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Bipolar Disorder: how effective is our<br />

screening in primary care<br />

April 2010 By Helena Du Toit, Raja Mukherjee, Rebecca Farrell <strong>and</strong> Sudhir Rastogi<br />

Introduction<br />

Bipolar Affective Disorder (BPD) is a<br />

serious, recurrent psychiatric illness<br />

characterised by periods of mania or<br />

hypomania, <strong>and</strong> depression (ICD-10,<br />

1992). BPD has a global prevalence of<br />

approximately 1-2%, which is stable over<br />

all population groups, however, when all<br />

forms of Bipolar Spectrum Disorder are<br />

included; the global lifetime prevalence<br />

rises to approximately 5% (Kessler RC et<br />

al, 1994; Angst J, 1998).<br />

It is a leading worldwide cause of disability<br />

(Hunter R et al, 2004), is associated with a<br />

high suicide risk (Sachs GS, 2003; Kasper,<br />

2003) <strong>and</strong> costs the UK economy about<br />

£2 billion per annum through active costs<br />

of managing the disorder as well as<br />

through loss of productivity (Das Gupta R<br />

& Guest JF, 2002).<br />

The condition usually presents in<br />

adolescence or early adulthood <strong>and</strong> has a<br />

recurring, often lifelong course, <strong>and</strong><br />

greatly affects the individual’s functioning<br />

in several areas <strong>and</strong> has wide reaching<br />

implications for close family, friends <strong>and</strong><br />

colleagues (Kasper S, 2003; Weissman<br />

MM et al, 1988; Stang P et al, 2007).<br />

In spite of this, it is often several years<br />

from the first presentation of the illness<br />

until the diagnosis is finally established,<br />

sometimes being delayed by as long as<br />

10 years. The under-recognition of BPD is<br />

due to several factors. Firstly, the illness<br />

often first presents with a depressive<br />

episode, <strong>and</strong> there may be several<br />

depressive episodes before the sufferer<br />

experiences a manic/hypomanic episode.<br />

These depressive episodes are often very<br />

difficult to distinguish from unipolar<br />

depression. Equally, the marked shifts in<br />

affect characteristic of emotionally<br />

unstable personality disorder <strong>and</strong><br />

cyclothymia can be mistaken for BPD<br />

(Corona et al, 2007). Additionally,<br />

patients often do not present to medical<br />

services during hypomanic <strong>and</strong><br />

sometimes even manic phases, as they<br />

find their increased energy levels <strong>and</strong><br />

creativity during these periods quite<br />

enjoyable <strong>and</strong> often do not recognize<br />

them as pathological. Furthermore,<br />

clinicians often fail to screen for a past<br />

history of manic/hypomanic symptoms in<br />

patients presenting with a depressive<br />

episode (Brickman et al, 2002). Delayed<br />

diagnosis often leads to inadequate<br />

management of the illness, with<br />

associated recurrent illness, diminished<br />

social <strong>and</strong> occupational functioning <strong>and</strong><br />

significant distress for both the sufferer<br />

<strong>and</strong> his/her family. To make matters<br />

worse, treating bipolar depression with<br />

antidepressant monotherapy is not only<br />

associated with a high rate of treatment<br />

failure, but also with a switch to rapid<br />

cycling BPD, increased mood instability<br />

<strong>and</strong> greater treatment resistance (Wehr<br />

TA & Goodwin FK, 1987).<br />

Conversely, there is good evidence that if<br />

the condition is diagnosed early <strong>and</strong><br />

managed appropriately, it is associated<br />

with a significantly improved outcome<br />

<strong>and</strong> preserved social <strong>and</strong> occupational<br />

functioning (Bauer MS et al, 2006; Perry<br />

A et al, 1999), as well as a significant<br />

decrease in the suicide risk.<br />

The Mood Disorders Questionnaire<br />

(MDQ) is a short, self administered<br />

questionnaire that has been validated in<br />

several countries (including the UK) as<br />

being an appropriate screening tool for<br />

use in the community or a primary care<br />

setting (Hirschfeld RM 2002; de Dois et<br />

al, 2008). It has both acceptable<br />

sensitivity <strong>and</strong> specificity to be used as a<br />

screening tool, <strong>and</strong> although some<br />

studies have suggested that the false<br />

positive rate is unacceptably high, the<br />

Research <strong>and</strong> Audit<br />

<strong>Surrey</strong> <strong>and</strong> <strong>Borders</strong> Online Journal www.sabp.nhs.uk/journal 9

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