Complex Regional Pain Syndrome - Reflex Sympathetic Dystrophy ...

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Sensory Abnormalities in CRPS • Hypoesthesia/hypoalgesia throughout the affected half of the body (Rommel et al, 2001) – Increased thresholds to mechanical and thermal stimuli on the affected side • Due to changes in the thalamus and cortex (Maleki et al, 2000) – PET studies have demonstrated adaptive changes in the thalamus (Fukumoto et al, 1999) – Shortened distance between little finger and thumb representations in the primary sensory cortex (Juottonen et al, 2002; Baron et al, 2000)
Sensory Abnormalities in CRPS What we know • Numerous sensory abnormalities exist • Sensory abnormalities not limited to the painful area but may include entire half of body What we don’t know • Are these sensory abnormalities the result of the ongoing nociceptive input or are they specific to the disease?
Page 1 and 2: Complex Regional Pain Syndrome: Pat
Page 5: HEAT HYPERALGESIA IN CRPS • Early
Page 9 and 10: COLD ALLODYNIA IN CRPS • Late phe
Page 11: Pathophysiologic Mechanisms of CPRS
Page 15 and 16: Neuropathic Pain Sympathetically In
Page 17 and 18: Complex Regional Pain Syndrome and
Page 19 and 20: Sympathetic Nervous System and Pain
Page 21 and 22: Nerve Injury •Cross talk between
Page 23 and 24: Autonomic Dysfunction • Hyperhydr
Page 25 and 26: Neurogenic Inflammation • Extensi
Page 27 and 28: Motor Abnormalities • About 50% o
Page 29 and 30: Other Possible Mechanisms • Persi
Page 31 and 32: Nerve Injury •Cross talk between
Page 33 and 34: Nerve Injury Dorsal Horn Sprouting
Page 35 and 36: Nerve Injury Activation of non neur
Page 37 and 38: Summary • CRPS has an extremely c

Complex Regional Pain Syndrome - Reflex Sympathetic Dystrophy ...

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