Dr. M. Ashraful Hoque - Rajshahi University

Profile of Md. Ashraful Hoque
Name
Designation
Md. Ashraful Hoque
Assistant Professor
Mailing Address Department of Biochemistry and Molecular Biology
University of Rajshahi, Rajshahi-6205, Bangladesh.
E-Mail
ashraf_bio2003@yahoo.com
Cell Phone +88 01556 309076
Nationality Bangladeshi by birth
Specialization Synthetic Organic Chemistry, Peptide Chemistry,
Epigenetic Drug Design and Synthesis.
Research Skills
Experienced in the design, synthesis and characterization of organic compounds
especially biologically important compounds and peptides as possible candidate for
epigenetic drugs. Familiar with chromatographic techniques like TLC, column
chromatography, gel filtration, HPLC and with many other analytical techniques
including NMR, LC-MS, CD spectroscopy.
Educational
Qualifications
• Ph.D. in Peptide and Organic Chemistry (March 2012)
Department of Biological Functions and Engineering, Graduate School of Life
Science and Systems Engineering, Kyushu Institute of Technology, Japan.
Thesis Title: Design and Synthesis of CyclicTetrapeptides Containing Thioester
& Disulfide Bridge as Inhibitors of Histone Deacetylases.
• M.Sc. in Biochemistry (1992), University of Rajshahi, Bangladesh.
Result: First class.
Major courses: Molecular Biology & Genetics, Biophysical Chemistry,
Intermediary Metabolism, Endocrinology & Clinical Biochemistry etc.
• B.Sc. in Biochemistry (1991), University of Rajshahi, Bangladesh.
Result: First class.
Major courses: Physiology & Microbial Biochemistry, Nutrition,
Bio-energetics, Organic Chemistry & Biomolecules etc.
• H.S.C. in Science (1988), Rajshahi Education Board, Bangladesh.
Result: First division.
• S.S.C. in Science (1886), Rajshahi Education Board, Bangladesh.
Result: First division.
Employment Dec, 2003 - Date Assistant Professor, Dept. of Biochemistry & Molecular
Biology University of Rajshahi, Bangladesh.
Dec, 2002 - Dec, 2003 Lecturer, Dept. of Biochemistry & Molecular Biology
University of Rajshahi, Bangladesh.
Oct, 1998 - Dec, 2002 Lecturer, Dept. of Biochemistry, JRR Medical College,
Sylhet, Bangladesh.

Publications 1. Md. Ashraful Hoque, Toru Arai, Norikazu Nishino, Hyun-Jung Kim, Akihiro Ito and
Minoru Yoshida. 2012. Cyclic tetrapeptides with thioacetate tails or intramolecular
disulfide bridge as potent inhibitors of histone deacetylases. Bioorganic & Medicinal
Chemistry Letters, Ms. Ref. No.: BMCL-D-11-02414R1 (Accepted).
2. Md. Ashraful Hoque, Norikazu Nishino, Hyun-Jung Kim, Akihiro Ito and Minoru
Yoshida. 2010. Bicyclic Tetrapeptides with Disulfide as Histone Deacetylase
Inhibitors. Peptide Science, p.243.
3. Ali N, Hoque M.A, Haque A, Salam KA, Karim MR, Rahman A, Islam K, Saud ZA, Khalek
MA, Akhand AA, Hossain M, Mandal A, Karim MR, Miyataka H, Himeno S, Hossain K.
2010 Jul 10; Association between arsenic exposure and plasma cholinesterase
activity: a population based study in Bangladesh. Environ Health. 9:36.
4. Hossain, K., Kawamoto, Y., Hamada, M., Akhand, AA., Yanagishita, T., Hoque,
M.A., Tsuboi, H., Kato, M. and Nakashima, I. 2009 Oct 14. 1,4-butanediylbismethanethiosulfonate
(BMTS) induces apoptosis through reactive oxygen
species-mediated mechanism. J Cell Biochem.
5. Imtiaj Hasan, Syed Rashel Kabir, Md. Ashraful Hoque, Nurul Absar. 2009.
Biochemical Analysis and Physicochemical Stability of a partially purified lectin
from Hilsha Eggs. Journal of Bio-science (JB), J. bio-sci.17: 35-40, ISSN
1023-8654. http://www.banglajol.info/bd/index.php/JBS/article/view/7097
6. Nikkon, F., Hasan, S., Hoque, M.A., Habibur, M.H., Mosaddik, A. and
Haque,M.E. 2008. Biochemical, hematological and histopathologocal effects of
Duranta repens stems on rats. Asian J. Biochem., 3(6): 366-372.
7. Hoque, M.A., Hoque, S., Karim, M.R. and Absar, N. 2008. Activities of protease,
amylase and cellulase in ber (Zizypus mauritiana Lam.) at three different
maturity levels. J. Bangladesh Soc. Agril. Sci. Tech., 5(1&2): 33-36.
8. Hoque, M.A., Salam, K.A., Hoque, S., Karim, M.R. and Absar. N. 2008.
Physico-chemical properties of ber (Zizypus mouritiana lam.) at three different
maturity levels. J. Bangladesh Soc. Agril. Sci. Tech., 5(3&4): 67-70.
9. Noman, A.S.M., Hoque, M.A., Hoque, M.M., Pervin, F. and Karim, M.R. 2007.
Nutritional and anti-nutritional components in pachyrhizus erosus L. tuber. Food
Chemistry, 102(4): 1112-1118. www.elsevier.com/locate/foodchem.
10. Noman, A.S.M., Hoque, M.A., Sen, P.K. and Karim, M.R. 2006. Purification and
some properties of -amylase from post harvest pachyrhizus eroses L. tuber.
Food chemistry, 99: 444-449. www.elsevier.com/locate/foodchem.
11. Quaium, S.M.M.A., Hoque, M.A., Haque, A.K.M.A. and Ahmad, R.U. 2003.
Prevalence of iron deficiency in children. Bangladesh Medical Review, XXIX(1-
2): 13-14.
12. Rahman, M.L., Absar, N., Hoque, M.A. and Ali, M.M. 2002. A Comparative
analysis on the characteristics of five different varieties of rice bran. J. Bio-Sci.,
10: 69-73.
13. Hoque, M.A., Absar, N., Karim, M.R. and Hassan, P. 1998. Purification and
characterization of amylase (Zizypus mauritiana Lam) flesh of local-3 variety at
mature stage. J. Bio-Sci., 6: 41-50.
Conference
presentation
1. Poster presentation: Bicyclic Tetrapeptides with Disulfide as Histone Deacetylase
Inhibitors. Md. Ashraful Hoque, Norikazu Nishino, Hyun-Jung Kim, Akihiro Ito
and Minoru Yoshida. 5 th International Peptide symposium, Kyoto, Japan 2010.
Language
proficiency
Bengali
English
Japanese
Mother Tongue
Able to speak read and write fluently
Poor in listening and speaking.