Autologous Bone Marrow Transplantation - Blog Science Connections

766 Acetaldophosphamide Ex Vivo Chemotherapy
i i -i i i i i _j ' i
0 2 4 8 8A-ALD 0 2 4 6 8 A-ALD
jjg/mt/60 min
)jg/ml/60 mln
Figure 1. Survival of human marrow-derived granulocyte-macrophage colony-forming
cells (GM-CFC) at 7 days or 15 days as a function of increased doses of acetaldophosphamide
(A-ALD) or 4-hydroperoxycyclophosphamide (4-HC). Bone marrow was
exposed to each drug at2*10 6 cells/ml. Each value represents the mean plus or minus the
standard deviation of triplicate cultures.
0 2 4 8 8 A-ALD A" 2 ^ k 8 A-ALD
pg/ml/60 min
MO/ml/60 mki
Figure 2. Survival of human marrow-derived granulocyte-macrophage colony-forming
cells (GM-CFC) at 7 days or 15 days as a function of increased doses of acetaldophosphamide
(A-ALD) or 4-hydroperoxycyclophosphamide (4-HC). Bone marrow was
exposed to each drug at 10 * 10 6 cells/ml. Each value represents the mean plus or minus
the standard deviation of triplicate cultures.
4-HC