Autologous Bone Marrow Transplantation - Blog Science Connections

More documents

Recommendations

Info

214 ABMTin Hodgkin's Disease Postmortem examination showed no evidence of disease recurrence at the time of death. Six patients are alive and disease-free at 7,16,17,18,28, and 39 months post-ABMT. The median follow-up of these 11 patients is 15 months. We show in Figure 4 the disease-free survival of this group. Eleven patients had disease that only partially responded to 1MT, four from the responding relapse group and seven from the resistant relapse group. Three patients have died of progressive disease at 5,6, and 7 months post-ABMT. The remaining eight patients are alive at 3, 6 (3 patients), 7 (2 patients), 8, and 12 months post-ABMT. Four patients have shown further resolution of their disease on CAT scanning after initial follow-up at 3 months. One patient whose response we defined as partial at 3 months has no evidence of disease at 6 months posttransplantation with no further therapy given. One patient has a mediastinal mass that has remained unchanged for 9 months and may not have active disease. Two patients received localized radiotherapy to sites of residual disease and subsequently entered CR. The median follow-up of this group is 6 months. The overall survival rate was significantly improved in those who achieved CR after ABMT compared with that of those who did not (P < .001 ) (Fig 5). Two patients were not évaluable after ABMT, and one patient has shown no response to 1MT. 100 s o S m •0 2 «H # III > 40+ < ml a 3 a u IS 20 28 •S TIME(MONTHS) Figure 4. Disease-free survival of 11 patients with Hodgkin's disease who underwent autologous bone marrow transplantation and achieved complete remission.
ABMT in Hodgkin's Disease 215 LLLLL •o+ 20+ non-CR n 1* 10 20 26 TIME (MONTHS) 36 Figure 5. Overall survival of those with Hodgkin's disease who achieved complete remission (CR) after autologous bone marrow transplantation compared with those who did not. Overall survival of the first group is significantly better (P
Page 1:
Autologous Bone Marrow Transplantat
Page 5 and 6:
Page 7:
To our colleagues, Drs. R. Lee Clar
Page 10 and 11:
via ABMT Autologous Bone Marrow Tra
Page 12 and 13:
X ABMT Pharmacological Manipulation
Page 14 and 15:
XII ABMT C. INTERNATIONAL RANDOMIZE
Page 16 and 17:
xiu ABMT Session IV - Breast Cancer
Page 18 and 19:
xui ABMT Panel Discussion: Session
Page 20 and 21:
xuiii ABMT Effect of Interleukin 2
Page 23:
Acknowledgments The publication of
Page 27 and 28:
Page 29 and 30:
AML in First Remission 5 performed
Page 31:
AML in First Remission 7 than 50% o
Page 34 and 35:
10 BAVC + ABMT in Patients With AML
Page 36 and 37:
BAVC + ABMT in Patients With AML in
Page 38 and 39:
14 BAVC + ABMTin Patients With AML
Page 40 and 41:
16 Purged ABMT in CR of Acute Leuke
Page 42 and 43:
Page 44 and 45:
Page 46 and 47:
Page 48 and 49:
24 First-Remission Autograft forAML
Page 50 and 51:
Page 52 and 53:
Page 55 and 56:
Page 57:
Transplantation in CRI AML 33 DISCU
Page 60 and 61:
36 ABMT in ALL compared the results
Page 62 and 63:
38 ABMT in ALL were administered un
Page 64 and 65:
40 ABMT in ALL CR1 patients receive
Page 66 and 67:
42 ABMT in ALL 19. Rizzoli V, Mango
Page 68 and 69:
44 ABMTin CRI program in CR1 is the
Page 70 and 71:
46 ABMTin CRI RESULTS The AML inves
Page 73 and 74:
Leukemia: First Remission K A. Dick
Page 75 and 76:
Panel Discussion: Session IA 51 DR.
Page 77:
IB. Clinical Studies in Second- or
Page 80 and 81:
56 ABMTIn CR2 RESULTS OF VARIOUS TR
Page 82 and 83:
58 ABMTIn CR2 antibodies; for non-T
Page 84 and 85:
60 ABMT in Acute Nonlymphocytic Leu
Page 86 and 87:
Page 88 and 89:
Page 90 and 91:
Page 92 and 93:
Page 94 and 95:
70 ABMT in AML With Monoclonal Anti
Page 96 and 97:
Page 98 and 99:
Page 100 and 101:
Page 102 and 103:
Page 104 and 105:
80 Mafosfamide Purging in Leukemia
Page 106 and 107:
Page 108 and 109:
Page 110 and 111:
Page 113 and 114:
Page 115 and 116:
ABMT in CR2 Pediatric ALL 91 follow
Page 117 and 118:
Ex Vivo Use of Monoclonal Antibodie
Page 119 and 120:
Ex Vivo Marrow Purging 95 Table 1.
Page 121 and 122:
De Viuo Marrow Purging 97 WBC-f- AN
Page 123 and 124:
Conditioning Regimens Before Bone M
Page 125 and 126:
Conditioning Regimens in AML 101 Le
Page 127:
Conditioning Regimens in AML 103 co
Page 130 and 131:
106 Double (Jnpurged ABMT in Leukem
Page 132 and 133:
108 Double Unpurged ABMT in Leukemi
Page 134 and 135:
770 Double (Jnpurged ABMT in Leukem
Page 136 and 137:
7/2 Double Autografting in Acute Le
Page 138 and 139:
114 Double Autografting in Acute Le
Page 140 and 141:
Page 142 and 143:
Page 144 and 145:
120 Recovery After 4-Hydroperoxycyc
Page 146 and 147:
122 Recovery After 4-Hydroperoxycyc
Page 149 and 150:
Page 151 and 152:
Panel Discussion: Session IB 127 di
Page 153:
Panel Discussion: Session IB 129 tu
Page 157 and 158:
Magnetic Affinity Colloid Eliminati
Page 159 and 160:
Magnetic Separation of Marrow Cells
Page 161 and 162:
Page 163 and 164:
*r r- r» u. >>• O S ^ CO ai a> C
Page 165 and 166:
Page 167 and 168:
4-Hydroperoxycyclophosphamide and V
Page 169 and 170:
Chemopurging 145 incubation, the ce
Page 171 and 172:
Chemopurging 147 To date, four pati
Page 173 and 174:
Chemopurging 149 4-HC + VCR IC75 AM
Page 175 and 176:
Decontaminating Bone Marrow With Me
Page 177 and 178:
Merocyanine 540 Marrow Decontaminat
Page 179 and 180:
Merocyanine 540 Marrow Decontaminat
Page 181 and 182:
CALLA-Negative Clonogenic Cultures
Page 183 and 184:
CALLA-Negatiœ Clonogenic BCell ALL
Page 185:
CALLA-Negative Clonogenic BCell ALL
Page 188 and 189: 164 Acetaldophosphamide Ex Vivo Che
Page 190 and 191: 766 Acetaldophosphamide Ex Vivo Che
Page 192 and 193: 168 Acetaldophosphamide Ex Viuo Che
Page 195 and 196: Detecting Residual Disease in Bone
Page 197 and 198: Detecting Residual Disease in Bone
Page 199: Detecting Residual Disease in Bone
Page 202 and 203: 178 Pharmacological Manipulation an
Page 211: ID. Chronic Myelogenous Leukemia
Page 214 and 215: 190 CML Chronic Phase Autografting
Page 220 and 221: 196 CML Blast Crisis Autografting e
Page 223 and 224: Autologous Transplantation of Phila
Page 225 and 226: Autografting in Chronic Granulocyti
Page 227: Autografting in Chronic Granulocyti
Page 230 and 231: 206 Panel Discussion: Session ID DR
Page 233 and 234: Natural History of Relapsed Hodgkin
Page 235 and 236: ABMT in Hodgkin's Disease 211 50%.
Page 237: ABMTin Hodgkin, 's Disease 213 (62%
Page 241 and 242: Updated Results of CBV and Autologo
Page 243 and 244: CBV and ABMT in Hodgkin's Disease 2
Page 245: CBV and ABMT in Hodgkin 's Disease
Page 248 and 249: 224 Chemotherapy and ABMT in Hodgki
Page 250 and 251: 226 Chemotherapy and ABMTin Hodgkin
Page 256 and 257: 232 ABMT for Advanced Hodgkin's Dis
Page 258 and 259: 234 ABMTfor Advanced Hodgkin's Dise
Page 261 and 262: Hodgkin's Disease J. O. Armitage an
Page 263 and 264: Panel Discussion: Session IIA 239 D
Page 265: IIB. Non-Hodgkin's Lymphoma
Page 268 and 269: 244 Salvage Chemotherapy for Lympho
Page 270 and 271: 246 Salvage Chemotherapy for Lympho
Page 273 and 274: Autologous Bone Marrow Transplantat
Page 275 and 276: ABMT in Burkitt's Lymphoma 251 Tabl
Page 277 and 278: ABMT in Burkitt's Lymphoma 253 medi
Page 279 and 280: ABMT in Burkitt's Lymphoma 255 Heal
Page 281 and 282: ABMT in Burkitt's Lymphoma 257 •
Page 283 and 284: ABMT in Burkitt's Lymphoma 259 init
Page 285: ABMT in Burkitt's Lymphoma 261 11.
Page 288 and 289:
264 Myeloma Biology and Therapy hig
Page 290 and 291:
266 Myeloma Biology and Therapy mon
Page 292 and 293:
265 Myeloma Biology and Therapy 5.
Page 294 and 295:
270 BMT in Relapsed Diffuse Large C
Page 296 and 297:
Page 298 and 299:
Page 300 and 301:
276 Transplantation for Malignant L
Page 303 and 304:
Optimum Timing of Autologous Bone M
Page 305 and 306:
ABMT Timing in Lymphoma 281 PATIENT
Page 307 and 308:
3 o + + + + o LO T— T— LO co Tf
Page 309 and 310:
ABMT Timing in Lymphoma 285 RESULTS
Page 311 and 312:
co co I I I I I I I I I I 2 2 2 CD
Page 313 and 314:
ABMT Timing in Lymphoma 289 Median
Page 315 and 316:
ABMT Timing in Lymphoma 291 in a mi
Page 317 and 318:
ABMT Timing in Lymphoma 293 Develop
Page 319:
ABMT Timing in Lymphoma 295 53. Sto
Page 322 and 323:
298 Treatment Strategies for NHL PA
Page 324 and 325:
300 Treatment Strategies for NHL 10
Page 326 and 327:
302 Treatment Strategies for NHL 2)
Page 328 and 329:
304 Treatment Strategies for NHL al
Page 330 and 331:
306 Treatment Strategies for NHL 31
Page 332 and 333:
308 Panel Discussion: Session IIB m
Page 335:
IIC. International Randomized Study
Page 338 and 339:
314 Proposed International Adult Ly
Page 340 and 341:
Page 342 and 343:
Page 344 and 345:
Page 346 and 347:
Page 348 and 349:
Page 350 and 351:
Page 352 and 353:
Page 354 and 355:
Page 356 and 357:
Page 359 and 360:
International Randomized Trial in N
Page 361 and 362:
International NHL Trial 337 dispari
Page 363 and 364:
International NHL Trial 339 cannot
Page 365 and 366:
International NHL Trial 341 ORGANIZ
Page 367 and 368:
Lymphoma T. Philip and G. Spitzer,
Page 369:
IID. Purging and Detection
Page 372 and 373:
348 Chemoimmunoseparation of T Lymp
Page 374 and 375:
350 Chemoimmunoseparation of T Lymp
Page 376 and 377:
352 Burkitt's Lymphoma Purging Assa
Page 378 and 379:
354 Burkitts Lymphoma Purging Assay
Page 380 and 381:
356 Burkitt's Lymphoma Purging Assa
Page 382 and 383:
358 Burkitts Lymphoma Purging Assay
Page 384 and 385:
360 Purging Methods in Burkitt's Ly
Page 386 and 387:
Page 388 and 389:
Page 390 and 391:
366 Leukemia Cell Sensitivity to Im
Page 392 and 393:
368 Leukemia Cell Sensitivity to Im
Page 394 and 395:
370 Leukemia Cell Sensitiuity to Im
Page 396 and 397:
372 Panel Discussion: Session IID D
Page 399 and 400:
Page 401 and 402:
ABMTfor Neuroblastoma 377 sedimenta
Page 403 and 404:
ABMT for Neuroblastoma 379 EX VIVO
Page 405 and 406:
ABMTfor Neuroblastoma 381 PATIENTS
Page 407 and 408:
Repeated High-Dose Chemotherapy Fol
Page 409 and 410:
ABMT in Metastatic Neuroblastoma 38
Page 411 and 412:
Page 413 and 414:
Page 415:
ABMT in Metastatic neuroblastoma 39
Page 418 and 419:
394 Clnpurged ABMTfor Neuroblastoma
Page 420 and 421:
396 Unpurged ABMTfor Neuroblastoma
Page 422 and 423:
398 Unpurged ABMTfor Neuroblastoma
Page 425 and 426:
ENSG 1—Randomized Study of High-D
Page 427 and 428:
High-Dose Melphalan in Neuroblastom
Page 429:
High-Dose Melphalan in Neuroblastom
Page 432 and 433:
408 ABMTin 65 Patients With Neurobl
Page 434 and 435:
410 ABMT in 65 Patients With. Neuro
Page 436 and 437:
Page 438 and 439:
Page 440 and 441:
416 ABMTin 65 Patients With neurobl
Page 443 and 444:
A Single Institution's Experience o
Page 445 and 446:
ABMT in Neuroblastoma 421 procedure
Page 447:
ABMT in Neuroblastoma 423 therapies
Page 450 and 451:
426 Purged Marrow Engraftment in Ne
Page 452 and 453:
Page 454 and 455:
Page 457 and 458:
Digital Image Analysis System for D
Page 459 and 460:
Digital Image Analysis System 435 d
Page 461 and 462:
Digital Image Analysis System 437 c
Page 463 and 464:
Digital Image Analysis System 439 C
Page 465:
Digital Image Analysis System 441 1
Page 468 and 469:
444 Immune-magnetic Purging ofBurki
Page 470 and 471:
Page 472 and 473:
Page 474 and 475:
450 Panel Discussion: Session III W
Page 476 and 477:
452 Panel Discussion: Session III e
Page 479 and 480:
High-Dose Chemotherapy Intensificat
Page 481 and 482:
High-Dose Chemotherapy and ABMT in
Page 483 and 484:
Page 485 and 486:
Page 487:
Page 490 and 491:
466 Treatment Strategies in Breast
Page 492 and 493:
Page 494 and 495:
Page 496 and 497:
10 CO 0) I- m c o a. a. 3 W ? o k_
Page 498 and 499:
Page 500 and 501:
476 Phase I and II Studies of Alkyl
Page 502 and 503:
Page 504 and 505:
Page 506 and 507:
482 High-Dose Therapy and ABMT in B
Page 508 and 509:
484 High-Dose Therapy and ABMT in B
Page 510 and 511:
486 Immunodetection of Breast Carci
Page 513 and 514:
Page 515 and 516:
ABMTfor Breast Cancer 491 only adju
Page 517 and 518:
ABMT for Breast Cancer 493 Table 3.
Page 519:
ABMTfor Breast Cancer 495 4. Eder J
Page 522 and 523:
498 Occult Breast Cancer Cells in M
Page 524 and 525:
Page 526 and 527:
Page 528 and 529:
504 Panel Discussion: Session IV DR
Page 530 and 531:
506 Panel Discussion: Session IV a
Page 533 and 534:
Detection of Bone Marrow Metastases
Page 535 and 536:
Tumor Cell Detection 511 Two separa
Page 537:
Tumor Cell Detection 513 immunofluo
Page 540 and 541:
516 Etoposide and Cisplatin for Lun
Page 542 and 543:
Page 544 and 545:
Page 547 and 548:
Lung Cancer G. Spitzer and H. Lazar
Page 549 and 550:
Panel Discussion: Session V 525 com
Page 551:
Panel Discussion: Session V 527 col
Page 555 and 556:
Treatment of Advanced Melanoma With
Page 557 and 558:
ABMT in Melanoma 533 Table 1. Three
Page 559 and 560:
ABMT in Melanoma 535 mg/m 2 ). The
Page 561 and 562:
Melanoma/ Sarcoma/ Carcinoma R. Ben
Page 563 and 564:
Panel Discussion: Session VI 539 re
Page 565:
VII. Brain Cancer
Page 568 and 569:
544 Carmustine and ABMT for Maligna
Page 570 and 571:
546 Carmustine and ABMTfor Malignan
Page 573 and 574:
Pilot Study of High-Dose Carmustine
Page 575 and 576:
High-Dose Carmustine and Transplant
Page 577 and 578:
Page 579 and 580:
Page 581 and 582:
High-Dose Chemotherapy With Autolog
Page 583 and 584:
High-Dose Therapy of CNS Gliomas Ta
Page 585 and 586:
High-Dose Therapy of CHS Gliomas 56
Page 587:
High-Dose Therapy of CHS Gliomas 56
Page 590 and 591:
566 Panel Discussion: Session VII A
Page 593:
VIII. New Regimens
Page 596 and 597:
572 Clinical Intensification Regime
Page 598 and 599:
574 Clinical Intensification Regime
Page 600 and 601:
Clinical Intensification Regimens f
Page 602 and 603:
Clinical Intensification Regimens f
Page 605 and 606:
High-Dose Busulfan and Cyclophospha
Page 607 and 608:
Busulfan + Cyclophosphamide in Chil
Page 609 and 610:
Page 611 and 612:
Page 613 and 614:
The Intensive Use of Carmustine Wit
Page 615:
Intensive Use ofCarmustine 591 6. P
Page 618 and 619:
594 BEAM: Cytoreductive Regimen for
Page 620 and 621:
596 BEAM: Cytoreductiue Regimen for
Page 622 and 623:
Page 624 and 625:
Page 626 and 627:
602 Total Body Irradiation, Cytarab
Page 628 and 629:
604 Total Body Irradiation, Cytarab
Page 630 and 631:
606 Panel Discussion: Session VIII
Page 633 and 634:
Herpesvirus Infections After Autolo
Page 635 and 636:
Herpesvirus Infections 611 Table 2.
Page 637:
Herpesvirus Infections 613 contrast
Page 640 and 641:
616 Peripheral Stem Cell Transplant
Page 642 and 643:
Page 644 and 645:
CO ^ CO COi-t'ycOi-T-CO O E « to T
Page 646 and 647:
Page 648 and 649:
fc CD rr ^ O < c E + o — ce S O O
Page 650 and 651:
o E ra o CD .Q Û ra co CL o E o 15
Page 652 and 653:
Page 654 and 655:
Page 656 and 657:
Page 658 and 659:
634 Toxic Deaths in ABMT PATIENTS A
Page 660 and 661:
636 Toxic Deaths in ABMT Table 2. D
Page 662 and 663:
638 Toxic Deaths in ABMT defined an
Page 664 and 665:
640 Infectious Complications ofABMT
Page 666 and 667:
Page 668 and 669:
Page 671 and 672:
Infectious Complications of Autolog
Page 673 and 674:
Infections in ABMT 649 Table 1. ABM
Page 675 and 676:
Infections in ABMT 651 herpes simpl
Page 677 and 678:
Newer Antibiotic Regimens in Cancer
Page 679 and 680:
Antibiotics in Cancer Patients 655
Page 681:
Antibiotics in Cancer Patients 657
Page 684 and 685:
660 Amphotericin B for Neutropenic
Page 686 and 687:
662 Amphotericin B for Neutropenie
Page 688 and 689:
664 Amphotericin B for Neutropenie
Page 690 and 691:
666 IVIg in ABMT in autologous tran
Page 692 and 693:
668 IVlg in ABMT 25. Neiman PE, Ree
Page 694 and 695:
670 Natural Killer Cells and Transp
Page 696 and 697:
672 Natural Killer Cells and Transp
Page 699 and 700:
Autologous Transplantation of Circu
Page 702 and 703:
678 Transplantation of Circulating
Page 705 and 706:
Restoration of Hematopoietic Functi
Page 707 and 708:
Peripheral Stem Cell Transplants 68
Page 709:
Peripheral Stem Cell Transplants 68
Page 712 and 713:
688 Peripheral Blood Stem Cell Tran
Page 714 and 715:
Page 716 and 717:
Page 718 and 719:
694 Bronchoscopy in Marrow Transpla
Page 720 and 721:
696 Bronchoscopy in Marrow Transpla
Page 722 and 723:
698 T Lymphocyte CFU After ABMT cer
Page 724 and 725:
700 T Lymphocyte CFCI After ABMT RE
Page 726 and 727:
702 T Lymphocyte CFU After ABMT CMV
Page 729 and 730:
Supportive Therapy H. Vriesendorp a
Page 731:
X. Molecular Biology
Page 734 and 735:
770 Human ADA in Monkeys years in a
Page 736 and 737:
7/2 Human ADA in Monkeys supernatan
Page 738 and 739:
714 Human ADA in Monkeys Number of
Page 740 and 741:
776 Human ADA in Monkeys primate ma
Page 742 and 743:
718 Electric Field-Mediated DMA Tra
Page 744 and 745:
720 Electric Field-Mediated DNA Tra
Page 747 and 748:
Aberrant Gene Expression in Acute M
Page 749 and 750:
+ z + + + les •ras a z E i ü (0
Page 751 and 752:
Aberrant Gene Expression in AML 727
Page 753:
Aberrant Gene Expression in AML 729
Page 756 and 757:
732 Clonal Detection of Remission p
Page 758 and 759:
734 Clonal Detection of Remission K
Page 760 and 761:
736 Clonal Detection of Remission 3
Page 763 and 764:
Summary D. W. van Bekkum Attempts t
Page 765 and 766:
Summary 741 T cell-depleted bone ma
Page 767 and 768:
Summary 743 hybridization technique
Page 769:
Summary 745 GENETIC THERAPY The las
Page 772 and 773:
748 Concluding Remarks time of the
Page 774 and 775:
750 Contributors and Participants F
Page 776 and 777:
Page 778 and 779:
754 Contributors and Participants P
Page 780 and 781:
756 Contributors and Participants A
Page 782 and 783:
758 Contributors and Participants P
Page 784 and 785:
Page 786 and 787:
762 Contributors and Participants H
Page 788 and 789:
764 Contributors and Participants A
Page 790 and 791:
766 Contributors and Participants G
Page 792 and 793:
Page 794 and 795:
770 Contributors and Participants S
Page 796 and 797:
772 Contributors and Participants C
Page 798 and 799:
Page 800:
776 Contributors and Participants D
show all

Autologous Bone Marrow Transplantation - Blog Science Connections

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?