Autologous Bone Marrow Transplantation - Blog Science Connections

Conditioning Regimens in AML 103
conditioning regimens explored in the BNML model were: CY followed by TBI,
8- to 9-log cell kill; TBI followed by CY, 9- to 10-log cell kill but 20% toxic deaths;
CY followed by Bu, 10-log cell kill; cytarabine preceding CY/TBI, more than
10-log cell kill but 25% toxic deaths; and Bu followed by CY, more than 10-log
cell kill.
In extrapolating to human AML (tumor load in remission equal or less than
10 10 cells), the difference between an 8- and a 10-log cell-kill conditioning
regimen might be of crucial importance in preventing patients from developing
a leukemia relapse after bone marrow transplantation from "minimal residual
disease." The results obtained with the BNML model are in line with those
recently summarized for humans ([ 1 ], see Table 1).
REFERENCES
1. Gale RP, Champlin R. Clin Haematol 1986;15:851.
2. Hagenbeek A, van Bekkum DW. Leuk Res 1977;1:75.
3. van Bekkum DW, Hagenbeek A. Blood Cells 1977;3:565.
4. Hagenbeek A, Martens ACM. Int J Radiat Oncol Biol Phys 1981 ;7:1075.
5. Hagenbeek A, Martens ACM. Eur J Cancer Clin Oncol 1982;18:763.
6. Hagenbeek A, Martens ACM. Cancer Res 1983;43:408.