Neurologische, neuromusculaire en psychiatrische pathologie
Neurologische, neuromusculaire en psychiatrische pathologie
Neurologische, neuromusculaire en psychiatrische pathologie
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Tricyclische antidepressiva<br />
(TAD)<br />
- Prototype : Imipramine 1957<br />
- Werkingmechanisme: Reuptake inhibitie<br />
Noradr<strong>en</strong>aline (serotonine,dopamine)<br />
- Competitieve antagonist<strong>en</strong> van H 1 , H 2 , α 1 <strong>en</strong> α 2<br />
adr<strong>en</strong>erge <strong>en</strong> muscarine receptor<strong>en</strong>.<br />
- Inhibitie van de Na + -K + APT-ase<br />
- Chronische therapie: down regulatie van<br />
α 2 , β <strong>en</strong> 5-HT receptor<strong>en</strong>
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