Autologous Bone Marrow Transplantation - Blog Science Connections

An International Randomized Study of Relapsed
Diffuse Intermediate- and High-Grade
Lymphoma in Adults
T. Philip, J. Armitage, G. Spitzer, F. Cabanillas, W. Velasquez,
S. Jagannath, T. Hagenbeek, P. Biron, J. Cahn, G. Zagars,
P. Carole, and F. Chauuin
The major objective of this international study of diffuse intermediate- and
high-grade lymphoma is to determine the rate of disease-free survival and
duration of response for a group of adults who are in relapse. Patients with
non-Hodgkin's lymphoma will be selected for the study on the basis of
chemosensitivity to the DHAP (dexamethasone, cytarabine, cisplatin) salvage
regimen. Patients will be randomized to undergo an effective conventional
rescue protocol followed by involved-field radiotherapy or to receive involvedfield
radiotherapy plus high-dose chemotherapy with autologous bone
marrow transplantation (ABMT). A secondary objective of the study is to
determine the crude survival in both groups and to confirm that the strategy
with ABMT does not lead to more than 15% mortality.
BACKGROUND FOR THE PRESENT PROPOSAL
A retrospective study of data from the France Autogreffe Study group
and London group was performed in July 1983 (1-3). From these data, as
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