Complex Regional Pain Syndrome - Reflex Sympathetic Dystrophy ...

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Nerve Injury Spinal Glutamate Release •Increased spontaneous activity of primary afferent •Loss of inhibitory neurons •Activation of immediate early genes •Phosphorylation of channels and receptors LONG TERM/PERSISTENT CHANGES IN FUNCTION
Nerve Injury Activation of non neuronal cells (astrocytes, spinal microglia) •Increased spinal expression of COX, NOS, glutamate transporters, proteinases LONG TERM/PERSISTENT CHANGES IN FUNCTION
Page 1 and 2: Complex Regional Pain Syndrome: Pat
Page 5: HEAT HYPERALGESIA IN CRPS • Early
Page 9 and 10: COLD ALLODYNIA IN CRPS • Late phe
Page 11 and 12: Pathophysiologic Mechanisms of CPRS
Page 13 and 14: Sensory Abnormalities in CRPS What
Page 15 and 16: Neuropathic Pain Sympathetically In
Page 17 and 18: Complex Regional Pain Syndrome and
Page 19 and 20: Sympathetic Nervous System and Pain
Page 21 and 22: Nerve Injury •Cross talk between
Page 23 and 24: Autonomic Dysfunction • Hyperhydr
Page 25 and 26: Neurogenic Inflammation • Extensi
Page 27 and 28: Motor Abnormalities • About 50% o
Page 29 and 30: Other Possible Mechanisms • Persi
Page 31 and 32: Nerve Injury •Cross talk between
Page 33: Nerve Injury Dorsal Horn Sprouting
Page 37 and 38: Summary • CRPS has an extremely c

Complex Regional Pain Syndrome - Reflex Sympathetic Dystrophy ...

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