Autologous Bone Marrow Transplantation - Blog Science Connections

High-Dose Therapy of CHS Gliomas 563
etoposide with the synergistic agent cisplatin. Pending the completion of the
phase II thio-TEPA study, this agent will be studied in combination chemotherapy.
Although high-dose carmustine is the most active agent, its use is
limited by the high frequency of fatal extramedullary toxicity. If this agent is to
be used in high-dose studies, a substantial reduction from the maximal dose
should be considered.
In summary, CNS tumors have been treated with high doses of a variety
of drugs, unfortunately, although high response rates have been observed,
survival has not yet been prolonged meaningfully. However, new combinations
are being investigated to create synergistic drug combinations that, it is
hoped, can be used as adjuvant therapy for high-grade gliomas.
REFERENCES
1. Shapiro WR. Semin Oncol 1986;13:38.
2. Frei E 111, Canellos GP. Am J Med 1980:69:585.
3. Herzig GP. Prog Hematol 1981 ;12:1.
4. Wilson CB, Crafts D, Levin V. NCI Monogr 1977;46:197.
5. Kaplan EL, Meier P. Journal of the American Statistical Association 1953:53:457.
6. Simon R. Ann Intern Med 1986:105:429.
7. Brown R, Herzig RH, Fay JW, Wolff S, Strandjord S, Egorin M, Herzig G. Proceedings of the
American Society of Clinical Oncology 1986:5:127.
8. Phillips GL, Wolff SN, Fay JW, Herzig RH, Lazarus HM, Schold C, Herzig GP. J Clin Oncol
1986;4:639.
9. Giannone L, Wolff SN. Proceedings of the American Society of Clinical Oncology (in press).
10. Wolff SN. Cancer Treat Rep (7n press).
11. Wolff SN, Phillips GL, Herzig GP. Cancer Treat Rep (in press).
12. Burger PC, Kamenar E, Schold SC, Fay JW, Phillips GL, Herzig GP. Cancer 1981;48:1318.
13. Kelly KA, Kirkwood JM, Kapp DS. Cancer Treat Rep 1984;11:1.
14. Calogero JA, Crafts DC, Wilson CB, Boldreg EB, Rosenberg AW, Enot KJ. J Neurosurg
1975:43:191.
15. Green SB, Byar DP, Walker MD, Pistenmaa DA, Alexander E Jr, Batzdorf V, Brooks WH,
Hunt WE, Mealey J Jr, Odom GL, Pauletti G, Ransohoff J 2nd, Robertson JT, Selker RG,
Shapiro WR, Smith KR Jr, Wilson CB, Strike TA. Cancer Treat Rep 1983:67:121.
16. Tirelli (J, D'lncalci M, Canetta R. J Clin Oncol 1984;2:432.
17. Johnson DH, Greco FA, Wolff SN. Cancer Treat Rep 1983:67:1023.
18. Edwards MS, Levin VA.Seager ML, Pischer TL, Wilson CB. Cancer TreatRep 1979:63:1419.