malignan
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Pilot Study of High-Dose Carmustine
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High-Dose Carmustine and Transplant
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High-Dose Chemotherapy With Autolog
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High-Dose Therapy of CNS Gliomas Ta
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High-Dose Therapy of CHS Gliomas 56
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High-Dose Therapy of CHS Gliomas 56
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566 Panel Discussion: Session VII A
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VIII. New Regimens
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572 Clinical Intensification Regime
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574 Clinical Intensification Regime
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Clinical Intensification Regimens f
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Clinical Intensification Regimens f
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Page 633 and 634: Herpesvirus Infections After Autolo
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Page 671 and 672: Infectious Complications of Autolog
Page 673 and 674: Infections in ABMT 649 Table 1. ABM
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Page 677 and 678: Newer Antibiotic Regimens in Cancer
Page 679 and 680: Antibiotics in Cancer Patients 655
Page 681: Antibiotics in Cancer Patients 657
Page 684 and 685: 660 Amphotericin B for Neutropenic
Page 686 and 687: 662 Amphotericin B for Neutropenie
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Page 690 and 691: 666 IVIg in ABMT in autologous tran
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Page 694 and 695: 670 Natural Killer Cells and Transp
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Page 699 and 700: Autologous Transplantation of Circu
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Page 705 and 706: Restoration of Hematopoietic Functi
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Peripheral Stem Cell Transplants 68
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Peripheral Stem Cell Transplants 68
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688 Peripheral Blood Stem Cell Tran
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694 Bronchoscopy in Marrow Transpla
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696 Bronchoscopy in Marrow Transpla
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698 T Lymphocyte CFU After ABMT cer
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700 T Lymphocyte CFCI After ABMT RE
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702 T Lymphocyte CFU After ABMT CMV
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Supportive Therapy H. Vriesendorp a
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X. Molecular Biology
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770 Human ADA in Monkeys years in a
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7/2 Human ADA in Monkeys supernatan
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714 Human ADA in Monkeys Number of
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776 Human ADA in Monkeys primate ma
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718 Electric Field-Mediated DMA Tra
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720 Electric Field-Mediated DNA Tra
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Aberrant Gene Expression in Acute M
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+ z + + + les •ras a z E i ü (0
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Aberrant Gene Expression in AML 727
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Aberrant Gene Expression in AML 729
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732 Clonal Detection of Remission p
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734 Clonal Detection of Remission K
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736 Clonal Detection of Remission 3
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Summary D. W. van Bekkum Attempts t
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Summary 741 T cell-depleted bone ma
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Summary 743 hybridization technique
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Summary 745 GENETIC THERAPY The las
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748 Concluding Remarks time of the
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750 Contributors and Participants F
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754 Contributors and Participants P
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756 Contributors and Participants A
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758 Contributors and Participants P
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762 Contributors and Participants H
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764 Contributors and Participants A
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766 Contributors and Participants G
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770 Contributors and Participants S
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772 Contributors and Participants C
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776 Contributors and Participants D
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