Autologous Bone Marrow Transplantation - Blog Science Connections

38 ABMT in ALL
were administered until the patients were free of fever and the total leukocyte
count rose above 1 x 10 9 /1 with absolute neutrophils more than 0.5 x 10 9 /1.
Statistical Analysis
Statistical calculations were performed according to the Kaplan and
Meier method (12). The analysis of disease-free survival (DFS) included both
patients who, before they could be discharged, had a relapse and patients
who died during ABMT. The significance of data was calculated by the
Wilcoxon rank sum test.
RESULTS
Figures 1-3 give the clinical results for DFS for ALL CR1 and CR2
patients. Among the 16 ALL CR1 patients with purged marrow, 6 had a
leukemic relapse, 1 died of leukemia, 3 obtained CR post-ABMT with conventional
therapy, and 1 will receive a second transplant in the near future. Two
other patients died of renal failure and severe hemorrhage with sepsis during
ABMT.
The DFS for ALL CR1 patients was 49.9% at 54 months. Six other ALL
too
sa
N. = 16
60
- 60
- sa
D
0
40
0
L 30
i
20
10
DFS
10 15 20 25 30 35
Moot, hit*
40 45 50 66 60
Figure 1. Autologous bone marrow transplantation in acute lymphocytic leukemia (first
complete response): survival and disease-free survival. Autograft was with mafosfamidetreated
marrow.