Neurologische, neuromusculaire en psychiatrische pathologie
Neurologische, neuromusculaire en psychiatrische pathologie
Neurologische, neuromusculaire en psychiatrische pathologie
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Gevolg<strong>en</strong> van chronische MAOI inname<br />
1) Verminderde tyrosine hydroxylase activiteit<br />
2) Opstapeling van echte <strong>en</strong> valse neurotransmittors<br />
in de vesicula van de OS<br />
3) Down regulatie van pre- <strong>en</strong> postsynaptische<br />
adr<strong>en</strong>erge receptor<strong>en</strong> (α 1 , α 2 , β , 5-HT)<br />
4) Verminderde bescherming van de extraneurale<br />
MAO werking:<br />
– “Cheese reaction” (tyramines)<br />
– ↑ response op indirect werk<strong>en</strong>de sympathicomimetica<br />
5) Matige inhibitie van de microsomiale lever<br />
<strong>en</strong>zymes
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