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294 ABMT Timing in Lymphoma Clift RA, Epstein RB, Fialkow PJ, Funk DD, Qiblett ER, Berner KG, Reynolds FA, Slichter S. Blood 1971;38:267. 28. Clarkson B, Ellis S, Little C, Gee T, Arlin Z, Mertelsmann M, Andreeff M, Kempin S, Koziner B, Chaganti R, Jhanwar S, McKenzie S, Cirrincione C, Gaynor J. Semin Oncol 1985;12:160. 29. Stiff PJ, DeRisi MF, Langleben A, Gulati S, Koester A, Lanzotti V, Clarkson BD. Ann NY Acad Sei 1983:411:378. 30. Sharkis SJ, Santos GW, Colvin M. Blood 1980;55:521. 31. Kaizer H, Stuart RK, Brookmeyer R, Beschorner WE, Braine HG, Burns WH, Fuller DJ, Korbling M, Mangan KF, Sarai R, Sensenbrenner L, Shadduck RK, Shende AC, Tutschka PJ, Yeager AM, Zinkham WH, Colvin OM, Santos GW. Blood 1985:65:1504. 32. Siena S, Castro-Malaspina H, Gulati S, Lu L, Colvin M, Clarkson BD, O'Reilly RJ, Moore M. Blood 1985:65:655. 33. Chang TT, Gulati SC, Chou TC, Vega R, Gandola L, Ezzat Ibrahim SM, Yopp J, Colvin M, Clarkson BD. Cancer Res 1985:45:2434. 34. Gulati SC, Gandola L, Vega R, Yopp J, Chang TT, Ibrahim S, Siena S, Castro-Malaspina H, Colvin M, Clarkson B. Proceedings of the American Association for Cancer Research 1984;25:201 (abstract). 35. Sarai R, Burns WH, Laskin OL, Santos GW, Lietman PS. N Engl J Med 1981 ;305:63. 36. Dinsmore RE, Straus DJ, Pollack MS, Woodruff JM, Garrett TJ, Young CW, Clarkson BD, Dupont BP. Blood 1980;55:831. 37. Yeager AM, Kaizer H, Santos GW, Sarai R, Colvin OM, Stuart RK, Braine HG, Burke PJ, Ambinder RF, Burns WH, Fuller DJ, Davis JM, Wingard JR. N Engl J Med 1986:315:141. 38. Goldstone AH. In Autologous Bone Marrow Transplantation: Proceedings of the First International Symposium, Dicke KA, Spitzer G, Zander AR, eds. The university of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, 1985:67. 39. Hartmann O, Pein R, Beaujean F, Kalifa C, Patte C, Parmentier C, Lemerle J. J Clin Oncol 1984;2:979. 40. Baumgartner C, Bleher EA, Brun del Re G, Bucher CI, Deubelbeiss KA, Greiner R, Hirt A, Imbach P, Luthy A, Odavic R, Wagner HP. Med Pediatr Oncol 1984;12:104. 41. Nadler LM, Takvorian T, Botnick L, Bast RC, Finberg R, Hellman S, Canellos GP, Schlossman SF. Lancet (in press). 42. Philip T, Biron D, Maraninchi D, Goldstone AH, Herve P, Souillet G, Gastaut JL, Plouvier E, Flesh Y, Philip I, Harousseau JL, Le Mevel A, Regattu P, Linch DC, Freycon F, Milan JJ, Souhami Rl. In Autologous Bone Marrow Transplantation: Proceedings of the First International Symposium, Dicke KA, Spitzer G, Zander AR, eds. The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, 1985:89. 43. Lumley HS, Powles R, Morgenstern G, Clink HM, McElwain TJ. In Bone Marrow Transplantaion in Europe, vol. 2, Touraine IL, Gluckman E, Griscelli C, eds. Excerpta Medica, Amsterdam, 1981:24. 44. Shipp M, KlattM, Harrington D, Pinkus G, Jochelson M, Rosenthal D, Skarin A, Canellos G. Proceedings of the American Society of Clinical Oncology 1985:4:799 (abstract). 45. Carde P, MacKintosh FR, Rosenberg SA. J Clin Oncol 1983:1:146. 46. Hryniuk W, Levine MN. J Clin Oncol 1986;4:1162. 47. Herzig GP, Herzig RH, Fay JW, Wolff SN, Hurd D, Lazarus HM, Phillips GL. In Autologous Bone Marrow Transplantation: Proceedings of the First International Symposium, Dicke KA, Spitzer G, Zander AR, eds. Institute at Houston, Houston, 1985:245. The university of Texas M. D. Anderson Hospital and Tumor 48. Duque-Hammershaimb L, Wollner N, Miller D. Cancer 1983;52:39. 49. Botnick LE, Hannon EC, Hellman S. Nature 1976;262:68. 50. MorleyA, Blake J. Blood 1974;44:49. 51. GorinNC. Clin Haematol 1986;15:19. 52. Bast RC Jr, de Fabritiis P, Lipton J, Gelber R, Maver C, Nadler L, Sallan S, Ritz J. Cancer Res 1985:45:499.
ABMT Timing in Lymphoma 295 53. Stong RC, YouleRJ, Kersey JH.Zanjani ED, Vallera DA. In Autologous Bone Marrow Transplantation: Proceedings of the First International Symposium, Dicke KA, Spitzer G, Zander AR, eds. The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, 1985:455. 54. Maizel AL, Morgan JW, Mehta SR, Kouttab NM, Bator JM, Sahasrabuddhe CG. Proc Natl Acad Sei USA 1983:80:5047. 55. Smith SD, Wood GW, Fried P, Lowman JT. Cancer 1981:48:2612.
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Autologous Bone Marrow Transplantat
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To our colleagues, Drs. R. Lee Clar
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via ABMT Autologous Bone Marrow Tra
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X ABMT Pharmacological Manipulation
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XII ABMT C. INTERNATIONAL RANDOMIZE
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xiu ABMT Session IV - Breast Cancer
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xui ABMT Panel Discussion: Session
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xuiii ABMT Effect of Interleukin 2
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Acknowledgments The publication of
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AML in First Remission 5 performed
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AML in First Remission 7 than 50% o
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10 BAVC + ABMT in Patients With AML
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BAVC + ABMT in Patients With AML in
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14 BAVC + ABMTin Patients With AML
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16 Purged ABMT in CR of Acute Leuke
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24 First-Remission Autograft forAML
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Transplantation in CRI AML 33 DISCU
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36 ABMT in ALL compared the results
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38 ABMT in ALL were administered un
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40 ABMT in ALL CR1 patients receive
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42 ABMT in ALL 19. Rizzoli V, Mango
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44 ABMTin CRI program in CR1 is the
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46 ABMTin CRI RESULTS The AML inves
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Leukemia: First Remission K A. Dick
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Panel Discussion: Session IA 51 DR.
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IB. Clinical Studies in Second- or
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56 ABMTIn CR2 RESULTS OF VARIOUS TR
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58 ABMTIn CR2 antibodies; for non-T
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60 ABMT in Acute Nonlymphocytic Leu
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70 ABMT in AML With Monoclonal Anti
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80 Mafosfamide Purging in Leukemia
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ABMT in CR2 Pediatric ALL 91 follow
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Ex Vivo Use of Monoclonal Antibodie
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Ex Vivo Marrow Purging 95 Table 1.
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De Viuo Marrow Purging 97 WBC-f- AN
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Conditioning Regimens Before Bone M
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Conditioning Regimens in AML 101 Le
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Conditioning Regimens in AML 103 co
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106 Double (Jnpurged ABMT in Leukem
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108 Double Unpurged ABMT in Leukemi
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770 Double (Jnpurged ABMT in Leukem
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7/2 Double Autografting in Acute Le
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114 Double Autografting in Acute Le
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120 Recovery After 4-Hydroperoxycyc
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122 Recovery After 4-Hydroperoxycyc
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Panel Discussion: Session IB 127 di
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Panel Discussion: Session IB 129 tu
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Magnetic Affinity Colloid Eliminati
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Magnetic Separation of Marrow Cells
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*r r- r» u. >>• O S ^ CO ai a> C
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4-Hydroperoxycyclophosphamide and V
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Chemopurging 145 incubation, the ce
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Chemopurging 147 To date, four pati
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Chemopurging 149 4-HC + VCR IC75 AM
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Decontaminating Bone Marrow With Me
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Merocyanine 540 Marrow Decontaminat
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Merocyanine 540 Marrow Decontaminat
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CALLA-Negative Clonogenic Cultures
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CALLA-Negatiœ Clonogenic BCell ALL
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CALLA-Negative Clonogenic BCell ALL
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164 Acetaldophosphamide Ex Vivo Che
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766 Acetaldophosphamide Ex Vivo Che
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168 Acetaldophosphamide Ex Viuo Che
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Detecting Residual Disease in Bone
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178 Pharmacological Manipulation an
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ID. Chronic Myelogenous Leukemia
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190 CML Chronic Phase Autografting
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196 CML Blast Crisis Autografting e
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Autologous Transplantation of Phila
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Autografting in Chronic Granulocyti
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Autografting in Chronic Granulocyti
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206 Panel Discussion: Session ID DR
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Natural History of Relapsed Hodgkin
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ABMT in Hodgkin's Disease 211 50%.
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ABMTin Hodgkin, 's Disease 213 (62%
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ABMT in Hodgkin's Disease 215 LLLLL
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Updated Results of CBV and Autologo
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CBV and ABMT in Hodgkin's Disease 2
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CBV and ABMT in Hodgkin 's Disease
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224 Chemotherapy and ABMT in Hodgki
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226 Chemotherapy and ABMTin Hodgkin
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232 ABMT for Advanced Hodgkin's Dis
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234 ABMTfor Advanced Hodgkin's Dise
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Hodgkin's Disease J. O. Armitage an
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Panel Discussion: Session IIA 239 D
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IIB. Non-Hodgkin's Lymphoma
Page 268 and 269: 244 Salvage Chemotherapy for Lympho
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Page 273 and 274: Autologous Bone Marrow Transplantat
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Page 277 and 278: ABMT in Burkitt's Lymphoma 253 medi
Page 279 and 280: ABMT in Burkitt's Lymphoma 255 Heal
Page 281 and 282: ABMT in Burkitt's Lymphoma 257 •
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Page 285: ABMT in Burkitt's Lymphoma 261 11.
Page 288 and 289: 264 Myeloma Biology and Therapy hig
Page 290 and 291: 266 Myeloma Biology and Therapy mon
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Page 294 and 295: 270 BMT in Relapsed Diffuse Large C
Page 300 and 301: 276 Transplantation for Malignant L
Page 303 and 304: Optimum Timing of Autologous Bone M
Page 305 and 306: ABMT Timing in Lymphoma 281 PATIENT
Page 307 and 308: 3 o + + + + o LO T— T— LO co Tf
Page 309 and 310: ABMT Timing in Lymphoma 285 RESULTS
Page 311 and 312: co co I I I I I I I I I I 2 2 2 CD
Page 313 and 314: ABMT Timing in Lymphoma 289 Median
Page 315 and 316: ABMT Timing in Lymphoma 291 in a mi
Page 317: ABMT Timing in Lymphoma 293 Develop
Page 322 and 323: 298 Treatment Strategies for NHL PA
Page 324 and 325: 300 Treatment Strategies for NHL 10
Page 326 and 327: 302 Treatment Strategies for NHL 2)
Page 328 and 329: 304 Treatment Strategies for NHL al
Page 330 and 331: 306 Treatment Strategies for NHL 31
Page 332 and 333: 308 Panel Discussion: Session IIB m
Page 335: IIC. International Randomized Study
Page 338 and 339: 314 Proposed International Adult Ly
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Page 361 and 362: International NHL Trial 337 dispari
Page 363 and 364: International NHL Trial 339 cannot
Page 365 and 366: International NHL Trial 341 ORGANIZ
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IID. Purging and Detection
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348 Chemoimmunoseparation of T Lymp
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350 Chemoimmunoseparation of T Lymp
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352 Burkitt's Lymphoma Purging Assa
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354 Burkitts Lymphoma Purging Assay
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356 Burkitt's Lymphoma Purging Assa
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358 Burkitts Lymphoma Purging Assay
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360 Purging Methods in Burkitt's Ly
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366 Leukemia Cell Sensitivity to Im
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368 Leukemia Cell Sensitivity to Im
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370 Leukemia Cell Sensitiuity to Im
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372 Panel Discussion: Session IID D
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ABMTfor Neuroblastoma 377 sedimenta
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ABMT for Neuroblastoma 379 EX VIVO
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ABMTfor Neuroblastoma 381 PATIENTS
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Repeated High-Dose Chemotherapy Fol
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ABMT in Metastatic Neuroblastoma 38
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ABMT in Metastatic neuroblastoma 39
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394 Clnpurged ABMTfor Neuroblastoma
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396 Unpurged ABMTfor Neuroblastoma
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398 Unpurged ABMTfor Neuroblastoma
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ENSG 1—Randomized Study of High-D
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High-Dose Melphalan in Neuroblastom
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High-Dose Melphalan in Neuroblastom
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408 ABMTin 65 Patients With Neurobl
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410 ABMT in 65 Patients With. Neuro
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416 ABMTin 65 Patients With neurobl
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A Single Institution's Experience o
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ABMT in Neuroblastoma 421 procedure
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ABMT in Neuroblastoma 423 therapies
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426 Purged Marrow Engraftment in Ne
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Digital Image Analysis System for D
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Digital Image Analysis System 435 d
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Digital Image Analysis System 437 c
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Digital Image Analysis System 439 C
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Digital Image Analysis System 441 1
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444 Immune-magnetic Purging ofBurki
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450 Panel Discussion: Session III W
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452 Panel Discussion: Session III e
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High-Dose Chemotherapy Intensificat
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High-Dose Chemotherapy and ABMT in
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466 Treatment Strategies in Breast
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10 CO 0) I- m c o a. a. 3 W ? o k_
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476 Phase I and II Studies of Alkyl
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482 High-Dose Therapy and ABMT in B
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484 High-Dose Therapy and ABMT in B
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486 Immunodetection of Breast Carci
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ABMTfor Breast Cancer 491 only adju
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ABMT for Breast Cancer 493 Table 3.
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ABMTfor Breast Cancer 495 4. Eder J
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498 Occult Breast Cancer Cells in M
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504 Panel Discussion: Session IV DR
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506 Panel Discussion: Session IV a
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Detection of Bone Marrow Metastases
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Tumor Cell Detection 511 Two separa
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Tumor Cell Detection 513 immunofluo
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516 Etoposide and Cisplatin for Lun
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Lung Cancer G. Spitzer and H. Lazar
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Panel Discussion: Session V 525 com
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Panel Discussion: Session V 527 col
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Treatment of Advanced Melanoma With
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ABMT in Melanoma 533 Table 1. Three
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ABMT in Melanoma 535 mg/m 2 ). The
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Melanoma/ Sarcoma/ Carcinoma R. Ben
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Panel Discussion: Session VI 539 re
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VII. Brain Cancer
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544 Carmustine and ABMT for Maligna
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546 Carmustine and ABMTfor Malignan
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Pilot Study of High-Dose Carmustine
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High-Dose Carmustine and Transplant
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High-Dose Chemotherapy With Autolog
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High-Dose Therapy of CNS Gliomas Ta
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High-Dose Therapy of CHS Gliomas 56
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High-Dose Therapy of CHS Gliomas 56
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566 Panel Discussion: Session VII A
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VIII. New Regimens
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572 Clinical Intensification Regime
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574 Clinical Intensification Regime
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Clinical Intensification Regimens f
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Clinical Intensification Regimens f
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High-Dose Busulfan and Cyclophospha
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Busulfan + Cyclophosphamide in Chil
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The Intensive Use of Carmustine Wit
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Intensive Use ofCarmustine 591 6. P
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594 BEAM: Cytoreductive Regimen for
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596 BEAM: Cytoreductiue Regimen for
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602 Total Body Irradiation, Cytarab
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604 Total Body Irradiation, Cytarab
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606 Panel Discussion: Session VIII
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Herpesvirus Infections After Autolo
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Herpesvirus Infections 611 Table 2.
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Herpesvirus Infections 613 contrast
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616 Peripheral Stem Cell Transplant
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CO ^ CO COi-t'ycOi-T-CO O E « to T
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fc CD rr ^ O < c E + o — ce S O O
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o E ra o CD .Q Û ra co CL o E o 15
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634 Toxic Deaths in ABMT PATIENTS A
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636 Toxic Deaths in ABMT Table 2. D
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638 Toxic Deaths in ABMT defined an
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640 Infectious Complications ofABMT
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Infectious Complications of Autolog
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Infections in ABMT 649 Table 1. ABM
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Infections in ABMT 651 herpes simpl
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Newer Antibiotic Regimens in Cancer
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Antibiotics in Cancer Patients 655
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Antibiotics in Cancer Patients 657
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660 Amphotericin B for Neutropenic
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662 Amphotericin B for Neutropenie
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664 Amphotericin B for Neutropenie
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666 IVIg in ABMT in autologous tran
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668 IVlg in ABMT 25. Neiman PE, Ree
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670 Natural Killer Cells and Transp
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672 Natural Killer Cells and Transp
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Autologous Transplantation of Circu
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678 Transplantation of Circulating
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Restoration of Hematopoietic Functi
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Peripheral Stem Cell Transplants 68
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Peripheral Stem Cell Transplants 68
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688 Peripheral Blood Stem Cell Tran
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694 Bronchoscopy in Marrow Transpla
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696 Bronchoscopy in Marrow Transpla
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698 T Lymphocyte CFU After ABMT cer
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700 T Lymphocyte CFCI After ABMT RE
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702 T Lymphocyte CFU After ABMT CMV
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Supportive Therapy H. Vriesendorp a
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X. Molecular Biology
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770 Human ADA in Monkeys years in a
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7/2 Human ADA in Monkeys supernatan
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714 Human ADA in Monkeys Number of
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776 Human ADA in Monkeys primate ma
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718 Electric Field-Mediated DMA Tra
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720 Electric Field-Mediated DNA Tra
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Aberrant Gene Expression in Acute M
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+ z + + + les •ras a z E i ü (0
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Aberrant Gene Expression in AML 727
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Aberrant Gene Expression in AML 729
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732 Clonal Detection of Remission p
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734 Clonal Detection of Remission K
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736 Clonal Detection of Remission 3
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Summary D. W. van Bekkum Attempts t
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Summary 741 T cell-depleted bone ma
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Summary 743 hybridization technique
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Summary 745 GENETIC THERAPY The las
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748 Concluding Remarks time of the
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750 Contributors and Participants F
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754 Contributors and Participants P
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756 Contributors and Participants A
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758 Contributors and Participants P
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762 Contributors and Participants H
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764 Contributors and Participants A
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766 Contributors and Participants G
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770 Contributors and Participants S
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772 Contributors and Participants C
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776 Contributors and Participants D
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