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Injuries of nerves and their consequences - Reflex Sympathetic ...

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TREATMENT. 271<br />

patient who receives a half-grain or more <strong>of</strong> morphia<br />

may become presently free from pain, <strong>and</strong> yet walk about<br />

with little or no desire to sleep. The ability to lessen<br />

pain is not therefore <strong>of</strong> necessity connected with the sleepcompelling<br />

potency. Where, however, the latter is inconveniently<br />

felt, <strong>and</strong> w^e desire the former only, it is possible<br />

to attain the end in view by using with the morphia<br />

a certain share <strong>of</strong> atropia. Thus, if we inject half a grain<br />

<strong>of</strong> sulphate <strong>of</strong> morphia, <strong>and</strong> with it the thirtieth <strong>of</strong> a<br />

grain <strong>of</strong> sulphate <strong>of</strong> atropia, the anaesthetic force <strong>of</strong> the<br />

morphia will rest unaltered, but the tendency to sleep<br />

will be greatly diminished. The views here set forth<br />

were reached after long <strong>and</strong> careful experiments on large<br />

numbers <strong>of</strong> men,* <strong>and</strong> seem to justify the practice <strong>of</strong> using<br />

atropia <strong>and</strong> morphia together.<br />

As regards the place <strong>of</strong> injection, I agree with most<br />

observers that it is generally <strong>of</strong> little moment, the effect<br />

being the same whether it be thrown into the atfected<br />

limb or into a remote part. The single exception to this<br />

I shall presently — mention.<br />

Manipulation. I have elsewhere spoken <strong>of</strong> the use <strong>of</strong><br />

massage in restoring the nutrition <strong>and</strong> motions <strong>of</strong> a limb.<br />

It is only <strong>of</strong> late that I have sought to control pain <strong>and</strong><br />

alter the nutritive state <strong>of</strong> a diseased nerve trunk by this<br />

means. A case <strong>of</strong> contusion <strong>of</strong> the ulnar nerve became<br />

subject to intense neuralgia, the nerve being hardened<br />

<strong>and</strong> enlarged, owing, probabl}^ to subacute neuritis. It<br />

was very tender, <strong>and</strong> no application <strong>of</strong> electricity<br />

was<br />

borne with any patience. The pain was relieved by<br />

hypodermic injections, but after using many remedies,<br />

* Antagonism <strong>of</strong> Atropia <strong>and</strong> Morphia, etc., S. Weir Mitchell, W. W.<br />

Keen, <strong>and</strong> G. R. Morehouse, Am. Joiirn. Med. Sci., July, 1865. These researches<br />

led us to the conclusion that the two drugs are mutually antagonistic<br />

thrnuL^h a part only <strong>of</strong> <strong>their</strong> range <strong>of</strong> symptoms, even agreeing<br />

as to some <strong>of</strong> <strong>their</strong> modes <strong>of</strong> activity.

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