IVIG brochure.pdf - NBN Group

NBN Infusions is a specialty pharmacy
dedicated to delivering world class comprehensive
homecare services. NBN
Infusions provides the highest quality of
care, clinical expertise, and patient satisfaction.
We are the “Champions of
Caring.”
It is important for patients to understand
the therapy that they are receiving. That
is why we are here to support you and
help answer any questions you may have
about this therapy.
Would You Like to Know More
About NBN Infusions?
Customer Service
1-800-253-9111
856-669-0217
Fax: 856-424-8913
Corporate Office
2 Pin Oak Lane, Suite 250
Cherry Hill, NJ 08003
Princeton Office
116 Village Boulevard
Princeton, NJ 08540
IVIG
Intravenous Immunoglobulin
Answers to some frequently
asked questions about IVIG
www.nbninfusions.com
Office Hours
Monday to Friday
8:30 AM to 5:00 PM
NBN Infusions, Inc. is privately owned. Our
mission is to integrate a caring approach with
“Champions of Caring”

What are Immunoglobulins?
Immunoglobulins are proteins manufactured
in the body via the blood. They help fight off
harmful bacteria, viruses, pollen and other
invaders. Immune globulin products are
derived from the plasma of a large number of
individuals who have developed antibodies
to various microorganisms. All donors and
their plasma go through careful screenings to
be sure that their blood is safe to use.
What are Primary Immune
Deficiency Diseases?
Primary immune deficiency diseases are
disorders in which part of the body’s immune
system is missing or does not function
properly. This is caused by intrinsic or
genetic defects in the immune system, unlike
secondary immune deficiency disease in
which the immune system is compromised by
factors outside the system (such as viruses or
chemotherapy).
What is the Purpose of IVIG?
There are four major classes of antibodies:
• Immunoglobulin G (Ig G)
• Immunoglobulin A (Ig A)
• Immunoglobulin M (Ig M)
• Immunoglobulin E (Ig E)
Each immunoglobulin class has special
chemical characteristics that provide it with
specific advantages.
Antibodies of the Ig G class are formed in
large quantities, last for over a month and
travel from the blood stream to the tissues
easily.
Antibodies of the Ig A class are produced
near mucous membranes and find their way
into secretions such as tears, bile, saliva and
mucus, where they protect against infection in
the respiratory tract and intestines.
Antibodies of the Ig M class are the first
antibodies formed in response to infection. They
are important in providing protection during the
early days of an infection.
Antibodies of the Ig E class are responsible for
protection during allergic reactions.
Is IVIG Safe?
Nearly 70% of primary immune deficient
patients use immune globulin intravenous
(IVIG) to maintain their health. IVIG is a pooled
plasma derivative administered intravenously
every three to four weeks that replaces
antibodies in the patients who are unable to
adequately produce these protective proteins
themselves.
IDF (Immune Deficiency Foundation) works
with the FDA and the IVIG manufacturers to
help ensure patient safety and adequate IVIG
supply.
Can IVIG Be Given During Pregnancy?
Yes, and no adjustments to therapy need to be
made.
Can IVIG Be Given In Any Other
Way Besides By Vein?
There have been a number of studies over the
years that demonstrate that immune globulin
(IG) can be infused subcutaneously (SQ) under
the skin in restricted volumes, with good clinical
results. Use of SQIG may be a good choice for
those with poor vascular access, very young
children, and those with numerous reactions to
the intravenous infusions. Immunology
specialists will be familiar with this technique
and can advise you whether or not it is
appropriate for you.
In 2006, an immune globulin preparation for
subcutaneous administration was licensed in the
United States.
What Are Some Types of Reactions
to Immune Globulin?
Some reactions are common during the first
infusion of IVIG after the diagnosis has been
established.
True allergic reactions are rare and occur early
during the time of infusion and are
characterized by hives, chest tightening,
difficulty swallowing or breathing, feeling
faint, abdominal discomfort and blood
pressure or pulse changes. The first response
should be to stop the infusion. Your medical
provider may then take steps if the symptoms
do not rapidly subside.
Headache, flushing, nausea, vomiting and/or
fatigue are the more common side effects.
These side effects generally occur at higher
infusion rates.
Is It OK to Exercise and Play Sports?
Yes. Physical activity and sports may help
improve your sense of well-being as you
participate in some of life’s enjoyable
activities.
Is it OK to Have Pets ?
Yes, but be aware that animals may carry
infections such as streptococcal infections that
can be transmitted to humans. Also, live
vaccines may be given to domestic pets and
could potentially pose a risk to the person
with primary immunodeficiency.
How is IVIG Reimbursed?
Ask your provider for an itemized bill to
clarify any questions, or ask your insurance
company of an Explanation of Benefits (EOB).
Reimbursement for IVIG may vary from year
to year and from plan to plan. It is very
important to understand your plan and
coverages.