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216 ABMTin Hodgkin's Disease prognosis is already known to be poor. In the future it seems sensible to investigate ABMT, comparing it with conventional therapy, in Hodgkin's disease in the following groups of patients: 1) patients with poor prognosis (see above) whose first-line therapy fails; 2) patients whose alternating first-line chemotherapy fails; and 3) patients whose disease fails to respond to any two sequential modalities of therapy. There may be an additional role for local boost radiotherapy, either before or after the graft (11), though analysis in NHL suggests that the bulk of the mass may be critical (T. Philip et at, unpublished data). Finally, another parallel with NHL may be that patients who never enter remission (i.e., those who have primary refractory disease) may never do well with any therapy, including ABMT (12). REFERENCES 1. DeVita VT, Simon RM, Hubbard SM, Young RC, Berard CW, Moxley JH, Frei E, Carbone PP, Canellos GP. Ann Intern Med 1980;92:587. 2. Bonadonna G, Valagussa P, Santoro A. Ann Intern Med 1986;104(6):739. 3. Santoro A, Bonfante V, Bonadonna G. Ann Intern Med 1982:96:139. 4. Canellos GP. J Clin Oncol 1985:3:1451 (editorial). 5. Goldstone AH, Anderson CC, Linch DC, Souhami RL, Jelliffe AM, Harper PG. Bone Marrow Transplantation 1986;l(Suppl 1):297. 6. Philip T, Dumont J, Teillet F, Maraninchi D, Gorin MC, Kuentz M, Harousseau JL, Marty M, Anketon R, Herve P. Br J Cancer 1986;53(6):737. 7. Thomas ED, Buckner D, Clift RA. N Engl J Med 1979:301:597. 8. Hancock BW for the British National Lymphoma Investigation. Radiother Oncol (in press). 9. Linch DC, Knott U, Patterson KG, Cowan DA, Harper PG. J Clin Pathol 1982:35:186. 10. GoldstoneAH. Bone Marrow Transplantation 1986;l(Suppl 1 ):289. 11. Phillips GL, Reece DE. Clin Haematol 1986:15:155. 12. Phillips GL, WolffS, Herzig G, Herzig R, Lazarus H, Fay J, Glasgow G, Lin HS, Malcolm A, Shina D, Thomas P. Blood 1983;62(Suppl 1):228.
Updated Results of CBV and Autologous Bone Marrow Transplantation for Hodgkin's Disease Sundar Jagannath, James O. Armitage, Karel A. Dicke, Fredrick B. Hagemeister, Kathleen Smith, Leonard J. Horwitz, William S. Velasquez, William P. Vaughan, Anne Kessinger, Fernando Cabanillas, and Gary Spitzer We developed a high-dose chemotherapy combination of cyclophosphamide, BCNCJ (carmustine), and VP-16-213 (etoposide) (CBV) with autologous bone marrow rescue and reported our experience in the treatment of leukemia, lymphoma, and solid tumors (1-3). The preliminary experience with this combination in patients with Hodgkin's disease failing both mechlorethamine, Oncovin (vincristine), procarbazine, and prednisone (MOPP)-like and Adriamycin (doxorubicin), bleomycin, vinblastine, and dacarbazine (ABVD)- like regimens has been very encouraging (4,5). We report here the updated results on 62 patients undergoing treatment at both the University of Nebraska Medical School in Omaha and The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston. 217
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Autologous Bone Marrow Transplantat
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To our colleagues, Drs. R. Lee Clar
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via ABMT Autologous Bone Marrow Tra
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X ABMT Pharmacological Manipulation
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XII ABMT C. INTERNATIONAL RANDOMIZE
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xiu ABMT Session IV - Breast Cancer
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xui ABMT Panel Discussion: Session
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xuiii ABMT Effect of Interleukin 2
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Acknowledgments The publication of
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AML in First Remission 5 performed
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AML in First Remission 7 than 50% o
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10 BAVC + ABMT in Patients With AML
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BAVC + ABMT in Patients With AML in
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14 BAVC + ABMTin Patients With AML
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16 Purged ABMT in CR of Acute Leuke
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24 First-Remission Autograft forAML
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Transplantation in CRI AML 33 DISCU
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36 ABMT in ALL compared the results
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38 ABMT in ALL were administered un
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40 ABMT in ALL CR1 patients receive
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42 ABMT in ALL 19. Rizzoli V, Mango
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44 ABMTin CRI program in CR1 is the
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46 ABMTin CRI RESULTS The AML inves
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Leukemia: First Remission K A. Dick
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Panel Discussion: Session IA 51 DR.
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IB. Clinical Studies in Second- or
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56 ABMTIn CR2 RESULTS OF VARIOUS TR
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58 ABMTIn CR2 antibodies; for non-T
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60 ABMT in Acute Nonlymphocytic Leu
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70 ABMT in AML With Monoclonal Anti
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80 Mafosfamide Purging in Leukemia
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ABMT in CR2 Pediatric ALL 91 follow
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Ex Vivo Use of Monoclonal Antibodie
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Ex Vivo Marrow Purging 95 Table 1.
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De Viuo Marrow Purging 97 WBC-f- AN
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Conditioning Regimens Before Bone M
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Conditioning Regimens in AML 101 Le
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Conditioning Regimens in AML 103 co
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106 Double (Jnpurged ABMT in Leukem
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108 Double Unpurged ABMT in Leukemi
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770 Double (Jnpurged ABMT in Leukem
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7/2 Double Autografting in Acute Le
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114 Double Autografting in Acute Le
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120 Recovery After 4-Hydroperoxycyc
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122 Recovery After 4-Hydroperoxycyc
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Panel Discussion: Session IB 127 di
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Panel Discussion: Session IB 129 tu
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Magnetic Affinity Colloid Eliminati
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Magnetic Separation of Marrow Cells
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*r r- r» u. >>• O S ^ CO ai a> C
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4-Hydroperoxycyclophosphamide and V
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Chemopurging 145 incubation, the ce
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Chemopurging 147 To date, four pati
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Chemopurging 149 4-HC + VCR IC75 AM
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Decontaminating Bone Marrow With Me
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Merocyanine 540 Marrow Decontaminat
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Merocyanine 540 Marrow Decontaminat
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CALLA-Negative Clonogenic Cultures
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CALLA-Negatiœ Clonogenic BCell ALL
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CALLA-Negative Clonogenic BCell ALL
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164 Acetaldophosphamide Ex Vivo Che
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Page 195 and 196: Detecting Residual Disease in Bone
Page 197 and 198: Detecting Residual Disease in Bone
Page 199: Detecting Residual Disease in Bone
Page 202 and 203: 178 Pharmacological Manipulation an
Page 211: ID. Chronic Myelogenous Leukemia
Page 214 and 215: 190 CML Chronic Phase Autografting
Page 220 and 221: 196 CML Blast Crisis Autografting e
Page 223 and 224: Autologous Transplantation of Phila
Page 225 and 226: Autografting in Chronic Granulocyti
Page 227: Autografting in Chronic Granulocyti
Page 230 and 231: 206 Panel Discussion: Session ID DR
Page 233 and 234: Natural History of Relapsed Hodgkin
Page 235 and 236: ABMT in Hodgkin's Disease 211 50%.
Page 237 and 238: ABMTin Hodgkin, 's Disease 213 (62%
Page 239: ABMT in Hodgkin's Disease 215 LLLLL
Page 243 and 244: CBV and ABMT in Hodgkin's Disease 2
Page 245: CBV and ABMT in Hodgkin 's Disease
Page 248 and 249: 224 Chemotherapy and ABMT in Hodgki
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Page 258 and 259: 234 ABMTfor Advanced Hodgkin's Dise
Page 261 and 262: Hodgkin's Disease J. O. Armitage an
Page 263 and 264: Panel Discussion: Session IIA 239 D
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Page 275 and 276: ABMT in Burkitt's Lymphoma 251 Tabl
Page 277 and 278: ABMT in Burkitt's Lymphoma 253 medi
Page 279 and 280: ABMT in Burkitt's Lymphoma 255 Heal
Page 281 and 282: ABMT in Burkitt's Lymphoma 257 •
Page 283 and 284: ABMT in Burkitt's Lymphoma 259 init
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Page 288 and 289: 264 Myeloma Biology and Therapy hig
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266 Myeloma Biology and Therapy mon
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265 Myeloma Biology and Therapy 5.
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270 BMT in Relapsed Diffuse Large C
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276 Transplantation for Malignant L
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Optimum Timing of Autologous Bone M
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ABMT Timing in Lymphoma 281 PATIENT
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3 o + + + + o LO T— T— LO co Tf
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ABMT Timing in Lymphoma 285 RESULTS
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co co I I I I I I I I I I 2 2 2 CD
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ABMT Timing in Lymphoma 289 Median
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ABMT Timing in Lymphoma 291 in a mi
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ABMT Timing in Lymphoma 293 Develop
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ABMT Timing in Lymphoma 295 53. Sto
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298 Treatment Strategies for NHL PA
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300 Treatment Strategies for NHL 10
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302 Treatment Strategies for NHL 2)
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304 Treatment Strategies for NHL al
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306 Treatment Strategies for NHL 31
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308 Panel Discussion: Session IIB m
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IIC. International Randomized Study
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314 Proposed International Adult Ly
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International Randomized Trial in N
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International NHL Trial 337 dispari
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International NHL Trial 339 cannot
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International NHL Trial 341 ORGANIZ
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Lymphoma T. Philip and G. Spitzer,
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IID. Purging and Detection
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348 Chemoimmunoseparation of T Lymp
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350 Chemoimmunoseparation of T Lymp
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352 Burkitt's Lymphoma Purging Assa
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354 Burkitts Lymphoma Purging Assay
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356 Burkitt's Lymphoma Purging Assa
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358 Burkitts Lymphoma Purging Assay
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360 Purging Methods in Burkitt's Ly
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366 Leukemia Cell Sensitivity to Im
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368 Leukemia Cell Sensitivity to Im
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370 Leukemia Cell Sensitiuity to Im
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372 Panel Discussion: Session IID D
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ABMTfor Neuroblastoma 377 sedimenta
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ABMT for Neuroblastoma 379 EX VIVO
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ABMTfor Neuroblastoma 381 PATIENTS
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Repeated High-Dose Chemotherapy Fol
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ABMT in Metastatic Neuroblastoma 38
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ABMT in Metastatic neuroblastoma 39
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394 Clnpurged ABMTfor Neuroblastoma
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396 Unpurged ABMTfor Neuroblastoma
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398 Unpurged ABMTfor Neuroblastoma
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ENSG 1—Randomized Study of High-D
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High-Dose Melphalan in Neuroblastom
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High-Dose Melphalan in Neuroblastom
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408 ABMTin 65 Patients With Neurobl
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410 ABMT in 65 Patients With. Neuro
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416 ABMTin 65 Patients With neurobl
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A Single Institution's Experience o
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ABMT in Neuroblastoma 421 procedure
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ABMT in Neuroblastoma 423 therapies
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426 Purged Marrow Engraftment in Ne
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Digital Image Analysis System for D
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Digital Image Analysis System 435 d
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Digital Image Analysis System 437 c
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Digital Image Analysis System 439 C
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Digital Image Analysis System 441 1
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444 Immune-magnetic Purging ofBurki
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450 Panel Discussion: Session III W
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452 Panel Discussion: Session III e
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High-Dose Chemotherapy Intensificat
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High-Dose Chemotherapy and ABMT in
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466 Treatment Strategies in Breast
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10 CO 0) I- m c o a. a. 3 W ? o k_
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476 Phase I and II Studies of Alkyl
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482 High-Dose Therapy and ABMT in B
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484 High-Dose Therapy and ABMT in B
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486 Immunodetection of Breast Carci
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ABMTfor Breast Cancer 491 only adju
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ABMT for Breast Cancer 493 Table 3.
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ABMTfor Breast Cancer 495 4. Eder J
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498 Occult Breast Cancer Cells in M
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504 Panel Discussion: Session IV DR
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506 Panel Discussion: Session IV a
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Detection of Bone Marrow Metastases
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Tumor Cell Detection 511 Two separa
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Tumor Cell Detection 513 immunofluo
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516 Etoposide and Cisplatin for Lun
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Lung Cancer G. Spitzer and H. Lazar
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Panel Discussion: Session V 525 com
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Panel Discussion: Session V 527 col
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Treatment of Advanced Melanoma With
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ABMT in Melanoma 533 Table 1. Three
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ABMT in Melanoma 535 mg/m 2 ). The
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Melanoma/ Sarcoma/ Carcinoma R. Ben
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Panel Discussion: Session VI 539 re
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VII. Brain Cancer
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544 Carmustine and ABMT for Maligna
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546 Carmustine and ABMTfor Malignan
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Pilot Study of High-Dose Carmustine
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High-Dose Carmustine and Transplant
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High-Dose Chemotherapy With Autolog
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High-Dose Therapy of CNS Gliomas Ta
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High-Dose Therapy of CHS Gliomas 56
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High-Dose Therapy of CHS Gliomas 56
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566 Panel Discussion: Session VII A
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VIII. New Regimens
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572 Clinical Intensification Regime
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574 Clinical Intensification Regime
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Clinical Intensification Regimens f
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Clinical Intensification Regimens f
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High-Dose Busulfan and Cyclophospha
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Busulfan + Cyclophosphamide in Chil
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The Intensive Use of Carmustine Wit
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Intensive Use ofCarmustine 591 6. P
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594 BEAM: Cytoreductive Regimen for
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596 BEAM: Cytoreductiue Regimen for
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602 Total Body Irradiation, Cytarab
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604 Total Body Irradiation, Cytarab
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606 Panel Discussion: Session VIII
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Herpesvirus Infections After Autolo
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Herpesvirus Infections 611 Table 2.
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Herpesvirus Infections 613 contrast
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616 Peripheral Stem Cell Transplant
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CO ^ CO COi-t'ycOi-T-CO O E « to T
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fc CD rr ^ O < c E + o — ce S O O
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o E ra o CD .Q Û ra co CL o E o 15
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634 Toxic Deaths in ABMT PATIENTS A
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636 Toxic Deaths in ABMT Table 2. D
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638 Toxic Deaths in ABMT defined an
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640 Infectious Complications ofABMT
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Infectious Complications of Autolog
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Infections in ABMT 649 Table 1. ABM
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Infections in ABMT 651 herpes simpl
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Newer Antibiotic Regimens in Cancer
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Antibiotics in Cancer Patients 655
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Antibiotics in Cancer Patients 657
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660 Amphotericin B for Neutropenic
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662 Amphotericin B for Neutropenie
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664 Amphotericin B for Neutropenie
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666 IVIg in ABMT in autologous tran
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668 IVlg in ABMT 25. Neiman PE, Ree
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670 Natural Killer Cells and Transp
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672 Natural Killer Cells and Transp
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Autologous Transplantation of Circu
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678 Transplantation of Circulating
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Restoration of Hematopoietic Functi
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Peripheral Stem Cell Transplants 68
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Peripheral Stem Cell Transplants 68
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688 Peripheral Blood Stem Cell Tran
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694 Bronchoscopy in Marrow Transpla
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696 Bronchoscopy in Marrow Transpla
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698 T Lymphocyte CFU After ABMT cer
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700 T Lymphocyte CFCI After ABMT RE
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702 T Lymphocyte CFU After ABMT CMV
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Supportive Therapy H. Vriesendorp a
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X. Molecular Biology
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770 Human ADA in Monkeys years in a
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7/2 Human ADA in Monkeys supernatan
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714 Human ADA in Monkeys Number of
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776 Human ADA in Monkeys primate ma
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718 Electric Field-Mediated DMA Tra
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720 Electric Field-Mediated DNA Tra
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Aberrant Gene Expression in Acute M
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+ z + + + les •ras a z E i ü (0
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Aberrant Gene Expression in AML 727
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Aberrant Gene Expression in AML 729
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732 Clonal Detection of Remission p
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734 Clonal Detection of Remission K
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736 Clonal Detection of Remission 3
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Summary D. W. van Bekkum Attempts t
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Summary 741 T cell-depleted bone ma
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Summary 743 hybridization technique
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Summary 745 GENETIC THERAPY The las
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748 Concluding Remarks time of the
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750 Contributors and Participants F
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754 Contributors and Participants P
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756 Contributors and Participants A
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758 Contributors and Participants P
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762 Contributors and Participants H
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764 Contributors and Participants A
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766 Contributors and Participants G
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770 Contributors and Participants S
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772 Contributors and Participants C
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776 Contributors and Participants D
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