Autologous Bone Marrow Transplantation - Blog Science Connections

ABMT in ALL 37
Table 1. Patient Characteristics
ABMT in ALL 8 ABMT in CR1 ALL 6
(No. of Patients)
ABMT remission
CR1 16
CR2 11
(No. of Patients)
FAB classification
L, 5 1
L 2 13 2
La 4 1
ND 5 2
Immunologic class
pre-B B 3 —
T 3 1
C 7 2
non-T 8 3
non-B 8 3
ND 6 —
Mean age at diagnosis (yr) 25 28
Range 17-56 22-44
Preparative regimen
CY + TBI 24 6
Other 3
Abbreviations: ABMT, autologous bone marrow transplantation; ALL, acute
lymphocytic leukemia; CR1, first complete remission; CR2, second complete
remission; FAB, French-American-British; CY, cyclophosphamide; TBI, total body
irradiation.
1
Mafosi'amide-treated marrow received by 27 patients.
"Untreated marrow received by six patients.
Bone Marrow Transplantation
Before reinfusion, the cells were thawed by a rapid immersion in a water
bath of 37° C. The viability of cells was evaluated by the trypan blue dye exclusion
test and the cells were infused into patients 24 hours after completing the
conditioning regimen and were reinjected at doses ranging from 0.9 to 2 x
10 8 /kg. Engraftment was documented by the daily evaluation of hematologic
recovery. None of the patients received chemotherapy after ABMT.
Supportive Care
All patients were hospitalized in laminar air flow rooms. During posttransplant
aplasia, patients were supported with platelets and packed RBC
transfusions that were previously irradiated (15-30 Gy). A broad spectrum of
antibiotics, antimycotic and antiviral drugs, and gamma immunoglobulin