Complex Regional Pain Syndrome - Reflex Sympathetic Dystrophy ...

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Nerve Injury Dorsal horn “dark staining” neurons Reduced dorsal horn GABA/ Glycine Tactile Allodynia (reflects ongoing role of tonic or evoked inhibition of large afferent evoked dorsal horn Excitation, which is read out as a “painful state”)
Nerve Injury Dorsal Horn Sprouting Normal terminations of primary afferents in the dorsal horn After nerve injury, C-fiber terminals atrophy and A-fiber terminals sprout into the superficial dorsal horn Adapted from Woolf CJ, Mannion RJ. Lancet. 1999;353:1959-1964.
Page 1 and 2: Complex Regional Pain Syndrome: Pat
Page 5: HEAT HYPERALGESIA IN CRPS • Early
Page 9 and 10: COLD ALLODYNIA IN CRPS • Late phe
Page 11 and 12: Pathophysiologic Mechanisms of CPRS
Page 13 and 14: Sensory Abnormalities in CRPS What
Page 15 and 16: Neuropathic Pain Sympathetically In
Page 17 and 18: Complex Regional Pain Syndrome and
Page 19 and 20: Sympathetic Nervous System and Pain
Page 21 and 22: Nerve Injury •Cross talk between
Page 23 and 24: Autonomic Dysfunction • Hyperhydr
Page 25 and 26: Neurogenic Inflammation • Extensi
Page 27 and 28: Motor Abnormalities • About 50% o
Page 29 and 30: Other Possible Mechanisms • Persi
Page 31: Nerve Injury •Cross talk between
Page 35 and 36: Nerve Injury Activation of non neur
Page 37 and 38: Summary • CRPS has an extremely c

Complex Regional Pain Syndrome - Reflex Sympathetic Dystrophy ...

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